Uterine artery Doppler at 11 + 0 to 13 + 6 weeks in the prediction of pre‐eclampsia
Open accessAbstract
Objective: To determine the performance of screening for pre‐eclampsia (PET) by maternal characteristics and uterine artery pulsatility index (PI) at 11 + 0 to 13 + 6 weeks' gestation. Methods: In women with singleton pregnancies attending for routine care at 11 + 0 to 13 + 6 weeks' gestation we recorded maternal variables and measured the uterine artery PI. We identified 107 cases that subsequently developed PET and 5041 that were unaffected by PET, gestational hypertension or delivery of newborns with birth weight below the 10 th centile. A multivariate Gaussian model was fitted to the distribution of log multiples of the median (MoM) PI in the PET and unaffected groups. Likelihood ratios for log MoM PI were computed and used together with maternal variables to produce patient‐specific risks for each case. Predicted detection rates (DR) and false‐positive rates (FPR) were calculated by taking the proportions with risks above a given risk threshold. Results: In the unaffected group log MoM PI was influenced by maternal ethnic origin, body mass index, previous history of PET and fetal crown–rump length. In the prediction of PET significant contributions were provided by log MoM PI, ethnic origin, body mass index and previous and family history of PET. For an FPR of 10% the DRs of all PET and PET leading to delivery before 34 weeks' gestation by log MoM PI and maternal variables were 61.7% and 81.8%, respectively. Conclusion: Maternal variables together with uterine artery PI at 11 + 0 to 13 + 6 weeks' gestation provide sensitive prediction of the development of PET, especially of severe early‐onset PET. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.
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Uterine artery Doppler velocimetry is associated with the development of preeclampsia and placental pathology.
“Ultrasound can be used to measure Doppler velocimetry in the uterine artery, which is associated with development of preeclampsia and placental pathology21,22”
From Multi-centre deep learning for placenta segmentation in obstetric ultrasound with multi-observer and cross-country generalization (2023) · cites this paper as [22]
The Methods describe ultrasound Doppler measurement of uterine artery pulsatility index, and the paper reports that this measure predicts pre-eclampsia. The Discussion interprets higher values as evidence of impaired placentation, but the paper does not report a direct association between Doppler measurements and measured placental pathology. (LLM, conf=0.83)
Experimental — accuracy not yet measured
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Abnormal blood biomarkers in early pregnancy are associated with preeclampsia: a meta-analysis
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First-trimester maternal plasma cell-free fetal DNA and preeclampsia
Sifakis, S., Zaravinos, A., Maíz, N., Spandidos, D. A., & Nicolaides, K. H. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.05.025 · Cited by 93 · see citing works
Self-citationMacdonald-Wallis, C. M., Silverwood, R. J., Stavola, B. L. D., Inskip, H. M., Cooper, C. C., Godfrey, K. M., Crozier, S., Fraser, A., Nelson, S. M., Lawlor, D. A., et al. (2015) · BMJ · doi:10.1136/bmj.h5948 · Cited by 92 · see citing works
Aspirin delays the development of preeclampsia
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Self-citationPoon, L. C., Kametas, N. A., Valencia, C. M. M., Chelemen, T., & Nicolaides, K. H. (2010) · Hypertension in Pregnancy · doi:10.3109/10641955.2010.484086 · Cited by 87 · see citing works
Self-citationPoon, L. C., Rolnik, D. L., Tan, M. Y., Delgado⋈, J. L., Tsokaki, T., Akolekar, R., Singh, M., Andrade, W., Efetürk, T., Jani, J. C., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.19019 · Cited by 86 · see citing works
Self-citationPulse wave analysis: a preliminary study of a novel technique for the prediction of pre‐eclampsia
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Maternal hemodynamics at 11–13 weeks' gestation and risk of pre‐eclampsia
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Self-citationMaternal plasma soluble endoglin at 11–13 weeks' gestation in pre‐eclampsia
Foidart, J., Munaut, C., Chantraine, F., Akolekar, R., & Nicolaides, K. H. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7621 · Cited by 84 · see citing works
