Abdominal wall reconstruction by a regionally distinct biocomposite of extracellular matrix digest and a biodegradable elastomer: Abdominal wall reconstruction by a new biocomposite scaffold
Open accessAbstract
Current extracellular matrix (ECM) derived scaffolds offer promising regenerative responses in many settings, however in some applications there may be a desire for more robust and long lasting mechanical properties. A biohybrid composite material that offers both strength and bioactivity for optimal healing towards native tissue behavior may offer a solution to this problem. A regionally distinct biocomposite scaffold composed of a biodegradable elastomer (poly(ester urethane)urea) and porcine dermal ECM gel was generated to meet this need by a concurrent polymer electrospinning/ECM gel electrospraying technique where the electrosprayed component was varied temporally during the processing. A sandwich structure was achieved with polymer fiber rich upper and lower layers for structural support and an ECM-rich inner layer to encourage cell ingrowth. Increasing the upper and lower layer fiber content predictably increased tensile strength. In a rat full thickness abdominal wall defect model, the sandwich scaffold design maintained its thickness whereas control biohybrid scaffolds lacking the upper and lower fiber-rich regions failed at 8 weeks. Sandwich scaffold implants also showed higher collagen content 4 and 8 weeks after implantation, exhibited an increased M2 macrophage phenotype response at later times and developed biaxial mechanical properties better approximating native tissue. By employing a processing approach that creates a sheet-form scaffold with regionally distinct zones, it was possible to improve biological outcomes in body wall repair and provide the means for further tuning scaffold mechanical parameters when targeting other applications. Copyright © 2013 John Wiley & Sons, Ltd.
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Self-citation
- Authors
- Takanari, K., Hong, Y., Hashizume, R., Huber, A., Amoroso, N. J., D'Amore, A., Badylak, S. F., & Wagner, W. R.
- Affiliations
- University of Pittsburgh (US)
- University of Pittsburgh; McGowan Institute for Regenerative Medicine; Pittsburgh PA USA
- Corresponding author
- Wagner, William R.
- ORCID
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Wiley
- Published
- 2013-12-27
- Volume
- 10
- Issue
- 9
- Pages
- 748-761
- ISSN
- 1932-6254 (ISSN-L)
- OpenAlex
- W2116149220
- Cited by
- 35
- References
- 54
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 7 · 2016: 9 · 2015: 1 · 2014: 2
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Tissue Engineering and Regenerative Medicine (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Funders
- Armed Forces Institute for Regenerative Medicine (#W81XWH-08-2-0032)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- abdominal wall reconstruction, extracellular matrix gel, poly(ester urethane)urea, biodegradable elastomers, electrospinning, electrospraying, full-thickness abdominal wall defect, tensile strength, collagen deposition, biaxial mechanical properties, tissue engineering
- MeSH terms
- Animals, Extracellular Matrix, Female, Rats, Inbred Lew, Swine, Absorbable Implants, Dermis, Elastomers, Abdominal Wall
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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