Cited by 856Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

The DOI matches its Crossref record.

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

von Zglinicki, Thomas, Saretzki, Gabriele, Döcke, Wolf, Lotze, Christian·1995·Experimental Cell Research

DOI 10.1006/excr.1995.1305

Open this paper in CoChat — free account

Abstract

Mild oxidative stress as exerted by culture of human WI-38 fibroblasts under 40% oxygen partial pressure blocks proliferation irreversibly after one to three population doublings. Hyperoxically blocked cells are similar to senescent ones in terms of general morphology and lipofuscin accumulation. Moreover, they, like senescent fibroblasts, are blocked preferentially in G1 as evident from DNA content measurements by flow cytometry. Southern blotting of AluI- and HinfI-restricted genomic DNA shows an increase of the rate of telomere shortening from 90 bp per population doubling under normoxia to more than 500 bp per population doubling under hyperoxia. In every case, proliferation is blocked if a telomere cutoff length of about 4 kb is arrived at. The fact that telomere length correlates with the final inhibition of proliferation under conditions of varied oxidative stress, while the population doubling level does not, suggests that telomere shortening provides the signal for cell cycle exit in senescence. In postmitotic cells, no further telomere shortening occurs. However, the sensitivity of terminal restriction fragments to S1 nuclease increases, indicating the accumulation of single-strand breaks in telomeres of nondividing fibroblasts. This effect is found both under normoxic and hyperoxic culture, although it is more pronounced under conditions of higher oxidative stress. It might be speculated that accumulation of single-strand breaks and the resultant loss of distal single-stranded fragments during replication could be a major cause of telomere shortening, possibly more important than incomplete replication per se.

Integrity signals

Registry

Crossref · 10.1006/excr.1995.1305

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Still being checked.

