Screening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks’ gestation
Open accessAbstract
OBJECTIVE: To examine the performance of screening for early, preterm and term pre-eclampsia (PE) at 11-13 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery (UtA) pulsatility index (PI), serum placental growth factor (PlGF) and serum pregnancy-associated plasma protein-A (PAPP-A). METHODS: The data for this study were derived from three previously reported prospective non-intervention screening studies at 11 + 0 to 13 + 6 weeks' gestation in a combined total of 61 174 singleton pregnancies, including 1770 (2.9%) that developed PE. Bayes' theorem was used to combine the prior distribution of gestational age at delivery with PE, obtained from maternal characteristics, with various combinations of biomarker multiples of the median (MoM) values to derive patient-specific risks of delivery with PE at < 37 weeks' gestation. The performance of such screening was estimated. RESULTS: In pregnancies that developed PE, compared to those without PE, the MoM values of UtA-PI and MAP were increased and those of PAPP-A and PlGF were decreased, and the deviation from normal was greater for early than late PE for all four biomarkers. Combined screening by maternal factors, UtA-PI, MAP and PlGF predicted 90% of early PE, 75% of preterm PE and 41% of term PE, at a screen-positive rate of 10%; inclusion of PAPP-A did not improve the performance of screening. The performance of screening depended on the racial origin of the women; on screening by a combination of maternal factors, MAP, UtA-PI and PlGF and using a risk cut-off of 1 in 100 for PE at < 37 weeks in Caucasian women, the screen-positive rate was 10% and detection rates for early, preterm and term PE were 88%, 69% and 40%, respectively. With the same method of screening and risk cut-off in women of Afro-Caribbean racial origin, the screen-positive rate was 34% and detection rates for early, preterm and term PE were 100%, 92% and 75%, respectively. CONCLUSION: Screening by maternal factors and biomarkers at 11-13 weeks' gestation can identify a high proportion of pregnancies that develop early and preterm PE. © 2018 Crown copyright. Ultrasound in Obstetrics & Gynecology © 2018 ISUOG.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
For women of Afro-Caribbean origin, the prediction rates for early, preterm and term preeclampsia are 100%, 92% and 75%, respectively.
“while for women of Afro-Caribbean origin, the rates are 100%, 92% and 75%, respectively [71].”
From First-Trimester Ultrasound: A Comparative Review of Guidelines (2026) · cites this paper as [71]
The combination of maternal characteristics, MAP, and maternal biochemistry (free β-hCG, PAPP-A and PlGF), with the exception of PAPP-A, leads to prediction of early, preterm and term preeclampsia in Caucasian women at rates of 88%, 69% and 40%, respectively.
“More specifically, the combination of the above-mentioned, with the exception of PAPP-A, leads to the prediction of early, preterm and term preeclampsia in Caucasian women at rates of 88%, 69% and 40%, respectively”
From First-Trimester Ultrasound: A Comparative Review of Guidelines (2026) · cites this paper as [71]
A combination of uterine arteries' Doppler, mean arterial pressure and placental growth factor resulted in a prediction of 90% for early, 75% for preterm and 41% for term preeclampsia.
“More specifically, a combination of uterine arteries’ Doppler, mean arterial pressure (MAP) and PlGF resulted in a prediction of 90% for early, 75% for preterm and 41% for term preeclampsia [71].”
