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Cited by 1,358Lanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsHeavy Metal Exposure and Toxicity

Intracranial gadolinium deposition after contrast-enhanced MR imaging

McDonald, Robert J., McDonald, Jennifer S., Kallmes, David F., Jentoft, Mark E., Murray, David L., Thielen, Kent R., Williamson, Eric E., Eckel, Laurence J.·2015·Radiology
DOI 10.1148/radiol.15150025
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Abstract

PURPOSE: To determine if repeated intravenous exposures to gadolinium-based contrast agents (GBCAs) are associated with neuronal tissue deposition. MATERIALS AND METHODS: In this institutional review board-approved single-center study, signal intensities from T1-weighted magnetic resonance (MR) images and postmortem neuronal tissue samples from 13 patients who underwent at least four GBCA-enhanced brain MR examinations between 2000 and 2014 (contrast group) were compared with those from 10 patients who did not receive GBCA (control group). Antemortem consent was obtained from all study participants. Neuronal tissues from the dentate nuclei, pons, globus pallidus, and thalamus of these 23 deceased patients were harvested and analyzed with inductively coupled plasma mass spectrometry (ICP-MS), transmission electron microscopy, and light microscopy to quantify, localize, and assess the effects of gadolinium deposition. Associations between cumulative gadolinium dose, changes in T1-weighted MR signal intensity, and ICP-MS-derived tissue gadolinium concentrations were examined by using the Spearman rank correlation coefficient (ρ). RESULTS: Compared with neuronal tissues of control patients, all of which demonstrated undetectable levels of gadolinium, neuronal tissues of patients from the contrast group contained 0.1-58.8 μg gadolinium per gram of tissue, in a significant dose-dependent relationship that correlated with signal intensity changes on precontrast T1-weighted MR images (ρ = 0.49-0.93). All patients in the contrast group had relatively normal renal function at the time of MR examination. Gadolinium deposition in the capillary endothelium and neural interstitium was observed only in the contrast group. CONCLUSION: Intravenous GBCA exposure is associated with neuronal tissue deposition in the setting of relatively normal renal function. Additional studies are needed to investigate the clinical significance of these findings and the generalizability to other GBCAs. Online supplemental material is available for this article.

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  • Ferumoxytol does not extravasate into surrounding tissue and allows more reliable rCBV measurements, depicting GBM treatment success more precisely than gadolinium agents.

    “In contrast, ferumoxytol does not extravasate into the surrounding tissue and hence allows more reliable rCBV measurements depicting treatment success of GBM more precisely [191] (Figure 5A).”

    From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [191]

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Authors
McDonald, R. J., McDonald, J. S., Kallmes, D. F., Jentoft, M. E., Murray, D. L., Thielen, K. R., Williamson, E. E., & Eckel, L. J.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Radiology
Publisher
Radiological Society of North America (RSNA)
Published
2015-06
Volume
275
Issue
3
Pages
772-782
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
DOI
10.1148/radiol.15150025
OpenAlex
W2169262628
Cited by
1,358
References
27
Citations by year
2026: 48 · 2025: 55 · 2024: 62 · 2023: 98 · 2022: 95 · 2021: 129 · 2020: 152 · 2019: 148 · 2018: 181 · 2017: 181 · 2016: 160 · 2015: 46 · 2014: 2
FWCI
76.84
Type
journal article
Language
en
Open access
closed
Locations
  • Radiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
gadolinium-based contrast agents, gadolinium deposition, neuronal tissue, T1-weighted signal intensity, postmortem brain, normal renal function, capillary endothelium, neurotoxicity
MeSH terms
Adult, Aged, Aged, 80 and over, Brain, Contrast Media, Gadolinium, Humans, Magnetic Resonance Imaging, Middle Aged, Retrospective Studies, Tissue Distribution, Young Adult

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