The DOI matches its Crossref record.
THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY
Abstract
There is some evidence that, in humans and experimental animals, psychological stress may suppress or enhance immune functions, depending on the nature of the stressor and the immune variables under consideration. The possibility that psychological stress may affect the production of pro-inflammatory and immunoregulatory cytokines was investigated in 38 medical students, who had blood samplings a few weeks before and after as well as one day before an academic examination. Psychological stress significantly increased the stimulated production of tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-1 receptor antagonist (IL-1Ra), interferon gamma (IFN-gamma) and IL-10. Students with high stress perception during the stressful condition had a significantly higher production of TNF-alpha, IL-6, IL-1Ra and IFN-gamma than students with a low-stress perception. Students with a high anxiety response had a significantly higher production of IFN-gamma and a lower production of the negative immunoregulatory cytokines, IL-10 and IL-4, than students without anxiety. These findings suggest that, in humans, changes in the production of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IFN-gamma, and negative immunoregulatory cytokines, IL-10 and IL-4, take part in the homeostatic responses to psychological stress and that stress-induced anxiety is related to a T-helper-1-like response.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Production of IL-6 and other proinflammatory cytokines can be directly stimulated by depression and other negative emotions and stressful experiences (16-20).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [19]
In the citing paper
“Studies dating back to 1990 have shown that psychological stress increase circulating levels of IL6 in humans and laboratory animals (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
In the citing paper
“We found that standard laboratory models of acute stress—including tube restraint, cage switching, and social isolation—induced high levels of circulating IL6 (Figure 1A), consistent with previous studies demonstrating that stress alone induced IL6 (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
In the citing paper
“Psychological stress has been known to induce endocrine IL6 for nearly 30 years and has been shown in multiple species, including rats, mice, and humans (Cheng et al., 2015; LeMay et al., 1990; Maes et al., 1998).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Maes et al., 1998
Citations
Cited by
Sorted by citations
Items 201–300 of 772
Stress-associated immunomodulation and herpes simplex virus infections
Sáinz, B., Loutsch, J. M., Marquart, M. E., & Hill, J. M. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1219 · Cited by 78
Robust Association Between Inflammatory Bowel Disease and Generalized Anxiety Disorder
Fuller‐Thomson, E., Lateef, R., & Sulman, J. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000518 · Cited by 77
Muscle relaxants for pain management in rheumatoid arthritis
Richards, B. L., Whittle, S., & Buchbinder, R. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008922.pub2 · Cited by 80
Painsipp, E., Köfer, M. J., Sinner, F. M., & Holzer, P. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020719 · Cited by 83
Pathobiological targets of depression
Chopra, K., Kumar, B., & Kuhad, A. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.553603 · Cited by 76
“(1998) [94] and also other studies reported that psychological stress may induce an inflammatory response with increased production of pro-inflammatory cytokines in humans [93] and also in animals [95].”
BackgroundResultPucak, M. L., Carroll, K. A. L., Kerr, D. A., & Kaplin, A. L. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.2/mpucak · Cited by 82
Relationships and Inflammation across the Lifespan: Social Developmental Pathways to Disease
Fagundes, C. P., Bennett, J. M., Derry, H. M., & Kiecolt‐Glaser, J. K. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00392.x · Cited by 83
Liu, J. J., Galfalvy, H. C., Cooper, T. B., Oquendo, M. A., Grunebaum, M. F., Mann, J. J., & Sublette, M. E. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07970 · Cited by 73
Social instability and immunity in rhesus monkeys: the role of the sympathetic nervous system
Capitanio, J. P., & Cole, S. W. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0104 · Cited by 76
Brain interference: Revisiting the role of IFNγ in the central nervous system
Monteiro, S., Roque, S., Marques, F., Correia‐Neves, M., & Cerqueira, J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.003 · Cited by 75
“Conversely, mice in which IL-4 was deleted (IL-4 knock-out (KO)) present a pro-inflammatory meningeal milieu that correlates with poor cognitive performance (Derecki et al., 2011).”
