The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gadolinium‐based contrast agents for magnetic resonance cancer imaging
Open accessAbstract
Magnetic resonance imaging (MRI) is a clinical imaging modality effective for anatomical and functional imaging of diseased soft tissues, including solid tumors. MRI contrast agents (CA) have been routinely used for detecting tumor at an early stage. Gadolinium‐based CA are the most commonly used CA in clinical MRI. There have been significant efforts to design and develop novel Gd(III) CA with high relaxivity, low toxicity, and specific tumor binding. The relaxivity of the Gd(III) CA can be increased by proper chemical modification. The toxicity of Gd(III) CA can be reduced by increasing the agents' thermodynamic and kinetic stability, as well as optimizing their pharmacokinetic properties. The increasing knowledge in the field of cancer genomics and biology provides an opportunity for designing tumor‐specific CA. Various new Gd(III) chelates have been designed and evaluated in animal models for more effective cancer MRI. This review outlines the design and development, physicochemical properties, and in vivo properties of several classes of Gd(III)‐based MR CA tumor imaging. WIREs Nanomed Nanobiotechnol 2013, 5:1–18. doi: 10.1002/wnan.1198 This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
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Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes
Lucock, M. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3027 · Cited by 815
Current status of gadolinium toxicity in patients with kidney disease
Perazella, M. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06011108 · Cited by 275
Cited by
Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683
Intracranial gadolinium deposition after contrast-enhanced MR imaging
McDonald, R. J., McDonald, J. S., Kallmes, D. F., Jentoft, M. E., Murray, D. L., Thielen, K. R., Williamson, E. E., & Eckel, L. J. (2015) · Radiology · doi:10.1148/radiol.15150025 · Cited by 1,358
Molecular imaging of the tumor microenvironment
Zhou, Z., & Lu, Z.-R. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.012 · Cited by 253
Self-citationGadolinium as a new emerging contaminant of aquatic environments
Rogowska, J., Olkowska, E., Ratajczyk, W., & Wolska, L. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4116 · Cited by 242
Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles
Arms, L., Smith, D. W., Flynn, J., Palmer, W., Martin, A., Woldu, A., & Hua, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00802 · Cited by 159
Metadata
- Authors
- Zhou, Z., & Lu, Z.
- Venue
- WIREs Nanomedicine and Nanobiotechnology
- Publisher
- Wiley
- Published
- 2012-10-09
- Volume
- 5
- Issue
- 1
- Pages
- 1-18
- ISSN
- 1939-0041 (ISSN-L)
- 1939-5116
- OpenAlex
- W2033116451
- Cited by
- 427
- References
- 2
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- green
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