The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology: Forum - The Research Domain Criteria Project
Open accessAbstract
In 2008, the National Institute of Mental Health (NIMH) included in its new Strategic Plan the following aim: "Develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures". The implementation of this aim was named the Research Domain Criteria project, or RDoC. RDoC is a programmatic initiative that will fund grants, contracts, early-phase trials, and similar activities for the purpose of generating studies to build a research literature that can inform future versions of psychiatric nosologies based upon neuroscience and behavioral science rather than descriptive phenomenology. RDoC departs markedly from the DSM and ICD processes, in which extensive workgroup meetings generate final and finely-honed sets of diagnoses that are modified in field tests only if problems with clinical utility arise. Rather, in keeping with its provenance as an experimental system, the RDoC provides a framework for conducting research in terms of fundamental circuit-based behavioral dimensions that cut across traditional diagnostic categories. While an important aim of the project is to validate particular dimensions as useful for eventual clinical work, an equally important goal is to provide information and experience about how to conceive and implement such an alternative approach to future diagnostic practices that can harness genetics and neuroscience in the service of more effective treatment and prevention. This paper summarizes the rationale for the RDoC project, its essential features, and potential methods of transitioning from DSM/ICD categories to dimensionally-oriented designs in research studies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Transdiagnostic approaches have been endorsed by paradigms that propose dimensional approaches that cut across diagnostic criteria such as the Research Domain Criteria (RDoC) and the clinical staging model of psychiatry.
“Transdiagnostic approaches have subsequently been endorsed by paradigms that propose dimensional approaches that cut across diagnostic criteria such as the Research Domain Criteria (RDoC) and the clinical staging model of psychiatry (Scott et al., 2013; Cuthbert, 2014).”
From An Emotion Regulation and Impulse Control (ERIC) Intervention for Vulnerable Young People: A Multi-Sectoral Pilot Study (2021) · cites this paper as Cuthbert, 2014
The RDoC plan considers psychopathology in terms of maladaptive extremes along a continuum of normal functioning, to promote a translational emphasis.
“The RDoC plan considers psychopathology in terms of maladaptive extremes along a continuum of normal functioning, to promote a translational emphasis (Cuthbert, 2014).”
From Social functioning in major depressive disorder (2016) · cites this paper as Cuthbert, 2014
The present results and previous research comport with the idea that these traditional diagnostic categories are not neurobiologically separable, which contributes to their poor prediction of treatment response or prognosis.
“The present results and previous research comport with the idea that these traditional diagnostic categories are not neurobiologically separable, which contributes to their poor prediction of treatment response or prognosis (Cuthbert, 2014).”
From Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders (2019) · cites this paper as Cuthbert, 2014
The RDoC initiative has prompted few methods to study heterogeneity within clinical cohorts or to meaningfully stratify clinical cohorts.
“However, to date, Research Domain Criteria have prompted few methods to meaningfully stratify clinical cohorts.”
From Understanding heterogeneity in clinical cohorts using normative models: Beyond case-control studies (2016) · cites this paper as [4]
During development, risk factors may contribute to a range of psychopathologies.
“during development risk factors may contribute to a range of psychopathologies”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [27]
Early indicators of later risk are often dimensional.
“early indicators of later risk are often dimensional [27]”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [27]
Continuous symptom spectra may overlap across defined psychopathologies and may better align with neurobiological systems.
“Alternately, as proposed in the National Institute of Mental Health’s Research Domain Criteria (RDoC) (Cuthbert, 2014) continuous symptom spectra, which may overlap across defined psychopathologies, may better align with neurobiological systems.”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Cuthbert, 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176 · see citing works
Food reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901 · see citing works
Ochsner, K. N., Silvers, J. A., & Buhle, J. T. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06751.x · Cited by 1,879 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Kapur, S., Phillips, A. G., & Insel, T. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.105 · Cited by 980 · see citing works
Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893 · see citing works
Developing constructs for psychopathology research: Research domain criteria
Sanislow, C. A., Pine, D. S., Quinn, K. J., Kozak, M. J., Garvey, M. A., Heinssen, R. K., Wang, P. S.-E., & Cuthbert, B. N. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0020909 · Cited by 793 · see citing works
Self-citationSnitz, B. E. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi048 · Cited by 714 · see citing works
Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior
Morris, S. E., & Cuthbert, B. N. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.1/smorris · Cited by 638 · see citing works
Self-citationNeural systems involved in fear and anxiety measured with fear-potentiated startle.