BackgroundInfluentialCytomegalovirus is associated with depression and anxiety in older adults
Phillips, A. C., Carroll, D., Khan, N., & Moss, P. A. H. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.06.012 · Cited by 74
Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE−/− mice
Bernberg, E., Ulleryd, M. A., Johansson, M. E., & Bergström, G. M. L. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.041 · Cited by 73
Mahapatra, S. K., Bhattacharjee, S., Chakraborty, S. P., Majumdar, S., & Roy, S. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2010.12.020 · Cited by 73
Gene expression biomarkers of response to citalopram treatment in major depressive disorder
Mamdani, F., Berlim, M. T., Beaulieu, M.-M., Labbe, A., Mérette, C., & Turecki, G. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.12 · Cited by 72
Environmental Risk Factors in Pediatric Psoriasis: A Multicenter Case–Control Study
Özden, M. G., Tekin, N. S., Gürer, M. A., Akdemir, D., DOGRAMACİ, C., Utaş, S., Akman, A., Evans, S. E., Bahadır, S., Öztürkcan, S., et al. (2011) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2011.01408.x · Cited by 74
West, D. V., & Maes, M. H. J. (1999) · PubMed · Cited by 70
Self-citationChronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain
Girotti, M., Donegan, J. J., & Morilak, D. A. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.008 · Cited by 72
“…immune system is increasingly found to be associated with central nervous system (CNS) dysfunctions, such as neurodegeneration and age related cognitive decline (Kiecolt-Glaser et al., 2003), as well as mood and anxiety disorders (Maes et al., 1998; Dantzer et al., 2008b; Miller et al., 2009).”
BackgroundCyranowski, J. M., Marsland, A. L., Bromberger, J. T., Whiteside, T. L., Chang, Y., & Matthews, K. A. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.07.005 · Cited by 70
“For example, the experience of brief psychological stress (such as preparing for academic examinations) has been associated with increases in the production of such proinXammatory cytokines as IL-6 (Maes et al., 1998; Segerstrom and Miller, 2004) and TNF- ( Maes et al., 1998 ).”
BackgroundTampa, M. Ş., Sârbu, M. I., Mitran, M.-I., Mitran, C. I., Matei, C., & Georgescu, S. R. (2018) · Disease Markers · doi:10.1155/2018/5823684 · Cited by 69
“High levels of TNF-α, IL-6, IFN-γ, and IL-1Ra were identified in those students who perceived stress as high when exposed to the stressful event, and high levels of IFN-γ and low levels of IL-10 and IL-4 were identified in those with a high anxiety response [23].”
BackgroundAssociation between anxiety and depression and nonalcoholic fatty liver disease
Choi, J. M., Chung, G. E., Kang, S. J., Kwak, M.-S., Yang, J. I., Park, B., & Yim, J. Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.585618 · Cited by 68
Stress in the Adult Rat Exacerbates Muscle Pain Induced by Early-Life Stress
Álvarez, P., Green, P. G., & Levine, J. D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.006 · Cited by 69
“And, plasma levels of TNFα and IL-6 are raised after exposure to psychological stressors in humans (33).”
BackgroundKhandaker, G. M., Zammit, S., Lewis, G., & Jones, P. B. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.02.003 · Cited by 65
“Similarly, in humans acute or chronic stress is associated with increase in levels of circulating proin fl ammatory cytokines (Maes et al., 1998; Kiecolt-Glaser et al., 2003).”
The factors considered as trigger for the attacks in patients with familial Mediterranean fever
Karadağ, Ö., Tufan, A., Yazısız, V., et al. (2012) · Rheumatology International · doi:10.1007/s00296-012-2453-x · Cited by 66
“[12] had reported increments in the production of the pro-inflammatory cytokines and decrements in the immuno-regulatory cytokines during the homeostatic responses to psychological stress and that stress-induced anxiety is related to a T-helper-1-like response.”
BackgroundGidron, Y., Deschepper, R., Couck, M., Thayer, J. F., & Velkeniers, B. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100371 · Cited by 65
“Finally, psychosocial stress is related to elevated pro-inflammatory cytokines and to reduced anti-inflammatory cytokines, in vulnerable individuals [26].”