Sorted by citations

Items 201–300 of 854

A Stochastic Model of Cell Replicative Senescence Based on Telomere Shortening, Oxidative Stress, and Somatic Mutations in Nuclear and Mitochondrial DNA
Sozou, P. D., & Kirkwood, T. B. L. (2001) · Journal of Theoretical Biology · doi:10.1006/jtbi.2001.2432 · Cited by 115
Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
Lee, D., Im, J., Kim, J., Lee, H.-R., & Shim, J. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.4.471 · Cited by 114
Telomerase inhibition as cancer therapy
Saretzki, G. C. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00708-5 · Cited by 114
Self-citation
Oxidative Stress, Mitochondrial Dysfunction and the Mitochondria Theory of Aging
Kong, Y., Trabucco, S. E., & Zhang, H. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358901 · Cited by 117
Shorter telomeres are associated with obesity and weight gain in the elderly
study, F. T. H. A., Njajou, O. T., Cawthon, R., Blackburn, E. H., Harris, T. B., Li, R., Sanders, J. L., Newman, A. B., Nalls, M. A., Cummings, S. R., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.196 · Cited by 114
Telomeres, Telomerase and Ageing
Saretzki, G. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_9 · Cited by 120
Self-citation
Mitochondria, Telomeres and Telomerase Subunits
Zheng, Q., Huang, J., & Wang, G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00274 · Cited by 118
p16INK4a and the control of cellular proliferative life span
Huschtscha, L. I. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.921 · Cited by 110
Aging and cancer: are telomeres and telomerase the connection?
Shay, J. W. (1995) · Molecular Medicine Today · doi:10.1016/s1357-4310(95)93872-9 · Cited by 109
The role of telomeres in the ageing of human skin: Telomeres and skin ageing
Buckingham, E. M., & Klingelhutz, A. J. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01242.x · Cited by 109
The Influence of Alcohol Consumption, Cigarette Smoking, and Physical Activity on Leukocyte Telomere Length
Latifovic, L., Peacock, S. D., Massey, T. E., & King, W. D. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-1364 · Cited by 111
Current understanding of ovarian aging
Li, Q., Geng, X., Zheng, W., Tang, J., Xu, B., & Shi, Q. (2012) · Science China Life Sciences · doi:10.1007/s11427-012-4352-5 · Cited by 108
Stress‐Induced Premature Senescence: Essence of Life, Evolution, Stress, and Aging
Toussaint, O., DUMONT, P., Dierick, J., Pascal, T. G., Frippiat, C. C., Debacq‐Chainiaux, F., Sluse, F. E., Eliaers, F., & Remacle, J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06638.x · Cited by 108
Telomere Length, Aging, and Somatic Cell Turnover
Hodes, R. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.153 · Cited by 108
Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice
Rolyan, H., Scheffold, A., Heinrich, A., Begus-Nahrmann, Y., Langkopf, B. H., Hölter, S. M., Vogt-Weisenhorn, D. M., Liss, B., Wurst, W., Lie, D. C., et al. (2011) · Brain · doi:10.1093/brain/awr133 · Cited by 106
Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci
Buxton, J. L., Suderman, M. J., Pappas, J. J., Borghol, N., McArdle, W. L., Blakemore, A. I. F., Hertzman, C., Power, C., Szyf, M., & Pembrey, M. E. (2014) · Scientific Reports · doi:10.1038/srep04954 · Cited by 112
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress
Rubio, M. Á., Davalos, A. R., & Campisi, J. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.004 · Cited by 105
From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing
de Magalhães, J. P. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.006 · Cited by 108
Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence
MIN, L., MOGI, M., IWANAMI, J., LI, J., SAKATA, A., FUJITA, T., TSUKUDA, K., IWAI, M., & HORIUCHI, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.07.008 · Cited by 105
Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: Role for p38 mitogen-activated protein kinase
Müller, M. K., Li, Z., & Maitz, P. (2009) · Burns · doi:10.1016/j.burns.2008.11.010 · Cited by 105
Characterization of Multipotent Mesenchymal Stem Cells from the Bone Marrow of Rhesus Macaques
Izadpanah, R., Joswig, T., Tsien, F., Dufour, J., Kirijan, J. C., & Bunnell, B. A. (2005) · Stem Cells and Development · doi:10.1089/scd.2005.14.440 · Cited by 104
Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
