RETRACTED: Engineered whole organs and complex tissues

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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Reconstituting organ-level lung functions on a chip

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An overview of tissue and whole organ decellularization processes

Crapo, P. M., Gilbert, T. W., & Badylak, S. F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.057 · Cited by 3,591 · see citing works

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

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Self-organizing optic-cup morphogenesis in three-dimensional culture

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Tissue-engineered autologous bladders for patients needing cystoplasty

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Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development.

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Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522 · see citing works

How does the extracellular matrix direct gene expression?

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Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

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Chronic kidney disease: the global challenge

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Tissue-Engineered Lungs for in Vivo Implantation

Petersen, T. H., Calle, E. A., Zhao, L., Lee, E. J., Gui, L., Raredon, M. S. B., Gavrilov, K., Yi, T., Zhuang, Z. W., Breuer, C. K., et al. (2010) · Science · doi:10.1126/science.1189345 · Cited by 1,177 · see citing works

Regeneration and orthotopic transplantation of a bioartificial lung

Ott, H. C., Clippinger, B., Conrad, C., Schuetz, C., Pomerantseva, I., Ikonomou, L., Kotton, D., & Vacanti, J. P. (2010) · Nature Medicine · doi:10.1038/nm.2193 · Cited by 1,090 · see citing works

The extracellular matrix as a biologic scaffold material

Badylak, S. F. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.04.043 · Cited by 1,022 · see citing works

Deaths: final data for 2006.

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Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component

Brown, B. N., Valentin, J. E., Stewart-Akers, A. M., McCabe, G. P., & Badylak, S. F. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.040 · Cited by 896 · see citing works

Transplantation of a Tissue-Engineered Pulmonary Artery

Shinoka, T., Imai, Y., & Ikada, Y. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440717 · Cited by 634 · see citing works

II. Clinical Application

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Basal lamina scaffold-anatomy and significance for maintenance of orderly tissue structure.

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Tracheal replacement: a critical review

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Decellularized Native and Engineered Arterial Scaffolds for Transplantation

Dahl, S. L. M., Koh, J., Prabhakar, V., & Niklason, L. E. (2003) · Cell Transplantation · doi:10.3727/000000003108747136 · Cited by 406 · see citing works

Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation

Cortiella, J., Niles, J. A., Cantu, A., Brettler, A. C., Pham, A. N., Vargas, G., Winston, S., Wang, J. P., Walls, S., & Nichols, J. E. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0730 · Cited by 381 · see citing works

Human Bone Marrow Mesenchymal Stem Cells Accelerate Recovery of Acute Renal Injury and Prolong Survival in Mice

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Embryonic Stem Cells Proliferate and Differentiate when Seeded into Kidney Scaffolds

Ross, E. A., Williams, M. J., Hamazaki, T., Terada, N., Clapp, W. L., Adin, C. A., Ellison, G. W., Jorgensen, M. J., & Batich, C. D. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008111196 · Cited by 380 · see citing works

Acellular collagen matrix as a possible “off the shelf” biomaterial for urethral repair

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Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth

Barkan, D., Green, J. E., & Chambers, A. F. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.027 · Cited by 378 · see citing works

Decellularized Rhesus Monkey Kidney as a Three-Dimensional Scaffold for Renal Tissue Engineering

Nakayama, K. H., Batchelder, C. A., Lee, C. I., & Tarantal, A. F. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0602 · Cited by 360 · see citing works

Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds

Valentin, J. E., Stewart-Akers, A. M., Gilbert, T. W., & Badylak, S. F. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0419 · Cited by 356 · see citing works

Development of a Decellularized Lung Bioreactor System for Bioengineering the Lung: The Matrix Reloaded

Price, A., England, K. A., Matson, A. M., Blazar, B. R., & Panoskaltsis‐Mortari, A. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0659 · Cited by 344 · see citing works

Tissue engineering of heart valves – human endothelial cell seeding of detergent acellularized porcine valves1

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Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation

Nelson, C. M., & Bissell, M. J. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.001 · Cited by 332 · see citing works

Skin Tissue Engineering for Tissue Repair and Regeneration

Priya, S. G., Jungvid, H., & Kumar, A. (2008) · Tissue Engineering Part B Reviews · doi:10.1089/teb.2007.0318 · Cited by 317 · see citing works