BackgroundThe negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway
Maes, M. H. J., Kenis, G., Kubera, M., de Baets, M., Steinbusch, H. W. M., & Bosmans, E. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.11.008 · Cited by 64
Self-citationGlucocorticoids: Dr. Jekyll and Mr. Hyde of Hippocampal Neuroinflammation
Bolshakov, A. P., Tret’yakova, L. V., Kvichansky, A. A., & Gulyaeva, N. V. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921020048 · Cited by 66
Johnson, R. J., Hurtado, A., Merszei, J., Rodríguez‐Iturbe, B., & Feng, L. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00801-1 · Cited by 63
Body mass index and musculoskeletal pain: is there a connection?
Seaman, D. R. (2013) · Chiropractic & Manual Therapies · doi:10.1186/2045-709x-21-15 · Cited by 70
“In other words, immune cells release the same mediators whether there is overt tissue injury or noxious homeostatic challenges, such as inadequate sleep, stress, and a high glycemic meal [62,63,74,79-82].”
BackgroundLate Anxiety-Like Behavior and Neuroinflammation in Mice Subjected to Sublethal Polymicrobial Sepsis
Calsavara, A. J. C., Rodrigues, D. H., de Miranda, A. S., Costa, P. A., Lima, C. X., Vilela, M. C., Rachid, M. A., & Teixeira, A. L. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9364-1 · Cited by 65
Neurobiological correlates of coping through emotional approach
Master, S. L., Amodio, D. M., Stanton, A. L., Yee, C. M., Hilmert, C. J., & Taylor, S. E. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.04.007 · Cited by 62
“…to stressful events, such as laboratory stressors and some psychological stressors (e.g., examinations , public speaking) (Ackerman et al., 1998; Brydon et al., 2004; Dickerson et al., 2004; Maes et al., 1998; Pace et al., 2006; von Känel et al., 2006; see Steptoe et al., 2007 for a review).”
BackgroundGledhill, A., Forsdyke, D., & Murray, E. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097694 · Cited by 62
Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
Baritaki, S., de Bree, E., Chatzaki, Ε., & Pothoulakis, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101669 · Cited by 67
“Acute and chronic stressors have been reported to increase various inflammatory markers [47,48].”
Inflammatory markers in depressed post-myocardial infarction patients
Schins, A., Tulner, D. M., Lousberg, R. L., Kenis, G., Joris, D., Harry, J. C., Grauls, G., Stassen, F. R. M., Maes, M. H. J., & Honig, A. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.05.009 · Cited by 62
Self-citationA Study of TNF-α, TGF-β, IL-10, IL-6, and IFN-γ Gene Polymorphisms in Patients with Depression
Mihailova, S., Ivanova-Genova, E., Lukanov, T., Stoyanova, V., Milanova, V., & Naumova, E. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.03.005 · Cited by 61
“(Maes et al., 1998), later developed further by Michael Мaes and Robert Dantzer.”
BackgroundPlatero, J. L., Cuerda‐Ballester, M., Valle, V. I.-D., Sancho, D., López‐Rodriguez, M. M., Drehmer, E., & Ortí, J. E. D. L. R. (2020) · Nutrients · doi:10.3390/nu12020305 · Cited by 61
“Anxiety has been observed to influence the level of inflammation, increasing the risk of developing inflammatory diseases [11].”
BackgroundMaes, M. H. J., van der Planken, M., Gastel, A. V., Bruyland, K., Hunsel, F. V., Neels, H. M., Hendriks, D. F., Wauters, A., Demedts, P., Janca, A., et al. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00059-6 · Cited by 61
Self-citationA Proposed Role for Pro-Inflammatory Cytokines in Damaging Behavior in Pigs
Nordgreen, J., Edwards, S. A., Boyle, L. A., Bolhuis, J. E., Veit, C., Sayyari, A., Marin, D. E., Dimitrov, I., Janczak, A. M., & Valros, A. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00646 · Cited by 68
Kuroda, K., Nakagawa, K., Horikawa, T., Moriyama, A., Ojiro, Y., Takamizawa, S., Ochiai, A., Matsumura, Y., Ikemoto, Y., Yamaguchi, K., et al. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13429 · Cited by 60
Liu, M., Li, J., Dai, P., Zhao, F., Zheng, G., Jing, J., Wang, J., Luo, W., & Chen, J. (2014) · Stress · doi:10.3109/10253890.2014.995085 · Cited by 61
“Studies of human psychological stress show that psychological stress can enhance the expression of proinflammatory factors such as TNF-a, interleukin 6 (IL-6) and interferon g (IFN-g) (Maes et al., 1998).”
