Influence of glial‐derived matrix molecules, especially chondroitin sulfates, on neurite growth and survival of cultured mouse embryonic motoneurons
Abstract
Mechanisms controlling neuronal survival and regeneration play an important role during development, after birth, and under lesion conditions. Isolated embryonic mouse motoneurons have been a useful tool for studying such basic mechanisms. These cultured motoneurons depend on extracellular matrix (ECM) molecules, which are potent mediators of survival and axonal growth and guidance in the CNS and in vitro, exhibiting either attractive or repellent guidance cues. Additionally, ECM proteoglycans and glycoproteins are components of the glial scar acting as a growth barrier for regenerating axons. Compared with CNS axon outgrowth, less is known about the cues that guide motoneurons toward their peripheral targets. Because we are interested in the effects of glial‐derived chondroitin sulfate proteoglycans (CSPGs), we have worked out a model system for investigating the influences of glial‐derived matrix molecules on motoneuron outgrowth and survival. We used cultured embryonic mouse motoneurons to investigate axon growth effects of matrix molecules produced by the glial‐derived cell lines A7, Neu7, and Oli‐neu primary astrocytes as wellas the immortalized Schwann cell line IMS32. The results indicate that molecules of the ECM, especially chondroitin sulfates, play an important role as axon growth‐promoting cues. We could demonstrate a modifying effect of the matrix components on motoneuron survival and caspase3‐induced apoptosis. © 2010 Wiley‐Liss, Inc.
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PNN formation is critically dependent on glial cells, which secrete and organize CSPGs and other ECM molecules.
“This process is critically dependent on glial cells, which secrete and organize CSPGs and other ECM molecules.35, 36, 37”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [36]
Glial cells are a major source of CSPGs and critically contribute to PNN formation and maintenance.
“Glial cells are a main source of chondroitin sulfate proteoglycans (abbreviated here as CSPGs), and have been shown to critically contribute to the formation and maintenance of PNNs (Faissner et al., 2010; John et al., 2006; Klausmeyer et al., 2011; Wiese et al., 2012).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Klausmeyer et al., 2011
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“CSPGs, and versican in particular, promote axon outgrowth (Wu et al., 2004; Maeda, 2010; Klausmeyer et al., 2011).”
Background
- Authors
- Klausmeyer, A., Conrad, R., Faissner, A., & Wiese, S.
- Affiliations
- Ruhr University Bochum (DE)
- Corresponding author
- Wiese, Stefan
- ORCID
- Wiese, Stefan
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2010-12-08
- Volume
- 89
- Issue
- 2
- Pages
- 127-141
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2062696235
- Cited by
- 24
- References
- 90
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- chondroitin sulfate proteoglycans, extracellular matrix, neurite outgrowth, motoneuron survival, glial scar, axon guidance, Schwann cells, astrocytes, caspase-3, apoptosis, peripheral nerve regeneration
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Cell Survival, Chondroitin Sulfates, Embryo, Mammalian, Extracellular Matrix, Fluorescent Antibody Technique, Motor Neurons, Neuroglia, Neurites, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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