The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering
Open accessAbstract
Regenerative medicine is targeted to improve, restore or replace damaged tissues or organs using a combination of cells, materials and growth factors. Both tissue engineering and developmental biology currently deal with the process of tissue self-assembly and extracellular matrix (ECM) deposition. In this investigation, additive manufacturing (AM) with a multihead deposition system (MHDS) was used to fabricate three-dimensional (3D) cell-printed scaffolds using layer-by-layer (LBL) deposition of polycaprolactone (PCL) and chondrocyte cell-encapsulated alginate hydrogel. Appropriate cell dispensing conditions and optimum alginate concentrations for maintaining cell viability were determined. In vitro cell-based biochemical assays were performed to determine glycosaminoglycans (GAGs), DNA and total collagen contents from different PCL-alginate gel constructs. PCL-alginate gels containing transforming growth factor-β (TGFβ) showed higher ECM formation. The 3D cell-printed scaffolds of PCL-alginate gel were implanted in the dorsal subcutaneous spaces of female nude mice. Histochemical [Alcian blue and haematoxylin and eosin (H&E) staining] and immunohistochemical (type II collagen) analyses of the retrieved implants after 4 weeks revealed enhanced cartilage tissue and type II collagen fibril formation in the PCL-alginate gel (+TGFβ) hybrid scaffold. In conclusion, we present an innovative cell-printed scaffold for cartilage regeneration fabricated by an advanced bioprinting technology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Cited by
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
Pati, F., Jang, J., Ha, D.-H., Won Kim, S., Rhie, J.-W., Shim, J.-H., Kim, D.-H., & Cho, D.-W. (2014) · Nature Communications · doi:10.1038/ncomms4935 · Cited by 1,904
Self-citation3D bioprinting for engineering complex tissues
Mandrycky, C., Wang, Z., Kim, K., & Kim, D.-H. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.011 · Cited by 1,754
Recent advances in 3D printing of biomaterials
Chia, H. N., & Wu, B. M. (2015) · Journal of Biological Engineering · doi:10.1186/s13036-015-0001-4 · Cited by 1,734
Progress in 3D bioprinting technology for tissue/organ regenerative engineering
Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119536 · Cited by 1,156
Das, S., Pati, F., Choi, Y.-J., Rijal, G., Shim, J.-H., Kim, S. W., Ray, A. R., Cho, D.-W., & Ghosh, S. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.09.023 · Cited by 553
Self-citationAlginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review
Hernández-González, A. C., Téllez-Jurado, L., & Rodríguez-Lorenzo, L. M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115514 · Cited by 549
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
Ashammakhi, N., Ahadian, S., Xu, C., Montazerian, H., Ko, H., Nasiri, R., Barros, N., & Khademhosseini, A. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100008 · Cited by 549
Unagolla, J. M., & Jayasuriya, A. C. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2019.100479 · Cited by 544
Yang, X., Lu, Z., Wu, H., Li, W., Zheng, L., & Zhao, J. (2018) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.09.002 · Cited by 533
Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 509
Current advances and future perspectives of 3D printing natural-derived biopolymers
Liu, J., Sun, L., Xu, W., Wang, Q., Yu, S., & Sun, J. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.11.077 · Cited by 428
Arif, Z. U., Khalid, M. Y., Noroozi, R., Sadeghianmaryan, A., Jalalvand, M., & Hossain, M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.140 · Cited by 395
Biomimetic 3D tissue printing for soft tissue regeneration
Pati, F., Ha, D.-H., Jang, J., Han, H. H., Rhie, J.-W., & Cho, D.-W. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.043 · Cited by 368
Self-citationAskari, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A., & Bodaghi, M. (2021) · Biomaterials Science · doi:10.1039/d0bm00973c · Cited by 369
Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma
Kong, B., Chen, Y., Liu, R., Liu, X., Liu, C., Shao, Z., Xiong, L., Liu, X., Sun, W., & Mi, S. (2020) · Nature Communications · doi:10.1038/s41467-020-14887-9 · Cited by 319
An Overview on Materials and Techniques in 3D Bioprinting Toward Biomedical Application
Vanaei, S., Parizi, M. S., Vanaei, S., Salemizadehparizi, F., & Vanaei, H. R. (2021) · Engineered Regeneration · doi:10.1016/j.engreg.2020.12.001 · Cited by 308
Polyelectrolyte gelatin-chitosan hydrogel optimized for 3D bioprinting in skin tissue engineering
Ng, W. L., Yeong, W. Y., & Naing, M. W. (2024) · International Journal of Bioprinting · doi:10.18063/ijb.2016.01.009 · Cited by 293
Narayanan, L. K., Huebner, P., Fisher, M. B., Spang, J. T., Starly, B., & Shirwaiker, R. A. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00196 · Cited by 293
Ilyas, R., Zuhri, M., Norrrahim, M., Misenan, M., Jenol, M., Samsudin, S., Nurazzi, N., Asyraf, M., Supian, A., Bangar, S., et al. (2022) · Polymers · doi:10.3390/polym14010182 · Cited by 268
Repair of Damaged Articular Cartilage: Current Approaches and Future Directions
Medvedeva, E. V., Grebenik, E. A., Gornostaeva, S. N., Telpuhov, V. I., Lychagin, A. V., Timashev, P. S., & Chagin, A. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082366 · Cited by 266
Natural Polymers for Organ 3D Bioprinting
Liu, F., Chen, Q., Liu, C., Ao, Q., Tian, X., Fan, J., Tong, H., & Wang, X. (2018) · Polymers · doi:10.3390/polym10111278 · Cited by 170
3D printing to innovate biopolymer materials for demanding applications: A review
Li, N., Qiao, D., Zhao, S., Lin, Q., Zhang, B., & Xie, F. (2021) · Materials Today Chemistry · doi:10.1016/j.mtchem.2021.100459 · Cited by 142
Advanced 3D-Printing Bioinks for Articular Cartilage Repair
Liang, Q., Ma, Y., Yao, X., & Wei, W. (2022) · International Journal of Bioprinting · doi:10.18063/ijb.v8i3.511 · Cited by 55
Current advances in three-dimensional tissue/organ printing
Park, J. H., Jang, J., Lee, J.-S., & Cho, D.-W. (2016) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-016-8111-8 · Cited by 51
Self-citation
Metadata
- Authors
- Kundu, J., Shim, J.-H., Jang, J., Kim, S.-W., & Cho, D.-W.
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Hindawi Limited
- Published
- 2013-01-24
- Volume
- 9
- Issue
- 11
- Pages
- 1286-1297
- ISSN
- 1932-6254 (ISSN-L)
- OpenAlex
- W1778072505
- Cited by
- 552
- References
- 1
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
