Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles
Open accessAbstract
Nanomedicines are typically submicrometer-sized carrier materials (nanoparticles) encapsulating therapeutic and/or imaging compounds that are used for the prevention, diagnosis and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. Nanomedicine technology aims to improve the balance between the efficacy and the toxicity of therapeutic compounds. Nanoparticles, one of the key technologies of nanomedicine, can exhibit a combination of physical, chemical and biological characteristics that determine their in vivo behavior. A key component in the translational assessment of nanomedicines is determining the biodistribution of the nanoparticles following in vivo administration in animals and humans. There are a range of techniques available for evaluating nanoparticle biodistribution, including histology, liquid scintillation counting (LSC), indirectly measuring drug concentrations, in vivo optical imaging, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine imaging. Each technique has its own advantages and limitations, as well as capabilities for assessing real-time, whole-organ and cellular accumulation. This review will address the principles and methodology of each technique and their advantages and limitations for evaluating in vivo biodistribution of nanoparticles.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dynamic contrast-enhanced CT has been utilized to evaluate intratumoral perfusion, permeability, and aggregation of CT contrast agent-carrying NPs in tumors in mice.
“However, dynamic contrast-enhanced (DCE)CT has been utilized to evaluate the intratumoral perfusion, permeability, and aggregation of CT contrast agent-carrying NPs in tumors in mice [19,132,133].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [133]
The Computed tomography (CT) section (page unavailable) says CT has been used for real-time, in vivo imaging of nanoparticles carrying contrast agents, including repeated imaging in animals. It does not describe dynamic contrast-enhanced CT measuring intratumoral perfusion, permeability, or nanoparticle aggregation in mouse tumors. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Band Gap Fluorescence from Individual Single-Walled Carbon Nanotubes
O’Connell, M. J., Bachilo, S. M., Huffman, C., Moore, V. C., Strano, M. S., Hároz, E. H., Rialon, K. L., Boul, P. J., Noon, W. H., Kittrell, C., et al. (2002) · Science · doi:10.1126/science.1072631 · Cited by 3,881 · see citing works
Advances and Challenges of Liposome Assisted Drug Delivery
Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00286 · Cited by 2,672 · see citing works
Self-citationMagnetic nanoparticles in MR imaging and drug delivery
Sun, C., Lee, J. S. H., & Zhang, M. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.018 · Cited by 2,595 · see citing works
A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors
Hardman, R. C. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8284 · Cited by 2,304 · see citing works
Molecular imaging in living subjects: seeing fundamental biological processes in a new lightPreprint
Massoud, T. F., & Gambhir, S. S. (2003) · Genes & Development · doi:10.1101/gad.1047403 · Cited by 2,205 · see citing works
Designing dendrimers for biological applications
Lee, C., MacKay, J. A., Fréchet, J. M. J., & Szoka, F. C. (2005) · Nature Biotechnology · doi:10.1038/nbt1171 · Cited by 2,046 · see citing works
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
Liu, Z., Cai, W., He, L., Nakayama-Ratchford, N., Chen, K., Sun, X., Chen, X. S., & Dai, H. (2006) · Nature Nanotechnology · doi:10.1038/nnano.2006.170 · Cited by 1,440 · see citing works
Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress
Lammers, T., Kiessling, F., Hennink, W. E., & Storm, G. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.063 · Cited by 1,324 · see citing works
Imaging and drug delivery using theranostic nanoparticles
Janib, S. M., Moses, A. S., & MacKay, J. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.08.004 · Cited by 1,249 · see citing works
Challenges and strategies in anti-cancer nanomedicine development: An industry perspective
Hare, J. I., Lammers, T., Ashford, M. B., Puri, S., Storm, G., & Barry, S. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.025 · Cited by 1,246 · see citing works
Kim, J., Kim, H. S., Lee, N., Kim, T., Kim, H., Yu, T., Song, I. C., Moon, W. K., & Hyeon, T. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200802469 · Cited by 1,222 · see citing works
In vivo Biodistribution and Highly Efficient Tumour Targeting of Carbon Nanotubes in Mice
Liu, Z., Cai, W., He, L., Nakayama-Ratchford, N., Chen, K., Sun, X., Chen, X. S., & Dai, H. (2020) · doi:10.1201/9780429399039-14 · Cited by 1,213 · see citing works
X-ray-Computed Tomography Contrast Agents
Lusic, H., & Grinstaff, M. W. (2012) · Chemical Reviews · doi:10.1021/cr200358s · Cited by 1,118 · see citing works
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles
Rabin, O., Perez, J. M., Grimm, J., Wojtkiewicz, G. R., & Weissleder, R. (2006) · Nature Materials · doi:10.1038/nmat1571 · Cited by 941 · see citing works
High Quantum Yield Blue Emission from Water-Soluble Au 8 Nanodots
Zheng, J., Petty, J. T., & Dickson, R. M. (2003) · Journal of the American Chemical Society · doi:10.1021/ja035473v · Cited by 725 · see citing works
Multifunctional Gold Nanoparticles for Diagnosis and Therapy of Disease
Mieszawska, A. J., Mulder, W. J. M., Fayad, Z. A., & Cormode, D. P. (2013) · Molecular Pharmaceutics · doi:10.1021/mp3005885 · Cited by 719 · see citing works
Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents
Busquets, M. A., Estelrich, J., & Sánchez‐Martín, M. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s76501 · Cited by 632 · see citing works
Jung, C. W., & Jacobs, P. M. (1995) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(95)00024-b · Cited by 625 · see citing works
Core/shell nanoparticles in biomedical applications
Chatterjee, K., Sarkar, S., Rao, K. J., & Paria, S. (2014) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2013.12.008 · Cited by 613 · see citing works
Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective
Moghimi, S. M., Hunter, A. C., & Andresen, T. L. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134623 · Cited by 550 · see citing works
Magnetic Resonance Imaging: Principles and Techniques: Lessons for Clinicians
Grover, V. P. B., Tognarelli, J. M., Crossey, M. M. E., Cox, I. J., Taylor-Robinson, S. D., & McPhail, M. J. W. (2015) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2015.08.001 · Cited by 519 · see citing works
Boswell, C. A., Sun, X., Niu, W., Weisman, G. R., Wong, E. H., Rheingold, A. L., & Anderson, C. J. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030383m · Cited by 481 · see citing works
Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects
Kunjachan, S., Ehling, J., Storm, G., Kiessling, F. M., & Lammers, T. (2015) · Chemical Reviews · doi:10.1021/cr500314d · Cited by 480 · see citing works
PEG-based micelles as carriers of contrast agents for different imaging modalities
Torchilin, V. P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00019-4 · Cited by 470 · see citing works
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Shin, D. (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s2824 · Cited by 463 · see citing works
Mesoporous Silica Nanospheres as Highly Efficient MRI Contrast Agents
Taylor-Pashow, K. M. L., Kim, J. S., Rieter, W. J., An, H., Lin, W., & Lin, W. (2008) · Journal of the American Chemical Society · doi:10.1021/ja710193c · Cited by 458 · see citing works
Martina, M.-S., Fortin, J.-P., Ménager, C., Clémеnt, O., BARRATT, G. M., Grabielle-Madelmont, C., Gazeau, F., Cabuil, V., & Lesieur, S. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0516460 · Cited by 441 · see citing works
Yang, X., Hong, H., Grailer, J. J., Rowland, I. J., Javadi, A., Hurley, S. A., Xiao, Y., Yang, Y., Zhang, Y., Nickles, R. J., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.006 · Cited by 436 · see citing works
Gadolinium‐based contrast agents for magnetic resonance cancer imaging
Zhou, Z., & Lu, Z. (2012) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1198 · Cited by 431 · see citing works
Histological Stains: A Literature Review and Case Study
Alturkistani, H. A., Tashkandi, F. M., & Mohammedsaleh, Z. M. (2015) · Global Journal of Health Science · doi:10.5539/gjhs.v8n3p72 · Cited by 428 · see citing works
Molecular tracers for the PET and SPECT imaging of disease
Pimlott, S. L., & Sutherland, A. J. (2010) · Chemical Society Reviews · doi:10.1039/b922628c · Cited by 379 · see citing works
Omid Veiseh, A., Sun, C., Fang, C., Bhattarai, N., Gunn, J., Kievit, F. M., Du, K. N., Pullar, B. J., Lee, D., Ellenbogen, R. G., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1157 · Cited by 378 · see citing works
