Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
Abstract
OBJECTIVE: The therapeutic effects of methylphenidate in the treatment of attention deficit disorder have been attributed to its ability to increase the synaptic concentration of dopamine by blocking the dopamine transporters. However, the levels of dopamine transporter blockade achieved by therapeutic doses of methylphenidate are not known. This study measured, for the first time, dopamine transporter occupancy by orally administered methylphenidate in the human brain and its rate of uptake in the brain. METHOD: Positron emission tomography (PET) and [11C]cocaine were used to estimate dopamine transporter occupancies after different doses of oral methylphenidate in seven normal subjects (mean age=24 years, SD=7). In addition, the pharmacokinetics of oral methylphenidate were measured in the baboon brain through use of PET and [11C]methylphenidate administered through an orogastric tube. RESULTS: At 120 minutes after administration, oral methylphenidate produced a dose-dependent blockade of dopamine transporter; means=12% (SD= 4%) for 5 mg, 40% (SD=12%) for 10 mg, 54% (SD=5%) for 20 mg, 72% (SD=3%) for 40 mg, and 74% (SD=2%) for 60 mg. The estimated dose of oral methylphenidate required to block 50% of the dopamine transporter corresponded to 0.25 mg/kg. Oral methylphenidate did not reach peak concentration in brain until 60 minutes after its administration. CONCLUSIONS: Oral methylphenidate is very effective in blocking dopamine transporters, and at the weight-adjusted doses used therapeutically (0.3 to 0.6 mg/kg), it is likely to occupy more than 50% of the dopamine transporters. The time to reach peak brain uptake for oral methylphenidate in brain corresponds well with the reported time course to reach peak behavioral effects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Methylphenidate and similar stimulants act on dopamine reward circuitry that is disrupted in ADHD and may explain the broad effects of stimulant treatment.
“Stimulant treatment, such as methylphenidate, is known to act directly on brain regions associated with disrupted dopamine reward pathways in ADHD [62,63] and may be responsible for the global effects seen with stimulant treatment in ADHD.”
From Will Working Memory Training Generalize to Improve Off-Task Behavior in Children with Attention-Deficit/Hyperactivity Disorder? (2012) · cites this paper as [62]
Methylphenidate blood levels are associated with the level of dopamine transporter blockade.
“Because MP blood levels are associated with the level of DAT blockade (Volkow et al., 1998) and the concentration of MP in plasma after intravenous MP did not differ for treatment-naive and long-term treatment conditions, the lower DA increases in striatum over the year of treatment suggest changes that decrease DA release.”
From Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder (2012) · cites this paper as Volkow et al., 1998
Cites
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070 · see citing works
Logan, J., Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., HITZEMANN, R. J., Bendriem, B., Gatley, S. J., et al. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.127 · Cited by 1,481 · see citing works
Self-citationRelationship between subjective effects of cocaine and dopamine transporter occupancy
Volkow, N. D., Wang, G., Fischman, M. W., Foltin, R. W., Fowler, J. S., Abumrad, N. N., Vitkun, S. A., Logan, J., Gatley, S. J., Pappas, N. R., et al. (1997) · Nature · doi:10.1038/386827a0 · Cited by 646 · see citing works
Self-citationAttention-deficit hyperactivity disorder and hyperkinetic disorder
Jm, S., Sergeant, J. A., Taylor, E. A., Sonuga-Barke, E. J. S., Jensen, P. S., & Dp, C. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11450-7 · Cited by 602 · see citing works
Volkow, N. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950180042006 · Cited by 575 · see citing works
Self-citationBergman, J., Madras, B. K., Johnson, S. E., & Spealman, R. D. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20689-9 · Cited by 394 · see citing works
Medication treatment strategies in the MTA Study: relevance to clinicians and researchers
GREENHILL, L. L., ABIKOFF, H. B., ARNOLD, L. E., CANTWELL, D. P., CONNERS, C. K., ELLIOTT, G., HECHTMAN, L., HINSHAW, S. P., HOZA, B., JENSEN, P. S., et al. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199610000-00017 · Cited by 297 · see citing works
Mapping cocaine binding sites in human and baboon brain in vivo
Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., HITZEMANN, R. J., Logan, J., Bendriem, B., Gatley, S. J., et al. (1989) · Synapse · doi:10.1002/syn.890040412 · Cited by 290 · see citing works
Self-citationFIXED‐INTERVAL SCHEDULE OF COCAINE REINFORCEMENT: EFFECT OF DOSE AND INFUSION DURATION<sup>1</sup>
Balster, R. L., & Schuster, C. R. (1973) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1973.20-119 · Cited by 290 · see citing works
Utility of subjective‐effects measurements in assessing abuse liability of drugs in humans
Fischman, M. W., & Foltin, R. W. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01749.x · Cited by 267 · see citing works
A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey.