Ramirez, R. D., Herbert, B., Vaughan, M. B., Zou, Y. S., Gandia, K., Morales, C. P., Wright, W. E., & Shay, J. W. (2003) · Oncogene · doi:10.1038/sj.onc.1206046 · Cited by 103
Smurf2 up-regulation activates telomere-dependent senescence
Zhang, H., & Cohen, S. N. (2004) · Genes & Development · doi:10.1101/gad.1253004 · Cited by 100
Histopathological lesions, oxidative stress and genotoxic effects in liver and kidneys following long term exposure of rabbits to diazinon and propoxur
Tsitsimpikou, C., Tzatzarakis, M. N., Fragkiadaki, P., Kovatsi, L., Stivaktakis, P. D., Kalogeraki, A. M., Kouretas, D., & Tsatsakis, A. M. (2012) · Toxicology · doi:10.1016/j.tox.2012.11.002 · Cited by 101
Telomere Shortening and Cellular Senescence in a Model of Chronic Renal Allograft Rejection
Joosten, S. A., van Ham, V., Nolan, C. E., Borrias, M. C., Jardine, A. G., Shiels, P. G., van Kooten, C., & Paul, L. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63926-0 · Cited by 101
Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-seq
Marthandan, S., Baumgart, M., Priebe, S., Groth, M., Schaer, J., Kaether, C., Guthke, R., Cellerino, A., Platzer, M., Diekmann, S., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154531 · Cited by 91
“Some of the major factors responsible for cellular senescence include DNA damage [6–8], oxidative stress [9, 10] and other factors [6, 11–14], resulting in an induction of cyclin-dependent kinase inhibitors (CDKIs) [15].”
Background
Human skeletal muscle satellite cells: aging, oxidative stress and the mitotic clock
Renault, V. M., Thornell, L., Butler-Browne, G. S., & Mouly, V. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00129-8 · Cited by 105
Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression
Welford, S. M., & Giaccia, A. J. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0065 · Cited by 103
Metabolism in cancer metastasis
Weber, G. F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29839 · Cited by 102
RPE cell senescence: A key contributor to age-related macular degeneration
Kozlowski, M. R. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.01.018 · Cited by 103
Telomere Length As a Marker of Oxidative Stress in Primary Human Fibroblast Cultures
Serra, V., Grune, T., Sitte, N., Saretzki, G. C., & von Zglinicki, T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06666.x · Cited by 99
Self-citation
A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer
Morris, B. J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000173509.45363.dd · Cited by 98
The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells
Lener, B., Kozieł, R., Pircher, H., Hütter, E., Greussing, R., Herndler‐Brandstetter, D., Hermann, M., Unterluggauer, H., & Jansen‐Dürr, P. (2009) · Biochemical Journal · doi:10.1042/bj20090666 · Cited by 97
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells
Wang, L., Lu, Z., Zhao, J., Schank, M., Cao, D., Dang, X., Nguyen, L. N., Nguyen, L. N. T., Khanal, S., Zhang, J., et al. (2021) · Aging Cell · doi:10.1111/acel.13513 · Cited by 96
Telomere Dynamics in Macaques and Humans
Gardner, J. P., Kimura, M., Chai, W., Durrani, J. F., Tchakmakjian, L., Cao, X., Lu, X., Li, G., Peppas, A. P., Skurnick, J., et al. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.4.367 · Cited by 100
Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link?
Nousis, L., Kanavaros, P., & Barbouti, A. (2023) · Antioxidants · doi:10.3390/antiox12061250 · Cited by 103
Short telomeres in patients with chronic schizophrenia who show a poor response to treatment
Yu, W., Chang, H., Lin, C., & Cho, C.-L. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0825 · Cited by 98
Modelling telomere shortening and the role of oxidative stress
Proctor, C. J., & Kirkwood, T. B. L. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00380-3 · Cited by 96
Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells
Suzuki, T., Minagawa, S., Michishita, E., Ogino, H., Fujii, M., Mitsui, Y., & Ayusawa, D. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00223-0 · Cited by 95
Hydroxyl radical‐induced apoptosis in human tumor cells is associated with telomere shortening but not telomerase inhibition and caspase activation
Ren, J., Xia, H., Just, T., & Dai, Y. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02377-2 · Cited by 96
Increased Melanogenesis is a Risk Factor for Oxidative DNA Damage— Study on Cultured Melanocytes and Atypical Nevus Cells†
