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THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY
Abstract
There is some evidence that, in humans and experimental animals, psychological stress may suppress or enhance immune functions, depending on the nature of the stressor and the immune variables under consideration. The possibility that psychological stress may affect the production of pro-inflammatory and immunoregulatory cytokines was investigated in 38 medical students, who had blood samplings a few weeks before and after as well as one day before an academic examination. Psychological stress significantly increased the stimulated production of tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-1 receptor antagonist (IL-1Ra), interferon gamma (IFN-gamma) and IL-10. Students with high stress perception during the stressful condition had a significantly higher production of TNF-alpha, IL-6, IL-1Ra and IFN-gamma than students with a low-stress perception. Students with a high anxiety response had a significantly higher production of IFN-gamma and a lower production of the negative immunoregulatory cytokines, IL-10 and IL-4, than students without anxiety. These findings suggest that, in humans, changes in the production of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IFN-gamma, and negative immunoregulatory cytokines, IL-10 and IL-4, take part in the homeostatic responses to psychological stress and that stress-induced anxiety is related to a T-helper-1-like response.
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“Production of IL-6 and other proinflammatory cytokines can be directly stimulated by depression and other negative emotions and stressful experiences (16-20).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [19]
In the citing paper
“Studies dating back to 1990 have shown that psychological stress increase circulating levels of IL6 in humans and laboratory animals (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
In the citing paper
“We found that standard laboratory models of acute stress—including tube restraint, cage switching, and social isolation—induced high levels of circulating IL6 (Figure 1A), consistent with previous studies demonstrating that stress alone induced IL6 (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
In the citing paper
“Psychological stress has been known to induce endocrine IL6 for nearly 30 years and has been shown in multiple species, including rats, mice, and humans (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
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Burgado, J., Harrell, C. S., Eacret, D., Reddy, R., Barnum, C. J., Tansey, M. G., Miller, A. H., Wang, H., & Neigh, G. N. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.060 · Cited by 42
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Srivastava, S., & Boyer, J. L. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02333.x · Cited by 39
Fan, F., Zou, Y., Zhang, Y., Ma, X., Zhang, J., Liu, C., Li, J., Pei, M., Jiang, Y., & Dart, A. M. (2018) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-018-1798-x · Cited by 39
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Chimenti, M. S., Fonti, G. L., Conigliaro, P., Triggianese, P., Bianciardi, E., Coviello, M., Lombardozzi, G., Tarantino, G., Niolu, C., Siracusano, A., et al. (2021) · Annals of General Psychiatry · doi:10.1186/s12991-020-00322-2 · Cited by 48
de Andrade, E. G., Šimončičová, E., Carrier, M., Vecchiarelli, H. A., Robert, M.-È., & Tremblay, M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.647378 · Cited by 39
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Murison, R. C. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800538-5.00002-9 · Cited by 54
Choukri, M., Conner, T., Haszard, J., Harper, M. J., & Houghton, L. (2018) · Journal of Nutritional Science · doi:10.1017/jns.2018.14 · Cited by 38
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“Email: msorenso@depaul.edu maladaptive, are part and parcel of the homeostatic response to psychological stress (Maes, 2001; Maes et al., 1998).”
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Ferguson, E., & Cassaday, H. J. (2001) · Behavioural Neurology · doi:10.1155/2002/418758 · Cited by 38
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Maekawa, T., Liu, B., Nakai, D., Yoshida, K., Nakamura, K., Yasukawa, M., Koike, M., Takubo, K., Chatton, B., Ishikawa, F., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky155 · Cited by 42
Zhang, X., Feng, S., Peng, R., & Li, H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095142 · Cited by 42
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Maes, M. H. J. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00020-1 · Cited by 37
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Hua, M., Lai, M., Kuo, M., Yao, T., Huang, J., & Chen, S. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181fd9816 · Cited by 36
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Lee, S. T. H. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112809 · Cited by 34
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Kimura, Y., Sumiyoshi, M., Suzuki, T., Suzuki, T., & Sakanaka, M. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.8.0012 · Cited by 34
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Haake, P., Krueger, T. H. C., Goebel, M. U., Heberling, K. M., Hartmann, U. H., & Schedlowski, M. (2004) · NeuroImmunoModulation · doi:10.1159/000079409 · Cited by 34
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Schmulson, M. J., & Chey, W. D. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.427 · Cited by 34
Sachdeva, A. K., Kuhad, A., Tiwari, V., Arora, V. K., & Chopra, K. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00525.x · Cited by 33
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Bottasso, O. A., Bay, M. L., Besedovsky, H. O., & del Rey, A. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.11.002 · Cited by 32
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Risk factors for multiple myeloma: evidence from the Japan Collaborative Cohort (JACC) study.