Johanson, C. E., & Schuster, C. R. (1975) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30186-2 · Cited by 235 · see citing works
Pharmacokinetics of methylphenidate in man, rat and monkey.
Wargin, W. A., Patrick, K. S., Kilts, C. D., Gualtieri, C. T., Ellington, K. R., Mueller, R. A., Kraemer, G. W., & Breese, G. R. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21542-7 · Cited by 223 · see citing works
Dewey, S. L., Smith, G., Logan, J., Brodie, J. D., Yu, D.-W., Ferrieri, R. A., King, P., MacGregor, R. R., Martin, T., & Wolf, A. P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-10-03773.1992 · Cited by 211 · see citing works
Self-citationLogan, J., Volkow, N. D., Fowler, J. S., Wang, G., Dewey, S. L., MacGregor, R. R., Schlyer, D. J., Gatley, S. J., Pappas, N. R., King, P. T., et al. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.132 · Cited by 167 · see citing works
Self-citationMETABOLISM AND DISPOSITION OF METHYLPHENIDATE-14C: STUDIES IN MAN AND ANIMALS
Faraj, B. A., Israili, Z. H., Perel, J. M., Jenkins, M. L., Holtzman, S. G., Cucinell, S. A., & Dayton, P. G. (1974) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30016-9 · Cited by 161 · see citing works
Schweri, M. M., Skolnick, P., Rafferty, M. F., Rice, K. C., Janowsky, A. J., & Paul, S. M. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb05524.x · Cited by 151 · see citing works
Relationship between psychostimulant-induced "high" and dopamine transporter occupancy.
Volkow, N. D., Wang, G. J., Fowler, J. S., Gatley, S. J., Ding, Y. S., Logan, J., Dewey, S. L., Hitzemann, R., & Lieberman, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10388 · Cited by 149 · see citing works
Self-citationIntravenous methylphenidate abuse. Prototype for prescription drug abuse
Parran, T. V. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.4.781 · Cited by 143 · see citing works
Perez‐Reyes, M., Guiseppi, S. D., Ondrusek, G., et al. (1982) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1982.189 · Cited by 142 · see citing works
Castellanos, F. X., Elia, J., Kruesi, M. J. P., Marsh, W., Gulotta, C. S., Potter, W. Z., Ritchie, G. F., Hamburger, S. D., & Rapoport, J. L. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00077-q · Cited by 129 · see citing works
More Frequent Diagnosis of Attention Deficit–Hyperactivity Disorder
Swanson, J. M., Lerner, M., & Williams, L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510053331419 · Cited by 129 · see citing works
Srinivas, N. R., Hubbard, J. W., Quinn, D., & Midha, K. K. (1992) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1992.185 · Cited by 120 · see citing works
Shaywitz, S. E., Hunt, R. D., Jatlow, P. L., Cohen, D. J., Young, J. G., Pierce, R. N., Anderson, G., & Shaywitz, B. A. (1982) · PEDIATRICS · doi:10.1542/peds.69.6.688 · Cited by 104 · see citing works
From Coca Leaves to Crack: The Effects of Dose and Routes of Administration in Abuse Liability
Verebey, K., & Gold, M. S. (1988) · Psychiatric Annals · doi:10.3928/0048-5713-19880901-06 · Cited by 99 · see citing works
Ding, Y., Fowler, J. S., Volkow, N. D., Gatley, S. J., Logan, J., Dewey, S. L., Alexoff, D. L., Fazzini, E., & Wolf, A. P. (1994) · Synapse · doi:10.1002/syn.890180207 · Cited by 71 · see citing works
Self-citationWang, G., Volkow, N. D., HITZEMANN, R. J., Wong, C., ANGRIST, B. M., Burr, G., Pascani, K., Pappas, N. R., Lu, A., Cooper, T. B., et al. (2009) · European Addiction Research · doi:10.1159/000259147 · Cited by 70 · see citing works
Self-citationReinforcing and subjective effects of methylphenidate in humans
Chait, L. D. (1994) · Behavioural Pharmacology · doi:10.1097/00008877-199406000-00005 · Cited by 69 · see citing works
Localization of GTP cyclohydrolase in monoaminergic but not nitric oxide-producing cells
Hwang, O., Baker, H. A., Gross, S. S., & JOH, T. H. (1998) · Synapse · doi:10.1002/(sici)1098-2396(199802)28:2 · Cited by 62 · see citing works
Plasma input function determination for PET using a commercial laboratory robot
Alexoff, D. L., Shea, C. E., Fowler, J. S., et al. (1995) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(95)00042-v · Cited by 52 · see citing works
Self-citationCarbon-11-cocaine binding compared at subpharmacological and pharmacological doses: a PET study.
