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Cited by 49Pregnancy and preeclampsia studiesPrenatal Screening and DiagnosticsBirth, Development, and Health

Two‐dimensional sonographic placental measurements in the prediction of small‐for‐gestational‐age infants

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Schwartz, N., Wang, E., Parry, S.·2012·Ultrasound in Obstetrics & Gynecology
DOI 10.1002/uog.11136
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Abstract

Objectives: To determine the utility of two‐dimensional (2D) sonographic placental measurements in the prediction of small‐for‐gestational‐age (SGA) infants. Methods: The maximal diameter along the fetal surface of the placenta and the maximal placental thickness were measured at 18–24 weeks' gestation, and the measurements repeated in the orthogonal plane. ‘Biometric lags’ were calculated as the difference between sonographic gestational age, estimated using each of a number of fetal biometric measurements, and actual gestational age. These variables were analyzed individually and in combination as predictors of birth weight < 10 th percentile (SGA < 10) and < 5 th percentile (SGA < 5). Results: 1909 singleton pregnancies were included. Mean placental diameter (SGA < 10, P < 0.001; SGA < 5, P = 0.002) and thickness (SGA < 10, P < 0.006; SGA < 5, P = 0.065) were significantly smaller in SGA pregnancies. The biometric lags were greater in SGA pregnancies, the lag in abdominal circumference (AC) being the most predictive of SGA (P < 0.0001). Multivariable models were significantly predictive of both SGA < 10 th percentile (area under the receiver–operating characteristics curve (AUC) = 0.7404) and < 5 th percentile (AUC = 0.7204), the best fitting models including AC lag and mean placental diameter and thickness. Conclusions: 2D placental measurements taken in mid‐gestation are significantly associated with the incidence of SGA. Biometric lags can improve the predictive ability further. These easily obtained variables should be considered in future efforts to develop a clinically useful predictive model for adverse outcome of pregnancy.

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  • Placental volume is often smaller in hypertensive pregnancies and cases with growth restriction.

    “It is well-documented that placental volume is often smaller in hypertensive pregnancies and cases with growth restriction23,24.”

    From Multi-centre deep learning for placenta segmentation in obstetric ultrasound with multi-observer and cross-country generalization (2023) · cites this paper as [24]

    The Results report smaller two-dimensional placental diameter and thickness in small-for-gestational-age pregnancies. The Discussion links early placental volume with fetal growth restriction and pre-eclampsia, but does not say that volume is smaller in those pregnancies; the study also lacked pre-eclampsia diagnoses. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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  • Early in utero placental size measured with 2D ultrasound has weak associations with adverse outcomes.

    “Early, in utero placental size as measured with 2D ultrasound has demonstrated weak associations with adverse outcomes [4].”

    From Fully Automated Placental Volume Quantification From<scp>3D</scp>Ultrasound for Prediction of Small‐for‐Gestational‐Age Infants (2022) · cites this paper as [4]

  • Two-dimensional and three-dimensional ultrasound have been used to study in utero placental size and morphology early in pregnancy in relation to birthweight and preeclampsia.

    “In particular, two-dimensional and three-dimensional ultrasound (3DUS) have been used to study in utero placental size and morphology early in pregnancy in relation to birthweight 4 and preeclampsia. 5,6”

    From Minimally interactive placenta segmentation from three-dimensional ultrasound images (2020) · cites this paper as [4]

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Research works printed but not linked: 2

  1. American College of Obstetricians and Gynecologists (ACOG). Practice Bulletin No. 12: Intrauterine growth restric- tion. ACOG, Washington, DC, 2008. http://www.acog.org/ publications/educational_bulletins/pb012.cfm.
  2. Copyright  2012 ISUOG. Published by John Wiley & Sons, Ltd. Ultrasound Obstet Gynecol 2012; 40: 674-679. 14690705, 2012, 6, Downloaded from https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.11136 by Readcube (Labtiva Inc.), Wiley Online Library on [11/07/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI

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Authors
Schwartz, N., Wang, E., & Parry, S.
Affiliations
Hospital of the University of Pennsylvania (US)
Corresponding author
Schwartz, N.
ORCID
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2012-11-21
Volume
40
Issue
6
Pages
674-679
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
DOI
10.1002/uog.11136
OpenAlex
W2096905739
Cited by
49
References
28
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2
FWCI
2.31
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
small for gestational age, placental diameter, placental thickness, abdominal circumference, birth weight prediction, gestational age estimation, fetal growth restriction
MeSH terms
Adult, Epidemiologic Methods, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Small for Gestational Age, Organ Size, Placenta, Placenta Diseases, Pregnancy, Ultrasonography, Prenatal

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