From First-Trimester Ultrasound: A Comparative Review of Guidelines (2026) · cites this paper as [71]
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
pROC: an open-source package for R and S+ to analyze and compare ROC curves
Robin, X., Turck, N., Hainard, A., Tiberti, N., Lisacek, F., Sanchez, J.-C., & Müller, M. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-77 · Cited by 13,697 · see citing works
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
Rolnik, D. L., Wright, D., Poon, L. C., O’Gorman, N., Syngelaki, A., de Paco Matallana, C., Akolekar, R., Cicero, S., Janga, D., Singh, M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1704559 · Cited by 2,287 · see citing works
Self-citationBrown, M. A., Lindheimer, M. D., de Swiet, M., Assche, A. V., & Moutquin, J. (2001) · Hypertension in Pregnancy · doi:10.1081/prg-100104165 · Cited by 1,894 · see citing works
A CRITICAL EVALUATION OF SONAR “CROWN‐RUMP LENGTH” MEASUREMENTS
Robinson, H. P., & Fleming, J. E. E. (1975) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1975.tb00710.x · Cited by 1,413 · see citing works
O’Gorman, N., Wright, D., Syngelaki, A., Akolekar, R., Wright, A., Poon, L. C., & Nicolaides, K. H. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.034 · Cited by 629 · see citing works
Self-citationAspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis
Roberge, S., Bujold, E., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.561 · Cited by 628 · see citing works
Self-citationCompeting Risks Model in Early Screening for Preeclampsia by Biophysical and Biochemical Markers
Akolekar, R., Syngelaki, A., Poon, L. C., Wright, D. E., & Nicolaides, K. H. (2012) · Fetal Diagnosis and Therapy · doi:10.1159/000341264 · Cited by 601 · see citing works
Self-citationAkolekar, R., Syngelaki, A., Sarquis, R., Zvanca, M. E., & Nicolaides, K. H. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2660 · Cited by 444 · see citing works
Self-citationUterine artery Doppler at 11 + 0 to 13 + 6 weeks in the prediction of pre‐eclampsia
Plasencia, W., Maiz, N., Bonino, S., Kaihura, C., & Nicolaides, K. H. (2007) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.5157 · Cited by 425 · see citing works
Self-citationCompeting risks model in screening for preeclampsia by maternal characteristics and medical history
Wright, D. E., Syngelaki, A., Akolekar, R., Poon, L. C., & Nicolaides, K. H. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.02.018 · Cited by 419 · see citing works
Self-citationTan, M. Y., Wright, D., Syngelaki, A., Akolekar, R., Cicero, S., JANGA, D., Singh, M., Greco, E., Wright, A., Maclagan, K., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.19039 · Cited by 395 · see citing works
Self-citationWorld Health Organization Systematic Review of Screening Tests for Preeclampsia
Conde‐Agudelo, A., Villar, J., & Lindheimer, M. D. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000147599.47713.5d · Cited by 325 · see citing works
Protocol for Measurement of Mean Arterial Pressure at 11-13 Weeks' Gestation
Poon, L. C., Zymeri, N. A., Zamprakou, A., Syngelaki, A., & Nicolaides, K. H. (2012) · Fetal Diagnosis and Therapy · doi:10.1159/000335366 · Cited by 262 · see citing works
Self-citationO’Gorman, N., Wright, D. E., Poon, L. C., Rolnik, D. L., Syngelaki, A., Wright, A., Akolekar, R., Cicero, S., JANGA, D., Jani, J. C., et al. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.17399 · Cited by 260 · see citing works
Self-citationWorld Health Organization Systematic Review of Screening Tests for Preeclampsia
Cnossen, J. S., Mol, B. W., van der Post, J., Bossuyt, P. M., & ter Riet, G. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000162539.68541.c2 · Cited by 249 · see citing works
A Competing Risks Model in Early Screening for Preeclampsia
Wright, D. E., Akolekar, R., Syngelaki, A., Poon, L. C., & Nicolaides, K. H. (2012) · Fetal Diagnosis and Therapy · doi:10.1159/000338470 · Cited by 235 · see citing works
Self-citationPoon, L. C., Wright, D. E., Rolnik, D. L., Syngelaki, A., Delgado⋈, J. L., Tsokaki, T., Leipold, G., Akolekar, R., Shearing, S., Stefani, L. F. B. D., et al. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.07.038 · Cited by 200 · see citing works
Self-citationWright, D. E., Poon, L. C., Rolnik, D. L., Syngelaki, A., Delgado⋈, J. L., Vojtassakova, D., de Alvarado, M., Kapeti, E., Rehal, A., Pazos, A., et al. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.08.110 · Cited by 172 · see citing works
Self-citationChronic hypertension and adverse pregnancy outcome: a cohort study
