Cerebral networks and functional brain asymmetry: evidence from regional metabolic changes during word repetition
Abstract
Word repetition causes a significant bilateral metabolic increase in both superior temporal cortices. Frontal speech areas are less activated despite their presumable speech competence. We investigated in this study the relationship between frontal and temporal cortical areas during word repetition. We measured regional cerebral metabolic rates of glucose (CMRGI) in 15 normal subjects with positron emission tomography (PET) at rest and during word repetition. Significant correlations connected frontal and temporal areas of both hemispheres, notwithstanding their different levels of mean metabolic activation. The left planum temporale was a hub of significant interregional correlations, in contrast to its contralateral mate. This study indicates that an asymmetric network of significant connections orchestrates the speech-relevant cortical areas according to the actual needs of speech processing.
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There is little posterior inferior frontal activation during auditory word repetition and reading aloud.
“The first was that there was surprisingly little posterior inferior frontal activation during auditory word repetition and reading aloud (Karbe et al., 1998; Wise et al., 1999)”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Karbe et al., 1998
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- Authors
- Karbe, H., Herholz, K., Weber-Luxenburger, G., Ghaemi, M., & Heiss, W.-D.
- Affiliations
- University Hospital Cologne (DE)
- Max Planck Society (DE)
- Venue
- Brain and Language
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 63
- Issue
- 1
- Pages
- 108-121
- ISSN
- 0093-934X (ISSN-L)
- OpenAlex
- W2066563149
- Cited by
- 37
- References
- 45
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 2
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Language (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- word repetition, functional brain asymmetry, brain networks, regional cerebral glucose metabolism, planum temporale, superior temporal cortex, interhemispheric connectivity, speech processing, hemispheric lateralization
- MeSH terms
- Adult, Brain Mapping, Female, Frontal Lobe, Glucose, Humans, Functional Laterality, Male, Models, Neurological, Speech, Temporal Lobe, Tomography, Emission-Computed
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