Davis, M. (2006) · American Psychologist · doi:10.1037/0003-066x.61.8.741 · Cited by 592 · see citing works
The Kraepelinian dichotomy – going, going … but still not gone
Craddock, N., & Owen, M. J. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.073429 · Cited by 587 · see citing works
The Hippocampal Formation in Schizophrenia
Tamminga, C. A., Stan, A. D., & Wagner, A. D. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09081187 · Cited by 583 · see citing works
Psychotic symptoms in non-clinical populations and the continuum of psychosis
Verdoux, H., & van Os, J. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00352-8 · Cited by 557 · see citing works
Wyatt, R. J., Alexander, R., Egan, M. F., & Kirch, D. G. (1988) · Schizophrenia Research · doi:10.1016/0920-9964(88)90034-5 · Cited by 478 · see citing works
A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation
Lanius, R. A., Bluhm, R., Lanius, U., & Pain, C. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.007 · Cited by 380 · see citing works
Krueger, R. F., & Eaton, N. R. (2010) · Personality Disorders: Theory, Research, and Treatment · doi:10.1037/a0018990 · Cited by 244 · see citing works
THE ANXIETY SPECTRUM AND THE REFLEX PHYSIOLOGY OF DEFENSE: FROM CIRCUMSCRIBED FEAR TO BROAD DISTRESS
McTeague, L. M., & Lang, P. J. (2012) · Depression and Anxiety · doi:10.1002/da.21891 · Cited by 230 · see citing works
Keshavan, M. S., Nasrallah, H. A., & Tandon, R. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.01.011 · Cited by 227 · see citing works
Patrick, C. J., Venables, N. C., Yancey, J. R., Hicks, B. M., Nelson, L. D., & Kramer, M. D. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0032807 · Cited by 218 · see citing works
Smith, G. T., McCarthy, D., & Zapolski, T. (2009) · Psychological Assessment · doi:10.1037/a0016699 · Cited by 190 · see citing works
The Cognitive Neuroscience of Working Memory: Relevance to CNTRICS and Schizophrenia
Barch, D. M., & Smith, E. E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.003 · Cited by 168 · see citing works
Frontolimbic Response to Negative Feedback in Clinical Depression.
Tucker, D. M., Luu, P., Frishkoff, G. A., Quiring, J., & Poulsen, C. (2003) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.112.4.667 · Cited by 166 · see citing works
Wong, E. H. F., Yocca, F. D., Smith, M. A., & Lee, C. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000866 · Cited by 133 · see citing works
Historical Trends and Milestones in Hypertension Research
Kotchen, T. A. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.177766 · Cited by 108 · see citing works
Neurophysiological Studies of Auditory Verbal Hallucinations
Ford, J. M., Dierks, T., Fisher, D. J., Herrmann, C. S., Hubl, D., Kindler, J., Koenig, T. W., Mathalon, D. H., Spencer, K., Strik, W. K., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs009 · Cited by 97 · see citing works
The Matter of the Mind : Philosophical Essays on Psychology, Neuroscience and Reduction
Schouten, M. K. D., & de Jong, H. L. (2007) · Data Archiving and Networked Services (DANS) · Cited by 71 · see citing works
Wakefield, J. C. (2008) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2008.03.009 · Cited by 61 · see citing works
Bolton, D. (2013) · World Psychiatry · doi:10.1002/wps.20004 · Cited by 40 · see citing works
An updated overview of animal models in neuropsychiatry
Razafsha, M., Behforuzi, H., Harati, H., Wafai, R. A., Khaku, A. S., Mondello, S., Gold, M. S., & Kobeissy, F. H. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.045 · Cited by 36 · see citing works
Gaudiano, B. A., & Zimmerman, M. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07788 · Cited by 31 · see citing works
Wakefield, J. C. (2012) · World Psychiatry · doi:10.1016/j.wpsyc.2012.01.024 · Cited by 16 · see citing works
Cells, Circuits, and Syndromes: A Critical Commentary on the NIMH Research Domain Criteria Project
McLaren, N. (2012) · Ethical Human Psychology and Psychiatry · doi:10.1891/1559-4343.13.3.229 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Baddeley AD, Hitch G. Working memo- ry. In: Bower GH (ed). Recent advances in learning and motivation, Vol. 8. New York: Academic Press, 1974:47-89.