Panaitescu, A. M., Syngelaki, A., Prodan, N., Akolekar, R., & Nicolaides, K. H. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.17493 · Cited by 159 · see citing works
Self-citationTsiakkas, A., Duvdevani, N., Wright, A., Wright, D. E., & Nicolaides, K. H. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14811 · Cited by 152 · see citing works
Self-citationRoberge, S., Bujold, E., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.238 · Cited by 135 · see citing works
Self-citationTayyar, A., Guerra, L., Wright, A., Wright, D. E., & Nicolaides, K. H. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14789 · Cited by 126 · see citing works
Self-citationWright, D. E., Rolnik, D. L., Syngelaki, A., Matallana, C. D. P., Machuca, M., de Alvarado, M., Mastrodima, S., Tan, M. Y., Shearing, S., Persico, N., et al. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.02.014 · Cited by 118 · see citing works
Self-citationWright, A., Wright, D. E., Ispas, C. A., Poon, L. C., & Nicolaides, K. H. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14783 · Cited by 108 · see citing works
Self-citation(2015) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000001049 · Cited by 102 · see citing works
Screening for pre‐eclampsia at 35–37 weeks' gestation
Panaitescu, A. M., Ciobanu, A.-M., Syngelaki, A., Wright, A., Wright, D. E., & Nicolaides, K. H. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.19111 · Cited by 91 · see citing works
Self-citationPoon, L. C., Rolnik, D. L., Tan, M. Y., Delgado⋈, J. L., Tsokaki, T., Akolekar, R., Singh, M., Andrade, W., Efetürk, T., Jani, J. C., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.19019 · Cited by 86 · see citing works
Self-citationWright, D. E., Silva, M. D. L., Papadopoulos, S., Wright, A., & Nicolaides, K. H. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14870 · Cited by 60 · see citing works
Self-citationContingent screening for preterm pre-eclampsia
Wright, D., Gallo, D. M., Gil Pugliese, S., Casanova, C., & Nicolaides, K. H. (2016) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.15807 · Cited by 40 · see citing works
Self-citationImpaired placentation in women with chronic hypertension who develop pre‐eclampsia
Panaitescu, A. M., Akolekar, R., Kametas, N. A., Syngelaki, A., & Nicolaides, K. H. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.17517 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Poon, L. C., Shennan, A. H., Hyett, J. A., Kapur, A., Hadar, E., Divakar, H., McAuliffe, F. M., Costa, F. D. S., von Dadelszen, P., McIntyre, D. H., et al. (2019) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12802 · Cited by 1,343 · see citing works
Self-citationDimitriadis, E., Rolnik, D. L., Zhou, W., Estrada‐Gutiérrez, G., Koga, K., Francisco, R. P. V., Whitehead, C. L., Hyett, J. A., Costa, F. D. S., Nicolaides, K. H., et al. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00417-6 · Cited by 1,006 · see citing works
Self-citationFirst trimester preeclampsia screening and prediction
Chaemsaithong, P., Sahota, D. S., & Poon, L. C. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.07.020 · Cited by 388 · see citing works
Self-citationAdvanced maternal age and adverse pregnancy outcomes
Frick, A. (2020) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2020.07.005 · Cited by 324 · see citing works
ISUOG Practice Guidelines (updated): performance of 11–14‐week ultrasound scan
International Society of Ultrasound in Obstetrics and Gynecology, Bilardo, C. M., Chaoui, R., Hyett, J. A., Kagan, K. O., Karim, J. N., Papageorghiou, A. T., Poon, L. C., Salomon, L. J., Syngelaki, A., et al. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.26106 · Cited by 283 · see citing works
Self-citationThe competing risk approach for prediction of preeclampsia
Wright, D. E., Wright, A., & Nicolaides, K. H. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.11.1247 · Cited by 269 · see citing works
Self-citationCombining Biomarkers to Predict Pregnancy Complications and Redefine Preeclampsia
Stepan, H., Hund, M., & Andraczek, T. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.13763 · Cited by 241 · see citing works
Preeclampsia in 2018: Revisiting Concepts, Physiopathology, and Prediction
Mayrink, J., Costa, M. L., & Cecatti, J. G. (2018) · The Scientific World JOURNAL · doi:10.1155/2018/6268276 · Cited by 244 · see citing works
RNA profiles reveal signatures of future health and disease in pregnancy
Rasmussen, M., Reddy, M., Nolan, R., Camuñas-Soler, J., Khodursky, A. B., Scheller, N. M., Cantonwine, D. E., Engelbrechtsen, L., Mi, J. D., Dutta, A., et al. (2022) · Nature · doi:10.1038/s41586-021-04249-w · Cited by 190 · see citing works