BackgroundInflammatory response to mental stress and mental stress induced myocardial ischemia
Hammadah, M., Sullivan, S. M., Pearce, B. D., Mheid, I. A., Wilmot, K. A., Ramadan, R., Tahhan, A. S., O’Neal, W. T., Obideen, M., Alkhoder, A. A., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.004 · Cited by 61
“…inflammatory state and hence to progression of CAD and clinical CAD events (Endrighi et al., 2016; Hackett et al., 2012; Goldman-Mellor et al., 2010; Miller et al., 2002; Ackerman et al., 1998; Maes et al., 1998; Goebel et al., 2000; Lu et al., 2013; Kop et al., 2002; Marsland et al., 2017).”
Amani, M., Zolghadrnasab, M., & Salari, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.01.005 · Cited by 62
Membrane Phospholipids and Cytokine Interaction in Schizophrenia
Yao, J. K., & van Kammen, D. P. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59012-8 · Cited by 58
Nagarathna, R., Rao, R. M., Nagendra, H., Vinay, C., Chandrashekara, S., Gopinath, K., & Srinath, B. S. (2008) · International Journal of Yoga · doi:10.4103/0973-6131.36795 · Cited by 60
“Jan-Jun-200834 healing in early phases of wound repair through its effect on glucocorticoids and proinflammatory cytokines in blood such as TNF-alpha and IL-1.”
BackgroundIndividual differences in the interleukin-6 response to maximal and submaximal exercise tasks
Edwards, K. M., Burns, V. E., Ring, C., & Carroll, D. (2006) · Journal of Sports Sciences · doi:10.1080/02640410500245645 · Cited by 61
“Since psychological stress is associated with increases in IL-6 (Maes et al., 1998; Steptoe et al., 2002), exercise studies may do well to consider the psychological impact (e.g. perceived exertion, difficulty, pain) of the exercise task, particularly in an untrained population.”
BackgroundDahl, J., Ormstad, H., Aass, H. C. D., Sandvik, L., Malt, U. F., & Andreassen, O. A. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12576 · Cited by 60
Ahlberg, K., Ekman, T., & Gaston‐Johansson, F. (2004) · Biological Research For Nursing · doi:10.1177/1099800403259500 · Cited by 58
Song, C. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00012-0 · Cited by 58
Self-citationKulmatycki, K. M., & Jamali, F. (2005) · PubMed · Cited by 58
Bergmans, R. S., Palta, M., Robert, S., Berger, L. M., Ehrenthal, D. B., & Malecki, K. M. C. (2018) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2017.12.003 · Cited by 60
Sullivan, S. M., Young, A., Hammadah, M., Lima, B. B., Levantsevych, O. M., Ko, Y., Pearce, B. D., Shah, A. J., Kim, J. H., Moazzami, K., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.001 · Cited by 57
Multisystem Dysregulation in Painful Temporomandibular Disorders
Chen, H., Nackley, A. G., Miller, V. E., Diatchenko, L. B., & Maixner, W. D. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.03.011 · Cited by 62
How Stress and Mental Workload are Connected
Alsuraykh, N. H., Wilson, M. L., Tennent, P., & Sharples, S. (2019) · International Conference on Pervasive Computing Technologies for Healthcare · doi:10.1145/3329189.3329235 · Cited by 58
“For example, it has been used to evaluate the UX of software [34] and used to adapt tasks [1] [56].”
BackgroundMethodRole of cytokines and reactive oxygen species in brain aging
MohanKumar, S. M. J., Murugan, A., Palaniyappan, A., & MohanKumar, P. S. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111855 · Cited by 59
Effect of Bacoside Extract fromBacopa monnieraon Physical Fatigue Induced by Forced Swimming
Anand, T., Kumar, G. P., Pandareesh, M. D., Swamy, M. S., Khanum, F., & Bawa, A. S. (2011) · Phytotherapy Research · doi:10.1002/ptr.3611 · Cited by 55
“It has been demonstrated that exercise leads to an increase in free radical formations thus causing oxidative damage to membranes (lipid peroxidation), thus, fatigue causes various disorders in relation to bio-regulatory, autonomic nervous, endocrine and immune systems (Maes et al., 1998).”
