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Cited by 1,022

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Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

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Ischiropoulos, Harry·1998·Archives of Biochemistry and Biophysics

Abstract

Analytical and immunological methodologies and occasionally both methodologies have been applied to detect and quantify 3-nitrotyrosine in almost every major organ system. In certain diseases increased levels of 3-nitrotyrosine have been correlated with elevated levels of other indices of oxidative stress. Numerous reports have established that nitration is a biological process derived from the biochemical interaction of nitric oxide or nitric oxide-derived secondary products with reactive oxygen species. This article addresses critical issues regarding this biological process, namely the biochemical pathways for nitration of tyrosine residues in vivo, potential protein targets, and pathophysiological consequences of protein tyrosine nitration.

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Crossref · 10.1006/abbi.1998.0755

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Metadata

Authors
Ischiropoulos, H.
Venue
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Published
1998-08
Volume
356
Issue
1
Pages
1-11
ISSN
0003-9861 (ISSN-L)
OpenAlex
W2128022125
Cited by
1,022
References
3
FWCI
34.53
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species. https://app.cochat.ai/papers/10.1006/abbi.1998.0755
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Ischiropoulos, H. (1998). Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species. Archives of Biochemistry and Biophysics. https://doi.org/10.1006/abbi.1998.0755

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.