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Cited by 297

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double‐blind, placebo‐controlled trial

Open access
O'Brien, J. M., Adair, C. D., Lewis, D. F., Hall, D. R., DEfranco, E. A., Fusey, S., Soma‐Pillay, P., Porter, K., How, H., Schackis, R., Eller, D., Trivedi, Y., Vanburen, G., Khandelwal, M., Trofatter, K., Vidyadhari, D., Vijayaraghavan, J., Weeks, J., Dattel, B., Newton, E., Chazotte, C., Valenzuela, G., Calda, P., Bsharat, M., Creasy, G. W.·2007·Ultrasound in Obstetrics & Gynecology
DOI 10.1002/uog.5158
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Abstract

Objective: Preterm birth is the leading cause of perinatal morbidity and mortality worldwide. Treatment of preterm labor with tocolysis has not been successful in improving infant outcome. The administration of progesterone and related compounds has been proposed as a strategy to prevent preterm birth. The objective of this trial was to determine whether prophylactic administration of vaginal progesterone reduces the risk of preterm birth in women with a history of spontaneous preterm birth. Methods: This randomized, double‐blind, placebo‐ controlled, multinational trial enrolled and randomized 659 pregnant women with a history of spontaneous preterm birth. Between 18 + 0 and 22 + 6 weeks of gestation, patients were assigned randomly to once‐daily treatment with either progesterone vaginal gel or placebo until either delivery, 37 weeks' gestation or development of preterm rupture of membranes. The primary outcome was preterm birth at ≤ 32 weeks of gestation. The trial was analyzed using an intent‐to‐treat strategy. Results: Baseline characteristics were similar in the two treatment groups. Progesterone did not decrease the frequency of preterm birth at ≤ 32 weeks. There was no difference between the groups with respect to the mean gestational age at delivery, infant morbidity or mortality or other maternal or neonatal outcome measures. Adverse events during the course of treatment were similar for the two groups. Conclusion: Prophylactic treatment with vaginal progesterone did not reduce the frequency of recurrent preterm birth (≤ 32 weeks) in women with a history of spontaneous preterm birth. The effect of progesterone administration in patients at high risk for preterm delivery as determined by methods other than history alone (e.g. sonographic cervical length) requires further investigation. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.

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Metadata

Authors
O'Brien, J. M., Adair, C. D., Lewis, D. F., Hall, D. R., DEfranco, E. A., Fusey, S., Soma‐Pillay, P., Porter, K., How, H., Schackis, R., Eller, D., Trivedi, Y., Vanburen, G., Khandelwal, M., Trofatter, K., Vidyadhari, D., Vijayaraghavan, J., Weeks, J., Dattel, B., Newton, E., Chazotte, C., Valenzuela, G., Calda, P., Bsharat, M., & Creasy, G. W.
Venue
Ultrasound in Obstetrics & Gynecology
Publisher
Wiley
Published
2007-09-26
Volume
30
Issue
5
Pages
687-696
ISSN
  • 0960-7692 (ISSN-L)
  • 1469-0705
DOI
10.1002/uog.5158
OpenAlex
W1999217201
Cited by
297
References
48
FWCI
9.00
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double‐blind, placebo‐controlled trial. https://app.cochat.ai/papers/10.1002/uog.5158
The paper
O'Brien, J. M., Adair, C. D., Lewis, D. F., Hall, D. R., DEfranco, E. A., Fusey, S., Soma‐Pillay, P., Porter, K., How, H., Schackis, R., Eller, D., Trivedi, Y., Vanburen, G., Khandelwal, M., Trofatter, K., Vidyadhari, D., Vijayaraghavan, J., Weeks, J., Dattel, B., . . . Creasy, G. W. (2007). Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double‐blind, placebo‐controlled trial. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.5158

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.