Oh, M. H., Lee, N., Kim, H., Park, S. P., Piao, Y., Lee, J., Jun, S. W., Moon, W. K., Choi, S. H., & Hyeon, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja200120k · Cited by 369 · see citing works
Nanoparticle contrast agents for computed tomography: a focus on micelles
Cormode, D. P., Naha, P. C., & Fayad, Z. A. (2014) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.1551 · Cited by 368 · see citing works
In Vitro and in Vivo Studies of FePt Nanoparticles for Dual Modal CT/MRI Molecular Imaging
Chou, S., Shau, Y.-H., Wu, P., Yang, Y.-S. S., Shieh, D.-B., & Chen, C. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1035013 · Cited by 368 · see citing works
Biogenic gas nanostructures as ultrasonic molecular reporters
Shapiro, M. G., Goodwill, P. W., Neogy, A., Yin, M., Foster, F. S., Schaffer, D. V., & Conolly, S. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.32 · Cited by 367 · see citing works
Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform
Cormode, D. P., Skajaa, T., van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., Calcagno, C., Barazza, A., Gordon, R. E., Zanzonico, P., et al. (2008) · Nano Letters · doi:10.1021/nl801958b · Cited by 328 · see citing works
Needleless Electrospinning of Uniform Nanofibers Using Spiral Coil Spinnerets
Wang, X., Niu, H., Wang, X., & Lin, T. (2012) · Journal of Nanomaterials · doi:10.1155/2012/785920 · Cited by 315 · see citing works
In Vivo Transchelation of Copper-64 from TETA-Octreotide to Superoxide Dismutase in Rat Liver
Bass, L. A., Wang, M., Welch, M. J., & Anderson, C. J. (2000) · Bioconjugate Chemistry · doi:10.1021/bc990167l · Cited by 311 · see citing works
Cho, M., Cho, W., Choi, M., Kim, S. J., Han, B. S., Kim, S. H., Kim, H. O., Sheen, Y. Y., & Jeong, J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.04.017 · Cited by 305 · see citing works
Mercer, R. R., Scabilloni, J. F., Wang, L., Kisin, E. R., Murray, A. R., Schwegler‐Berry, D., Shvedova, A. A., & Castranova, V. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00186.2007 · Cited by 291 · see citing works
MRI Contrast Agents: Current Status and Future Perspectives
Strijkers, G. J., Mulder, W. J. M., van Tilborg, G. A. F., & Nicolay, K. (2007) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152007780618135 · Cited by 276 · see citing works
Current trends in using polymer coated gold nanoparticles for cancer therapy
Muddineti, O. S., Ghosh, B., & Biswas, S. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.02.038 · Cited by 259 · see citing works
Bharali, D. J., & Mousa, S. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.007 · Cited by 251 · see citing works
Covalently Combining Carbon Nanotubes with Anticancer Agent: Preparation and Antitumor Activity
Wu, W., Li, R., Bian, X., Zhu, Z., Ding, D., Li, X., Jia, Z., Jiang, X., & Hu, Y. (2009) · ACS Nano · doi:10.1021/nn9005686 · Cited by 247 · see citing works
Molecular imaging and therapy of cancer with radiolabeled nanoparticles
Hong, H., Zhang, Y., Sun, J., & Cai, W. (2009) · Nano Today · doi:10.1016/j.nantod.2009.07.001 · Cited by 243 · see citing works
Xiao, Y., Hong, H., Javadi, A., Engle, J. W., Xu, W., Yang, Y., Zhang, Y., Barnhart, T. E., Cai, W., & Gong, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.030 · Cited by 235 · see citing works
Advantages and Limitations of Current Imaging Techniques for Characterizing Liposome Morphology
Robson, A.-L., Dastoor, P. C., Flynn, J. R., Palmer, W., Martin, A. P., Smith, D. W., Woldu, A. S., & Hua, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00080 · Cited by 232 · see citing works
Self-citationComputed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles
Wang, H., Zheng, L., Peng, C., Guo, R., Shen, M., Shi, X., & Zhang, G. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.001 · Cited by 225 · see citing works
Sample preparation in analysis of pharmaceuticals
Pavlović, D. M., Babić, S., Horvat, A. J. M., & Kaštelan‐Macan, M. (2007) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2007.09.010 · Cited by 222 · see citing works
Positron Emission Tomography Imaging Using Radiolabeled Inorganic Nanomaterials
Sun, X., Cai, W., & Chen, X. (2015) · Accounts of Chemical Research · doi:10.1021/ar500362y · Cited by 219 · see citing works
SPECT detectors: the Anger Camera and beyond
Peterson, T. E., & Furenlid, L. R. (2011) · Physics in Medicine and Biology · doi:10.1088/0031-9155/56/17/r01 · Cited by 218 · see citing works
You, J., Zhang, R., Xiong, C., Zhong, M., Melancon, M. P., Gupta, S. K., Nick, A. M., Sood, A. K., & Li, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1003 · Cited by 215 · see citing works
In Vivo Evaluation of 64Cu-Labeled Magnetic Nanoparticles as a Dual-Modality PET/MR Imaging Agent
Glaus, C., Rossin, R., Welch, M. J., & Bao, G. (2010) · Bioconjugate Chemistry · doi:10.1021/bc900511j · Cited by 209 · see citing works
Ultrasmall Near‐Infrared Non‐cadmium Quantum Dots for in vivo Tumor Imaging
Gao, J., Chen, K., Xie, R., Xie, J., Lee, S., Cheng, Z., Peng, X., & Chen, X. S. (2009) · Small · doi:10.1002/smll.200901672 · Cited by 193 · see citing works
Hepatic MRI with SPIO: detection and characterization of focal liver lesions
Reimer, P., & Tombach, B. (1998) · European Radiology · doi:10.1007/s003300050535 · Cited by 188 · see citing works
PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice
McDevitt, M. R., Chattopadhyay, D., Jaggi, J. S., Finn, R. D., ZANZONICO, P. B., Villa, C. H., Rey, D. A., Mendenhall, J., Batt, C. A., Njardarson, J. T., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000907 · Cited by 184 · see citing works
Audenhaege, K. V., Holen, R. V., Vandenberghe, S., Vanhove, C., Metzler, S. D., & Moore, S. C. (2015) · Medical Physics · doi:10.1118/1.4927061 · Cited by 173 · see citing works
Schrand, A. M., Schlager, J. J., Dai, L., & Hussain, S. M. (2010) · Nature Protocols · doi:10.1038/nprot.2010.2 · Cited by 168 · see citing works
X-ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles
Guo, R., Wang, H., Peng, C., Shen, M., Pan, M., Cao, X., Zhang, G., & Shi, X. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp9078986 · Cited by 166 · see citing works
Richard, C., Doan, B., Belœil, J., Bessodes, M., Tóth, É., & Scherman, D. (2007) · Nano Letters · doi:10.1021/nl072509z · Cited by 158 · see citing works
Marco, M. D., Sadun, C., Port, M., Guilbert, I., Couvreur, P., & Dubernet, C. (2007) · PubMed Central · Cited by 156 · see citing works
Liu, Y., Chen, Z., Liu, C., Yu, D., Lu, Z., & Zhang, N. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.077 · Cited by 154 · see citing works
Madru, R., Kjellman, P., Olsson, F., Wingårdh, K., Ingvar, C., Ståhlberg, F., Olsrud, J., Lätt, J., Fredriksson, S., Knutsson, L., et al. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.092437 · Cited by 154 · see citing works
Physical Principles and Technology of Clinical PET Imaging
Dw, T. (2004) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v33n2p133 · Cited by 154 · see citing works
Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography
Kim, J., Chhour, P., Hsu, J. C., Litt, H. I., Ferrari, V. A., Popovtzer, R., & Cormode, D. P. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00194 · Cited by 153 · see citing works
Saito, R., Krauze, M. T., Bringas, J. R., Noble, C. O., McKnight, T. R., Jackson, P., Wendland, M. F., Mamot, C., Drummond, D. C., Kirpotin, D. B., et al. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.016 · Cited by 150 · see citing works
Synthesis and Characterization of Core–Shell Star Copolymers for In Vivo PET Imaging Applications
Fukukawa, K., Rossin, R., Hagooly, A., Pressly, E. D., Hunt, J. N., Messmore, B. W., & Hawker, C. J. (2008) · Biomacromolecules · doi:10.1021/bm7014152 · Cited by 150 · see citing works
Zhao, Y., Sultan, D. H., Detering, L., Cho, S., Sun, G., Pierce, R. A., Wooley, K. L., & Liu, Y. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201308494 · Cited by 149 · see citing works
Non‐Invasive <i>in vivo</i> Imaging in Small Animal Research
Koo, V., Hamilton, P. W., & Williamson, K. (2006) · Analytical Cellular Pathology · doi:10.1155/2006/245619 · Cited by 145 · see citing works
In Vivo Tumor-Targeted Fluorescence Imaging Using Near-Infrared Non-Cadmium Quantum Dots
Gao, J., Chen, K., Xie, R., Xie, J., Yan, Y., Cheng, Z., Peng, X., & Chen, X. S. (2010) · Bioconjugate Chemistry · doi:10.1021/bc900323v · Cited by 143 · see citing works
Mühlfeld, C., Rothen‐Rutishauser, B., Vanhecke, D., Blank, F., Gehr, P., & Ochs, M. (2007) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-4-11 · Cited by 141 · see citing works
Pan, D., Schirra, C. O., Senpan, A., Schmieder, A. H., Stacy, A. J., Roessl, E., Thran, A., Wickline, S. A., Proska, R., & Lanza, G. M. (2012) · ACS Nano · doi:10.1021/nn300392x · Cited by 139 · see citing works
Zhao, M., & Zeng, E. (2015) · Nanoscale Research Letters · doi:10.1186/s11671-015-0873-8 · Cited by 139 · see citing works
Liposomal Gd-DTPA: preparation and characterization of relaxivity.
