The long‐term treatment of schizophrenia with antipsychotics: a perennial debate
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uninterrupted treatment, including longacting injectable formulations.Finally, there is an urgent need for further studies aimed at better identifying individuals who are more likely to successfully discontinue treatment, as well as at characterizing clinically useful early warning signs of impending relapse and developing treatment strategies more likely to result in successful discontinuation.In the meantime, recommending ongoing maintenance treatment with the safest and best tolerated antipsychotic at the lowest therapeutic dose is the best option for achieving optimal outcomes.
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The advent of LAIs appeared to overcome poor adherence but did not solve the widespread lack of adherence because LAIs remain largely underutilized.
“The advent of new long-acting injectable antipsychotics (LAIs) had appeared to overcome the issue of poor adherence [21–24], but did not solve the widespread lack of adherence, as these drugs still remain largely underutilized.”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [22]
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Bhusal, J., Molloy, H., Aparna, A. P., & Kolamunna, D. N. (2026) · Communications Health · doi:10.1038/s44528-026-00050-1
- Authors
- Fleischhacker, W. W.
- Affiliations
- Innsbruck Medical University (AT)
- Corresponding author
- Fleischhacker, W. Wolfgang
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2018-05-24
- Volume
- 17
- Issue
- 2
- Pages
- 169-170
- ISSN
- 1723-8617 (ISSN-L)
- 2051-5545
- PMC
- PMC5980630
- OpenAlex
- W2805539532
- Cited by
- 6
- References
- 10
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- World Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
- Keywords
- schizophrenia, antipsychotic drugs, long-term maintenance therapy, long-acting injectable antipsychotics, treatment discontinuation, recurrence prediction, early warning signs, dose optimization, medication adherence
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