Self-citationZumaeta, A. M., Wright, A., Syngelaki, A., Maritsa, V., Silva, A. B. D., & Nicolaides, K. H. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.22093 · Cited by 88 · see citing works
Self-citationRolnik, D. L., Costa, F. D. S., Lee, T. J., Schmid, M., & McLennan, A. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18993 · Cited by 84 · see citing works
Role of uteroplacental and fetal Doppler in identifying fetal growth restriction at term
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Early prediction and prevention of pre-eclampsia
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Combined Screening for Early Detection of Pre-Eclampsia
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Utero-placental Doppler ultrasound for improving pregnancy outcome
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Self-citationFrancisco, C., Wright, D., Benkő, Z., Syngelaki, A., & Nicolaides, K. H. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.17531 · Cited by 68 · see citing works
Self-citationKhalil, A. A., Tsikas, D., Akolekar, R., Jordan, J., & Nicolaides, K. H. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.109 · Cited by 68 · see citing works
Self-citationMaternal plasma inhibin A at 11–13 weeks of gestation in hypertensive disorders of pregnancy
Akolekar, R., Minekawa, R., Veduță, A., Infante, X. C. R., & Nicolaides, K. H. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2279 · Cited by 65 · see citing works
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Self-citationLongitudinal changes in uterine artery Doppler and blood pressure and risk of pre‐eclampsia
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Self-citationTwo-stage screening for preterm preeclampsia at 11–13 weeks’ gestation
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Self-citationUterine and umbilical artery doppler in women with pre-eclampsia and their pregnancy outcomes
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Impact of new definitions of pre‐eclampsia on incidence and performance of first‐trimester screening
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Self-citationFirst‐trimester maternal serum matrix metalloproteinase‐9 (MMP‐9) and adverse pregnancy outcome
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Self-citationFirst‐trimester maternal ophthalmic artery Doppler analysis for prediction of pre‐eclampsia
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Self-citationQuality of first trimester risk prediction models for pre‐eclampsia: a systematic review
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Aspirin Versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
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Self-citationUtero-placental Doppler ultrasound for improving pregnancy outcome
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Maternal thyroid function at 11 to 13 weeks of gestation and subsequent development of preeclampsia
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First‐trimester pre‐eclampsia biomarker profiles in Asian population: multicenter cohort study
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Maternal serum vitamin D levels at 11–13 weeks of gestation in preeclampsia
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- Authors
- Plasencia, W., Maiz, N., Bonino, S., Kaihura, C., & Nicolaides, K. H.
- Affiliations
- Harris Birthright Research Centre for Fetal Medicine (GB)
- Corresponding author
- Nicolaides, K. H.
- Venue
- Ultrasound in Obstetrics & Gynecology
- Publisher
- Wiley
- Published
- 2007-09-26
- Volume
- 30
- Issue
- 5
- Pages
- 742-749
- ISSN
- 0960-7692 (ISSN-L)
- 1469-0705
- OpenAlex
- W2130645342
- Cited by
- 425
- References
- 28
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 17 · 2023: 27 · 2022: 21 · 2021: 22 · 2020: 26 · 2019: 22 · 2018: 31 · 2017: 33 · 2016: 19 · 2015: 20 · 2014: 20 · 2013: 14 · 2012: 23
- FWCI
- 28.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Ultrasound in Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Fetal Medicine Foundation (1 037 116)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- preeclampsia, uterine artery pulsatility index, Doppler ultrasound, preeclampsia screening, early pregnancy, maternal risk factors, body mass index, likelihood ratios, detection rate, false positive rate
- MeSH terms
- Adolescent, Adult, Arteries, Female, Humans, Middle Aged, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Prospective Studies, Sensitivity and Specificity, Uterus, Ultrasonography, Doppler, Color, Hypertension, Pregnancy-Induced
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