BackgroundMansur, R. B., Zugman, A., Asevedo, E. D. M., da Cunha, G. R., Bressan, R. A., & Brietzke, E. M. (2012) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2012.02354.x · Cited by 55
Haastrup, E. K., Bukh, J. D., Bock, C., Vinberg, M., Thørner, L. W., Hansen, T. F., Werge, T. M., Kessing, L. V., & Ullum, H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.025 · Cited by 56
Nausheen, B., Carr, N. J., Peveler, R., Moss-Morris, R. E., Verrill, C. L., Robbins, E., Nugent, K. P., Baker, A. M., Judd, M. A., & Gidron, Y. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181f0bc1c · Cited by 54
“Interestingly, recent accumulating evidence has shown that serum (and plasma) levels of VEGF and IL-6 are associated with psychosocial factors (16,17).”
BackgroundCognitive word use during marital conflict and increases in proinflammatory cytokines.
Graham‐Engeland, J. E., Glaser, R., Loving, T. J., Malarkey, W. B., Stowell, J. R., & Kiecolt‐Glaser, J. K. (2009) · Health Psychology · doi:10.1037/a0015208 · Cited by 54
C57BL/6 Mice Are Resistant to Acute Restraint Modulation of Cutaneous Hypersensitivity
Flint, M. S. (2001) · Toxicological Sciences · doi:10.1093/toxsci/62.2.250 · Cited by 59
“Glucocorticoids, such as corticosterone, modulate antigen presentation, cytokine production, T-cell expansion, and natural killer cell activity (Belsito et al., 1982; Bonneau et al., 1997; Chrousos and Gold, 1992; Maes et al., 1998; Snyder and Unanue, 1982; Steer et al., 1998; Wiegers and Reul, 1998).”
Audet, M. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00156 · Cited by 57
The impact of maternal high-fat diet consumption on neural development and behavior of offspring
Sullivan, E. L., Nousen, E. K., Chamlou, K. A., & Grove, K. L. (2012) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2012.15 · Cited by 54
Risk factors for bacterial vaginosis during pregnancy among African American women
Trabert, B. L., & Misra, D. P. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.03.085 · Cited by 53
The in vitro immunosuppressive effects of moclobemide in healthy volunteers
Lin, A., Song, C., Kenis, G., Bosmans, E., Jongh, R. F. D., Scharpé, S., & Maes, M. H. J. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00076-2 · Cited by 53
Self-citationErusalimsky, J. D. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.008 · Cited by 56
Neuroinflammation and neuroprogression in depression: Effects of alternative drug treatments
Richardson, B., MacPherson, A., & Bambico, F. R. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100554 · Cited by 57
“Psychological stress has been consistently shown to increase inflammatory response and as a key factor in inflammatory disease (Wirtz and Kanel, 2017; Peters et al., 2012; Mawdsley and Rampton, 2006; Maes et al., 1998; de Pablos et al., 2006).”