Tilcock, C., Unger, E. C., Cullis, P. R., & MacDougall, P. (1989) · Radiology · doi:10.1148/radiology.171.1.2928549 · Cited by 137 · see citing works
Margerum, L. D., Campion, B. K., Koo, M., Shargill, N. S., Lai, J., Marumoto, A. K., & Sontum, P. C. (1997) · Journal of Alloys and Compounds · doi:10.1016/s0925-8388(96)02830-7 · Cited by 134 · see citing works
Chelator‐Free Synthesis of a Dual‐Modality PET/MRI Agent
Chen, F., Ellison, P. A., Lewis, C. M., Hong, H., Zhang, Y., Shi, S., Hernandez, R. T., Meyerand, M. E., Barnhart, T. E., & Cai, W. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201306306 · Cited by 133 · see citing works
Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents
de Vries, A., Aussems-Custers, E. M. G., Lub, J., van den Bosch, S., Nicolay, K., & Grüll, H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.056 · Cited by 132 · see citing works
Naha, P. C., Zaki, A. A., Hecht, E. M., Chorny, M., Chhour, P., Blankemeyer, E. R., Yates, D. M., Witschey, W. R. T., Litt, H. I., Tsourkas, A., et al. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01159g · Cited by 130 · see citing works
64Cu loaded liposomes as positron emission tomography imaging agents
Petersen, A. L., Binderup, T., Rasmussen, P., Henriksen, J. R., Elema, D. R., Kjær, A., & Andresen, T. L. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.059 · Cited by 130 · see citing works
Gadonanotubes as Ultrasensitive pH-Smart Probes for Magnetic Resonance Imaging
Hartman, K. B., Laus, S., Bolskar, R. D., Muthupillai, R., Helm, L., Tóth, É., Merbach, A. E., & Wilson, L. J. (2008) · Nano Letters · doi:10.1021/nl0720408 · Cited by 129 · see citing works
PET Imaging and Biodistribution of Silicon Quantum Dots in Mice
Tu, C., Ma, X., House, A. E., Kauzlarich, S. M., & Louie, A. Y. (2011) · ACS Medicinal Chemistry Letters · doi:10.1021/ml1002844 · Cited by 128 · see citing works
Intrinsically Copper‐64‐Labeled Organic Nanoparticles as Radiotracers
Liu, T. W. B., MacDonald, T. D., Shi, J., Wilson, B. C., & Zheng, G. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201206939 · Cited by 128 · see citing works
Kojima, C., Umeda, Y., Ogawa, M., Harada, A., Magata, Y., & Kono, K. (2010) · Nanotechnology · doi:10.1088/0957-4484/21/24/245104 · Cited by 127 · see citing works
Bonitatibus, P. J., Torres, A. S., Goddard, G. D., FitzGerald, P. F., & Kulkarni, A. M. (2010) · Chemical Communications · doi:10.1039/c0cc03302b · Cited by 126 · see citing works
Mayhew, T. M., Mühlfeld, C., Vanhecke, D., & Ochs, M. (2008) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2008.11.001 · Cited by 125 · see citing works
Intrinsically Radiolabeled Nanoparticles: An Emerging Paradigm
Goel, S., Chen, F., Ehlerding, E. B., & Cai, W. (2014) · Small · doi:10.1002/smll.201401048 · Cited by 124 · see citing works
Ducongè, F., Pons, T., Pestourie, C., Herin, L., Thezé, B., Gombert, K., Mahler, B., Hinnen, F., Kühnast, B., Dollé, F., et al. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800179j · Cited by 123 · see citing works
Positron Emission Tomography: Principles, Technology, and Recent Developments
Ziegler, S. I. (2005) · Nuclear Physics A · doi:10.1016/j.nuclphysa.2005.02.067 · Cited by 121 · see citing works
CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles
Torchilin, V. P., Frank-Kamenetsky, M. D., & Wolf, G. L. (1999) · Academic Radiology · doi:10.1016/s1076-6332(99)80063-4 · Cited by 120 · see citing works
Iodine-125 radiolabeling of silver nanoparticles for in vivo SPECT imaging
Schnitzer (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s11677 · Cited by 119 · see citing works
Morales-Ávila, E., Ferro‐Flores, G., Ocampo‐García, B., Rodriguez, L. M. D. L., Santos‐Cuevas, C., Garcı́a-Becerra, R., Medina, L. A., & Gómez‐Oliván, L. M. (2011) · Bioconjugate Chemistry · doi:10.1021/bc100551s · Cited by 118 · see citing works
Nanoparticles Labeled with Positron Emitting Nuclides: Advantages, Methods, and Applications
Liu, Y., & Welch, M. J. (2012) · Bioconjugate Chemistry · doi:10.1021/bc200264c · Cited by 117 · see citing works
Zhang, Y., Sun, Y., Xu, X., Zhang, X., Zhu, H., Huang, L., Qi, Y., & Shen, Y. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm901910j · Cited by 117 · see citing works
Zhao, Y., Sultan, D. H., Detering, L., Cho, S., Sun, G., Pierce, R. A., Wooley, K. L., & Liu, Y. (2013) · Angewandte Chemie · doi:10.1002/ange.201308494 · Cited by 117 · see citing works
Near‐Infrared Molecular Probes for In Vivo Imaging
Zhang, X., Bloch, S. R., Akers, W. J., & Achilefu, S. A. (2012) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy1227s60 · Cited by 116 · see citing works
Milane, L. S., Duan, Z., & Amiji, M. M. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.12.009 · Cited by 116 · see citing works
Contrast agents for preclinical targeted X-ray imaging
Li, X., Anton, N., Zuber, G., & Vandamme, T. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.07.013 · Cited by 113 · see citing works
Progress in the Development of Microscopical Techniques for Diagnostic Pathology
Titford, M. (2009) · Journal of Histotechnology · doi:10.1179/his.2009.32.1.9 · Cited by 113 · see citing works
Guerrero, S., Herance, J. R., Rojas, S., Mena, J. F., Gispert, J. D., Acosta, G., Alberício, F., & Kogan, M. J. (2012) · Bioconjugate Chemistry · doi:10.1021/bc200362a · Cited by 112 · see citing works
Novel Iodinated Dendritic Nanoparticles for Computed Tomography (CT) Imaging
Yordanov, A. T., Lodder, A., Woller, E. K., Cloninger, M. J., Patronas, N. J., Milenic, D. E., & Brechbiel, M. W. (2002) · Nano Letters · doi:10.1021/nl020246x · Cited by 110 · see citing works
Fu, Y., Nitecki, D. E., Maltby, D. A., SIMON, G. H., Berejnoi, K., Raatschen, H., Yeh, B. M., Shames, D. M., & Brasch, R. C. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060019c · Cited by 106 · see citing works
Goldberg, M. S., Xing, D., Ren, Y., Oršulić, S., Bhatia, S. N., & Sharp, P. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016538108 · Cited by 105 · see citing works
Emerging clinical applications of computed tomography
Schena, E., Liguori, C., Frauenfelder, G., Massaroni, C., Saccomandi, P., Giurazza, F., Pitocco, F., & Marano, R. (2015) · Medical Devices Evidence and Research · doi:10.2147/mder.s70630 · Cited by 104 · see citing works
Xie, H., Wang, Z. J., Bao, A., Goins, B., & Phillips, W. T. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.06.005 · Cited by 101 · see citing works
Herth, M. M., Barz, M., Moderegger, D., Allmeroth, M., Jahn, M., Thews, O., Zentel, R., & Rösch, F. (2009) · Biomacromolecules · doi:10.1021/bm8014736 · Cited by 100 · see citing works
Liu, Y., Tseng, Y.-C., & Huang, L. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0818-1 · Cited by 100 · see citing works
Ostrowski, A., Nordmeyer, D., Boreham, A., Holzhausen, C., Mundhenk, L., Graf, C. M., Meinke, M. C., Vogt, A., Hadam, S., Lademann, J. M., et al. (2015) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.6.25 · Cited by 96 · see citing works