Khan, M. M. H., Mori, M., Sakauchi, F., Matsuo, K., Ozasa, K., & Tamakoshi, A. (2006) · PubMed · Cited by 33
Studies characterizing 60 kda autoantibodies in subjects with schizophrenia
Wang, X., Wang, D., Zhu, W., Delrahim, K. K., Dolnak, D., & Rapaport, M. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01972-8 · Cited by 31
Beshai, S., Mishra, S., Mishra, S., & Carleton, R. N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189666 · Cited by 40
Amano, H., Fukuda, Y., Yokoo, T., & Yamaoka, K. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.42036 · Cited by 33
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van Raalte, L. J., & Floyd, K. (2020) · Western Journal of Communication · doi:10.1080/10570314.2020.1850851 · Cited by 30
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Svensson, M., Brundin, L., Erhardt, S., Hållmarker, U., James, S. K., & Deierborg, T. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.714014 · Cited by 36
Association of serum cytokine concentrations with psychological symptoms in midlife women
Yasui, T., Maegawa, M., Tomita, J., Miyatani, Y., Yamada, M., Uemura, H., Ueno, S., Numata, S., Ohmori, T., Tsuchiya, N., et al. (2007) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2007.02.004 · Cited by 31
Narita, K., Murata, T., Hamada, T., Takahashi, T., Kosaka, H., Yoshida, H., & Wada, Y. (2006) · International Psychogeriatrics · doi:10.1017/s1041610206004571 · Cited by 32
Mandelli, L., Milaneschi, Y., Hiles, S. A., Serretti, A., & Penninx, B. W. J. H. (2022) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000437 · Cited by 33
“Anxiety disorders and depression are strongly characterized by alterations of biological systems of stress response (Maes et al., 1998; Raison et al., 2006; Sgoifo et al., 2015).”
BackgroundImmunomodulatory effect of antidepressants
Szelényi, J. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00173-x · Cited by 31
Matheny, M. E., Miller, R. R., Shardell, M. D., Hawkes, W., Lenze, E. J., Magaziner, J., & Orwig, D. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03727.x · Cited by 31
Parruti, G., Vadini, F., Sozio, F., Mazzott, E., Ursini, T., Polill, E., Stefano, P. D., Tontodonati, M., Verrocchio, M. C., Fulcheri, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054555 · Cited by 31
Lee, H.-J., Park, H.-J., Starkweather, A., An, K., & Shim, I. (2016) · Mediators of Inflammation · doi:10.1155/2016/3501905 · Cited by 30
Santos, P. C. D., Herrmann, A. P., Elisabetsky, E., & Piato, Â. (2018) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2018-0005 · Cited by 33
da Cunha, D. T., Cipullo, M. A. T., Stedefeldt, E., & de Rosso, V. V. (2014) · Food Control · doi:10.1016/j.foodcont.2014.10.012 · Cited by 31
Tariverdian, N., Rücke, M., Szekeres‐Barthó, J., Blois, S. M., Karpf, E., Sedlmayr, P., Klapp, B. F., Kentenich, H., Siedentopf, F., & Arck, P. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0559-8 · Cited by 30
“Although high perception of stress and stress-related anxiety are known to be strongly associated with inflammatory cytokines in healthy humans [ 29 ], it remains to be elucidated whether psychological stress and up-regulation of CRH can be made attributable for the peritoneal inflammation present in endometriosis.”
BackgroundLeung, T., Chen, C.-H., Tsai, S.-Y., et al. (2012) · The Chinese Journal of Physiology · doi:10.4077/cjp.2012.baa037 · Cited by 30
“Our earlier studies on BIOCERAMIC showed that BIOCERAMIC promotes microcirculation and other effects by up-regulating calcium-dependent nitric oxide and calmodulin in different cell lines (33-35, 39).”
