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Cited by 73Congenital Anomalies and Fetal SurgeryPrenatal Screening and DiagnosticsAssisted Reproductive Technology and Twin Pregnancy

Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta‐analysis

Voskamp, B. J., Fleurke‐Rozema, H., Oude‐Rengerink, K., Snijders, R. J. M., Bilardo, C. M., Mol, B. W. J., Pajkrt, E.·2013·Ultrasound in Obstetrics & Gynecology
DOI 10.1002/uog.12541
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Abstract

Objective: To review the available literature on outcome of pregnancy when an isolated single umbilical artery (iSUA) is diagnosed at the time of the mid‐trimester anomaly scan. Methods: We searched MEDLINE (1948–2012), EMBASE (1980–2012) and the Cochrane Library (until 2012) for relevant citations reporting on outcome of pregnancy with iSUA seen on ultrasound. Data were extracted by two reviewers. Where appropriate, we pooled odds ratios (ORs) for the dichotomous outcome measures: small for gestational age (SGA), perinatal mortality and aneuploidy. For birth weight we determined the mean difference with 95% CI. Results: We identified three cohort studies and four case–control studies reporting on 928 pregnancies with iSUA. There was significant heterogeneity between cohort and case–control studies. Compared to fetuses with a three‐vessel cord, fetuses with an iSUA were more likely to be SGA (OR 1.6 (95% CI, 0.97–2.6); n = 489) or suffer perinatal mortality (OR 2.0 (95% CI, 0.9–4.2); n = 686), although for neither of the outcomes was statistical significance reached. The difference in mean birth weight was 51 g (95% CI, –154.7 to 52.6 g): n = 407), but again this difference was not statistically significant. We found no evidence that fetuses with iSUA have an increased risk for aneuploidy. Conclusion: In view of the non‐significant association between iSUA and fetal growth and perinatal mortality, and in view of the heterogeneity in studies on aneuploidy, we feel that large‐scale, prospective cohort studies are needed to reach definitive conclusions on the appropriate work‐up in iSUA pregnancies. At present, targeted growth assessment after diagnosis of iSUA should not be routine practice. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.

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Authors
Voskamp, B. J., Fleurke‐Rozema, H., Oude‐Rengerink, K., Snijders, R. J. M., Bilardo, C. M., Mol, B. W. J., & Pajkrt, E.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • University Medical Center Groningen (NL)
  • Department of Obstetrics University Medical Centre AMC Amsterdam Amsterdam The Netherlands
Corresponding author
Voskamp, B. J.
ORCID
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2013-10-24
Volume
42
Issue
6
Pages
622-628
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
DOI
10.1002/uog.12541
OpenAlex
W1554669476
Cited by
73
References
37
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 3
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords
isolated single umbilical artery, fetal growth restriction, small for gestational age, perinatal mortality, fetal aneuploidy, birth weight, fetal anomaly scan, umbilical cord, pregnancy outcomes
MeSH terms
Aneuploidy, Birth Weight, Female, Fetal Growth Retardation, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy, Risk, Odds Ratio, Ultrasonography, Prenatal, Fetal Development, Perinatal Mortality, Single Umbilical Artery

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