Kong, W. H., Lee, W. J., Cui, Z., Bae, K. H., Park, T. G., Kim, J. H., Park, K., & Seo, S. W. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.08.044 · Cited by 94 · see citing works
Pham, B. T. T., Colvin, E. K., Pham, N. T., Kim, B., Fuller, E. S., Moon, E. A., Barbey, R., Yuen, S., Rickman, B. H., Bryce, N. S., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010205 · Cited by 94 · see citing works
Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging.
Unger, E. C., Winokur, T. S., MacDougall, P., Rosenblum, J., Clair, M. R., Gatenby, R. A., & Tilcock, C. (1989) · Radiology · doi:10.1148/radiology.171.1.2928550 · Cited by 92 · see citing works
Conquering the Dark Side: Colloidal Iron Oxide Nanoparticles
Senpan, A., Caruthers, S. D., Rhee, I., Mauro, N. A., Pan, D., Hu, G., Scott, M. J., Fuhrhop, R. W., Gaffney, P. J., Wickline, S. A., et al. (2009) · ACS Nano · doi:10.1021/nn900819y · Cited by 91 · see citing works
Poly-ε-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography
Jakhmola, A., Anton, N., Anton, H., Messaddeq, N., Hallouard, F., Klymchenko, A. S., Mély, Y., & Vandamme, T. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.032 · Cited by 87 · see citing works
Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging
Kamaly, N., & Miller, A. D. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041759 · Cited by 85 · see citing works
Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology
Rosen, J. E., Yoffe, S., & Meerasa, A. (2011) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000115 · Cited by 81 · see citing works
Zhou, J., Lu, Z., Shan, G., Wang, S., & Liao, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.088 · Cited by 80 · see citing works
Chang, Y., Chang, C.-H., Yu, C., Chang, T., Chen, L., Chen, M., Lee, T., & Ting, G. (2009) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2009.08.006 · Cited by 80 · see citing works
Novel Method to Label Solid Lipid Nanoparticles with 64Cu for Positron Emission Tomography Imaging
Andreozzi, E. M., Seo, J. W., Ferrara, K. W., & Louie, A. Y. (2011) · Bioconjugate Chemistry · doi:10.1021/bc100478k · Cited by 80 · see citing works
Gibson, P. N., Holzwarth, U., Abbas, K., Simonelli, F., Kozempel, J., Cydzik, I., Cotogno, G., Bulgheroni, A., Gilliland, D. D., Ponti, J., et al. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0701-6 · Cited by 79 · see citing works
High resolution SEM imaging of gold nanoparticles in cells and tissues
Goldstein, A., Soroka, Y., Frušić‐Zlotkin, M., Popov, I., & Kohen, R. (2014) · Journal of Microscopy · doi:10.1111/jmi.12179 · Cited by 76 · see citing works
Chang, M.-Y., Seideman, J. H., & Sofou, S. (2008) · Bioconjugate Chemistry · doi:10.1021/bc700440a · Cited by 73 · see citing works
Gd‐DOTA Conjugate of RGD as a Potential Tumor‐Targeting MRI Contrast Agent
Park, J. A., Lee, J., Jung, J., Yu, D., Oh, C. H., Ha, S., Kim, T., & Chang, Y. (2008) · ChemBioChem · doi:10.1002/cbic.200800529 · Cited by 73 · see citing works
Xu, R., Kang, L., Wang, X., Jeong, E., Parker, D. L., & Lu, Z. (2007) · Experimental Biology and Medicine · doi:10.3181/0702-rm-33 · Cited by 72 · see citing works
Allmeroth, M., Moderegger, D., Gündel, D., Buchholz, H., Mohr, N., Koynov, K., Rösch, F., Thews, O., & Zentel, R. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.027 · Cited by 67 · see citing works
Nanotechnology: Toxicologic Pathology
Hubbs, A. F., Sargent, L. M., Porter, D. W., Sager, T. M., Chen, B. T., Frazer, D. G., Castranova, V., Sriram, K., Nurkiewicz, T. R., Reynolds, S. H., et al. (2013) · Toxicologic Pathology · doi:10.1177/0192623312467403 · Cited by 66 · see citing works
Plassat, V., Martina, M.-S., BARRATT, G. M., Ménager, C., & Lesieur, S. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.05.018 · Cited by 64 · see citing works
Hua, S. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/e199 · Cited by 63 · see citing works
Self-citationGadolinium DTPA‐Monoamide Complexes Incorporated into Mixed Micelles as Possible MRI Contrast Agents
Parac‐Vogt, T. N., Kimpe, K., Laurent, S., Piérart, C., Elst, L. V., Müller, R. N., & Binnemans, K. (2004) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.200400187 · Cited by 62 · see citing works
Elrod, D. B., Partha, R., Danila, D. C., Casscells, S. W., & Conyers, J. L. (2008) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2008.06.007 · Cited by 62 · see citing works
Multifunctional hollow nanoparticles based on graft-diblock copolymers for doxorubicin delivery
Lu, P.-L., Chen, Y., Ou, T.-W., Chen, H., Tsai, H., Wen, C.-J., Lo, C.-L., Wey, S., Lin, K., Yen, T., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.051 · Cited by 61 · see citing works
PET imaging of brain cancer with positron emitter-labeled liposomes
Oku, N., Yamashita, M., Katayama, Y., Urakami, T., Hatanaka, K., Shimizu, K., Asai, T., Tsukada, H., Akai, S., & Kanazawa, H. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.10.001 · Cited by 60 · see citing works
Tasciotti, E., Godin, B., Martinez, J. O., Chiappini, C., Bhavane, R. C., Liu, X., & Mauro Ferrari, B. (2011) · Molecular Imaging · doi:10.2310/7290.2011.00011 · Cited by 60 · see citing works
Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate
Zhang, Y., Sun, Y., Xu, X., Zhu, H., Huang, L., Zhang, X., Qi, Y., & Shen, Y. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.12.075 · Cited by 58 · see citing works
Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation
Vats, M., Mishra, S. K., Baghini, M. S., Chauhan, D. S., Srivastava, R., & De, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050924 · Cited by 56 · see citing works
Sachse, A., LEIKE, J. U., THOMAS SCHNEIDER, Wagner, S., RÖling, G. L., Kŕause, W., & Brandl, M. (1997) · Investigative Radiology · doi:10.1097/00004424-199701000-00007 · Cited by 53 · see citing works
Skupin-Mrugalska, P., Sobotta, Ł., Warowicka, A., Wereszczyńska, B., Zalewski, T., Gierlich, P., Jarek, M., Nowaczyk, G., Kempka, M., Gapiński, J., et al. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.11.025 · Cited by 53 · see citing works
Yuan, H., Wilks, M. Q., Normandin, M. D., Fakhri, G. E., Kaittanis, C., & Josephson, L. (2018) · Nature Protocols · doi:10.1038/nprot.2017.133 · Cited by 52 · see citing works
Hua, S., & Cabot, P. J. (2013) · PubMed · Cited by 51 · see citing works
Self-citationSingle‐Molecule I2@US‐Tube Nanocapsules: A New X‐ray Contrast‐Agent Design
Ashcroft, J. M., Hartman, K., Kissell, K. R., Mackeyev, Y., Pheasant, S. T., Young, S. W., van der Heide, P. A. W., Mikos, A. G., & Wilson, L. J. (2007) · Advanced Materials · doi:10.1002/adma.200601424 · Cited by 51 · see citing works
Smith, C. E., Shkumatov, A. A., Withers, S. G., Yang, B., Glockner, J. F., Misra, S., Roy, E. J., Wong, C., Zimmerman, S. C., & Kong, H. (2013) · ACS Nano · doi:10.1021/nn4026228 · Cited by 49 · see citing works