A Whole-Organ Regenerative Medicine Approach for Liver Replacement

Soto-Gutierrez, A., Zhang, L., Medberry, C., Fukumitsu, K., Faulk, D., Jiang, H., Reing, J., Gramignoli, R., Komori, J., Ross, M., et al. (2011) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2010.0698 · Cited by 311 · see citing works

Clinical Application of Tissue Engineered Human Heart Valves Using Autologous Progenitor Cells

Cebotari, S., Lichtenberg, A., Tudorache, I., Hilfiker, A., Mertsching, H., Leyh, R. G., Breymann, T., Kallenbach, K., Liviu, M., Batrinac, A., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.001065 · Cited by 300 · see citing works

Clinical Application of an Acellular Biologic Scaffold for Surgical Repair of a Large, Traumatic Quadriceps Femoris Muscle Defect

Mase, V. J., Hsu, J. R., Wolf, S. E., Wenke, J. C., Baer, D. G., Owens, J. G., Badylak, S. F., & Walters, J. (2010) · Orthopedics · doi:10.3928/01477447-20100526-24 · Cited by 291 · see citing works

Maintenance of Human Hepatocyte Function In Vitro by Liver-Derived Extracellular Matrix Gels

Sellaro, T. L., Ranade, A. R., Faulk, D. M., McCabe, G. P., Dorko, K., Badylak, S. F., & Strom, S. C. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0587 · Cited by 276 · see citing works

Degradation and Remodeling of Small Intestinal Submucosa in Canine Achilles Tendon Repair

Gilbert, T. W., Stewart‐Akers, A. M., Simmons-Byrd, A., & Badylak, S. F. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.e.00742 · Cited by 274 · see citing works

Functional skeletal muscle formation with a biologic scaffold

Valentin, J. E., Turner, N. J., Gilbert, T. W., & Badylak, S. F. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.039 · Cited by 272 · see citing works

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

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A transitional extracellular matrix instructs cell behavior during muscle regeneration

Calve, S., Odelberg, S. J., & Simon, H. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.05.007 · Cited by 234 · see citing works

Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development

Vlodavsky, I., Goldshmidt, O., Zcharia, E., Atzmon, R., Guatta-Rangini, Z., Elkin, M., Peretz, T., & Friedmann, Y. (2002) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0420 · Cited by 226 · see citing works

Esophageal Preservation in Five Male Patients After Endoscopic Inner-Layer Circumferential Resection in the Setting of Superficial Cancer: A Regenerative Medicine Approach with a Biologic Scaffold

Badylak, S. F., Hoppo, T., Nieponice, A., Gilbert, T. W., Davison, J. M., & Jobe, B. A. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0739 · Cited by 222 · see citing works

Chemoattraction of Progenitor Cells by Remodeling Extracellular Matrix Scaffolds

Beattie, A. J., Gilbert, T. W., Guyot, J. P., Yates, A. J., & Badylak, S. F. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0162 · Cited by 218 · see citing works

Tissue engineered human tracheas for in vivo implantation

Baiguera, S., Jungebluth, P., Burns, A. J., Mavilia, C., Haag, J. C., Coppi, P. D., & Macchiarini, P. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.005 · Cited by 203 · see citing works

Initial Binding and Recellularization of Decellularized Mouse Lung Scaffolds with Bone Marrow-Derived Mesenchymal Stromal Cells

Daly, A. B., Wallis, J. M., Borg, Z. D., Bonvillain, R. W., Deng, B., Ballif, B. A., Jaworski, D. M., Allen, G. B., & Weiss, D. J. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0301 · Cited by 203 · see citing works

Life-Sparing Effect of Human Cord Blood-Mesenchymal Stem Cells in Experimental Acute Kidney Injury

Morigi, M., Rota, C., Montemurro, T., Montelatici, E., Cicero, V. L., Imberti, B., Abbate, M., Zoja, C., Cassis, P., Longaretti, L., et al. (2010) · Stem Cells · doi:10.1002/stem.293 · Cited by 181 · see citing works

Recruitment of Progenitor Cells by an Extracellular Matrix Cryptic Peptide in a Mouse Model of Digit Amputation

Agrawal, V., Tottey, S., Johnson, S. A., Freund, J. M., Siu, B. F., & Badylak, S. F. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0036 · Cited by 180 · see citing works

Macrophage Elastase (Matrix Metalloproteinase-12) Suppresses Growth of Lung Metastases