Volkow, N. D., Fowler, J. S., Logan, J., Gatley, S. J., Dewey, S. L., MacGregor, R. R., Schlyer, D. J., Pappas, N. R., King, P., & Wang, G. (1995) · PubMed · Cited by 47 · see citing works
Self-citationSome Relationships Between Addiction and Drug Delivery to the Brain
Oldendorf, W. H. (1992) · PsycEXTRA Dataset · doi:10.1037/e496142006-004 · Cited by 44 · see citing works
Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humans
Srinivas, N. R., Hubbard, J. W., Quinn, D., Korchinski, E. D., & Midha, K. K. (1991) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(91)90083-d · Cited by 38 · see citing works
Aoyama, T., Kotaki, H., Sasaki, T., et al. (1993) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315285 · Cited by 37 · see citing works
Ding, Y., Sugano, Y., Fowler, J. S., et al. (1994) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.2580341012 · Cited by 33 · see citing works
Self-citationPharmacological Treatment of Psychiatric Disorders in Children and Adolescents
CARREY, N. J., Wiggins, D. M., & Milin, R. (1996) · Drugs · doi:10.2165/00003495-199651050-00004 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
Self-citationInsights into the ageing mind: a view from cognitive neuroscience
Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Attention-deficit hyperactivity disorder
Biederman, J., & Faraone, S. V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66915-2 · Cited by 1,463 · see citing works
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035 · see citing works
Greenhill, L. L., Pliszka, S., & Dulcan, M. K. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200202001-00003 · Cited by 927 · see citing works
Misuse and Diversion of Stimulants Prescribed for ADHD: A Systematic Review of the Literature
WILENS, T. E., ADLER, L. A., ADAMS, J., SGAMBATI, S., ROTROSEN, J., SAWTELLE, R., UTZINGER, L., & FUSILLO, S. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31815a56f1 · Cited by 824 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y.-S., Gatley, S. J., Gifford, A., & Franceschi, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-j0001.2001 · Cited by 770 · see citing works
Self-citationdel Campo, N., Chamberlain, S. R., Sahakian, B. J., & Robbins, T. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.036 · Cited by 685 · see citing works
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
Ekstrand, M. I., Terzioglu, M., Galter, D., Zhu, S., Hofstetter, C., Lindqvist, E., Thams, S., Bergstrand, A., Hansson, F. S., Trifunovic, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605208103 · Cited by 605 · see citing works
Aging and functional brain networks
Tomasi, D., & Volkow, N. D. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.81 · Cited by 578 · see citing works
Self-citationSwanson, J. M., Kinsbourne, M., Nigg, J., Lanphear, B., Stefanatos, G. A., Volkow, N., Taylor, E., Casey, B. J., Castellanos, F. X., & Wadhwa, P. D. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9019-9 · Cited by 580 · see citing works
Self-citationVolkow, N. D., Wang, G., Fowler, J. S., Tomasi, D., Telang, F., & Baler, R. (2010) · BioEssays · doi:10.1002/bies.201000042 · Cited by 532 · see citing works
Self-citationKrause, K.-H., Dresel, S. H., Krause, J., Kung, H. F., & Tatsch, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01040-5 · Cited by 521 · see citing works
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Jayne, M., Ma, Y., Pradhan, K., & Wong, C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3371-07.2007 · Cited by 494 · see citing works
Self-citationTripp, G., & Wickens, J. R. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.026 · Cited by 492 · see citing works
Variables That Affect the Clinical Use and Abuse of Methylphenidate in the Treatment of ADHD
Volkow, N. D., & Swanson, J. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.1909 · Cited by 475 · see citing works
Self-citationHalperin, J. M., & Schulz, K. P. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.4.560 · Cited by 446 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D., Wong, C., Gatley, S. J., Gifford, A. N., Ding, Y., et al. (2002) · Synapse · doi:10.1002/syn.10075 · Cited by 452 · see citing works
Self-citationDIAMOND, A. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050388 · Cited by 428 · see citing works
