Effects of chronic antidepressant drug administration and electroconvulsive shock on activity of dopaminergic neurons in the ventral tegmentum
Open accessAbstract
Increasing attention is now focused on reduced dopaminergic neurotransmission in the forebrain as participating in depression. The present paper assessed whether effective antidepressant (AD) treatments might counteract, or compensate for, such a change by altering the neuronal activity of dopaminergic neurons in the ventral tegmental area (VTA-DA neurons), the cell bodies of the mesocorticolimbic dopaminergic system. Eight AD drugs or vehicle were administered to rats for 14 d via subcutaneously implanted minipumps, at which time single-unit electrophysiological activity of VTA-DA neurons was recorded under anaesthesia. Further, animals received a series of five electroconvulsive shocks (ECS) or control procedures, after which VTA-DA activity was measured either 3 d or 5 d after the last ECS. Results showed that the chronic administration of all AD drugs tested except for the monoamine oxidase inhibitor increased the spontaneous firing rate of VTA-DA neurons, while effects on 'burst' firing activity were found to be considerably less notable or consistent. ECS increased both spontaneous firing rate and burst firing of VTA-DA neurons. It is suggested that the effects observed are consistent with reports of increased dopamine release in regions to which VTA neurons project after effective AD treatment. However, it is further suggested that changes in VTA-DA neuronal activity in response to AD treatment should be most appropriately assessed under conditions associated with depression, such as stressful conditions.
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Other antidepressants or electroconvulsive therapy increase burst firing.
“other antidepressants or electroconvulsive therapy increase burst firing [63, 64].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [63]
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- Authors
- West, C. H. K., & Weiss, J. M.
- Affiliations
- Emory University (US)
- ORCID
- Weiss, Jay M.
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05-19
- Volume
- 14
- Issue
- 02
- Pages
- 201-210
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- PMC
- PMC3032823
- OpenAlex
- W2131711336
- Cited by
- 30
- References
- 99
- Citations by year
- 2024: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH065737, R01MH079794, MH65737, MH79794)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- antidepressants, electroconvulsive shock, ventral tegmental area, dopaminergic neurons, spontaneous firing rate, burst firing, mesocorticolimbic dopamine system, depression, dopamine release, monoamine oxidase inhibitors, chronic drug administration
- MeSH terms
- Animals, Antidepressive Agents, Dopamine, Electroshock, Male, Synaptic Transmission, Neurons, Time Factors, Infusion Pumps, Implantable, Rats, Sprague-Dawley, Ventral Tegmental Area, Rats, Electrophysiological Phenomena
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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