Chaemsaithong, P., Pooh, R. K., Zheng, M., Ma, R., Chaiyasit, N., Tokunaka, M., Shaw, S. W., Seshadri, S., Choolani, M. A., Wataganara, T., et al. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.09.041 · Cited by 174 · see citing works
Self-citationPravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia
Döbert, M., Varouxaki, A.-N., Mu, A. C., Syngelaki, A., Ciobanu, A. M., Akolekar, R., Matallana, C. D. P., Cicero, S., Greco, E., Singh, M., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.053963 · Cited by 122 · see citing works
Self-citationCovella, B., Vinturache, A., Cabiddu, G., Attini, R., Gesualdo, L., Versino, E., & Piccoli, G. B. (2019) · Kidney International · doi:10.1016/j.kint.2019.03.033 · Cited by 114 · see citing works
Poon, L. C., Magee, L. A., Verlohren, S., Shennan, A. H., von Dadelszen, P., Sheiner, E., Hadar, E., Visser, G. H. A., Costa, F. D. S., Kapur, A., et al. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13763 · Cited by 118 · see citing works
Self-citationImmunomodulation and preeclampsia
Rambaldi, M. P., Weiner, E., Mecacci, F., Bar, J., & Petraglia, F. (2019) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2019.06.005 · Cited by 83 · see citing works
Zumaeta, A. M., Wright, A., Syngelaki, A., Maritsa, V., Silva, A. B. D., & Nicolaides, K. H. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.22093 · Cited by 88 · see citing works
Self-citationSapantzoglou, I., Wright, A., Arozena, M. G., Campos, R. V., Charakida, M., & Nicolaides, K. H. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23528 · Cited by 81 · see citing works
Self-citationAngiogenic Biomarkers in Preeclampsia
Burwick, R. M., & Rodriguez, M. H. (2024) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005532 · Cited by 94 · see citing works
Prediction of imminent preeclampsia at 35–37 weeks gestation
Ciobanu, A. M., Wright, A., Panaitescu, A. M., Syngelaki, A., Wright, D. E., & Nicolaides, K. H. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.01.235 · Cited by 68 · see citing works
Self-citationTwo-stage screening for preterm preeclampsia at 11–13 weeks’ gestation
Wright, A., Wright, D. E., Syngelaki, A., Georgantis, A., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.10.092 · Cited by 63 · see citing works
Self-citationŞeyhanlı, Z., Bayraktar, B., Baysoz, O. B., Karabay, G., Sucu, S. T., Ulusoy, C. O., Aktemur, G., Bucak, M., Çakır, B. T., Kurt, D. S., et al. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.104190 · Cited by 64 · see citing works
Papastefanou, I., Wright, D., Syngelaki, A., Souretis, K., Chrysanthopoulou, E. L., & Nicolaides, K. H. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23523 · Cited by 61 · see citing works
Self-citationLiu, M., Yang, X., Chen, G., Ding, Y., Shi, M., Sun, L., Huang, Z., Liu, J., Liu, T., Yan, R., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.896969 · Cited by 63 · see citing works
Ansbacher‐Feldman, Z., Syngelaki, A., Meiri, H., Cirkin, R., Nicolaides, K. H., & Louzoun, Y. (2022) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.26105 · Cited by 62 · see citing works
Self-citationOphthalmic artery Doppler in prediction of pre‐eclampsia at 35–37 weeks' gestation
Sarno, M., Wright, A., Vieira, N., Sapantzoglou, I., Charakida, M., & Nicolaides, K. H. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.22184 · Cited by 57 · see citing works
Self-citationMendoza, M., Bonacina, E., García‐Manau, P., López, M., Caamiña, S., Vives, À., López‐Quesada, E., Ricart, M., Maroto, A., de Mingo, L., et al. (2023) · JAMA · doi:10.1001/jama.2023.0691 · Cited by 62 · see citing works
Ghesquière, L., Guerby, P., Marchant, I., Kumar, N., Zare, M., Foisy, M.-A., Roberge, S., & Bujold, E. (2023) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2023.101000 · Cited by 63 · see citing works
Cavoretto, P. I., Salmeri, N., Candiani, M., & Farina, A. (2022) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.26092 · Cited by 56 · see citing works
From Biomarkers to the Molecular Mechanism of Preeclampsia—A Comprehensive Literature Review
Rybak-Krzyszkowska, M., Staniczek, J., Kondracka, A., Bogusławska, J., Kwiatkowski, S., Góra, T., Strus, M., & Górczewski, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713252 · Cited by 58 · see citing works
Angiogenic Marker Prognostic Models in Pregnant Women With Hypertension
Perry, H., Binder, J., Kalafat, E., Jones, S., Thilaganathan, B., & Khalil, A. A. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.13997 · Cited by 52 · see citing works