Nutt, D., Demyttenaere, K., Janka, Z., Aarre, T., Bourin, M., Canonico, P. L., Carrasco, J. L., & Stahl, S. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106069938 · Cited by 366 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Ding, Y.-S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.006 · Cited by 368 · see citing works
Self-citationAttention-Deficit/Hyperactivity Disorder and Attention Networks
Bush, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.120 · Cited by 358 · see citing works
Assessing the molecular genetics of attention networks
Fossella, J., Sommer, T., Fan, J., Wu, Y., Swanson, J. M., Pfaff, D. W., & Posner, M. I. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-14 · Cited by 339 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Franceschi, D., Maynard, L., Ding, Y., Gatley, S. J., Gifford, A., Zhu, W., et al. (2002) · Synapse · doi:10.1002/syn.10038 · Cited by 321 · see citing works
Self-citationImaging studies on the role of dopamine in cocaine reinforcement and addiction in humans
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300406 · Cited by 315 · see citing works
Self-citationKuczenski, R., & Segal, D. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07264.2002 · Cited by 316 · see citing works
Cingulate, Frontal, and Parietal Cortical Dysfunction in Attention-Deficit/Hyperactivity Disorder
Bush, G. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.022 · Cited by 304 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Telang, F., Maynard, L., Logan, J., Gatley, S. J., Pappas, N., Wong, C., Vaska, P., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1173 · Cited by 281 · see citing works
Self-citationDresel, S., Krause, J., Krause, K.-H., LaFougere, C., Brinkbäumer, K., Kung, H. F., Hahn, K., & Tatsch, K. (2000) · European Journal of Nuclear Medicine · doi:10.1007/s002590000330 · Cited by 278 · see citing works
Wilens, T. E. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318173312f · Cited by 269 · see citing works
Lower dopamine transporter binding potential in striatum during depression
Meyer, J. H., Krüger, S., Wilson, A. A., Christensen, B. K., Goulding, V. S., Schaffer, A., Minifie, C., Houle, S., Hussey, D., & Kennedy, S. H. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00052 · Cited by 269 · see citing works
GREENHILL, L. L., HALPERIN, J. M., & ABIKOFF, H. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199905000-00011 · Cited by 268 · see citing works
Nutt, D. J., Fone, K., Asherson, P., Bramble, D., Hill, P., Matthews, K., Morris, K. A., Santosh, P., Sonuga-Barke, E., Taylor, E., et al. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073219 · Cited by 259 · see citing works
Brandon, C. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00281-0 · Cited by 259 · see citing works
Swanson, J., Baler, R. D., & Volkow, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.160 · Cited by 252 · see citing works
Self-citationEvidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain
Volkow, N. D., Tomasi, D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Benveniste, H., Kim, R., Thanos, P. K., & Ferré, S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0045-12.2012 · Cited by 254 · see citing works
Self-citationThe role of the brain reward system in depression
Naranjo, C. A., Tremblay, L. K., & Busto, U. E. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00156-7 · Cited by 245 · see citing works
Brain dopamine transporter levels in treatment and drug naive adults with ADHD
Volkow, N. D., Wang, G.-J., Newcorn, J., Fowler, J. S., Telang, F., Solanto, M. V., Logan, J., Wong, C., Ma, Y., Swanson, J. M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.014 · Cited by 249 · see citing works
Self-citationVolkow, N. D., Wang, G.-J., Tomasi, D., Kollins, S. H., Wigal, T. L., Newcorn, J. H., Telang, F. W., Fowler, J. S., Logan, J., Wong, C. T., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4461-11.2012 · Cited by 237 · see citing works
Self-citationHannestad, J., Gallezot, J.-D., Planeta-Wilson, B., Lin, S.-F., Williams, W. A., van Dyck, C. H., Malison, R. T., Carson, R. E., & Ding, Y.-S. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.017 · Cited by 236 · see citing works
Self-citationSwanson, J. M., & Volkow, N. D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00433-8 · Cited by 173 · see citing works