BackgroundMethodInfluentialBaker, M. L., Noisakran, S., Gebhardt, B. M., Kriesel, J. D., & Carr, D. J. J. (1999) · Brain Behavior and Immunity · doi:10.1006/brbi.1999.0572 · Cited by 30
Gidron, Y., Armon, T., Gilutz, H., & Huleihel, M. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00061-8 · Cited by 29
Munhoz, C. D., Madrigal, J. L. M., García‐Bueno, B., Pradillo, J. M., Moro, M. Á., Lizasoaín, I., Lorenzo, P. L., Scavone, C., & Leza, J. C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03560.x · Cited by 30
Preclinical models of antipsychotic drug action
Moreno, J. L., & González‐Maeso, J. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000606 · Cited by 28
“Numerous experimental investigations have provided robust evidence that adverse life experiences profoundly modulate immune cell functions (Maes et al., 1998; Steptoe et al., 2001; Vanbesien-Mailliot et al., 2007; Garcia-Bueno et al., 2008) and it is thought that activation of the maternal immune…”
Does inflammation link stress to poor COVID‐19 outcome?
Lamontagne, S. J., Pizzagalli, D. A., & Olmstead, M. C. (2020) · Stress and Health · doi:10.1002/smi.3017 · Cited by 30
Anxiety, neuroticism and oxidative stress: Cross‐sectional study in non‐smoking college students
Matsushita, M., Kumano‐go, T., Suganuma, N., Adachi, H., Yamamura, S., Morishima, H., Shigedo, Y., Mikami, A., Takeda, M., & Sugita, Y. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02109.x · Cited by 31
Depression and anxiety in nonalcoholic steatohepatitis: is there any association?
Blaga, T. S., & Dumitrascu, D. L. (2011) · PubMed · Cited by 29
Evron, T., Greenberg, D., Mor, T. S., & Soreq, H. (2006) · Toxicology · doi:10.1016/j.tox.2006.08.018 · Cited by 29
Hasselhorn, H. M., Theorell, T., & Vingård, E. (2001) · Spine · doi:10.1097/00007632-200102010-00005 · Cited by 29
Anticytokine therapy – new approach to the treatment of autoimmune and cytokine-disturbance diseases
Skurkovich, S. V., Skurkovich, B., & Kelly, J. (2002) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00346-8 · Cited by 29
Zheng, L.-L., Tan, X.-W., Cui, X.-Z., Yuan, H.-J., Li, H., Jiao, G.-Z., Ji, C.-L., & Tan, J.-H. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw052 · Cited by 29
Imbalance in the Stress-Adaptation System in Patients With Inflammatory Bowel Disease
Kuroki, T., Ohta, A., Sherriff-Tadano, R., Matsuura, E., Takashima, T., Iwakiri, R., & Fujimoto, K. (2011) · Biological Research For Nursing · doi:10.1177/1099800410388638 · Cited by 28
“Cytokines are mediators in the inflammatory-immune system, including tumor necrosis factor (TNF)-a, interleukin (IL)-1, IL-6, interferon (IFN)-g, IL-4, and IL-10, most of which are related to homeostatic maintenance during stress (Maes et al., 1998).”
BackgroundCompare, A., Grossi, E., Buscema, M., Zarbo, C., Mao, X., Faletra, F. F., Pasotti, E., Moccetti, T., Mommersteeg, P. M. C., & Auricchio, A. (2013) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2013/814967 · Cited by 28
Metadata
- Authors
- Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., Demedts, P., Janca, A., Scharpé, S., & Smith, R. S.
- Affiliations
- Vanderbilt University (US)
- Carleton University (CA)
- University of Antwerp (BE)
- Corresponding author
- Maes, Michael
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 10
- Issue
- 4
- Pages
- 313-318
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2066503688
- Cited by
- 772
- References
- 0
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 31 · 2023: 21 · 2022: 27 · 2021: 31 · 2020: 32 · 2019: 28 · 2018: 41 · 2017: 23 · 2016: 35 · 2015: 19 · 2014: 32 · 2013: 39 · 2012: 36
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- psychological stress, stress-induced anxiety, inflammatory cytokines, TNF-α, interleukin-6, interferon-gamma, IL-10, IL-4, interleukin-1 receptor antagonist, perceived stress, immune function, medical students
- MeSH terms
- Adult, Anxiety, Female, Humans, Male, Stress, Physiological, Cytokines, Th1 Cells
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