Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice
Open accessAbstract
Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after administration of fluoxetine in normal adult mice. We find that 64 miRNAs showed significant changes between fluoxetine treatment and control groups by analyzing 626 mouse miRNAs. Many miRNAs in response to fluoxetine are involved in neural-related signaling pathways by analyzing miRNA-target gene pairs using the Kyoto encyclopedia of genes and genomes (KEGG) and Gene Ontology (GO). Moreover, miRNAs with altered expression are mainly associated with the repression of the dopaminergic synapse signals, which may affect hippocampal function after fluoxetine treatment. Our results demonstrate that a number of miRNAs respond to antidepressants even in normal mice and may affect target gene expression, which supports the safety consideration of inappropriate treatment and off-label use of antidepressant drugs.
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Fluoxetine downregulated miR-598-5p and miR-451 in hippocampus of mouse brain.
“and downregulated miR-598-5p and miR-451 in hippocampus of mouse brain.331”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [331]
Results §2.1 reports that fluoxetine-treated adult mice had lower hippocampal expression of 25 miRNAs than controls. However, the passages retrieved for miR-598-5p and miR-451 do not identify either among those downregulated miRNAs, so the specific claim is not established by our copy. (LLM, conf=0.76)
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- Authors
- Miao, N., Jin, J., Kim, S.-N., & Sun, T.
- Affiliations
- Huaqiao University (CN)
- Cornell University (US)
- Dongguk University (KR)
- Corresponding author
- Sun, Tao
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-02-27
- Volume
- 19
- Issue
- 3
- Pages
- 671
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5877532
- OpenAlex
- W2793099401
- Cited by
- 19
- References
- 74
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- NIH/NIMH (R01-MH083680)
- National Natural Science Foundation of China (81471152, 31771141, 81701132)
- China Postdoctoral Science Foundation (2017M622053)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fluoxetine, microRNA, hippocampus, antidepressants, depression, anxiety, miRNA target genes, antidepressant safety, gene expression changes
- MeSH terms
- Animals, Antidepressive Agents, Fluoxetine, Gene Expression Regulation, Hippocampus, Synaptic Transmission, Computational Biology, Gene Expression Profiling, RNA Interference, MicroRNAs, Mice, Gene Regulatory Networks, Dopaminergic Neurons, Gene Ontology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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