Cited by
Sorted by citations
The Lancet Commission on global mental health and sustainable development
Patel, V., Saxena, S., Lund, C., Thornicroft, G., Baingana, F., Bolton, P., Chisholm, D., Collins, P. Y., Cooper, J. L., Eaton, J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31612-x · Cited by 3,692 · see citing works
The role of prefrontal cortex in cognitive control and executive function
Friedman, N. P., & Robbins, T. W. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01132-0 · Cited by 1,737 · see citing works
“Such refinements could perhaps enhance genetic studies, as well as improve new nosological systems such as United States’ National Institute of Mental Health’s Research Domain Criteria (RDoC) [231], a research framework that advocates examining mental disorders from the perspective of basic dimensions of functioning,…”
BackgroundDrug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225 · see citing works
Social cognition in schizophrenia
Green, M. F., Horan, W. P., & Lee, J. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4005 · Cited by 1,159 · see citing works
Understanding heterogeneity in clinical cohorts using normative models: Beyond case-control studies
Marquand, A. F., Rezek, I., Buitelaar, J., & Beckmann, C. F. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.023 · Cited by 683 · see citing works
Colizzi, M., Lasalvia, A., & Ruggeri, M. (2020) · International Journal of Mental Health Systems · doi:10.1186/s13033-020-00356-9 · Cited by 727 · see citing works
Social functioning in major depressive disorder
Kupferberg, A., Bicks, L., & Hasler, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.002 · Cited by 663 · see citing works
Nonsocial and social cognition in schizophrenia: current evidence and future directions
Green, M. F., Horan, W. P., & Lee, J. (2019) · World Psychiatry · doi:10.1002/wps.20624 · Cited by 612 · see citing works
Newby, J. M., McKinnon, A., Kuyken, W., Gilbody, S., & Dalgleish, T. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.06.002 · Cited by 545 · see citing works
Altering the course of schizophrenia: progress and perspectives
Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., et al. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.28 · Cited by 516 · see citing works
Lower synaptic density is associated with depression severity and network alterations
Holmes, S. E., Scheinost, D., Finnema, S. J., Naganawa, M., Davis, M. T., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G. A., Pietrzak, R. H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09562-7 · Cited by 484 · see citing works
Progress in achieving quantitative classification of psychopathology
Krueger, R. F., Kotov, R., Watson, D., Forbes, M. K., Eaton, N. R., Ruggero, C. J., Simms, L. J., Widiger, T. A., Achenbach, T. M., Bach, B., et al. (2018) · World Psychiatry · doi:10.1002/wps.20566 · Cited by 490 · see citing works
A cross-disorder connectome landscape of brain dysconnectivity
van den Heuvel, M. P., & Sporns, O. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0177-6 · Cited by 462 · see citing works
Transdiagnostic psychiatry: a systematic review
Fusar‐Poli, P., Solmi, M., Brondino, N., Davies, C., Chae, C., Politi, P., Borgwardt, S., Lawrie, S. M., Parnas, J., & McGuire, P. (2019) · World Psychiatry · doi:10.1002/wps.20631 · Cited by 409 · see citing works
The WPA-Lancet psychiatry commission on the future of psychiatry
Bhugra, D., Tasman, A., Pathare, S., Priebe, S., Smith, S., Torous, J., Arbuckle, M. R., Langford, A., Alarcón, R. D., Chiu, H. F. K., et al. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30333-4 · Cited by 392 · see citing works
Tolin, D. F., Gilliam, C., Wootton, B. M., Bowe, W., Bragdon, L. B., Davis, E., Hannan, S. E., Steinman, S. A., Worden, B., & Hallion, L. S. (2018) · Assessment · doi:10.1177/1073191116638410 · Cited by 345 · see citing works
Fried, E. I., van Borkulo, C. D., Epskamp, S., Schoevers, R. A., Tuerlinckx, F., & Borsboom, D. (2016) · Psychological Assessment · doi:10.1037/pas0000275 · Cited by 314 · see citing works
Stein, D. J., Shoptaw, S. J., Vigo, D. V., Lund, C., Cuijpers, P., Bantjes, J., Sartorius, N., & Maj, M. (2022) · World Psychiatry · doi:10.1002/wps.20998 · Cited by 331 · see citing works
Transdiagnostic factors of mental disorders.