Self-citationCognitive effects of methylphenidate in healthy volunteers: a review of single dose studies
Linssen, A. M. W., Sambeth, A., Vuurman, E. F. P. M., & Riedel, W. J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001594 · Cited by 159 · see citing works
Pliszka, S. R. (2007) · Neuropsychology Review · doi:10.1007/s11065-006-9017-3 · Cited by 158 · see citing works
Wang, G.-J., Volkow, N. D., Wigal, T., Kollins, S. H., Newcorn, J. H., Telang, F., Logan, J., Jayne, M., Wong, C. T., Han, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063023 · Cited by 144 · see citing works
Self-citationMoll, G. H., Hause, S., Rüther, E., Rothenberger, A., & Huether, G. (2001) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454601750143366 · Cited by 147 · see citing works
Hodgkins, P., Shaw, M., Coghill, D., & Hechtman, L. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0286-5 · Cited by 147 · see citing works
Rosa-Neto, P., Lou, H. C., Cumming, P., Pryds, O., Karrebaek, H., Lunding, J., & Gjedde, A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.031 · Cited by 135 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Dewey, S. L., Hitzemann, R., Gifford, A. N., & Pappas, N. R. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37918-2 · Cited by 125 · see citing works
Self-citationCubillo, A., Smith, A. B., Barrett, N., Giampietro, V., Brammer, M. J., Simmons, A., & Rubia, K. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs296 · Cited by 116 · see citing works
Dodds, C. M., Muller, U., Clark, L., van Loon, A., Cools, R., & Robbins, T. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1153-08.2008 · Cited by 113 · see citing works
SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder
Krause, J. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.4.611 · Cited by 110 · see citing works
DURSTON, S., FOSSELLA, J. A., MULDER, M. J., CASEY, B. J., ZIERMANS, T. B., VESSAZ, M. N., & VAN ENGELAND, H. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31815a5f17 · Cited by 108 · see citing works
Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons
Brandon, C. L., Marinelli, M., & White, F. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00787-x · Cited by 107 · see citing works
Substance Abuse in Patients with Attention-Deficit Hyperactivity Disorder: Therapeutic Implications
Schubiner, H. (2005) · CNS Drugs · doi:10.2165/00023210-200519080-00001 · Cited by 104 · see citing works
The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009
Payton, A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9116-z · Cited by 95 · see citing works
Stoy, M., Schlagenhauf, F., Schlochtermeier, L., Wrase, J., Knutson, B., Lehmkuhl, U., Huss, M., Heinz, A., & Ströhle, A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2166-y · Cited by 91 · see citing works
Influences of dopaminergic system dysfunction on late-life depression
Taylor, W. D., Zald, D. H., Felger, J. C., Christman, S., Claassen, D. O., Horga, G., Miller, J. M., Gifford, K., Rogers, B., Szymkowicz, S. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01265-0 · Cited by 89 · see citing works
Hawk, L. W., Yartz, A. R., Pelham, W. E., & Lock, T. M. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1235-7 · Cited by 89 · see citing works
Methylphenidate facilitates learning-induced amygdala plasticity
Tye, K. M., Tye, L. D., Cone, J. J., Hekkelman, E. F., Janak, P. H., & Bonci, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2506 · Cited by 89 · see citing works
Psychopharmacology: concepts and opinions about the use of stimulant medications
Swanson, J. M., & Volkow, N. D. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.02062.x · Cited by 78 · see citing works
Self-citationChantiluke, K., Barrett, N., Giampietro, V., Brammer, M., Simmons, A., Murphy, D. G., & Rubia, K. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht365 · Cited by 59 · see citing works
Vanicek, T., Spies, M., Rami-Mark, C., Savli, M., Höflich, A., Kranz, G. S., Hahn, A., Kutzelnigg, A., Traub-Weidinger, T., Mitterhauser, M., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1226 · Cited by 61 · see citing works
Self-citationBalcioglu, A., Ren, J.-Q., McCarthy, D., Spencer, T. J., Biederman, J., & Bhide, P. G. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.025 · Cited by 60 · see citing works
Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks
Brown, A. B., Biederman, J., Valera, E., Makris, N., Doyle, A., Whitfield-Gabrieli, S., Mick, E., Spencer, T., Faraone, S., & Seidman, L. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.01.006 · Cited by 53 · see citing works
Jenson, D., Yang, K., Acevedo-Rodriguez, A., Levine, A., Broussard, J. I., Tang, J., & Dani, J. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.029 · Cited by 52 · see citing works
Katz, M., Adar Levine, A., Kol-Degani, H., & Kav-Venaki, L. (2010) · Journal of Attention Disorders · doi:10.1177/1087054709356388 · Cited by 48 · see citing works
van der Marel, K., Klomp, A., Meerhoff, G. F., Schipper, P., Lucassen, P. J., Homberg, J. R., Dijkhuizen, R. M., & Reneman, L. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.169 · Cited by 42 · see citing works
Yeh, C.-B., Lee, C.-S., Ma, K.-H., Lee, M.-S., Chang, C.-J., & Huang, W.-S. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.01.003 · Cited by 41 · see citing works
Sethi, A., Voon, V., Critchley, H. D., Cercignani, M., & Harrison, N. A. (2018) · Brain · doi:10.1093/brain/awy048 · Cited by 36 · see citing works
Isfandnia, F., El Masri, S., Radua, J., & Rubia, K. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105703 · Cited by 36 · see citing works
Govoni, S., Racchi, M., Masoero, E., Zamboni, M., & Ferini-Strambi, L. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000801 · Cited by 35 · see citing works
Véronneau-Veilleux, F., Robaey, P., Ursino, M., & Nekka, F. (2022) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2022.849323 · Cited by 32 · see citing works
Pennington, B. F., Willcutt, E., & Rhee, S. H. (2005) · Advances in Child Development and Behavior · doi:10.1016/s0065-2407(05)80010-2 · Cited by 31 · see citing works
The adult psychiatrist's dilemma: psychostimulant use in attention deficit/hyperactivity disorder
Ashton, H., Gallagher, P., & Moore, B. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106061710 · Cited by 31 · see citing works
Nikolaus, S., Wirrwar, A., Antke, C., Arkian, S., Schramm, N., M�ller, H.-W., & Larisch, R. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1615-9 · Cited by 29 · see citing works
Decision making: effects of methylphenidate on temporal discounting in nonhuman primates
Rajala, A. Z., Jenison, R. L., & Populin, L. C. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00278.2015 · Cited by 25 · see citing works
Gill, K. E., Beveridge, T. J. R., Smith, H. R., & Porrino, L. J. (2013) · Brain Research · doi:10.1016/j.brainres.2013.06.021 · Cited by 30 · see citing works
Mizuno, K., Yoneda, T., Komi, M., Hirai, T., Watanabe, Y., & Tomoda, A. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.03.004 · Cited by 30 · see citing works
Mahon, A. D., Stephens, B. R., & Cole, A. S. (2008) · Journal of Attention Disorders · doi:10.1177/1087054707308484 · Cited by 24 · see citing works
Colzato, L. S., & Arntz, F. E. (2017) · Theory-Driven Approaches to Cognitive Enhancement · doi:10.1007/978-3-319-57505-6_6 · Cited by 2 · see citing works
- Authors
- Volkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Hitzemann, R., & Pappas, N.
- Affiliations
- Brookhaven National Laboratory (US)
- Venue
- American Journal of Psychiatry
- Published
- 1998-10-01
- Volume
- 155
- Issue
- 10
- Pages
- 1325-1331
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1977634040
- Cited by
- 885
- References
- 36
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 19 · 2023: 7 · 2022: 15 · 2021: 12 · 2020: 26 · 2019: 20 · 2018: 14 · 2017: 38 · 2016: 35 · 2015: 28 · 2014: 46 · 2013: 42 · 2012: 48
- FWCI
- 18.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da009490-08)
- National Institute on Drug Abuse (DA-09490)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- methylphenidate, attention deficit disorder, oral administration, pharmacokinetics, dose-response relationship, baboon brain
- MeSH terms
- Administration, Oral, Adult, Animals, Attention Deficit Disorder with Hyperactivity, Brain, Brain Chemistry, Carbon Radioisotopes, Carrier Proteins, Cocaine, Dopamine, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Membrane Glycoproteins, Methylphenidate, Nerve Tissue Proteins, Papio, Tomography, Emission-Computed, Dopamine Antagonists, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review