Benkő, Z., Wright, A., Rehal, A., Cimpoca-Raptis, B. A., Syngelaki, A., Delgado⋈, J. L., Tsokaki, T., de Alvarado, M., Vojtassakova, D., Ntalianis, K. M., et al. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23531 · Cited by 51 · see citing works
Self-citationFirst‐trimester pre‐eclampsia biomarker profiles in Asian population: multicenter cohort study
Chaemsaithong, P., Sahota, D. S., Pooh, R. K., Zheng, M., Ma, R., Chaiyasit, N., Koide, K., Shaw, S. W., Seshadri, S., Choolani, M. A., et al. (2019) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.21905 · Cited by 49 · see citing works
Self-citationPoon, L. C., Galindo, A., Surbek, D., Chantraine, F., Stepan, H., Hyett, J. A., Tan, K. H., & Verlohren, S. (2019) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.21869 · Cited by 46 · see citing works
Self-citationChaiworapongsa, T., Romero, R. J., Gotsch, F., Suksai, M., Gallo, D. M., Jung, E., Krieger, A., Chaemsaithong, P., Erez, O., & Tarca, A. L. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.11.001 · Cited by 45 · see citing works
Externally validated prediction models for pre‐eclampsia: systematic review and meta‐analysis
Tiruneh, S. A., Vu, T. T. T., Moran, L., Callander, E. J., Allotey, J., Thangaratinam, S., Rolnik, D. L., Teede, H. J., Wang, R., & Enticott, J. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.27490 · Cited by 47 · see citing works
Self-citationTarca, A. L., Taran, A. B., Romero, R. J., Jung, E., Paredes, C., Bhatti, G., Ghita, C., Chaiworapongsa, T., Than, N. G., & Hsu, C. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.01.020 · Cited by 51 · see citing works
Preventive effect of aspirin on preeclampsia in high‐risk pregnant women with stage 1 hypertension
Huai, J., Lin, L., Juan, J., Chen, J., Li, X., Zhu, Y., Yu, M., & Yang, H. (2021) · Journal of Clinical Hypertension · doi:10.1111/jch.14149 · Cited by 45 · see citing works
First trimester risk of preeclampsia and rate of spontaneous birth in patients without preeclampsia
Cavoretto, P. I., Farina, A., Salmeri, N., Syngelaki, A., Tan, M. Y., & Nicolaides, K. H. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2024.01.008 · Cited by 42 · see citing works
Self-citationChaemsaithong, P., Gil, M. M., Chaiyasit, N., Cuenca-Gómez, D., Plasencia, W., Rollé, V., & Poon, L. C. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.03.032 · Cited by 64 · see citing works
Self-citationPapastefanou, I., Wright, D., Lolos, M., Anampousi, K., Mamalis, M., & Nicolaides, K. H. (2021) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.23118 · Cited by 40 · see citing works
Self-citationKadji, C., Cannie, M., Resta, S., Guez, D., Abi-Khalil, F., Angelis, R. D., & Jani, J. C. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.12.031 · Cited by 68 · see citing works
Self-citationCreswell, L., O’Gorman, N., Palmer, K. R., Costa, F. D. S., & Rolnik, D. L. (2023) · International Journal of Women s Health · doi:10.2147/ijwh.s368454 · Cited by 63 · see citing works
Self-citationPre‐eclampsia screening in Denmark ( PRESIDE ): national validation study
Riishede, I., Rode, L., Sperling, L., Overgaard, M., Ravn, J. D., Sandager, P., Skov, H. L., Wagner, S., Nørgaard, P., Clausen, T. D., et al. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.26183 · Cited by 40 · see citing works
Self-citationTiruneh, S. A., Vu, T. T. T., Rolnik, D. L., Teede, H. J., & Enticott, J. (2024) · Current Hypertension Reports · doi:10.1007/s11906-024-01297-1 · Cited by 43 · see citing works
Self-citationNguyen‐Hoang, L., Dinh, L. T., Tai, A. S. T., Nguyen, D.-A., Pooh, R. K., Shiozaki, A., Zheng, M., Hu, Y., Li, B., Kusuma, R. A., et al. (2024) · Circulation · doi:10.1161/circulationaha.124.069907 · Cited by 42 · see citing works
Self-citationGil, M. M., Cuenca-Gómez, D., Rollé, V., Pertegal, M., Díaz, C., Revello, R., Adiego, B., Mendoza, M., Molina, F. S., Santacruz, B., et al. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.27478 · Cited by 53 · see citing works
Self-citationOphthalmic artery Doppler at 11–13 weeks' gestation in prediction of pre‐eclampsia
Gana, N., Sarno, M., Vieira, N., Wright, A., Charakida, M., & Nicolaides, K. H. (2022) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.24914 · Cited by 43 · see citing works
Self-citationMelinte-Popescu, A.-S., Vasilache, I.-A., Socolov, D. G., & Melinte-Popescu, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12020418 · Cited by 43 · see citing works
Zhang, N., Tan, J., Yang, H., & Khalil, R. A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114247 · Cited by 42 · see citing works
