Cited by 409Mental Health Research TopicsPersonality Disorders and PsychopathologyAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Transdiagnostic psychiatry: a systematic review

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Fusar‐Poli, Paolo, Solmi, Marco, Brondino, Natascia, Davies, Cathy, Chae, Chungil, Politi, Pierluigi, Borgwardt, Stefan, Lawrie, Stephen M., Parnas, Josef, McGuire, Philip·2019·World Psychiatry

DOI 10.1002/wps.20631PMC PMC6502428

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Abstract

The usefulness of current psychiatric classification, which is based on ICD/DSM categorical diagnoses, remains questionable. A promising alternative has been put forward as the “transdiagnostic” approach. This is expected to cut across existing categorical diagnoses and go beyond them, to improve the way we classify and treat mental disorders. This systematic review explores whether self‐defining transdiagnostic research meets such high expectations. A multi‐step Web of Science literature search was performed according to an a priori protocol, to identify all studies that used the word “transdiagnostic” in their title, up to May 5, 2018. Empirical variables which indexed core characteristics were extracted, complemented by a bibliometric and conceptual analysis. A total of 111 studies were included. Most studies were investigating interventions, followed by cognition and psychological processes, and neuroscientific topics. Their samples ranged from 15 to 91,199 (median 148) participants, with a mean age from 10 to more than 60 (median 33) years. There were several methodological inconsistencies relating to the definition of the gold standard (DSM/ICD diagnoses), of the outcome measures and of the transdiagnostic approach. The quality of the studies was generally low and only a few findings were externally replicated. The majority of studies tested transdiagnostic features cutting across different diagnoses, and only a few tested new classification systems beyond the existing diagnoses. About one fifth of the studies were not transdiagnostic at all, because they investigated symptoms and not disorders, a single disorder, or because there was no diagnostic information. The bibliometric analysis revealed that transdiagnostic research largely restricted its focus to anxiety and depressive disorders. The conceptual analysis showed that transdiagnostic research is grounded more on rediscoveries than on true innovations, and that it is affected by some conceptual biases. To date, transdiagnostic approaches have not delivered a credible paradigm shift that can impact classification and clinical care. Practical “TRANSD”iagnostic recommendations are proposed here to guide future research in this field.

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Age at onset of mental disorders worldwide: Large-scale meta-analysis of 192 epidemiological studies
Solmi, M., Radua, J., Olivola, M., Croce, E., Soardo, L., Salazar de Pablo, G., Il Shin, J., Kirkbride, J. B., Jones, P., Kim, J. H., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01161-7 · Cited by 3,835
“It also represents the most comprehensive approach, encompassing all ICD-11 diagnostic spectra for which we found eligible studies, allowing comparative transdiagnostic analyses across different categories of mental disorders [39, 40].”
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Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019
Solmi, M., Seitidis, G., Mavridis, D., Correll, C. U., Dragioti, E., Guimond, S., Tuominen, L. J., Dargél, A., Carvalho, A. F., Fornaro, M., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02138-4 · Cited by 642
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Preventive psychiatry: a blueprint for improving the mental health of young people
Fusar‐Poli, P., Correll, C. U., Arango, C., Berk, M., Patel, V., & Ioannidis, J. P. A. (2021) · World Psychiatry · doi:10.1002/wps.20869 · Cited by 497
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Prevention of Psychosis: Advances in Detection, Prognosis, and Intervention
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NeuroMark: An automated and adaptive ICA based pipeline to identify reproducible fMRI markers of brain disorders
Du, Y., Fu, Z., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Gao, S., Xing, Y., Lin, D., Salman, M. S., Rahaman, M. A., Abrol, A., Chen, J., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102375 · Cited by 443

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Authors: Fusar‐Poli, P., Solmi, M., Brondino, N., Davies, C., Chae, C., Politi, P., Borgwardt, S., Lawrie, S. M., Parnas, J., & McGuire, P.
Affiliations: King's College London (GB)
University of Padua (IT)
University of Pavia (IT)
Pennsylvania State University (US)
University of Basel (CH)
University of Edinburgh (GB)
University of Copenhagen (DK)
ORCID: Fusar‐Poli, Paolo
Solmi, Marco
Brondino, Natascia
Davies, Cathy
Chae, Chungil
Politi, Pierluigi
Borgwardt, Stefan
Lawrie, Stephen M.
Parnas, Josef
McGuire, Philip
Venue: World Psychiatry
Publisher: Wiley
Published: 2019-05-06
Volume: 18
Issue: 2
Pages: 192-207
ISSN: 1723-8617 (ISSN-L)
2051-5545
DOI: 10.1002/wps.20631
PMC: PMC6502428
OpenAlex: W2944431228
Cited by: 409
References: 151
Citations by year: 2026: 59 · 2025: 70 · 2024: 48 · 2023: 52 · 2022: 52 · 2021: 67 · 2020: 40 · 2019: 20
FWCI: 6.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: World Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
Research Portal (King's College London) (submittedVersion, other-oa)
Padua Research Archive (University of Padova) (submittedVersion)
Funders: King's College London
Medical Research Council (MC_PC_16048)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: transdiagnostic psychiatry, psychiatric classification, DSM, ICD, mental illness, transdiagnostic features, anxiety disorders, depressive disorders, transdiagnostic treatment, research quality, research recommendations

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Transdiagnostic psychiatry: a systematic review

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