Houghton, A. M., Grisolano, J. L., Baumann, M. L., Kobayashi, D. K., Hautamaki, R. D., Nehring, L. C., Cornelius, L. A., & Shapiro, S. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-04-0297 · Cited by 178 · see citing works

Tissue-Engineered Lung: An In Vivo and In Vitro Comparison of Polyglycolic Acid and Pluronic F-127 Hydrogel/Somatic Lung Progenitor Cell Constructs to Support Tissue Growth

Cortiella, J., Nichols, J. E., Kojima, K., Bonassar, L. J., Dargon, P. T., Roy, A. K., Vacant, M. P., Niles, J. A., & Vacanti, C. A. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1213 · Cited by 172 · see citing works

From laminin to lamin: regulation of tissue-specific gene expression by the ECM

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Epimorphic regeneration approach to tissue replacement in adult mammals

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Clinical Application of in Situ Tissue Engineering Using a Scaffolding Technique for Reconstruction of the Larynx and Trachea

Omori, K., Tada, Y., Suzuki, T., Nomoto, Y., Matsuzuka, T., Kobayashi, K., Nakamura, T., Kanemaru, S., Yamashita, M., & Asato, R. (2008) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348940811700908 · Cited by 159 · see citing works

Effect of the αGal Epitope on the Response to Small Intestinal Submucosa Extracellular Matrix in a Nonhuman Primate Model

Daly, K. A., Stewart‐Akers, A. M., Hara, H., Ezzelarab, M. B., Long, C. E., Cordero, K. E., Johnson, S. A., Ayares, D., Cooper, D. K. C., & Badylak, S. F. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0089 · Cited by 156 · see citing works

Contractile Skeletal Muscle Tissue-Engineered on an Acellular Scaffold

Borschel, G. H., Dennis, R. G., & Kuzon, W. M. (2004) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000101064.62289.2f · Cited by 153 · see citing works

An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix

Hodde, J. P., Ernst, D. M. J., & Hiles, M. C. (2005) · Journal of Wound Care · doi:10.12968/jowc.2005.14.1.26721 · Cited by 148 · see citing works

Invited Review: Mechanochemical signal transduction in the fetal lung

Liu, M., & Post, M. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.5.2078 · Cited by 138 · see citing works

Cell-based tissue engineering for lung regeneration

Andrade, C., Wong, A. P., Waddell, T. K., Keshavjee, S. H., & Liu, M. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00175.2006 · Cited by 128 · see citing works

General Overview of Lung Transplantation and Review of Organ Allocation

Orens, J. B., & Garrity, E. R. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200807-072go · Cited by 119 · see citing works

A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs: From concept to clinical trial

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Skin Substitutes and Wound Healing

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Murine nasal septa for respiratory epithelial air-liquid interface cultures

Antunes, M. B., Woodworth, B. A., Bhargave, G. A., Xiong, G., Aguilar, J. L., Ratner, A. J., Kreindler, J. L., Rubenstein, R. C., & Cohen, N. A. (2007) · BioTechniques · doi:10.2144/000112531 · Cited by 107 · see citing works

Extracellular Matrix Remodeling by Dynamic Strain in a Three-Dimensional Tissue-Engineered Human Airway Wall Model

Choe, M. M., Sporn, P. H. S., & Swartz, M. A. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0443oc · Cited by 105 · see citing works

Development of bioengineered human larynx

Baiguera, S., Gonfiotti, A., Jaus, M. O., Comin, C., Paglierani, M., Gaudio, C. D., Bianco, A., Ribatti, D., & Macchiarini, P. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.055 · Cited by 103 · see citing works

A History Lesson for Stem Cells

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Extracellular Matrix Degradation Products and Low-Oxygen Conditions Enhance the Regenerative Potential of Perivascular Stem Cells

Tottey, S., Corselli, M., Jeffries, E. M., Londoño, R., Péault, B., & Badylak, S. F. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0188 · Cited by 101 · see citing works

Role of Tumor Cell Adhesion and Migration in Organ-Specific Metastasis Formation

Gaßmann, P., Enns, A., & Haier, J. (2004) · Oncology Research and Treatment · doi:10.1159/000081343 · Cited by 95 · see citing works

Reinforcement of Esophageal Anastomoses With an Extracellular Matrix Scaffold in a Canine Model

Nieponice, A., Gilbert, T. W., & Badylak, S. F. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.06.036 · Cited by 95 · see citing works