Krueger, R. F., & Eaton, N. R. (2015) · World Psychiatry · doi:10.1002/wps.20175 · Cited by 330 · see citing works
Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies
Solé, B., Jiménez, E., Torrent, C., Reinares, M., Bonnin, C. D. M., Torres, I., Varo, C., Grande, I., Valls, E., Salagre, E., et al. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx032 · Cited by 299 · see citing works
A Systematic Meta-Review of Impulsivity and Compulsivity in Addictive Behaviors
Lee, R. S. C., Hoppenbrouwers, S., & Franken, I. (2019) · Neuropsychology Review · doi:10.1007/s11065-019-09402-x · Cited by 284 · see citing works
The maternal brain and its plasticity in humans
Kim, P., Strathearn, L., & Swain, J. E. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.001 · Cited by 278 · see citing works
The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges
Lilienfeld, S. O. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.07.019 · Cited by 248 · see citing works
Hickie, I. B., Scott, E. M., Cross, S. P., Iorfino, F., Davenport, T. A., Guastella, A. J., Naismith, S. L., Carpenter, J. S., Rohleder, C., Crouse, J. J., et al. (2019) · Medical Journal of Australia · doi:10.5694/mja2.50383 · Cited by 208 · see citing works
Ross, R. M., McKay, R., Coltheart, M., & Langdon, R. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu187 · Cited by 198 · see citing works
Pietrzak, R. H., Tsai, J., Armour, C., Mota, N., Harpaz-Rotem, I., & Southwick, S. M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.007 · Cited by 173 · see citing works
Lewis-Fernández, R., & Kirmayer, L. J. (2019) · Transcultural Psychiatry · doi:10.1177/1363461519861795 · Cited by 166 · see citing works
The implications of the shared genetics of psychiatric disorders
O'Donovan, M. C., & Owen, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4196 · Cited by 157 · see citing works
Menon, B. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109385 · Cited by 154 · see citing works
Annual research review: on the developmental neuropsychology of substance use disorders
J. Conrod, P., & Nikolaou, K. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12516 · Cited by 137 · see citing works
Jewell, T., Gardner, T., Susi, K., Watchorn, K., Coopey, E., Simic, M., Fonagy, P., & Eisler, I. (2019) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.12.004 · Cited by 133 · see citing works
Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms
Satterthwaite, T. D., Wolf, D. H., Calkins, M. E., Vandekar, S. N., Erus, G., Ruparel, K., Roalf, D. R., Linn, K. A., Elliott, M. A., Moore, T. M., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.3463 · Cited by 132 · see citing works
Gorka, S. M., Lieberman, L., Shankman, S. A., & Phan, K. L. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000233 · Cited by 131 · see citing works
Millan, M. J., Goodwin, G. M., Meyer-Lindenberg, A., & Ove Ögren, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.016 · Cited by 132 · see citing works
Brain-heart interaction in perseverative cognition
Ottaviani, C. (2018) · Psychophysiology · doi:10.1111/psyp.13082 · Cited by 129 · see citing works
Solmi, M., Collantoni, E., Meneguzzo, P., Degortes, D., Tenconi, E., & Favaro, A. (2018) · International Journal of Eating Disorders · doi:10.1002/eat.22884 · Cited by 119 · see citing works
Naaijen, J., Lythgoe, D. J., Amiri, H., Buitelaar, J. K., & Glennon, J. C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.009 · Cited by 117 · see citing works
Glenn, C. R., Cha, C. B., Kleiman, E. M., & Nock, M. K. (2017) · Clinical Psychological Science · doi:10.1177/2167702616686854 · Cited by 113 · see citing works
Maj, M. (2018) · World Psychiatry · doi:10.1002/wps.20512 · Cited by 109 · see citing works
Posttraumatic stress disorder: a theoretical model of the hyperarousal subtype
Weston, C. S. E. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00037 · Cited by 114 · see citing works
