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Cited by 26Reproductive System and PregnancyPregnancy and preeclampsia studiesEctopic Pregnancy Diagnosis and Management

Early-pregnancy events and subsequent antenatal, delivery and neonatal outcomes: prospective cohort study

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Al‐Memar, M., Vaulet, T., Fourie, H., Nikolic, G., Bobdiwala, S., Saso, S., Farren, J., Pipi, M. +6 more·2019·Ultrasound in Obstetrics & Gynecology
DOI 10.1002/uog.20262
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Abstract

OBJECTIVE: To assess prospectively the association between pelvic pain, vaginal bleeding, and nausea and vomiting occurring in the first trimester of pregnancy and the incidence of later adverse pregnancy outcomes. METHODS: This was a prospective observational cohort study of consecutive women with confirmed intrauterine singleton pregnancy between 5 and 14 weeks' gestation recruited at Queen Charlotte's & Chelsea Hospital, London, UK, from March 2014 to March 2016. Serial ultrasound scans were performed in the first trimester. Participants completed validated symptom scores for vaginal bleeding, pelvic pain, and nausea and vomiting. The key symptom of interest was any pelvic pain and/or vaginal bleeding during the first trimester. Pregnancies were followed up until the final outcome was known. Antenatal, delivery and neonatal outcomes were obtained from hospital records. Logistic regression analysis was used to assess the association between first-trimester symptoms and pregnancy complications by calculating adjusted odds ratios (aOR) with correction for maternal age. RESULTS: Of 1003 women recruited, 847 pregnancies were included in the final analysis following exclusion of cases due to first-trimester miscarriage (n = 99), termination of pregnancy (n = 20), loss to follow-up (n = 32) or withdrawal from the study (n = 5). Adverse antenatal complications were observed in 166/645 (26%) women with pelvic pain and/or vaginal bleeding in the first trimester (aOR = 1.79; 95% CI, 1.17-2.76) and in 30/181 (17%) women with no symptoms. Neonatal complications were observed in 66/634 (10%) women with and 11/176 (6%) without pelvic pain and/or vaginal bleeding (aOR = 1.73; 95% CI, 0.89-3.36). Delivery complications were observed in 402/615 (65%) women with and 110/174 (63%) without pelvic pain and/or vaginal bleeding during the first trimester (aOR = 1.16; 95% CI, 0.81-1.65). For 18 of 20 individual antenatal complications evaluated, incidence was higher among women with pelvic pain and/or vaginal bleeding, despite the overall incidences being low. Nausea and vomiting in pregnancy showed little association with adverse pregnancy outcomes. CONCLUSIONS: Our study suggests that there is an increased incidence of antenatal complications in women experiencing pelvic pain and/or vaginal bleeding in the first trimester. This should be considered when advising women attending early-pregnancy units. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.

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  • Sperm DNA fragmentation is associated with miscarriage.

    “Sperm DNA fragmentation is associated with miscarriage (Table 6). 88”

    From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [88]

    The Results section discusses first-trimester symptoms and pregnancy outcomes; it says women who miscarried in the first trimester were excluded from the final analysis. Searches for sperm DNA fragmentation and paternal sperm DNA damage found no passage in our copy addressing an association with miscarriage. The cited paper therefore does not verify this claim. (LLM, conf=0.76)

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Authors
Al‐Memar, M., Vaulet, T., Fourie, H., Nikolic, G., Bobdiwala, S., Saso, S., Farren, J., Pipi, M., Van Calster, B., de Moor, B., Stalder, C., Bennett, P., Timmerman, D., & Bourne, T.
Affiliations
  • Queen Charlotte's and Chelsea Hospital (GB)
  • IMEC (BE)
  • Department of Development and Regeneration KU Leuven Leuven Belgium
  • ESAT‐STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics Leuven Belgium
  • Universitair Ziekenhuis Leuven (BE)
Corresponding author
Bourne, T.
ORCID
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2019-10
Volume
54
Issue
4
Pages
530-537
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
DOI
10.1002/uog.20262
OpenAlex
W2924955235
Cited by
26
References
35
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 1
FWCI
1.50
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3 d)
Locations
  • Ultrasound in Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (KU Leuven) (submittedVersion, other-oa)
  • Spiral (Imperial College London) (submittedVersion)
Funders
  • National Institute for Health and Care Research
  • Imperial College London
  • Imperial College Healthcare NHS Trust
  • Fonds Wetenschappelijk Onderzoek (1S93918N)
  • Tommy's
  • Vlaamse regering
  • Tommy's National Centre for Miscarriage Research
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
pelvic pain, vaginal bleeding, nausea and vomiting of pregnancy, first-trimester pregnancy complications, delivery complications, neonatal complications, singleton pregnancy, miscarriage, preterm birth, preeclampsia, gestational diabetes mellitus, cesarean section, stillbirth, neonatal intensive care admission, neonatal sepsis
MeSH terms
Abortion, Spontaneous, Abortion, Induced, Adult, Female, Gestational Age, Humans, London, Middle Aged, Nausea, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy Trimester, First, Prenatal Diagnosis, Prospective Studies, Ultrasonography, Uterine Hemorrhage, Vomiting, Pelvic Pain, Premature Birth

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