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THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY
Abstract
There is some evidence that, in humans and experimental animals, psychological stress may suppress or enhance immune functions, depending on the nature of the stressor and the immune variables under consideration. The possibility that psychological stress may affect the production of pro-inflammatory and immunoregulatory cytokines was investigated in 38 medical students, who had blood samplings a few weeks before and after as well as one day before an academic examination. Psychological stress significantly increased the stimulated production of tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-1 receptor antagonist (IL-1Ra), interferon gamma (IFN-gamma) and IL-10. Students with high stress perception during the stressful condition had a significantly higher production of TNF-alpha, IL-6, IL-1Ra and IFN-gamma than students with a low-stress perception. Students with a high anxiety response had a significantly higher production of IFN-gamma and a lower production of the negative immunoregulatory cytokines, IL-10 and IL-4, than students without anxiety. These findings suggest that, in humans, changes in the production of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IFN-gamma, and negative immunoregulatory cytokines, IL-10 and IL-4, take part in the homeostatic responses to psychological stress and that stress-induced anxiety is related to a T-helper-1-like response.
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“Production of IL-6 and other proinflammatory cytokines can be directly stimulated by depression and other negative emotions and stressful experiences (16-20).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [19]
In the citing paper
“Studies dating back to 1990 have shown that psychological stress increase circulating levels of IL6 in humans and laboratory animals (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
In the citing paper
“We found that standard laboratory models of acute stress—including tube restraint, cage switching, and social isolation—induced high levels of circulating IL6 (Figure 1A), consistent with previous studies demonstrating that stress alone induced IL6 (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
In the citing paper
“Psychological stress has been known to induce endocrine IL6 for nearly 30 years and has been shown in multiple species, including rats, mice, and humans (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
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Bizik, G., Bob, P., Raboch, J., Svetlak, M., Simek, J., Pec, O., Benakova, H., Uhrova, J., & Zima, T. (2011) · Activitas Nervosa Superior · doi:10.1007/bf03379937 · Cited by 5
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Tingelstad, H. C., Filion, L. G., Martin, J., Spivock, M., Tang, V. A., & Haman, F. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0551 · Cited by 5
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Javed, Q. (2014) · World Journal of Cardiovascular Diseases · doi:10.4236/wjcd.2014.49052 · Cited by 4
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Jung, M., Jo, A., Shin, J., et al. (2020) · Journal of Applied Biological Chemistry · doi:10.3839/jabc.2020.009 · Cited by 4
Cherni, A., Ouerghi, N., Jebabli, N., Ghouili, H., Bougrine, H., Bragazzi, N. L., & Bouassida, A. (2025) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.2024-0035 · Cited by 4
Chen, Q., Feng, J., Liu, L., Wang, X., Wan, Y., Mao, L., Wang, M.-H., & Zhang, C. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000183 · Cited by 4
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BackgroundLi, Y., Peng, X., Wang, X., Lin, R., Liu, X., Meng, F., Liu, X., Li, L., Bai, R., Wen, S., et al. (2023) · BMC Public Health · doi:10.1186/s12889-023-15740-6 · Cited by 5
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Lowe, A. C., Campbell, L. E., Ramaswamy, B., Horobin, H., & McLean, S. M. (2014) · Physical Therapy Reviews · doi:10.1179/1743288x13y.0000000132 · Cited by 4
Miura, H., Shirokawa, T., Ozaki, N., & Isobe, K. (2010) · Health · doi:10.4236/health.2010.23032 · Cited by 4
Oh, H. K., Choi, Y. H., Jin, Y. H., & Kim, Y. Y. (2012) · Journal of Life Science · doi:10.5352/jls.2012.22.10.1307 · Cited by 4
Maes, M. H. J., Song, C., Lin, A., Jongh, R. D., Gastel, A. V., Kenis, G., Bosmans, E., Meester, I. D., Neels, H. M., Janča, A., et al. (1999) · Cited by 4
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Maes, M. H. J. (1999) · Key topics in brain research · doi:10.1007/978-3-7091-6404-4_6 · Cited by 4
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Maes, M. H. J., Abe, Y., Sirichokchatchawan, W., Suwimonteerabutr, J., Sangkomkamhangd, U., Almulla, A. F., & Satthapisit, S. (2023) · medRxiv · doi:10.1101/2023.03.25.23287747 · Cited by 4
Self-citationWu, Z., Wu, C., Chen, X., Qian, Q., & Yao, Z. (2025) · Acta Dermato Venereologica · doi:10.2340/actadv.v105.43133 · Cited by 4
