Cited by 49Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchTreatment of Major Depression

Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

Sekine, Yoshimoto, Suzuki, Katsuaki, Ramachandran, P. Veeraraghavan, Blackburn, Thomas P., Ashby, Charles R.·2007·Synapse

Abstract

We examined the effect of the administration of the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, citalopram, and paroxetine on the activity of spontaneously active dopamine (DA) neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in anesthetized adult male Sprague–Dawley rats. This was accomplished using the technique of in vivo extracellular recording. A single injection of 2.5 mg/kg (i.p.) of fluoxetine significantly increased the number of spontaneously active SNC and VTA DA neurons. In contrast, a single injection of either 1 mg/kg (i.p.) of paroxetine or 5 mg/kg of fluoxetine significantly increased the number of spontaneously active VTA DA neurons. The repeated administration (one injection per day for 21 days) of all of the SSRIs produced a significant increase in the number of spontaneously active VTA DA neurons. Overall, our results indicate that the systemic administration of SSRI alters the activity of midbrain DA neurons with differential effects on VTA compared with SNC DA neurons. Synapse 61:72–77, 2007. © 2006 Wiley‐Liss, Inc.

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Crossref · 10.1002/syn.20349

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Authors
Sekine, Y., Suzuki, K., Ramachandran, P. V., Blackburn, T. P., & Ashby, C. R.
Affiliations
  • Hamamatsu University School of Medicine (JP)
  • Purdue University West Lafayette (US)
  • St. John's University (US)
Corresponding author
Ashby, Charles R.
Venue
Synapse
Publisher
Wiley
Published
2006-11-20
Volume
61
Issue
2
Pages
72-77
ISSN
  • 0887-4476 (ISSN-L)
  • 1098-2396
OpenAlex
W2103263767
Cited by
49
References
61
Citations by year
2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Locations
  • Synapse (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
fluoxetine, citalopram, paroxetine, selective serotonin reuptake inhibitors, dopaminergic neurons, substantia nigra pars compacta, ventral tegmental area, spontaneous neuronal activity, repeated dosing
MeSH terms
Action Potentials, Analysis of Variance, Animals, Dopamine, Drug Administration Schedule, Fluoxetine, Male, Mesencephalon, Neurons, Citalopram, Rats, Sprague-Dawley, Selective Serotonin Reuptake Inhibitors, Paroxetine, Rats

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