Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study
Abstract
We examined the effect of the administration of the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, citalopram, and paroxetine on the activity of spontaneously active dopamine (DA) neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in anesthetized adult male Sprague–Dawley rats. This was accomplished using the technique of in vivo extracellular recording. A single injection of 2.5 mg/kg (i.p.) of fluoxetine significantly increased the number of spontaneously active SNC and VTA DA neurons. In contrast, a single injection of either 1 mg/kg (i.p.) of paroxetine or 5 mg/kg of fluoxetine significantly increased the number of spontaneously active VTA DA neurons. The repeated administration (one injection per day for 21 days) of all of the SSRIs produced a significant increase in the number of spontaneously active VTA DA neurons. Overall, our results indicate that the systemic administration of SSRI alters the activity of midbrain DA neurons with differential effects on VTA compared with SNC DA neurons. Synapse 61:72–77, 2007. © 2006 Wiley‐Liss, Inc.
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Other antidepressants or electroconvulsive therapy increase burst firing.
“other antidepressants or electroconvulsive therapy increase burst firing [63, 64].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [64]
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Treutlein, J., Krämer, B., & Gruber, O. (2025) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2025.2522793
van den Buuse, M., Wilson, K.-E., Payet, J. M., & Hale, M. W. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.09.032
- Authors
- Sekine, Y., Suzuki, K., Ramachandran, P. V., Blackburn, T. P., & Ashby, C. R.
- Affiliations
- Hamamatsu University School of Medicine (JP)
- Purdue University West Lafayette (US)
- St. John's University (US)
- Corresponding author
- Ashby, Charles R.
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 2006-11-20
- Volume
- 61
- Issue
- 2
- Pages
- 72-77
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- OpenAlex
- W2103263767
- Cited by
- 49
- References
- 61
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- fluoxetine, citalopram, paroxetine, selective serotonin reuptake inhibitors, dopaminergic neurons, substantia nigra pars compacta, ventral tegmental area, spontaneous neuronal activity, repeated dosing
- MeSH terms
- Action Potentials, Analysis of Variance, Animals, Dopamine, Drug Administration Schedule, Fluoxetine, Male, Mesencephalon, Neurons, Citalopram, Rats, Sprague-Dawley, Selective Serotonin Reuptake Inhibitors, Paroxetine, Rats
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