Detection of the Presence of Gold Nanoparticles in Organs by Transmission Electron Microscopy
de Jong, W. H., Burger, M. C., Verheijen, M. A., & Geertsma, R. E. (2010) · Materials · doi:10.3390/ma3094681 · Cited by 49 · see citing works
Plascencia‐Villa, G., Starr, C. R., Armstrong, L. S., Ponce, A., & José–Yacamán, M. (2012) · Integrative Biology · doi:10.1039/c2ib20172k · Cited by 47 · see citing works
Chitosan coated tungsten trioxide nanoparticles as a contrast agent for X-ray computed tomography
Firouzi, M., Poursalehi, R., Hamid Delavari, H., Saba, F., & Oghabian, M. A. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.01.138 · Cited by 45 · see citing works
Leander, P., Höglund, P., Børseth, A., Kloster, Y., & Berg, A. S. (2001) · European Radiology · doi:10.1007/s003300000712 · Cited by 42 · see citing works
Kobayashi, Y., Imai, J., Nagao, D., Takeda, M., Ohuchi, N., Kasuya, A., & Konno, M. (2007) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2007.05.024 · Cited by 39 · see citing works
Asem, H., Zhao, Y. H., Ye, F., Barrefelt, Å., Abedi‐Valugerdi, M., El-Sayed, R., Serafi, I. E., Abu–Salah, K. M., Hamm, J., Muhammed, M. A., et al. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0239-0 · Cited by 38 · see citing works
Cancer Optical Imaging Using Fluorescent Nanoparticles
Coll, J. (2010) · Nanomedicine · doi:10.2217/nnm.10.144 · Cited by 36 · see citing works
Xiao, T., Wen, S., Wang, H., Liu, H., Shen, M., Zhao, J., Zhang, G., & Shi, X. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20399a · Cited by 35 · see citing works
In Vitro Assessment of Poly-iodinated Triglyceride Reconstituted Low-Density Lipoprotein
Hill, M. L., Corbin, I. R., Levitin, R. B., Cao, W., Mainprize, J. G., Yaffe, M. J., & Zheng, G. (2010) · Academic Radiology · doi:10.1016/j.acra.2010.06.006 · Cited by 34 · see citing works
Radiopaque iodinated nano-emulsions for preclinical X-ray imaging
Hallouard, F., Anton, N., Zuber, G., Choquet, P., Li, X., Arntz, Y., Aubertin-Kirch, G., Constantinesco, A., & Vandamme, T. (2011) · RSC Advances · doi:10.1039/c1ra00048a · Cited by 33 · see citing works
Cheng, C., Chang, Ho, Peng, Chang, Mai, Chen, Luo, & Huang (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s42003 · Cited by 31 · see citing works
Fluorescent nanoparticles for the accurate detection of drug delivery
Priem, B., Tian, C., Tang, J., Zhao, Y., & Mulder, W. J. M. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1074567 · Cited by 30 · see citing works
Hossann, M., Wang, T., Syunyaeva, Z., Wiggenhorn, M., Zengerle, A., Issels, R. D., Reiser, M. F., Lindner, L. H., & Peller, M. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.12.003 · Cited by 30 · see citing works
García-Negrete, C. A., de Haro, M. C. J., Blasco, J., Soto, M., & Fernández, A. (2015) · The Analyst · doi:10.1039/c4an01643b · Cited by 30 · see citing works
Kempen, P. J., Thakor, A. S., Zavaleta, C. L., Gambhir, S. S., & Sinclair, R. (2013) · Microscopy and Microanalysis · doi:10.1017/s143192761300192x · Cited by 29 · see citing works
Positive Contrast Imaging of SPIO Nanoparticles
Lin, C., Cai, S., & Feng, J. (2012) · Journal of Nanomaterials · doi:10.1155/2012/734842 · Cited by 28 · see citing works
Histological study of the biodynamics of iron oxide nanoparticles with different diameters
Tsuchiya, K., Nitta, N., Sonoda, A., Nitta‐Seko, A., Ohta, S., Otani, H., Takahashi, M., Murata, K., Murase, K., Nohara, S., et al. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s22189 · Cited by 28 · see citing works
Kumar, R., Ohulchanskyy, T. Y., Turowski, S. G., Thompson, M. E., Seshadri, M., & Prasad, P. N. (2010) · Head & Neck Oncology · doi:10.1186/1758-3284-2-35 · Cited by 27 · see citing works
Shigematsu, A., MOTOJI, N., Hatori, A., & Satoh, T. (1995) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1995.1078 · Cited by 24 · see citing works
Copper Loading of Preformed Nanoparticles for PET-Imaging Applications
Lu, H. D., Wang, L. Z., Wilson, B. K., McManus, S. A., Jumai’an, J., Padakanti, P. K., Alavi, A. A., Mach, R. H., & Prud’homme, R. K. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b07242 · Cited by 23 · see citing works
Tasciotti, E., Godin, B., Martinez, J. O., Chiappini, C., Bhavane, R. C., Liu, X., & Mauro Ferrari, B. (2011) · Molecular Imaging · doi:10.2310/7290.2011.00011s1 · Cited by 21 · see citing works
Holzhausen, C., Gröger, D., Mundhenk, L., Welker, P., Haag, R., & Gruber, A. D. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.02.003 · Cited by 18 · see citing works
Evaluation of two new gadolinium chelates as contrast agents for MRI
Wiegers, C. B., Welch, M. J., Sharp, T. L., Brown, J. J., Perman, W. H., Sun, Y., Motekaitis, R. J., & Martell, A. E. (1992) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(92)90444-5 · Cited by 17 · see citing works
Electron Microscopy of Nanoparticles in Cells
Brown, A., & Hondow, N. (2013) · Frontiers of nanoscience · doi:10.1016/b978-0-08-098338-7.00004-2 · Cited by 12 · see citing works
Ye, H., Zhu, H., Hu, J., Lin, X., Wang, F., Li, C., & Yang, Z. H. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.03.050 · Cited by 11 · see citing works
Liu, J., Xin, R., Li, Z., Golamaully, R., Zhang, Y., Zhang, J., Yuan, Q., & Liu, X. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611313040011 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Engineered algae: A novel oxygen-generating system for effective treatment of hypoxic cancer
Qiao, Y., Yang, F., Xie, T., Du, Z. H., Zhong, D., Qi, Y., Li, Y., Li, W., Lu, Z., Rao, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba5996 · Cited by 286 · see citing works
Kumar, M., Kulkarni, P., Liu, S., Chemuturi, N. V., & Shah, D. K. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114708 · Cited by 260 · see citing works
Sarbadhikary, P., George, B. P. A., & Abrahamse, H. (2021) · Theranostics · doi:10.7150/thno.62479 · Cited by 247 · see citing works
Nanotechnology in Cancer Diagnosis and Treatment
Alrushaid, N., Khan, F. A., Al-Suhaimi, E. A., & Elaı̈ssari, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15031025 · Cited by 204 · see citing works
Haripriyaa, M., & Suthindhiran, K. (2023) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00569-y · Cited by 189 · see citing works
In vivo Biodistribution and Clearance of Magnetic Iron Oxide Nanoparticles for Medical Applications
Nowak‐Jary, J., & Machnicka, B. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s415063 · Cited by 181 · see citing works
Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials
Vijayan, V., Mohapatra, A., Uthaman, S., & Park, I. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11100534 · Cited by 117 · see citing works
Jojo, G. M., Kuppusamy, G., De, A., & Karri, V. (2019) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2019.1593439 · Cited by 103 · see citing works
Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis
Subhan, M. A., Parveen, F., Filipczak, N., Yalamarty, S. S. K., & Torchilin, V. P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030389 · Cited by 98 · see citing works
Guo, C., Li, Y., Zhang, H., Zhang, Q., Wu, X., Wang, Y., Sun, F., Shi, S., & Xia, X. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13390 · Cited by 85 · see citing works
The role of imaging in targeted delivery of nanomedicine for cancer therapy
Li, P., Wang, D., Hu, J., & Yang, X. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114447 · Cited by 72 · see citing works
Yassin, M. T., Al-Otibi, F. O., Al-Sahli, S. A., El‐Wetidy, M. S., & Mohamed, S. (2024) · Cancers · doi:10.3390/cancers16244234 · Cited by 72 · see citing works
de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71 · see citing works
Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation
Desai, N., Tambe, V., Pofali, P., & Vora, L. K. (2024) · Advanced NanoBiomed Research · doi:10.1002/anbr.202400012 · Cited by 70 · see citing works
Analysis of the Exposure of Organisms to the Action of Nanomaterials
Staroń, A., Długosz, O., Pulit‐Prociak, J., & Banach, M. (2020) · Materials · doi:10.3390/ma13020349 · Cited by 66 · see citing works
Advanced Optical Imaging-Guided Nanotheranostics towards Personalized Cancer Drug Delivery
Murar, M., Albertazzi, L., & Pujals, S. (2022) · Nanomaterials · doi:10.3390/nano12030399 · Cited by 62 · see citing works
Reactive oxygen species: the root cause of nanoparticle-induced toxicity in Drosophila melanogaster
Mishra, M., & Panda, M. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1914335 · Cited by 61 · see citing works
Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer
Haider, M. A., Elsherbeny, A., Pittalà, V., Fallica, A. N., Alghamdi, M. A., Hussain, Z., Khoder, G., & Greish, K. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031853 · Cited by 59 · see citing works
Smart Luminescent Materials for Emerging Sensors: Fundamentals and Advances
Manna, A. S., Ghosh, S., Ghosh, T. K., Karchaudhuri, N., Das, S., Roy, A., & Maiti, D. K. (2025) · Chemistry - An Asian Journal · doi:10.1002/asia.202401328 · Cited by 59 · see citing works
Combining Nuclear Medicine With Other Modalities: Future Prospect for Multimodality Imaging
Archibald, S. J., Holland, J. P., Korde, A. G., Martins, A. F., Shuhendler, A. J., & Scott, P. J. H. (2024) · Molecular Imaging · doi:10.1177/15353508241245265 · Cited by 56 · see citing works
Jacinto, C., Javed, Y., Lavorato, G. C., Tárraga, W. A., Conde, B. I. C., Henao, J. M. O., Picco, A. S., Garcia, J., Dias, C. S. B., Malik, S., et al. (2025) · Nanoscale Advances · doi:10.1039/d5na00195a · Cited by 54 · see citing works
Tian, G., Pan, R., Zhang, B., Qu, M., Lian, B., Jiang, H., Gao, Z., & Wu, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00004 · Cited by 46 · see citing works
Fluorescent Carbon Nano-onion as Bioimaging Probe
Dalal, C., Saini, D., Garg, A. K., & Sonkar, S. K. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01192 · Cited by 46 · see citing works
Zhang, W., Liu, W., Qi, X., Chen, Y., Yu, Q., Shen, M., Wen, H., & Xie, J. (2025) · Food Packaging and Shelf Life · doi:10.1016/j.fpsl.2025.101484 · Cited by 45 · see citing works
Xue, J., Blesso, C. N., & Luo, Y. (2022) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-060721-025159 · Cited by 41 · see citing works
Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review
Crawford, H., Dimitriadi, M., Bassin, J. P., Cook, M. T., Abelha, T. F., & Calvo‐Castro, J. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202202366 · Cited by 41 · see citing works
Exploring the Role of Nanoparticles in Dental Materials: A Comprehensive Review
Bourgi, R., Doumandji, Z. M., Cuevas‐Suárez, C. E., Ammar, T. B., Laporte, C., Kharouf, N., & Haïkel, Y. (2025) · Coatings · doi:10.3390/coatings15010033 · Cited by 38 · see citing works
Therapeutic nanostructures and nanotoxicity
Sarma, A., Bania, R., Devi, J. R., & Deka, S. (2021) · Journal of Applied Toxicology · doi:10.1002/jat.4157 · Cited by 36 · see citing works
Xu, X., Mao, H., Wu, Y., Liu, S., Liu, J., Li, Q., Yang, M., Zhu, J., Zou, S., & Du, F. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01507-5 · Cited by 35 · see citing works
Nanoliposomes as safe and efficient drug delivery nanovesicles
Fatfat, Z., Karam, M., Maatouk, B. I., Fahs, D., & Gali‐Muhtasib, H. U. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91668-4.00002-2 · Cited by 33 · see citing works
Microfluidic encapsulation method to produce stable liposomes containing iohexol
Delama, A., Teixeira, M. I., Dorati, R., Genta, I., Conti, B., & Lamprou, D. A. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101340 · Cited by 31 · see citing works
Lim, A. W., Talley, N. J., Walker, M. M., Storm, G., & Hua, S. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2219423 · Cited by 30 · see citing works
Self-citationThe spatiotemporal journey of nanomedicines in solid tumors on their therapeutic efficacy
Qin, M., Xia, H., Xu, W., Chen, B., & Wang, Y. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115137 · Cited by 28 · see citing works
Wang, X., & Xiong, X. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s510972 · Cited by 27 · see citing works
A Review on AI-Based Data-Driven Models for Optimization of Nanocarriers as Drug Delivery Systems
Kantesaria, R., & Panda, H. S. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01998 · Cited by 27 · see citing works
Dogra, P., Butner, J. D., Nizzero, S., Ruiz-Ramírez, J., Noureddine, A., Peláez, M. J., Elganainy, D., Yang, Z., Le, A., Goel, S., et al. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1628 · Cited by 27 · see citing works
Zerrillo, L., Gupta, K. B. S. S., Lefeber, F., Silva, C. G. D., Galli, F., Chan, A. B., Veltien, A. A., Dou, W., Censi, R., Martino, P. D., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020235 · Cited by 26 · see citing works
Saleem, S., & Kannan, R. R. (2021) · Nanoscale Research Letters · doi:10.1186/s11671-021-03592-1 · Cited by 25 · see citing works
Delbreil, P., Rabanel, J., Banquy, X., & Brambilla, D. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114397 · Cited by 25 · see citing works
Nano‐embedded medical devices and delivery systems in interventional radiology
Valentin, E. M. D. S., Barcena, A. J. R., Klusman, C., Martin, B., & Melancon, M. P. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1841 · Cited by 25 · see citing works
Fuior, E. V., Mocanu, C. A., Deleanu, M., Voicu, G., Anghelache, M., Rebleanu, D., Simionescu, M., & Călin, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111066 · Cited by 25 · see citing works
Das, A., Mohanty, S., Kumar, R., & Kuanr, B. K. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c13690 · Cited by 23 · see citing works
Wang, H., & Guo, P. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00035 · Cited by 23 · see citing works