Prohedonic effect of cannabidiol in a rat model of depression
Shoval, G., Shbiro, L., Hershkovitz, L., Hazut, N., Zalsman, G., Mechoulam, R., & Weller, A. (2016) · Neuropsychobiology · doi:10.1159/000443890 · Cited by 110 · see citing works
Cuthbert, B. N. (2014) · Psychophysiology · doi:10.1111/psyp.12342 · Cited by 104 · see citing works
Self-citationColder Carras, M., & Kardefelt-Winther, D. (2018) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-018-1108-1 · Cited by 99 · see citing works
The Role of Chronic Stress in Anxious Depression
Ross, R. A., Foster, S. L., & Ionescu, D. F. (2017) · Chronic Stress · doi:10.1177/2470547016689472 · Cited by 92 · see citing works
Ioannidis, K., Chamberlain, S. R., Treder, M. S., Kiraly, F., Leppink, E. W., Redden, S. A., Stein, D. J., Lochner, C., & Grant, J. E. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.010 · Cited by 90 · see citing works
The registration continuum in clinical science: A guide toward transparent practices
Benning, S. D., Bachrach, R. L., Smith, E. A., Freeman, A. J., & Wright, A. G. C. (2019) · Journal of Abnormal Psychology · doi:10.1037/abn0000451 · Cited by 77 · see citing works
Karalunas, S. L., & Nigg, J. T. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.11.002 · Cited by 84 · see citing works
Becker, S. P., & Willcutt, E. G. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-018-1136-x · Cited by 85 · see citing works
Iatrogenic Factors in Psychopathology
Fava, G. A., & Rafanelli, C. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000500151 · Cited by 82 · see citing works
Montag, C., Sindermann, C., & Baumeister, H. (2020) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2020.03.013 · Cited by 86 · see citing works
Rasgon, A., Lee, W. H., Leibu, E., Laird, A., Glahn, D., Goodman, W., & Frangou, S. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.08.001 · Cited by 73 · see citing works
Attentional threat biases and their role in anxiety: A neurophysiological perspective
Wieser, M. J., & Keil, A. (2020) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2020.05.004 · Cited by 72 · see citing works
Friedman, N. P., Hatoum, A. S., Gustavson, D. E., Corley, R. P., Hewitt, J. K., & Young, S. E. (2020) · Clinical Psychological Science · doi:10.1177/2167702619898814 · Cited by 66 · see citing works
Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs
Fava, G. A., & Cosci, F. (2019) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.19com12794 · Cited by 69 · see citing works
Bias in emerging biomarkers for bipolar disorder
Carvalho, A. F., Köhler, C. A., Fernandes, B. S., Quevedo, J., Miskowiak, K. W., Brunoni, A. R., Machado-Vieira, R., Maes, M., Vieta, E., & Berk, M. (2016) · Psychological Medicine · doi:10.1017/s0033291716000957 · Cited by 63 · see citing works
Karcher, N. R., Michelini, G., Kotov, R., & Barch, D. M. (2021) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.09.008 · Cited by 55 · see citing works
Vichaya, E. G., & Dantzer, R. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.008 · Cited by 47 · see citing works
Raugh, I. M., & Strauss, G. P. (2024) · Emotion · doi:10.1037/emo0001308 · Cited by 47 · see citing works
Weinberger, D. R., & Goldberg, T. E. (2014) · World Psychiatry · doi:10.1002/wps.20096 · Cited by 42 · see citing works
Kalanthroff, E., & Wheaton, M. G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247379 · Cited by 35 · see citing works
Dajani, D. R., Burrows, C. A., Odriozola, P., Baez, A., Nebel, M. B., Mostofsky, S. H., & Uddin, L. Q. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101678 · Cited by 33 · see citing works
“The present results and previous research comport with the idea that these traditional diagnostic categories are not neurobiologically separable, which contributes to their poor prediction of treatment response or prognosis (Cuthbert, 2014).”