Smit, N. P. M., Van Nieuwpoort, F. A., Marrot, L., Out, C., Poorthuis, B., Van Pelt, H., Meunier, J., & Pavel, S. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00242.x · Cited by 91
Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence
Dierick, J.-F., Eliaers, F., Remacle, J., Raes, M., Fey, S. J., Larsen, P. M., & Toussaint, O. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01171-1 · Cited by 95
Telomere length and obesity
Zannolli, R., Mohn, A., Buoni, S., Pietrobelli, A., Messina, M., Chiarelli, F., & Miracco, C. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00783.x · Cited by 98
The Relationship between Telomere Length and Mortality in Chronic Obstructive Pulmonary Disease (COPD)
Lee, J., Sandford, A. J., Connett, J. E., Yan, J., Mui, T., Li, Y., Daley, D., Anthonisen, N. R., Brooks-Wilson, A. R., Man, S. F. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035567 · Cited by 94
Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress
Byrd, A. K., Zybailov, B. L., Maddukuri, L., Gao, J., Marecki, J. C., Jaiswal, M., Bell, M. R., Griffin, W. C., Reed, M. R., Chib, S., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.718478 · Cited by 99
Cell Donor Influences Success of Producing Cattle by Somatic Cell Nuclear Transfer
Powell, A. M., Talbot, N. C., Wells, K. D., Kerr, D. E., Pursel, V. G., & Wall, R. J. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.027193 · Cited by 94
From the Hayflick mosaic to the mosaics of ageing.
Toussaint, O., Remacle, J., Dierick, J.-F., Pascal, T., Frippiat, C., Zdanov, S., Magalhaes, J. P., Royer, V., & Chainiaux, F. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00034-1 · Cited by 92
Oxygen free radicals in cell senescence: Are they signal transducers?
Passos, J. F., & Von Zglinicki, T. (2006) · Free Radical Research · doi:10.1080/10715760600917151 · Cited by 122
Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts
Stöckl, P., Hütter, E., Zwerschke, W., & Jansen-Dürr, P. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.04.009 · Cited by 99
Signaling mechanisms of angiotensin II in regulating vascular senescence
Min, L., Mogi, M., Iwai, M., & Horiuchi, M. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.12.002 · Cited by 94
Ceroid/Lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
Terman, A., Abrahamsson, N., & Brunk, U. T. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00045-5 · Cited by 93
IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
Hubáčková, S., Kucerova, A., Michlits, G., Kyjacová, L., Reiniš, M., Korolov, O., Bártek, J., & Hodný, Z. (2015) · Oncogene · doi:10.1038/onc.2015.162 · Cited by 97
Oxidative stress, inflammation and hormesis: The role of dietary and lifestyle modifications on aging
Sharma, V., & Mehdi, M. M. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105490 · Cited by 100
Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells
Stöckl, P., Zankl, C., Hütter, E., Unterluggauer, H., Laun, P., Heeren, G., Bogengruber, E., Herndler‐Brandstetter, D., Breitenbach, M., & Jansen‐Dürr, P. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.005 · Cited by 95
The Effect of Stocking Density on Stress Related Genes and Telomeric Length in Broiler Chickens
Beloor, J., Kang, H.-G., Kim, Y. J., Subramani, V. K., Jang, I. S., Sohn, S. H., & Moon, Y. S. (2010) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2010.90400 · Cited by 92
Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts
de Magalhães, J. P., Chainiaux, F., Remacle, J., & Toussaint, O. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02973-3 · Cited by 90
Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres
Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 95
Genome-health nutrigenomics and nutrigenetics: nutritional requirements or ‘nutriomes’ for chromosomal stability and telomere maintenance at the individual level
Bull, C. F., & Fenech, M. F. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006988 · Cited by 91
Comparative Analysis of Telomere Lengths and Erosion with Age in Human Epidermis and Lingual Epithelium
Nakamura, K., Izumiyama‐Shimomura, N., Takubo, K., Sawabe, M., Arai, T., Aoyagi, Y., Fujiwara, M., Tsuchiya, E., Kobayashi, Y., Kato, M., et al. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.19523.x · Cited by 92
Cell division drives DNA methylation loss in late-replicating domains in primary human cells