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Hu, Y., Chavez, T., Eckel, S. P., Yang, T., Chen, X., Vigil, M. J., Pavlovic, N., Lurmann, F., Lerner, D. L., Lurvey, N., et al. (2024) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-024-00692-9 · Cited by 5
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Niha, M. M., Barough, M. S., Saniei, E., et al. (2024) · Journal of medical imaging and radiation sciences · doi:10.1016/j.jmir.2024.101832 · Cited by 3
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BackgroundEffects of experimentally induced panic attacks on neuroimmunological markers
de la Fontaine, L., Schwarz, M., Eser, D., Müller, N., Rupprecht, R., & Zwanzger, P. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0140-6 · Cited by 3
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Bae, S. J., Shimizu, K., Yozaki, M., Yamaoka, T., Akiyama, Y., Yoshizaki, A., Muroi, E., Hara, T., Ogawa, F., & Sato, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090322 · Cited by 3
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Grosso, C., Valentão, P., & Andrade, P. B. (2016) · Springer eBooks · doi:10.1007/978-3-319-14021-6_1 · Cited by 3
Gidron, Y. (2019) · Behavioral Medicine · doi:10.1007/978-3-030-18893-1_2 · Cited by 32
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Richards, B. L., Whittle, S., & Buchbinder, R. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008922 · Cited by 3
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O’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_3 · Cited by 2
Goldsmith, D. R., Yuan, Q. E., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Carrión, R. E., Keshavan, M. S., Mathalon, D. H., Perkins, D. O., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.07.023 · Cited by 3
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Chrysanthou‐Piterou, M., Havaki, S., Alevizos, V., Papadimitriou, G. N., & Issidorides, M. R. (2009) · Ultrastructural Pathology · doi:10.3109/01913120903288579 · Cited by 2
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BackgroundSuppressive effect of TRH and antidepressants on human interferon-γ productionin vitro
Kubera, M., Kenis, G., Basta‐Kaim, A., Bosmans, E., Budziszewska, B., Scharpe, S., & Maes, M. H. J. (2002) · Acta Neuropsychiatrica · doi:10.1034/j.1601-5215.2002.140505.x · Cited by 2
“Alternatively, stressful events have been shown to influence the concentration of circulating cytokines and we can speculate that stress associated with affective disorder promotes changes in cytokine levels (11).”
BackgroundSelf-citationСпирин, Н. А., & Kasatkin, D. S. (2008) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-008-9087-1 · Cited by 2
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BackgroundSchizophrenia: One Coat of Many Colors
Smythies, J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00043 · Cited by 2
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Koh, K. B. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7119-6_22 · Cited by 2
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Kanzaki, J., & Masuda, M. (2013) · AUDIOLOGY JAPAN · doi:10.4295/audiology.56.137 · Cited by 2
Cameron, L., Palikhe, N. S., Laratta, C. R., & Vliagoftis, H. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.05.001 · Cited by 2
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Jiang, W., Blumenthal, J. A., Wang, J. T., et al. (2022) · Springer eBooks · doi:10.1007/978-0-387-85960-6_46 · Cited by 2
Elsayed, M., & Connor, C. J. (2018) · EMJ Dermatology · doi:10.33590/emjdermatol/10312460 · Cited by 3
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Stowell, J. R., Robles, T. F., & Kane, H. S. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop209004 · Cited by 2
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Dawson, E. C. R. (2004) · Digital Commons - East Tennessee State University (East Tennessee State University) · Cited by 2
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Alomar, M. J., Abdi, A. M., Zaman, S., Abdi, H. M., & Quicho, M. F. (2018) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2018v10i2.21241 · Cited by 1
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Alkuwaiti, E., Alzahrani, N. M., Bugshan, A., et al. (2022) · The Open Dentistry Journal · doi:10.2174/18742106-v16-e221226-2022-110 · Cited by 1
Suresh, S., Gupta, R., Srivastava, S., Halder, S., & Garg, S. (2025) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.70023 · Cited by 1
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Ebrahimi-Ghiri, M., pirouti, P., & Zarrindast, M. (2026) · Physiology and Behavior · doi:10.1016/j.physbeh.2026.115349 · Cited by 1
Milkarizi, N., Barghchi, H., Nematizade, M., Belyani, S., Bahari, H., Rajabzade, F., Kheyrabadi, S. Y. G., Razavidarmian, M., & Nematy, M. (2026) · Health Science Reports · doi:10.1002/hsr2.72681 · Cited by 1
“In contrast, elevated levels of cortisol, epinephrine [33], and pro‐inflammatory cytokines in individuals with mood disorders [34–36] may present another plausible explanation for the association between these mood disorders and NAFLD.”
