The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Transdiagnostic psychiatry: a systematic review
Open accessAbstract
The usefulness of current psychiatric classification, which is based on ICD/DSM categorical diagnoses, remains questionable. A promising alternative has been put forward as the “transdiagnostic” approach. This is expected to cut across existing categorical diagnoses and go beyond them, to improve the way we classify and treat mental disorders. This systematic review explores whether self‐defining transdiagnostic research meets such high expectations. A multi‐step Web of Science literature search was performed according to an a priori protocol, to identify all studies that used the word “transdiagnostic” in their title, up to May 5, 2018. Empirical variables which indexed core characteristics were extracted, complemented by a bibliometric and conceptual analysis. A total of 111 studies were included. Most studies were investigating interventions, followed by cognition and psychological processes, and neuroscientific topics. Their samples ranged from 15 to 91,199 (median 148) participants, with a mean age from 10 to more than 60 (median 33) years. There were several methodological inconsistencies relating to the definition of the gold standard (DSM/ICD diagnoses), of the outcome measures and of the transdiagnostic approach. The quality of the studies was generally low and only a few findings were externally replicated. The majority of studies tested transdiagnostic features cutting across different diagnoses, and only a few tested new classification systems beyond the existing diagnoses. About one fifth of the studies were not transdiagnostic at all, because they investigated symptoms and not disorders, a single disorder, or because there was no diagnostic information. The bibliometric analysis revealed that transdiagnostic research largely restricted its focus to anxiety and depressive disorders. The conceptual analysis showed that transdiagnostic research is grounded more on rediscoveries than on true innovations, and that it is affected by some conceptual biases. To date, transdiagnostic approaches have not delivered a credible paradigm shift that can impact classification and clinical care. Practical “TRANSD”iagnostic recommendations are proposed here to guide future research in this field.
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“We performed a systematic review following the PRISMA statement guidelines (Page et al., 2021) and the TRANSD recommendation to improve transdiagnostic research in psychiatry (Fusar-Poli, 2019; Fusar-Poli, Solmi, et al., 2019).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Fusar-Poli, Solmi, et al., 2019
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“Furthermore, a systematic review and meta-analysis of electrophysiological correlates of performance monitoring in four common childhood disorders - attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), Tourette's syndrome, and obsessive-compulsive disorder -found a significant overlap in electrophysiological markers across these disorders 13,14”
From Candidate diagnostic biomarkers for neurodevelopmental disorders in children and adolescents: a systematic review (2023) · cites this paper as [14]
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“First, there are frequently reporting inconsistencies (e.g., definition of the gold-standard DSM/ICD diagnoses, outcome measures, and type of transdiagnostic approach) and low quality of studies, with few findings externally replicated 211”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [211]
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1 retracted
Pietrzak, R. H., Naganawa, M., Huang, Y. H., Corsi-Travali, S., Zheng, M., Stein, M. B., Henry, S. E., Lim, K., Ropchan, J. R., Lin, S.-F., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1221 · Cited by 72
RetractedDiagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575
Cognitive behaviour therapy for eating disorders: a “transdiagnostic” theory and treatment
Fairburn, C. G., Cooper, Z., & Shafran, R. (2003) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(02)00088-8 · Cited by 3,374
The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?
Caspi, A., Houts, R. M., Belsky, D. W., Goldman-Mellor, S. J., Harrington, H., Israel, S., Meier, M. H., Ramrakha, S., Shalev, I., Poulton, R., et al. (2014) · Clinical Psychological Science · doi:10.1177/2167702613497473 · Cited by 2,449
Fairburn, C. G., & Harrison, P. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12378-1 · Cited by 1,396
Cuthbert, B. N. (2014) · World Psychiatry · doi:10.1002/wps.20087 · Cited by 1,377
Barlow, D. H., Farchione, T. J., Bullis, J. R., Gallagher, M. W., Murray-Latin, H., Sauer-Zavala, S., Bentley, K. H., Thompson-Hollands, J., Conklin, L. R., Boswell, J. F., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2164 · Cited by 853
Fairburn, C. G., Cooper, Z., Doll, H. A., O’Connor, M. E., Bohn, K., Hawker, D. M., Wales, J. A., & Palmer, R. L. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08040608 · Cited by 829
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Age at onset of mental disorders worldwide: Large-scale meta-analysis of 192 epidemiological studies
Solmi, M., Radua, J., Olivola, M., Croce, E., Soardo, L., Salazar de Pablo, G., Il Shin, J., Kirkbride, J. B., Jones, P., Kim, J. H., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01161-7 · Cited by 3,835
“It also represents the most comprehensive approach, encompassing all ICD-11 diagnostic spectra for which we found eligible studies, allowing comparative transdiagnostic analyses across different categories of mental disorders [39, 40].”
BackgroundSelf-citationSolmi, M., Seitidis, G., Mavridis, D., Correll, C. U., Dragioti, E., Guimond, S., Tuominen, L. J., Dargél, A., Carvalho, A. F., Fornaro, M., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02138-4 · Cited by 642
Self-citationPreventive psychiatry: a blueprint for improving the mental health of young people
Fusar‐Poli, P., Correll, C. U., Arango, C., Berk, M., Patel, V., & Ioannidis, J. P. A. (2021) · World Psychiatry · doi:10.1002/wps.20869 · Cited by 497
Self-citationPrevention of Psychosis: Advances in Detection, Prognosis, and Intervention
Fusar-Poli, P., Salazar de Pablo, G., Correll, C. U., Meyer-Lindenberg, A., Millan, M. J., Borgwardt, S., Galderisi, S., Bechdolf, A., Pfennig, A., Kessing, L. V., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4779 · Cited by 476
Self-citationDu, Y., Fu, Z., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Gao, S., Xing, Y., Lin, D., Salman, M. S., Rahaman, M. A., Abrol, A., Chen, J., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102375 · Cited by 443
Metadata
- Authors
- Fusar‐Poli, P., Solmi, M., Brondino, N., Davies, C., Chae, C., Politi, P., Borgwardt, S., Lawrie, S. M., Parnas, J., & McGuire, P.
- Affiliations
- King's College London (GB)
- University of Padua (IT)
- University of Pavia (IT)
- Pennsylvania State University (US)
- University of Basel (CH)
- University of Edinburgh (GB)
- University of Copenhagen (DK)
- ORCID
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2019-05-06
- Volume
- 18
- Issue
- 2
- Pages
- 192-207
- ISSN
- 1723-8617 (ISSN-L)
- 2051-5545
- PMC
- PMC6502428
- OpenAlex
- W2944431228
- Cited by
- 409
- References
- 151
- Citations by year
- 2026: 59 · 2025: 70 · 2024: 48 · 2023: 52 · 2022: 52 · 2021: 67 · 2020: 40 · 2019: 20
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- World Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- King's College London
- Medical Research Council (MC_PC_16048)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- transdiagnostic psychiatry, psychiatric classification, DSM, ICD, mental illness, transdiagnostic features, anxiety disorders, depressive disorders, transdiagnostic treatment, research quality, research recommendations
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