Endicott, J. L., Nolte, P. A., Shen, H., & Laird, P. W. (2022) · Nature Communications · doi:10.1038/s41467-022-34268-8 · Cited by 93
l-Carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts
Shao, L., Li, Q., & Tan, Z. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.136 · Cited by 89
Senescence and immortality in hepatocellular carcinoma
Öztürk, M., Arslan-Ergül, A., Baǧışlar, S., Şentürk, Ş., & Yuzugullu, H. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.10.048 · Cited by 89
Biogerontology: The Next Step
Rattan, S. I. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06655.x · Cited by 87
Cellular Senescence: The Trojan Horse in Chronic Lung Diseases
Hamsanathan, S., Alder, J. K., Sellarés, J., Rojas, M. M., Gurkar, A. U., & Mora, A. L. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0410tr · Cited by 89
Lentivector-Mediated Transfer of Bmi-1 and Telomerase in Muscle Satellite Cells Yields a Duchenne Myoblast Cell Line with Long-Term Genotypic and Phenotypic Stability
Cudré-Mauroux, C., Occhiodoro, T., König, S., Salmon, P., Bernheim, L., & Trono, D. (2003) · Human Gene Therapy · doi:10.1089/104303403322495034 · Cited by 86
Cellular Senescence in the Development and Treatment of Cancer
Saretzki, G. C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161210789941874 · Cited by 92
Self-citation
Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: OneIn VivoReality, Two Possible Definitions?
Toussaint, O., Dumont, P., Remacle, J., Dierick, J., Pascal, T., Frippiat, C. C., de Magalhães, J. P., Zdanov, S., & Debacq‐Chainiaux, F. (2002) · The Scientific World JOURNAL · doi:10.1100/tsw.2002.100 · Cited by 85
Stress-induced Premature Senescence in hTERT-expressing Ataxia Telangiectasia Fibroblasts
Naka, K., Tachibana, A., Ikeda, K., & Motoyama, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309457200 · Cited by 91
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection
Lorenz, M., Saretzki, G. C., Sitte, N., Metzkow, S., & von Zglinicki, T. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00664-5 · Cited by 85
Self-citation
DNA damage, vascular senescence and atherosclerosis
Andreassi, M. G. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0358-7 · Cited by 86
Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells
Kashino, G., Kodama, S., Nakayama, Y., Suzuki, K., Fukase, K., Goto, M., & Watanabe, M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00326-5 · Cited by 85
The oxidative hypothesis of senescence
Gîlcă, M., Stoian, I. A.-M., Atanasiu, V., & Vîrgolici, B. (2007) · Journal of Postgraduate Medicine · doi:10.4103/0022-3859.33869 · Cited by 85
Telomere length of the skin in association with chronological aging and photoaging
Sugimoto, M., Yamashita, R., & Ueda, M. (2006) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.02.004 · Cited by 86
Telomerase and the Aging Cell
Fossel, M. (1998) · JAMA · doi:10.1001/jama.279.21.1732 · Cited by 86
Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains
CHOI, D., Whittier, P. S., Oshima, J., & Funk, W. D. (2001) · The FASEB Journal · doi:10.1096/fj.00-0104com · Cited by 85
Cardiac Aging: From Basic Research to Therapeutics
Yan, M., Sun, S., Xu, K., Huang, X., Dou, L., Pang, J., Tang, W., Shen, T., & Li, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9570325 · Cited by 86
Telomeres: Hallmarks of radiosensitivity
Ayouaz, A., Raynaud, C. M., Heride, C., Revaud, D., & Sabatier, L. (2007) · Biochimie · doi:10.1016/j.biochi.2007.09.011 · Cited by 88
Reversible Manipulation of Telomerase Expression and Telomere Length
Rubio, M. Á., Kim, S., & Campisi, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203747200 · Cited by 82
Oxidative Stress-Induced Premature Senescence in Wharton's Jelly-Derived Mesenchymal Stem Cells
Choo, K., Tai, L., Hymavathee, K. S., Wong, C. Y., Nguyen, P. N. N., Huang, C.-J., Cheong, S. K., & Kamarul, T. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.8356 · Cited by 83
Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
Munro, J., Steeghs, K., Morrison, V., Ireland, H., & Parkinson, E. K. (2001) · Oncogene · doi:10.1038/sj.onc.1204460 · Cited by 82
Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans
Bendix, L., Thinggaard, M., Fenger, M., Kølvraa, S., Avlund, K., Linneberg, A. R., & Osler, M. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt153 · Cited by 83