Sofat, N., Hamann, P., Barrick, T. R., & Howe, F. A. (2010) · Current Rheumatology Reviews · doi:10.2174/157339710791792694 · Cited by 1
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Naveen, S. V., & Anilakumar, K. R. (2014) · Cited by 1
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Currier, M. B. (2015) · Psychiatric Annals · doi:10.3928/00485713-20150501-07 · Cited by 1
Singhal, G., Jawahar, M. C., Morgan, J., Corrigan, F., Jaehne, E. J., Toben, C. G., Hannan, A. J., Leemaqz, S., & Baune, B. T. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113269 · Cited by 1
Gastel, A. V., Janča, A., Lin, A., Maes, M. H. J., Meester, I. D., Scharpé, S., Neels, H. M., Smith, R. S., Bosmans, E., Song, C., et al. (1998) · CRC Press eBooks · doi:10.1201/9781420048193.ch3 · Cited by 1
Self-citationDagnah, R., Alotaibi, O., Alasmari, N. A., Alsulami, B., Alzamzami, B., & Alhindi, Y. Z. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs22167929 · Cited by 1
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Matovic, S., Rummel, C. D., Feldotto, M., & Gouin, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-817558-3.00004-4 · Cited by 1
Sowa, J. E., Tokarski, K., & Hess, G. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10112-2 · Cited by 2
Wal, P., Kumar, P., Bhardwaj, H., Sharma, K., Tripathi, A. K., Gupta, A., Wal, A., & Sharma, M. C. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998288090240509105717 · Cited by 1
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Wilczyński, J. R. (2007) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.3.6.871 · Cited by 1
Muramatsu, S., Tamada, T., Nara, M., et al. (2012) · The Japanese Journal of Sarcoidosis and Other Granulomatous Disorders · doi:10.7878/jjsogd.32.161 · Cited by 1
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West, D. V., & Maes, M. H. J. (1999) · Acta Neuropsychiatrica · doi:10.1017/s0924270800035869 · Cited by 1
Self-citationSmirnova, O. V., & Kablukov, V. S. (2018) · В мире научных открытий · doi:10.12731/wsd-2018-5-108-118 · Cited by 1
Effect of casein and whey proteins on examination stress
Çelik, R., Kaymakci, M., AKALIN, D., KARADEMIR, E., TUNCER, B., Biçim, G., Yılmaz, A. M., & Yalçın, A. S. (2019) · Marmara medical journal · doi:10.5472/marumj.570904 · Cited by 2
Pro-inflammatory Cytokines and the Depressive Phenotype
Arıcıoğlu, F., Özkartal, C. Ş., & Leonard, B. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-71229-7_6 · Cited by 1
Estrés, depresión, inflamación y dolor
Sánchez, P. T., Sirera, R., Peiró, G., & Cantero, F. P. (2008) · REME · Cited by 1
Yussuf, S., Adewale, A. O., Opaleye, T., Wemambu, J. C., & Ademola, O. (2022) · Archives of Oral and Maxillofacial Surgery · doi:10.36959/379/377
Behavioural Mechanisms for Defence Against Pathogens
Larson, S. J., & Dunn, A. J. (2005) · Neuroimmune biology · doi:10.1016/s1567-7443(05)80022-5 · Cited by 1
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Bernberg, E. (2010) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1
Kimata, H. (2005) · Oto-Rhino-Laryngologia Nova · doi:10.1159/000083114 · Cited by 1
Exercise, stress and immune system functional responses
Smith, C. (2004) · SUNScholar (Stellenbosch University) · Cited by 1
Guest Editorial: anxiety and the immune system: the modulation of benzodiazepines
Song, C. (2001) · Stress and Health · doi:10.1002/smi.899 · Cited by 1
Self-citationde Souza, A. L. (2007) · doi:10.47749/t/unicamp.2007.427884 · Cited by 1
Yamamotová, A., Starec, M., Holecek, V., et al. (2000) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2000.pto870403.x · Cited by 1
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Litteljohn, D. (2016) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2016-11660
Wang, F., Lu, C., Lei, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.12.628082 · Cited by 1
Cognitive Symptoms and Immune Responses in Colorectal Cancer.
Visovatti, M. A. (2013) · Deep Blue (University of Michigan) · Cited by 1
Socioeconomic status and health: exploring biological pathways
Lucas, R. M. (2003) · ANU Open Research (Australian National University) · doi:10.25911/5d7a29797a747 · Cited by 1
Vascular depression: An early indicator of decline
Paulson, D. L. (2013) · Human Biology
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Gross, R. (2008) · Digital Commons - University of South Florida (University of South Florida)
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Bykowski, C. A. (2008) · Digital Commons - University of South Florida (University of South Florida)
Schnee, B. (2008) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-15215
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Brambilla, F. (2003) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4615-0323-1_13
“All together, these findings suggest that events which are stressful or are perceived as stressful are mostly accompanied by activation of the pro inflamatory response system (23,24, 26-28 ,32).”
BackgroundInfluentialWeber, C. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-10872
Traks, T. (2007) · DSpace repository (University of Tartu)
Girard, S. (2009) · Papyrus : Institutional Repository (Université de Montréal) · doi:10.71781/30754
Metadata
- Authors
- Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., Demedts, P., Janca, A., Scharpé, S., & Smith, R. S.
- Affiliations
- Vanderbilt University (US)
- Carleton University (CA)
- University of Antwerp (BE)
- Corresponding author
- Maes, Michael
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 10
- Issue
- 4
- Pages
- 313-318
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2066503688
- Cited by
- 772
- References
- 0
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 31 · 2023: 21 · 2022: 27 · 2021: 31 · 2020: 32 · 2019: 28 · 2018: 41 · 2017: 23 · 2016: 35 · 2015: 19 · 2014: 32 · 2013: 39 · 2012: 36
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- psychological stress, stress-induced anxiety, inflammatory cytokines, TNF-α, interleukin-6, interferon-gamma, IL-10, IL-4, interleukin-1 receptor antagonist, perceived stress, immune function, medical students
- MeSH terms
- Adult, Anxiety, Female, Humans, Male, Stress, Physiological, Cytokines, Th1 Cells
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