The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering
Open accessAbstract
Regenerative medicine is targeted to improve, restore or replace damaged tissues or organs using a combination of cells, materials and growth factors. Both tissue engineering and developmental biology currently deal with the process of tissue self-assembly and extracellular matrix (ECM) deposition. In this investigation, additive manufacturing (AM) with a multihead deposition system (MHDS) was used to fabricate three-dimensional (3D) cell-printed scaffolds using layer-by-layer (LBL) deposition of polycaprolactone (PCL) and chondrocyte cell-encapsulated alginate hydrogel. Appropriate cell dispensing conditions and optimum alginate concentrations for maintaining cell viability were determined. In vitro cell-based biochemical assays were performed to determine glycosaminoglycans (GAGs), DNA and total collagen contents from different PCL-alginate gel constructs. PCL-alginate gels containing transforming growth factor-β (TGFβ) showed higher ECM formation. The 3D cell-printed scaffolds of PCL-alginate gel were implanted in the dorsal subcutaneous spaces of female nude mice. Histochemical [Alcian blue and haematoxylin and eosin (H&E) staining] and immunohistochemical (type II collagen) analyses of the retrieved implants after 4 weeks revealed enhanced cartilage tissue and type II collagen fibril formation in the PCL-alginate gel (+TGFβ) hybrid scaffold. In conclusion, we present an innovative cell-printed scaffold for cartilage regeneration fabricated by an advanced bioprinting technology.
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Cites
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Cited by
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
Pati, F., Jang, J., Ha, D.-H., Won Kim, S., Rhie, J.-W., Shim, J.-H., Kim, D.-H., & Cho, D.-W. (2014) · Nature Communications · doi:10.1038/ncomms4935 · Cited by 1,904
Self-citationRecent advances in 3D printing of biomaterials
Chia, H. N., & Wu, B. M. (2015) · Journal of Biological Engineering · doi:10.1186/s13036-015-0001-4 · Cited by 1,734
Progress in 3D bioprinting technology for tissue/organ regenerative engineering
Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119536 · Cited by 1,156
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
Ashammakhi, N., Ahadian, S., Xu, C., Montazerian, H., Ko, H., Nasiri, R., Barros, N., & Khademhosseini, A. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100008 · Cited by 549
Unagolla, J. M., & Jayasuriya, A. C. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2019.100479 · Cited by 544
Metadata
- Authors
- Kundu, J., Shim, J.-H., Jang, J., Kim, S.-W., & Cho, D.-W.
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Hindawi Limited
- Published
- 2013-01-24
- Volume
- 9
- Issue
- 11
- Pages
- 1286-1297
- ISSN
- 1932-6254 (ISSN-L)
- OpenAlex
- W1778072505
- Cited by
- 552
- References
- 1
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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