BackgroundIFN-γ differentially modulates memory-related processes under basal and chronic stressor conditions
Litteljohn, D., Nelson, E., & Hayley, S. P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00391 · Cited by 53
Psychobiology of depression/distress in congestive heart failure
York, K. M., Hassan, M., & Sheps, D. S. (2008) · Heart Failure Reviews · doi:10.1007/s10741-008-9091-0 · Cited by 54
Use and Abuse of Academic Examinations in Stress Research
Stowell, J. R. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000097349.84109.1f · Cited by 52
Mormède, C., Castanon, N., Medina, C. F., Moze, E., Lestage, J., Neveu, P. J., & Dantzer, R. (2002) · NeuroImmunoModulation · doi:10.1159/000071477 · Cited by 54
Αntonogeorgos, G., Panagiotakos, D. B., Pitsavos, C., Papageorgiou, C., Chrysohoou, C. A., Papadimitriou, G. N., & Stefanadis, C. (2012) · Annals of Epidemiology · doi:10.1016/j.annepidem.2012.06.103 · Cited by 51
Overman, C. L., Bossema, E. R., van Middendorp, H., Meij, L. W., Verstappen, S. M. M., Bulder, M., Jacobs, J. W. G., Bijlsma, J. W. J., & Geenen, R. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200338 · Cited by 51
Optical Scanner for Immunoassays With Up-Converting Phosphorescent Labels
Li, J. J., Ouellette, A. L., Giovangrandi, L., Cooper, D. E., Ricco, A. J., & Kovacs, G. T. A. (2008) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.914674 · Cited by 51
Lee, K.-M., Jung, D., Hwang, H., Son, K., Kim, T., Im, S., Lee, K.-H., & Hahm, B. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.02.012 · Cited by 51
In-depth analysis of lupeol: delving into the diverse pharmacological profile
Dalimunthe, A., Carensia Gunawan, M., Dhiya Utari, Z., Dinata, M. R., Halim, P., Estherina S. Pakpahan, N., Sitohang, A. I., Sukarno, M. A., Yuandani, Harahap, Y., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1461478 · Cited by 50
Maes, M. H. J., & Twisk, F. (2009) · PubMed · Cited by 50
Self-citationAssociation between C-reactive protein and suicidal behavior in an adult inpatient population
Gibbs, H. M., Davis, L., Han, X., Clothier, J. L., Eads, L. A., & Cáceda, R. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.04.002 · Cited by 49
Academic stress-induced changes in Th1- and Th2-cytokine response
Assaf, A. M., Al-Abbassi, R., & Al-Binni, M. A. (2017) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2017.09.009 · Cited by 50
“Although some studies showed an increase in TNF- a release, but that was from mitogen stimulated whole blood cells (Maes et al., 1998, Paik et al., 2000).”
BackgroundFlint, M. S. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00413-6 · Cited by 49
“…cell ratios and CD4 /CD8 ratios (Belsito et al., 1982; Chrousos and Gold, 1992; Steer The cutaneous immune system and the hypothalamic– et al., 1998; Maes et al., 1998; Wiegers and Reul, 1998). pituitary–adrenal axis (HPAA) are activated by external GC have been shown to modulate…”
BackgroundHughes, A., Kumari, M., McMunn, A., & Bartley, M. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.012 · Cited by 47
“Laboratory studies involving both animals (Zhou et al., 1993) and humans (Maes et al., 1998, 1999) have shown production of pro-inflammatory cytokines can be directly stimulated by psychologically stressful experiences (KiecoltGlaser et al., 2003), while in human observational studies an elevated…”
BackgroundGryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 53
Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety
Chiu, G. S., Darmody, P. T., Walsh, J. P., Moon, M. L., Kwakwa, K. A., Bray, J. K., McCusker, R. H., & Freund, G. G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.018 · Cited by 51
Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat
Alvarez, P., Green, P. G., & Levine, J. D. (2014) · Pain · doi:10.1016/j.pain.2014.03.004 · Cited by 47
The influence of academic stress on gingival inflammation
Johannsen, A., Bjurshammar, N., & Gustafsson, A. K. (2009) · International Journal of Dental Hygiene · doi:10.1111/j.1601-5037.2009.00397.x · Cited by 47
Brumpton, B. M., Leivseth, L., Romundstad, P., Langhammer, A., Chen, Y., Camargo, C. A., & Mai, X. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt151 · Cited by 48
Cancer and post-traumatic stress disorder: Diagnosis, pathogenesis and treatment considerations
Rustad, J. K., David, D., & Currier, M. B. (2012) · Palliative and Supportive Care · doi:10.1017/s1478951511000897 · Cited by 48
Roomruangwong, C., Kanchanatawan, B., Sirivichayakul, S., Mahieu, B., Nowak, G., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9741-5 · Cited by 46
Self-citationIBS-Symptoms in IBD Patients—Manifestation of Concomitant or Different Entities
Szałwińska, P., Włodarczyk, J., Spinelli, A., Fichna, J., & Włodarczyk, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm10010031 · Cited by 49
Unkind cytokines: Current evidence for the potential role of cytokines in immune-mediated depression
Pucak, M. L., & Kaplin, A. I. (2005) · International Review of Psychiatry · doi:10.1080/02646830500381757 · Cited by 50
“Furthermore, students who perceived the situation as highly stressful had the greatest increases (Maes et al., 1998).”
