The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mapping cocaine binding sites in human and baboon brain in vivo
Abstract
The first direct measurements of cocaine binding in the brain of normal human volunteers and baboons have been made by using positron emission tomography (PET) and tracer doses of [N‐11 C‐methyl]‐(–)‐cocaine ([11 C]cocaine). Cocaine's binding and release from brain are rapid with the highest regional uptake of carbon‐11 occurring in the corpus striatum at 4–10 minutes after intravenous injection of labeled cocaine. This was followed by a clearance to half the peak value at about 25 minutes with the overall time course paralleling the previously documented time course of the euphoria experienced after intravenous cocaine administration. Blockade of the dopamine reuptake sites with nomifensine reduced the striatal but not the cerebellar uptake of [11 C]cocaine in baboons indicating that cocaine binding is associated with the dopamine reuptake site in the corpus striatum. A comparison of labeled metabolites of cocaine in human and baboon plasma showed that while cocaine is rapidly metabolized in both species, the profile of labeled metabolites is different, with baboon plasma containing significant amounts of labeled carbon dioxide, and human plasma containing no significant labeled carbon dioxide. These studies demonstrate the feasibility of using [11 C]cocaine and PET to map binding sites for cocaine in human brain, to monitor its kinetics, and to characterize its binding mechanism by using appropriate pharmacological challenges.
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Cites
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Gawin, F. H., & Ellinwood, E. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805053181806 · Cited by 965
Cited by
Acute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924
Self-citationVolkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Hitzemann, R., & Pappas, N. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1325 · Cited by 885
Self-citationEvaluating Dopamine Reward Pathway in ADHD: Clinical Implications
Volkow, N. D., Wang, G.-J., Kollins, S. H., Wigal, T. L., Newcorn, J. H., Telang, F., Fowler, J. S., Zhu, W., Logan, J., Ma, Y., et al. (2009) · JAMA · doi:10.1001/jama.2009.1308 · Cited by 728
“53Ci/μmolat endofbombardment)andwereobtained fora totalof60minutesaspreviouslydescribed.(18,19) Arterial blood was obtained to measure the concentration of unchanged [(11)C]raclopride(18) and [(11)C]cocaine(19) inplasma.”
Self-citationVolkow, N. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950180042006 · Cited by 575
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Metadata
- Authors
- Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., Hitzemann, R., Logan, J., Bendriem, B., Gatley, S. J., & Christman, D.
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 1989-01
- Volume
- 4
- Issue
- 4
- Pages
- 371-377
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- OpenAlex
- W2062608310
- Cited by
- 290
- References
- 2
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., Hitzemann, R., Logan, J., Bendriem, B., Gatley, S. J., & Christman, D. (1989). Mapping cocaine binding sites in human and baboon brain in vivo. Synapse. https://doi.org/10.1002/syn.890040412
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