Association of Circulating miRNA Expression with Preeclampsia, Its Onset, and Severity
Kolková, Z., Holubeková, V., Grendár, M., Ňachajová, M., Žúbor, P., Pribulová, T., Loderer, D., Zigo, I., Biringer, K., & Horňáková, A. (2021) · Diagnostics · doi:10.3390/diagnostics11030476 · Cited by 35 · see citing works
Ashoor, G., Syngelaki, A., Papastefanou, I., Nicolaides, K. H., & Akolekar, R. (2021) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.24795 · Cited by 36 · see citing works
Self-citationHromadníková, I., Kotlabová, K., & Krofta, L. (2022) · Biomedicines · doi:10.3390/biomedicines10030718 · Cited by 35 · see citing works
Guerby, P., Audibert, F., Johnson, J.-A. M., Okun, N. B., Giguère, Y., Forest, J., Chaillet, N., Mâsse, B. R., Wright, D. E., Ghesquière, L., et al. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.22584 · Cited by 36 · see citing works
Self-citationDöbert, M., Wright, A., Varouxaki, A.-N., Mu, A. C., Syngelaki, A., Rehal, A., Delgado⋈, J. L., Akolekar, R., Muscettola, G., JANGA, D., et al. (2021) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.24789 · Cited by 35 · see citing works
Self-citationMoar, L., Simela, C., Nanda, S., Marnerides, A., Al‐Adnani, M., Nelson‐Piercy, C., Nicolaides, K. H., & Shangaris, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.945543 · Cited by 33 · see citing works
Self-citationCuenca-Gómez, D., Matallana, C. D. P., Rollé, V., Valino, N., Revello, R., Adiego, B., Mendoza, M., Molina, F. S., Carrillo, M. P., Delgado⋈, J. L., et al. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.26233 · Cited by 35 · see citing works
Self-citationSlade, L. J., Mistry, H. D., Bone, J. N., Wilson, M., Blackman, M., Syeda, N., von Dadelszen, P., & Magee, L. A. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.10.004 · Cited by 35 · see citing works
Malone, S. L., Haj Yahya, R., & Kane, S. C. (2022) · International Journal of Women's Health · doi:10.2147/ijwh.s283239 · Cited by 32 · see citing works
Pregnancy Complications Can Foreshadow Future Disease—Long-Term Outcomes of a Complicated Pregnancy
Panaitescu, A. M., Popescu, M. R., Ciobanu, A. M., Gică, N., & Cimpoca-Raptis, B. A. (2021) · Medicina · doi:10.3390/medicina57121320 · Cited by 29 · see citing works
Pihl, K., Sørensen, S., & Jørgensen, F. S. (2019) · Fetal Diagnosis and Therapy · doi:10.1159/000503229 · Cited by 30 · see citing works
Comparison of different methods of first‐trimester screening for preterm pre‐eclampsia: cohort study
Cuenca-Gómez, D., Matallana, C. D. P., Rollé, V., Mendoza, M., Valino, N., Revello, R., Adiego, B., Pedraz, C. C., Molina, F. S., Delgado⋈, J. L., et al. (2024) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.27622 · Cited by 33 · see citing works
Self-citationFirst trimester PAPP-A serum levels and long-term metabolic outcome of mothers and their offspring
Fruscalzo, A., Cividino, A., Rossetti, E., Maurigh, A., Londero, A. P., & Driul, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-61830-5 · Cited by 29 · see citing works
Zhang, Z., Yang, Y., Xiao-mei, L., & Liu, H. (2022) · Bioengineered · doi:10.1080/21655979.2021.2020468 · Cited by 29 · see citing works
RetractedSalmeri, N., Farina, A., Candiani, M., Dolci, C., Bonavina, G., Poziello, C., Viganò, P., & Cavoretto, P. I. (2022) · Diagnostics · doi:10.3390/diagnostics12051024 · Cited by 30 · see citing works
Performance of machine‐learning approach for prediction of pre‐eclampsia in a middle‐income country
Torres‐Torres, J., Villafán-Bernal, J. R., Martinez-Portilla, R. J., Hidalgo-Carrera, J. A., Estrada‐Gutiérrez, G., Adalid‐Martinez‐Cisneros, R., Rojas‐Zepeda, L., Acevedo‐Gallegos, S., Camarena‐Cabrera, D. M., Cruz, Y., et al. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.27510 · Cited by 28 · see citing works
Placental Origins of Preeclampsia: Insights from Multi-Omic Studies
Cao, C. Q., Saxena, R., & Gray, K. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179343 · Cited by 28 · see citing works
for the IPPIC Collaborative Network, Snell, K. I. E., Allotey, J., Smuk, M., Hooper, R., Chan, C., Ahmed, A., Chappell, L. C., von Dadelszen, P., Green, M., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01766-9 · Cited by 27 · see citing works
Nicolaides, K. H., Papastefanou, I., Syngelaki, A., Ashoor, G., & Akolekar, R. (2021) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17066 · Cited by 175 · see citing works
Self-citationImpaired placental perfusion and major fetal cardiac defects
Fantasia, I., Andrade, W., Syngelaki, A., Akolekar, R., & Nicolaides, K. H. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20149 · Cited by 27 · see citing works