Nanotheranostic agents for neurodegenerative diseases
Padmanabhan, P., Palanivel, M., Kumar, A., Máthé, D., Radda, G. K., Lim, K., & Gulyás, B. Z. (2020) · Emerging Topics in Life Sciences · doi:10.1042/etls20190141 · Cited by 22 · see citing works
Moreira-Álvarez, B., Cid-Barrio, L., Ferreira, H. S., Costa-Fernandez, J. M., & Encinar, J. R. (2020) · Journal of Analytical Atomic Spectrometry · doi:10.1039/d0ja00147c · Cited by 21 · see citing works
Saher, O., Lehto, T., Gissberg, O., Gupta, D., Gustafsson, O., Andaloussi, S. E., Darbre, T., Lundin, K. E., Rjh, S., & Zain, R. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120666 · Cited by 20 · see citing works
Radiolabeled Tracing Techniques Illuminating Blood Pharmacokinetics in Nanomedicine
Zhou, W., Zhang, J., Wang, X., & Yang, M. (2023) · Nano Biomedicine and Engineering · doi:10.26599/nbe.2024.9290048 · Cited by 20 · see citing works
Kostiv, U., Kučka, J., Lobaz, V., Kotov, N., Janoušková, O., Šlouf, M., Krajnik, B., Podhorodecki, A., Francová, P., Šefc, L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77112-z · Cited by 20 · see citing works
The Role of Optical Imaging in Translational Nanomedicine
Hesemans, E., Buttiens, K., Manshian, B. B., & Soenen, S. J. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13030137 · Cited by 19 · see citing works
Recent advances and prospects in naringin nanocarrier drug delivery system for cancer management
Deshmukh, R., Prajapati, M. K., & Harwansh, R. K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105182 · Cited by 19 · see citing works
A comparative study on the use of microscopy in pharmacology and cell biology research
Reigoto, A. M., Andrade, S. A., Seixas, M. R., Costa, M. L., & Mermelstein, C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245795 · Cited by 19 · see citing works
Iterative nanoparticle bioengineering enabled by x-ray fluorescence imaging
Saladino, G. M., Brodin, B. A., Kakadiya, R., Toprak, M. S., & Hertz, H. M. (2024) · Science Advances · doi:10.1126/sciadv.adl2267 · Cited by 18 · see citing works
Nanoparticle Detection in Biology and Medicine: A Review
Kolesnikova, O. A., Shikvin, D. A., Antonova, A. O., Iureva, A. M., Komedchikova, E. N., Obozina, A. S., Kachan, V., Владимировна, С. А., Kukushkin, I. D., & Shipunova, V. O. (2025) · Biosensors · doi:10.3390/bios15120809 · Cited by 17 · see citing works
Application of magnetic particle imaging to evaluate nanoparticle fate in rodent joints
Ajayi, T. O., Liu, S., Rosen, C., Rinaldi, C., Allen, K. D., & Sharma, B. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.02.038 · Cited by 16 · see citing works
Magnetic PiezoBOTs: a microrobotic approach for targeted amyloid protein dissociation
Ning, S., Sanchis‐Gual, R., Franco, C., Wendel‐Garcia, P. D., Ye, H., Veciana, A., Tang, Q., Sevim, S., Hertle, L., Llacer‐Wintle, J., et al. (2023) · Nanoscale · doi:10.1039/d3nr02418k · Cited by 16 · see citing works
Alzahrani, A. R., Ibrahim, I. A. A., Shahzad, N., Shahid, I., Alanazi, I. M., Falemban, A. H., & Azlina, M. F. N. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126889 · Cited by 16 · see citing works
Campos, Y., Fuentes, G., Almirall, A., Que, I., Schomann, T., Chung, C. K., Jorquera‐Cordero, C., Quintanilla, L., Rodríguez‐Cabello, J. C., Chan, A. B., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020282 · Cited by 15 · see citing works
Winter, G., Eberhardt, N., Löffler, J., Raabe, M., Alam, M. N. A., Li, H., Abaei, A., Herrmann, H., Kuntner, C., Glatting, G., et al. (2022) · Nanomaterials · doi:10.3390/nano12244471 · Cited by 15 · see citing works
Targeted hyperthermia with plasmonic nanoparticles
Vilches, C., & Quidant, R. (2020) · Frontiers of nanoscience · doi:10.1016/b978-0-08-102828-5.00012-7 · Cited by 15 · see citing works
Improving hemocompatibility in tissue-engineered products employing heparin-loaded nanoplatforms
Beheshtizadeh, N., Mohammadzadeh, M., Mostafavi, M., Seraji, A. A., Ranjbar, F. E., Tabatabaei, S. Z., Ghafelehbashi, R., Afzali, M., & Lolasi, F. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107260 · Cited by 14 · see citing works
Nizzero, S., Li, F., Zhang, G., Venuta, A., Borsoi, C., Mai, J., Shen, H., Wolfram, J., Li, Z., Blanco, E., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.08.002 · Cited by 14 · see citing works
Albumin nanoparticles—A versatile and a safe platform for drug delivery applications
Zwain, T., Taneja, N., Zwayen, S., Shidhaye, A., Palshetkar, A., & Singh, K. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820757-4.00008-9 · Cited by 14 · see citing works
Farcaș, A., Janosi, L., & Aştilean, S. (2021) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2021.113581 · Cited by 14 · see citing works
Functional nanoparticle developments for 3D-printed biodegradable implants- A comprehensive review
Hossain, A., Shuvo, M. I. M., Khan, S., Sayem, A. S. M., Islam, S., & Hossain, N. (2025) · Results in Surfaces and Interfaces · doi:10.1016/j.rsurfi.2025.100541 · Cited by 13 · see citing works
Qiu, Q., Wen, Y., Dong, H., Shen, A., Zheng, X., Li, Y., & Feng, F. (2019) · Biomaterials Science · doi:10.1039/c9bm01083a · Cited by 13 · see citing works
Salimi, M., Kuddannaya, S., & Bulte, J. W. M. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c03553 · Cited by 12 · see citing works
Ghosh, A., Gupta, A., Jena, S., Kirti, A., Choudhury, A., Saha, U., Sinha, A., Kumari, S., Kujawska, M., Kaushik, A. K., et al. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20240042 · Cited by 12 · see citing works
Almasi, F., Abbasloo, F., Soltani, N., Dehbozorgi, M., Fard, A. M., Kiani, A., Ghasemzadeh, N., Mesgari, H., Hosseingholi, E. Z., Payandeh, Z., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04788-7 · Cited by 12 · see citing works
Beitzinger, B., Draphoen, B., Hald, J., Krämer, M., Rudolf, T., Schmitt, F., Schwarz, P., & Lindén, M. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2522245 · Cited by 11 · see citing works
González, C., Reyes, L. H., Muñoz-Camargo, C., & Cruz, J. C. (2020) · International Online Conference on Nanomaterials (IOCN) · doi:10.3390/iocn2020-07816 · Cited by 11 · see citing works
Islam, M. M., Rahman, M. F., Islam, A., Afroz, M. S., Mamun, M. A., Rahman, M. M., Maniruzzaman, M., Xu, L., Sakamoto, T., Takahashi, Y., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094840 · Cited by 11 · see citing works
Recent developments in cancer diagnosis and treatment using nanotechnology
Ltaief, O. O., Amor, I. B., Hemmami, H., Hamza, W., Zeghoud, S., Amor, A. B., Benzina, M., & Alhamad, A. A. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002271 · Cited by 11 · see citing works
Engineering Extracellular Vesicles for Cancer Therapy
Nedeva, C., & Mathivanan, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_14 · Cited by 11 · see citing works
Organic Nanoparticle Tracking During Pharmacokinetic Studies
