Cited by 219Proteoglycans and glycosaminoglycans researchNeurogenesis and neuroplasticity mechanismsOsteoarthritis Treatment and Mechanisms

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Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican.

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Milev, Peter, Maurel, Patrice, Chiba, Atsuro, Mevissen, Markus, Popp, Susanna, Yamaguchi, Yu, Margolis, Renée K., Margolis, Richard U.·1998·Biochemical and Biophysical Research Communications

DOI 10.1006/bbrc.1998.8759

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Abstract

We have used a slot-blot radioimmunoassay to quantitate the levels of hyaluronan-binding chondroitin sulfate proteoglycans in developing rat brain from embryonic day 14 (E 14) to eight months postnatal. Recombinant nonhomologous regions of the core proteins were used for immunization to obtain polyclonal antibodies specific for aggrecan, the alpha and beta domains of versican mRNA splice variants, and N- and C-terminal portions of neurocan, while brevican was quantitated using a specific monoclonal antibody. The concentration of aggrecan increased steadily during brain development up to 5 months of age, when it reached a level that was 18-fold higher than at E14. Alternatively spliced versican isoforms containing the alpha domain of the glycosaminoglycan attachment region were present at a relatively low level during the late embryonic and early postnatal period, decreased by approximately 50% between 1 and 2 weeks postnatal, and then increased steadily in concentration to reach a maximum at 100 days that was 7-fold that present at 10 days postnatal. In contrast to these results, versican isoforms containing the beta domain more than doubled in concentration between E14 and birth, after which they decreased by greater than 90% to reach a low "mature" level that remained unchanged between 2 and 8 months. The N- and C-terminal portions of neurocan (produced by a developmentally-regulated proteolytic cleavage in the middle of its chondroitin sulfate attachment region) both increased in embryonic brain during development, reached a peak in the early postnatal period, and then declined thereafter. As in the case of aggrecan, only traces of brevican were detected in embryonic brain and its concentration increased steadily after birth to reach an adult level that was approximately 14-fold higher than that present in neonatal brain. These striking and distinctive changes in the concentrations of the different members of this family of structurally related proteoglycans in developing brain, including changes in opposite directions for versican mRNA splice variants, indicate that the individual proteoglycans and their isoforms probably serve unique functions during nervous tissue histogenesis.

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Multiple domains of the large fibroblast proteoglycan, versican.
Zimmermann, D., & Ruoslahti, E. I. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08447.x · Cited by 652
Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.
Doege, K. J., Sasaki, M., Horigan, E. A., Hassell, J. R., & Yamada, Y. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45444-0 · Cited by 363
Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain.
Rauch, U., Karthikeyan, L., Maurel, P., Margolis, R. U., & Margolis, R. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41808-x · Cited by 333
Self-citation
Isolation and characterization of developmentally regulated chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies
Rauch, U., Gao, P., Janetzko, A., Flaccus, A., Hilgenberg, L., Tekotte, H., Margolis, R. K., & Margolis, R. U. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98755-7 · Cited by 267
Self-citation
A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican
Dours-Zimmermann, M. T., & Zimmermann, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30089-2 · Cited by 249
The Brain Chondroitin Sulfate Proteoglycan Brevican Associates with Astrocytes Ensheathing Cerebellar Glomeruli and Inhibits Neurite Outgrowth from Granule Neurons
Yamada, H., Fredette, B. J., Shitara, K., Hagihara, K., Miura, R., Ranscht, B., Stallcup, W. B., & Yamaguchi, Y. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-20-07784.1997 · Cited by 228
Self-citation
The Biology of hyaluronan
Evered, D. C., & Whelan, J. (1989) · Wiley eBooks · Cited by 224
Chondroitin sulfate proteoglycans as mediators of axon growth and pathfinding
Margolis, R. U., & Margolis, R. K. (1997) · Cell and Tissue Research · doi:10.1007/s004410050939 · Cited by 167
Self-citation
Neurocan and phosphacan: two major nervous tissue-specific chondroitin sulfate proteoglycans.
Margolis, R. K., Rauch, U., Maurel, P., & Margolis, R. U. (1996) · PubMed · Cited by 160
Self-citation
Expression of PG-M(V3), an Alternatively Spliced Form of PG-M without a Chondroitin Sulfate Attachment Region in Mouse and Human Tissues
Zako, M., Shinomura, T., Ujita, M., Ito, K., & Kimata, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.3914 · Cited by 127

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Yamaguchi, 1996, Perspect. Dev. Neurobiol., 3, 307

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Nobuhara, Y., Usuku, K., Saito, M., Izumo, S., Arimura, K., Bangham, C. R. M., & Osame, M. (2006) · Immunogenetics · doi:10.1007/s00251-005-0075-0 · Cited by 6
Multiple Species and Functions of Proteoglycans in the Central Nervous System
Oohira, A. (2007) · Elsevier eBooks · doi:10.1016/b978-044451967-2/00095-7 · Cited by 6
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Abiko, Y., Nishimura, M., Mitamura, J., Rahemtulla, F. G., Scott, P. G., Dodd, C. M., Mizoguchi, I., & Kaku, T. (1999) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.32.459 · Cited by 5
Transport of a hyaluronan-binding protein in brain tissue
Kappler, J., Hegener, O., Baader, S. L., Franken, S., Gieselmann, V., Häberlein, H., & Rauch, U. (2009) · Matrix Biology · doi:10.1016/j.matbio.2009.06.002 · Cited by 5
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Ramos, K. L. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2008.tde-30052008-123952
Review Neurocan: a brain chondroitin sulfate proteoglycan
Rauch, U., & Feng, K. (2001)
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Vignos, M. (2016) · OhioLink ETD Center (Ohio Library and Information Network)

Authors: Milev, P., Maurel, P., Chiba, A., Mevissen, M., Popp, S., Yamaguchi, Y., Margolis, R. K., & Margolis, R. U.
Affiliations: NYU Langone Health (US)
State University of New York (US)
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Margolis, Richard U.
ORCID: Yamaguchi, Yu
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 1998-06
Volume: 247
Issue: 2
Pages: 207-212
ISSN: 0006-291X (ISSN-L)
DOI: 10.1006/bbrc.1998.8759
OpenAlex: W2137502661
Cited by: 219
References: 20
Citations by year: 2026: 4 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 10
FWCI: 3.74
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1454 d)
Locations: Biochemical and Biophysical Research Communications (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: chondroitin sulfate proteoglycans, brain development, aggrecan, versican, neurocan, brevican, splice variants, proteolytic cleavage, embryonic brain, postnatal brain
MeSH terms: Animals, Brain, Carrier Proteins, Hyaluronic Acid, Nerve Tissue Proteins, Chondroitin Sulfate Proteoglycans, Proteoglycans, RNA, Messenger, Extracellular Matrix Proteins, Alternative Splicing, Gene Expression Regulation, Developmental, Lectins, C-Type, Rats, Aggrecans, Versicans, Neurocan, Brevican

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Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican.

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