Self-citationThong, E. P., Ghelani, D. P., Manoleehakul, P., Yesmin, A., Slater, K., Taylor, R., Collins, C. E., Hutchesson, M., Lim, S. S., Teede, H. J., et al. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9020055 · Cited by 28 · see citing works
Tiruneh, S. A., Rolnik, D. L., Teede, H. J., & Enticott, J. (2024) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2024.105645 · Cited by 29 · see citing works
Self-citationAhn, T. G., & Hwang, J. Y. (2023) · Obstetrics & Gynecology Science · doi:10.5468/ogs.22261 · Cited by 30 · see citing works
Zwertbroek, E. F., Groen, H., Fontanella, F., Maggio, L., Marchi, L., & Bilardo, C. M. (2021) · Fetal Diagnosis and Therapy · doi:10.1159/000512335 · Cited by 27 · see citing works
Litwińska, M., Litwińska, E., Lisnere, K., Syngelaki, A., Wright, A., & Nicolaides, K. H. (2021) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23623 · Cited by 25 · see citing works
Self-citationCardiovascular Deaths in Pregnancy: Growing Concerns and Preventive Strategies
Keepanasseril, A., Pfaller, B., Metcalfe, A., Siu, S. C., Davis, M. B., & Silversides, C. K. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.09.022 · Cited by 25 · see citing works
Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia
Docheva, N., Arenas, G. A., Nieman, K. M., Perdigao, J. L., Yeo, K.-T. J., & Rana, S. (2022) · Clinical Chemistry · doi:10.1093/clinchem/hvab281 · Cited by 24 · see citing works
Human Plasma Proteome During Normal Pregnancy
Tarca, A. L., Romero, R. J., Bhatti, G., Gotsch, F., Done, B., Gudicha, D. W., Gallo, D. M., Jung, E., Piqué-Regi, R., Berry, S. M., et al. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00391 · Cited by 25 · see citing works
Translation of mechanistic advances in preeclampsia to the clinic: Long and winding road
Thadhani, R., Cerdeira, A. S., & Karumanchi, S. A. (2024) · The FASEB Journal · doi:10.1096/fj.202301808r · Cited by 26 · see citing works
Perry, H., Gutiérrez, J., Binder, J., Thilaganathan, B., & Khalil, A. A. (2019) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.21893 · Cited by 23 · see citing works
Choorakuttil, R. M., Patel, H., Rajalingam, B., Devarajan, P., Kanhirat, S., Shenoy, R., Tiwari, O. P., Sodani, R. K., Sharma, L. K., & Nirmalan, P. K. (2019) · Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · doi:10.4103/ijri.ijri_386_19 · Cited by 25 · see citing works
Screening and Prevention of Preeclampsia
Poon, L. C., & Sahota, D. S. (2019) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000005 · Cited by 26 · see citing works
Self-citationHromadníková, I., Kotlabová, K., & Krofta, L. (2022) · Biomedicines · doi:10.3390/biomedicines10020256 · Cited by 25 · see citing works
Potential biomarkers for late-onset and term preeclampsia: A scoping review
Han, L., Holland, O. J., Costa, F. D. S., & Perkins, A. V. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1143543 · Cited by 24 · see citing works
Spiral, uterine artery doppler and placental ultrasound in relation to preeclampsia
Suárez, T. D. G., Matallana, C. D. P., & Plasencia, W. (2023) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102426 · Cited by 23 · see citing works
Self-citationPrasad, S., Sahota, D. S., Vanamail, P., Sharma, A., Arora, S., & Kaul, A. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-04283-6 · Cited by 24 · see citing works
Hromadníková, I., Kotlabová, K., & Krofta, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073951 · Cited by 23 · see citing works
Vasilache, I.-A., Scripcariu, I. S., Doroftei, B., Bernad, R. L., Cărăuleanu, A., Socolov, D. G., Melinte-Popescu, A.-S., Vicoveanu, P., Harabor, V. R., Mihălceanu, E., et al. (2024) · Diagnostics · doi:10.3390/diagnostics14040453 · Cited by 23 · see citing works
Papastefanou, I., Wright, D., Syngelaki, A., Lolos, M., Anampousi, K., & Nicolaides, K. H. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.22175 · Cited by 22 · see citing works
Self-citationThe Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia
Pankiewicz, K., Szczerba, E., Fijałkowska, A., Sierdziński, J., Issat, T., & Maciejewski, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216390 · Cited by 21 · see citing works
Prediction of preeclampsia in asymptomatic women
Lee, N. M. W., Chaemsaithong, P., & Poon, L. C. (2023) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102436 · Cited by 23 · see citing works
Self-citationCôté, M.-L., Giguère, Y., Forest, J., Audibert, F., Johnson, J.-A., Okun, N. B., Guerby, P., Ghesquière, L., & Bujold, E. (2024) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2024.102732 · Cited by 24 · see citing works