Bonnet, S., Elfatairi, R., Franconi, F., Roger, E., & Legeay, S. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0155 · Cited by 10 · see citing works
Modlitbová, P., Zikmundová, E., Pořízka, P., & Kaiser, J. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.118110 · Cited by 9 · see citing works
SERS-guided photodynamic therapy: pioneering strategies in advanced cancer diagnosis and treatment
Jaikumar, T., George, S., Saju, H., Raj, R., Nisarga, R., Sontakke, S., Sangshetti, J. N., Prakash, J., & Arote, R. B. (2025) · Discover Nano · doi:10.1186/s11671-025-04280-0 · Cited by 9 · see citing works
Polymer Nanoparticles in Medical Applications—Future Directions
Zawidlak-Węgrzyńska, B., & Rydz, J. (2026) · Nanomaterials · doi:10.3390/nano16100630 · Cited by 9 · see citing works
Kumar, P., Mangla, B., Imam, S. A., & Aggarwal, G. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124588 · Cited by 9 · see citing works
Nanomaterial-Mediated Theranostics for Vascular Diseases
Agrawal, S., Nooti, S. K., Singh, H., & Rai, V. (2020) · Journal of Nanotheranostics · doi:10.3390/jnt2010001 · Cited by 9 · see citing works
Novel Approaches of Solid Lipid Nanoparticles as Drug Carrier
Gad, H. A., Elezaby, R. S., Mansour, M., & Hathout, R. M. (2021) · Wiley eBooks · doi:10.1002/9783527832095.ch5 · Cited by 9 · see citing works
The clinical potential and limitations of metal-organic frameworks (MOFs) in dentistry
Hussein, W. S., Al‐Hussainy, A. F., Menon, S. V., Maharana, L., Sabarivani, A., Mukherjee, G., Sinha, A., Nigman, K., Sameer, H. N., Salih, R. M., et al. (2026) · Methods · doi:10.1016/j.ymeth.2026.01.006 · Cited by 8 · see citing works
Ermolenko, Y. V., Gorunova, O. N., Dunina, V. V., Petrenko, D. B., Novikova, N. G., Алексеева, А. И., Osipova, N., Кочетков, К. А., Морозов, А. Н., & Gelperina, S. E. (2021) · Journal of Analytical Atomic Spectrometry · doi:10.1039/d1ja00260k · Cited by 8 · see citing works
Su, S., Shen, X., Shi, X., Li, X., Chen, J., Yang, W., Sun, M., Tang, Y., Wang, H., Wang, S., et al. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1460973 · Cited by 7 · see citing works
Ribeiro, I. R. S., Harkiolaki, M., Plivelic, T. S., & Barbosa, L. R. S. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102599 · Cited by 7 · see citing works
Organic mechanoluminescent nanoparticles for biomedical applications
Gu, C., Liu, X., Song, B., Wang, W., He, W., & Wang, H. (2025) · Chemical Science · doi:10.1039/d5sc02526e · Cited by 7 · see citing works
Mallaiah, D., Sana, S. S., Madduri, R., Kim, S., Iravani, S., Varma, R. S., & Vadde, R. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114420 · Cited by 7 · see citing works
Targeting Cancer Stemness Using Nanotechnology in a Holistic Approach: A Narrative Review
Mitranovici, M.-I., Caravia, L. G., Moraru, L., & Pușcașiu, L. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030277 · Cited by 7 · see citing works
Das, A., Meena, R. K., Kumar, R., & Kuanr, B. K. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c00587 · Cited by 7 · see citing works
Nanotechnology in Oral Cancer Prevention and Therapeutics: A Literature Review
Kumar, R. R., Jha, K., & Barman, D. (2021) · Indian Journal of Medical and Paediatric Oncology · doi:10.1055/s-0041-1732856 · Cited by 7 · see citing works
ROCKETS – a novel one-for-all toolbox for light sheet microscopy in drug discovery
Mueller, J., Dobosz, M., O’Brien, N., Abdoush, N., Giusti, A. M., Lechmann, M., Osl, F., Wolf, A., Arellano-Viera, E., Shaikh, H., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1034032 · Cited by 7 · see citing works
Peter, A. E., Sandeep, B. V., Rao, B. G., & Kalpana, V. L. (2021) · Frontiers in Nanotechnology · doi:10.3389/fnano.2021.644023 · Cited by 7 · see citing works
Usman, M., Baig, Y., Nardiello, D., & Quinto, M. (2024) · Forensic Sciences Research · doi:10.1093/fsr/owae001 · Cited by 6 · see citing works
Blind Spots in Development of Nanomedicines
Salvi, B. V., Kantak, M., Kharangate, K., Trotta, F., Maher, T. J., & Shende, P. K. (2024) · Technology in Cancer Research & Treatment · doi:10.1177/15330338241245342 · Cited by 6 · see citing works
Greener nanomaterials for soft tissue regeneration: Diagnostic and therapeutic advances
Garima, Sharma, D., & Mittal, N. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106747 · Cited by 6 · see citing works
Recent Advances in Nanomaterials-Based Drug Delivery System for Cancer Treatment
Ramalingam, P., Prabakaran, D. S., Sivalingam, K., Nallal, V. U. M., Razia, M., Patel, M., Kanekar, T., & Dineshkumar, K. (2022) · Nanotechnology in the life sciences · doi:10.1007/978-3-030-80371-1_3 · Cited by 6 · see citing works
Considerations for using optical clearing techniques for 3D imaging of nanoparticle biodistribution
Arms, L., Robson, A.-L., Woldu, A. S., Martin, A. P., Palmer, W., Flynn, J. R., & Hua, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119739 · Cited by 6 · see citing works
Self-citationSuborgan Level Quantitation of Proteins in Tissues Delivered by Polymeric Nanocarriers
Agrohia, D. K., Goswami, R., Jantarat, T., Çiçek, Y. A., Thongsukh, K., Jeon, T., Bell, J. M., Rotello, V. M., & Vachet, R. W. (2024) · ACS Nano · doi:10.1021/acsnano.4c02344 · Cited by 5 · see citing works
Smeets, L. C. C., Sengun, E., Trayford, C., van Cranenbroek, B., de Jonge, M. I., Dallaglio, K., Hütten, M. C., Schoberer, M., Ophelders, D. R. M. G., Wolfs, T. G. A. M., et al. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01714 · Cited by 5 · see citing works
Usta, D. Y., Olğaç, S., Demi̇rel, M. A., Kula, S., Elmas, Ç., Sezginer, P., Kavgacı, A., & Teksin, Z. Ş. (2025) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2025.114725 · Cited by 5 · see citing works
Gutiérrez, I. Z., Lifante, J., Fernández, N., Villaverde, G., Jaque, D., Cascales, J. P., Rubio‐Retama, J., & Ximendes, E. C. (2025) · ACS Omega · doi:10.1021/acsomega.5c03435 · Cited by 5 · see citing works
- Authors
- Arms, L., Smith, D. W., Flynn, J., Palmer, W., Martin, A., Woldu, A., & Hua, S.
- Affiliations
- University of Newcastle Australia (AU)
- Hunter Medical Research Institute (AU)
- Corresponding author
- Hua, Susan
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2018-08-14
- Volume
- 9
- Pages
- 802-802
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC6102329
- OpenAlex
- W2885328264
- Cited by
- 159
- References
- 166
- Citations by year
- 2026: 15 · 2025: 31 · 2024: 23 · 2023: 18 · 2022: 17 · 2021: 29 · 2020: 18 · 2019: 8
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Funders
- Rebecca L. Cooper Medical Research Foundation
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Keywords
- nanoparticle biodistribution, nanomedicine, in vivo imaging, liquid scintillation counting, in vivo optical imaging, computed tomography, magnetic resonance imaging, scintigraphy, histology, nanoparticle accumulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