Long-term changes to in vitro preserved bioengineered human trachea and their implications for decellularized tissues

Baiguera, S., Gaudio, C. D., Jaus, M. O., Polizzi, L., Gonfiotti, A., Comin, C., Bianco, A., Ribatti, D., Taylor, D. A., & Macchiarini, P. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.064 · Cited by 93 · see citing works

A tissue-engineered model of fetal distal lung tissue

Mondrinos, M. J., Koutzaki, S. H., Lelkes, P. I., & Finck, C. M. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00403.2006 · Cited by 91 · see citing works

Aortic root replacement with a novel decellularized cryopreserved aortic homograft: Postoperative immunoreactivity and early results

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Lung Tissue Engineering Technique with Adipose Stromal Cells Improves Surgical Outcome for Pulmonary Emphysema

Shigemura, N., Okumura, M., Mizuno, S., Imanishi, Y., Matsuyama, A., Shiono, H., Nakamura, T., & Sawa, Y. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200603-406oc · Cited by 85 · see citing works

Tissue engineering and the use of stem/progenitor cells for airway epithelium repair.

Roomans, G. (2010) · European Cells & Materials · doi:10.22203/ecm.v019a27 · Cited by 82 · see citing works

Biologic Dressing in Burns

Lineen, E. B., & Namias, N. (2008) · Journal of Craniofacial Surgery · doi:10.1097/scs.0b013e318175b5ab · Cited by 81 · see citing works

Rescue of Lethal Hepatic Failure by Hepatized Lymph Nodes in Mice

Hoppo, T., Komori, J., Manohar, R., Stolz, D. B., & Lagasse, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.11.006 · Cited by 78 · see citing works

Biocompatibility of Poly-DL-lactic acid (PDLLA) for Lung Tissue Engineering

Lin, Y., Boccaccini, A. R., Polak, J. M., Bishop, A. E., & Maquet, V. (2006) · Journal of Biomaterials Applications · doi:10.1177/0885328206057952 · Cited by 76 · see citing works

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Cell surface heparan sulfate released by heparanase promotes melanoma cell migration and angiogenesis

Roy, M., & Marchetti, D. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22005 · Cited by 67 · see citing works

Human acellular dermal matrix for ventral hernia repair reduces morbidity in transplant patients

Brewer, M. B., Rada, E. M., Milburn, M. L., Goldberg, N. H., Singh, D. P., COOPER, M. M., & Silverman, R. (2010) · Hernia · doi:10.1007/s10029-010-0748-y · Cited by 54 · see citing works

Oxygen mass transfer in a human tissue-engineered trachea

Curcio, E., Macchiarini, P., & Bartolo, L. D. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.013 · Cited by 33 · see citing works

British boy receives trachea transplant built with his own stem cells

Laurance, J. (2010) · BMJ · doi:10.1136/bmj.c1633 · Cited by 32 · see citing works

Hope, Hype and Help: Ethically Assessing the Growing Market in Stem Cell Therapies

Caplan, A. L., & Levine, B. L. (2010) · The American Journal of Bioethics · doi:10.1080/15265161.2010.481980 · Cited by 30 · see citing works

Returning to Professionalism: The Re-emergence of Medicine's Art

Doukas, D. J. (2004) · The American Journal of Bioethics · doi:10.1162/152651604323097664 · Cited by 29 · see citing works

Facing Ourselves

Caplan, A. L. (2004) · The American Journal of Bioethics · doi:10.1080/15265160490496930 · Cited by 25 · see citing works

Generation of a bioartificial fibromuscular tissue with autoregenerative capacities for surgical reconstruction

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Epithelial Stem Cells

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Empiric Antibiotic Therapy for Sepsis Patients: Monotherapy With β-Lactam or β-Lactam Plus an Aminoglycoside?

Sinert, R. H., & Bright, L. (2008) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.12.013 · Cited by 6 · see citing works

Sinert R, Bright L. Empiric Antibiotic Therapy for Sepsis Patients: Monotherapy With β-Lactam or β-Lactam Plus an Aminoglycoside?

Reynolds, T. A., Schriger, D. L., & Barrett, T. W. (2008) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2008.09.013 · Cited by 2 · see citing works

Wound repair and regeneration: Mechanisms, signaling, and translation

Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works

Injectable hydrogels for cartilage and bone tissue engineering

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