Semmler, J., García-González, C., Sierra, A. S., Arozena, M. G., Nicolaides, K. H., & Charakida, M. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23521 · Cited by 20 · see citing works
Self-citationPreeclampsia: state of art and future perspectives. A special focus on possible preventions
Kahramanoğlu, Ö., Schiattarella, A., Demirci, O., Sisti, G., Ammaturo, F. P., Trotta, C., Ferrari, F. G., & Rapisarda, A. M. C. (2022) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2022.2048810 · Cited by 22 · see citing works
Morey, R. E., Poling, L., Srinivasan, S., Martinez‐King, C., Anyikam, A. L., Zhang‐Rutledge, K., To, C., Hakim, A., Mochizuki, M., Verma, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg7545 · Cited by 20 · see citing works
Lanssens, D., Thijs, I. M. V., Gyselaers, W., Gyselaers, W., Thijs, I. M. V., Lanssens, D., de Jonge, E. T., Holsbeke, C. V., Mesens, T., Jacquemyn, Y., et al. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-03291-2 · Cited by 19 · see citing works
Zakiyah, N., Tuytten, R., Baker, P. N., Kenny, L. C., Postma, M. J., & van Asselt, A. D. I. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267313 · Cited by 23 · see citing works
Tuytten, R., Syngelaki, A., Thomas, G. R., Panigassi, A. P., Brown, L. W., Ortea, P., & Nicolaides, K. H. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.12.012 · Cited by 19 · see citing works
Self-citationMendoza, M., Tur, H., García‐Manau, P., Hurtado, I., Serrano, B., López, R. M., Castellote, L., Martínez-Sánchez, L. M., Bonacina, E., & Carreras, E. (2020) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2020.101827 · Cited by 18 · see citing works
Quaresima, P., Visconti, F., Greco, E., Venturella, R., & Carlo, C. D. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05846-2 · Cited by 18 · see citing works
Self-citationReconsidering Race Adjustment in Prenatal Alpha-Fetoprotein Screening
Burns, R. N., Kolarova, T. R., Katz, R., Ma, K., & Delaney, S. S. (2023) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005045 · Cited by 18 · see citing works
Prevention of Pregnancy Complications Using a Multimodal Lifestyle, Screening, and Medical Model
Parker, J., Hofstee, P., & Brennecke, S. P. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154344 · Cited by 25 · see citing works
- Authors
- Tan, M. Y., Syngelaki, A., Poon, L. C., Rolnik, D. L., O'Gorman, N., Delgado, J. L., Akolekar, R., Konstantinidou, L., Tsavdaridou, M., Galeva, S., Ajdacka, U., Molina, F. S., Persico, N., Jani, J. C., Plasencia, W., Greco, E., Papaioannou, G., Wright, A., Wright, D., & Nicolaides, K. H.
- Affiliations
- King's College London (GB)
- King's College Hospital (GB)
- King's College Hospital London UK
- Hospital Clínico Universitario Virgen de la Arrixaca Murcia Spain
- Medway Maritime Hospital (GB)
- Homerton University Hospital (GB)
- North Middlesex Hospital (GB)
- University Hospital Lewisham (GB)
- Southend University Hospital NHS Foundation Trust (GB)
- Hospital Universitario San Cecilio Granada Spain
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Université Libre de Bruxelles (BE)
- Hospiten Group (ES)
- Royal London Hospital (GB)
- University General Hospital Attikon (GR)
- University of Exeter (GB)
- Corresponding author
- Nicolaides, K. H.
- ORCID
- Venue
- Ultrasound in Obstetrics & Gynecology
- Publisher
- Wiley
- Published
- 2018-07-11
- Volume
- 52
- Issue
- 2
- Pages
- 186-195
- ISSN
- 0960-7692 (ISSN-L)
- 1469-0705
- OpenAlex
- W2808436993
- Cited by
- 438
- References
- 31
- Citations by year
- 2026: 59 · 2025: 62 · 2024: 61 · 2023: 83 · 2022: 60 · 2021: 41 · 2020: 42 · 2019: 24 · 2018: 6
- FWCI
- 31.72
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Ultrasound in Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Funders
- Fetal Medicine Foundation ((UK Charity No: 1037116))
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- preeclampsia, preeclampsia screening, first-trimester screening, maternal risk factors, mean arterial pressure, uterine artery pulsatility index, placental growth factor, PAPP-A, Bayes' theorem, risk prediction, preterm preeclampsia, racial differences
- MeSH terms
- Placenta Growth Factor, Adult, Bayes Theorem, Female, Gestational Age, Humans, Pre-Eclampsia, Pregnancy, Pregnancy Trimester, First, Pregnancy-Associated Plasma Protein-A, Prospective Studies, Pulsatile Flow, Biomarkers, Risk Assessment, Vascular Endothelial Growth Factor Receptor-1, Uterine Artery, Arterial Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