BackgroundConti, B., Sugama, S., Kim, Y., Tinti, C., Kim, H., Baker, H. A., Volpe, B. T., Attardi, B., & Joh, T. H. (2000) · NeuroImmunoModulation · doi:10.1159/000026445 · Cited by 48
Lestra, V., Roméo, B., Martelli, C., Benyamina, A., & Hamdani, N. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.06.026 · Cited by 49
Volk, D. W. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.019 · Cited by 47
Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory
Shapira‐Lichter, I., Beilin, B., Ofek, K., Bessler, H., Gruberger, M., Shavit, Y., Seror, D., Grinevich, G., Posner, E., Reichenberg, A., et al. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.09.006 · Cited by 47
Effects of anxiety on TNF-α levels during psychological stress
Chandrashekara, S., Jayashree, K., Veeranna, H. B., Vadiraj, H. S., Ramesh, M. N., Shobha, A., Sarvanan, Y., & Vikram, Y. K. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.03.001 · Cited by 47
“Decreased TNF-a levels during examination-induced stress in students who had higher anxiety scores in the present study are not in agreement with previous studies [6,27].”
ResultCordero, M. D., Alcocer‐Gómez, E., Cano‐García, F. J., de Miguel, M., Carrión, Á. M., Navas, P., & Alcázar, J. A. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026915 · Cited by 46
“Firstly, emotional stressors induce inflammatory reactions with an increased production of pro-inflammatory cytokines [30], which cause ROS and reactive nitrogen species (RNS).”
BackgroundSilva, C. P., & Kamens, H. M. (2020) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000382 · Cited by 45
“Within this category, we identified two specific pathways: The Th2 Pathway, and the Th1 and Th2 Activation Pathway, both involved in immune and inflammatory responses (Table 4) (Djuretic et al., 2007; Maes et al., 1998).”
BackgroundHerpes Viruses, Cytokines, and Altered Hemostasis in Vital Exhaustion
van der Ven, A. J. A. M., van Diest, R., Hamulyák, K., Maes, M. H. J., Bruggeman, C. A., & Appels, A. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000058378.50240.80 · Cited by 46
Self-citationLitteljohn, D., Cummings, A., Brennan, A., Gill, A., Chunduri, S., Anisman, H., & Hayley, S. P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.12.001 · Cited by 48
“…has been reported that psychological stress in humans increased IFN-c, while down-regulating the Th2 anti-inflammatory cytokines, IL-4 and IL-10, the involvement of IFN-c in stressor-induced pathology might be related to a shift in the Th1/Th2 balance in favor of a Th1 response (Maes et al., 1998).”
Pain: Understanding and challenges for the rheumatologist
Fitzcharles, M., Al-Mahrezi, A. M., & Shir, Y. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21435 · Cited by 45
Haptoglobin polymorphism and schizophrenia: Genetic variation on chromosome 16
Maes, M. H. J., Delanghe, J., Bocchio‐Chiavetto, L., Bignotti, S., Tura, G. B., Pioli, R., Zanardini, R., & Altamura, C. A. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00298-0 · Cited by 46
Self-citationXiang, L., Ben, K. S. D., Rehm, K. E., & Marshall, G. D. (2011) · Neuropsychobiology · doi:10.1159/000328160 · Cited by 45
Metadata
- Authors
- Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., Demedts, P., Janca, A., Scharpé, S., & Smith, R. S.
- Affiliations
- Vanderbilt University (US)
- Carleton University (CA)
- University of Antwerp (BE)
- Corresponding author
- Maes, Michael
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 10
- Issue
- 4
- Pages
- 313-318
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2066503688
- Cited by
- 772
- References
- 0
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 31 · 2023: 21 · 2022: 27 · 2021: 31 · 2020: 32 · 2019: 28 · 2018: 41 · 2017: 23 · 2016: 35 · 2015: 19 · 2014: 32 · 2013: 39 · 2012: 36
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- psychological stress, stress-induced anxiety, inflammatory cytokines, TNF-α, interleukin-6, interferon-gamma, IL-10, IL-4, interleukin-1 receptor antagonist, perceived stress, immune function, medical students
- MeSH terms
- Adult, Anxiety, Female, Humans, Male, Stress, Physiological, Cytokines, Th1 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