Emotion dysregulation as a cross-cutting target for inpatient psychiatric intervention
Fowler, J. C., Clapp, J. D., Madan, A., Allen, J. G., Oldham, J. M., & Frueh, B. C. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.07.043 · Cited by 29 · see citing works
Shah, J. L. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.2003 · Cited by 29 · see citing works
Tanaka, M. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/197425 · Cited by 27 · see citing works
Fear and distress disorders as predictors of heart disease: a temporal perspective
Roest, A. M., de Jonge, P., Lim, C. W. W., Stein, D. J., Al-Hamzawi, A., Alonso, J., Benjet, C., Bruffaerts, R., Bunting, B., Caldas-de-Almeida, J. M., et al. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.03.015 · Cited by 22 · see citing works
Mier, D., Bailer, J., Ofer, J., Kerstner, T., Zamoscik, V., Rist, F., Witthöft, M., & Diener, C. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160081 · Cited by 20 · see citing works
Schwarz, K., Moessnang, C., Schweiger, J. I., Harneit, A., Schneider, M., Chen, J., Cao, H., Schwarz, E., Witt, S. H., Rietschel, M., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.016 · Cited by 18 · see citing works
Hall, K., Youssef, G., Simpson, A., Sloan, E., Graeme, L., Perry, N., Moulding, R., Baker, A. L., Beck, A. K., & Staiger, P. K. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.554100 · Cited by 17 · see citing works
“Transdiagnostic approaches have subsequently been endorsed by paradigms that propose dimensional approaches that cut across diagnostic criteria such as the Research Domain Criteria (RDoC) and the clinical staging model of psychiatry (Scott et al., 2013; Cuthbert, 2014).”
BackgroundRiesel, A., Härpfer, K., Thoma, L., Kathmann, N., & Klawohn, J. (2023) · Psychophysiology · doi:10.1111/psyp.14164 · Cited by 15 · see citing works
Trombello, J. M., Pizzagalli, D. A., Weissman, M. M., Grannemann, B. D., Cooper, C. M., Greer, T. L., Malchow, A. L., Jha, M. K., Carmody, T. J., Kurian, B. T., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.04.003 · Cited by 16 · see citing works
Clinical advances from a computational approach to anxiety
Pine, D. S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.020 · Cited by 14 · see citing works
Zheng, X., Luo, L., Li, J., Xu, L., Zhou, F., Gao, Z., Becker, B., & Kendrick, K. M. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01958-x · Cited by 10 · see citing works
Motor actions across psychiatric disorders: a research domain criteria (RDoC) perspective
Osborne, K. J., Walther, S., & Mittal, V. A. (2024) · Clinical Psychology Review · doi:10.1016/j.cpr.2024.102511 · Cited by 9 · see citing works
Pan, N., Ma, T., Liu, Y., Zhang, S., Hu, S., Shekara, A., Cao, H., Gong, Q., & Chen, Y. (2024) · Psychological Medicine · doi:10.1017/s003329172400285x · Cited by 7 · see citing works
“The task and corresponding Research Domain Criteria (RDoC) construct and domain were labeled for each included fMRI study (Cuthbert, 2014; Janiri et al., 2020; Pan et al., 2022) (approach to coding task experiments in Online Supplementary Appendix 2).”
Child and adolescent psychiatry: challenges, solutions, opportunities, and future directions
Cortese, S., Arango, C., Aymerich, C., Catalan, A., Chetouani, M., Cohen, D., Coghill, D., Gabellone, A., Iniesta, R., Kadan, A., et al. (2026) · World Psychiatry · doi:10.1002/wps.70044 · Cited by 4 · see citing works
- Authors
- Cuthbert, B. N.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Cuthbert, Bruce N.
- ORCID
- Cuthbert, Bruce N.
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2014-02
- Volume
- 13
- Issue
- 1
- Pages
- 28-35
- ISSN
- 1723-8617 (ISSN-L)
- PMC
- PMC3918011
- OpenAlex
- W1590571936
- Cited by
- 1,377
- References
- 32
- Citations by year
- 2026: 82 · 2025: 96 · 2024: 91 · 2023: 115 · 2022: 128 · 2021: 129 · 2020: 111 · 2019: 123 · 2018: 103 · 2017: 134 · 2016: 99 · 2015: 110 · 2014: 51 · 2013: 1 · 2012: 2
- FWCI
- 799.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- World Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Clinical Psychology › Psychology and Mental Health
- Keywords
- Research Domain Criteria, dimensional classification, psychiatric classification, DSM, ICD, psychiatric diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