Senescence of the retinal pigment epithelium.
Hjelmeland, L. M., Cristofolo, V. J., Funk, W., Rakoczy, E., & Katz, M. L. (1999) · PubMed · Cited by 82
Molecular mechanisms of replicative senescence in endothelial cells
Foreman, K. E., & Tang, J. M. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.005 · Cited by 81
Telomeres and replicative senescence: is it only length that counts?
von Zglinicki, T. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00546-8 · Cited by 82
Telomere Shortening and Chromosomal Abnormalities in Intestinal Metaplasia of the Urinary Bladder
Morton, M. J., Zhang, S., Antonio Lopez-beltran, B., MacLennan, G. T., Eble, J. N., Montironi, R., Sung, M., Tan, P., Zheng, S., Zhou, H., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0121 · Cited by 82
Oxidative stress-induced telomeric erosion as a mechanism underlying airborne particulate matter-related cardiovascular disease
Grahame, T. J., & Schlesinger, R. B. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-21 · Cited by 87
Reproductive ageing in women
Djahanbakhch, O., Ezzati, M., & Zosmer, A. (2007) · The Journal of Pathology · doi:10.1002/path.2108 · Cited by 80
Longitudinal studies of telomere length in feline blood cells
Brümmendorf, T. H., Mak, J., Sabo, K. M., Baerlocher, G. M., Dietz, K., Abkowitz, J. L., & Lansdorp, P. M. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00888-3 · Cited by 80
The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function
Doksani, Y. (2019) · Genes · doi:10.3390/genes10040318 · Cited by 83
Cellular Senescence in Lung Fibrosis
Hernández‐González, F., Faner, R., Rojas, M. M., Agustí, A. G. N., Serrano, M., & Sellarés, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137012 · Cited by 79
Chromosomal aberrations involving telomeres and interstitial telomeric sequences
Bolzán, A. D. (2011) · Mutagenesis · doi:10.1093/mutage/ger052 · Cited by 78
The role and therapeutic potential of melatonin in age‐related ocular diseases
Crooke, A., Huete‐Toral, F., Colligris, B., & Pintor, J. J. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12430 · Cited by 79
Systemic telomere length and preclinical atherosclerosis: the Asklepios Study
Meyer, T. D., Rietzschel, E. R., Buyzere, M. D., Langlois, M. R., Bacquer, D. D., Segers, P., Damme, P. V., Backer, G. D., Oostveldt, P. V., Criekinge, W. V., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp324 · Cited by 76
p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts
Chen, W., Kang, J., Xia, J., Li, Y., Yang, B., Chen, B., Sun, W., Song, X., WenZhong, X., Wang, X., et al. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.5.645 · Cited by 76
Expression of telomerase inhibits hydroxyl radical‐induced apoptosis in normal telomerase negative human lung fibroblasts
Ren, J., Xia, H., Tian, Y.-M., Just, T., Cai, G., & Dai, Y. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02397-8 · Cited by 74
Advanced Telomere Shortening in Respiratory Chain Disorders
Oexle, K., & Zwirner, A. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.6.905 · Cited by 80
Similar Gene Expression Pattern in Senescent and Hyperoxic-Treated Fibroblasts
Saretzki, G. C., Feng, J., von Zglinicki, T., & Villeponteau, B. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.6.b438 · Cited by 76
Self-citation
Theory and Practice of Coarse-Grained Molecular Dynamics of Biologically Important Systems
Liwo, A., Czaplewski, C. R., Sieradzan, A. K., Lipska, A. G., Samsonov, S. A., & Murarka, R. K. (2021) · Biomolecules · doi:10.3390/biom11091347 · Cited by 74
A Darwinian-evolutionary concept of age-related diseases
Wick, G., Berger, P., Jansen‐Dürr, P., & Grubeck‐Loebenstein, B. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00161-4 · Cited by 74
Telomeres, telomerase, and hematopoietic stem cell biology
Greenwood, M. J., & Lansdorp, P. M. (2003) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.07.003 · Cited by 79

Authors: von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C.
Affiliations: Humboldt-Universität zu Berlin (DE)
ORCID: Saretzki, Gabriele
Venue: Experimental Cell Research
Publisher: Elsevier BV
Published: 1995-09
Volume: 220
Issue: 1
Pages: 186-193
ISSN: 0014-4827 (ISSN-L)
DOI: 10.1006/excr.1995.1305
OpenAlex: W2071673220
Cited by: 856
References: 0
Citations by year: 2026: 5 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 23 · 2021: 27 · 2020: 18 · 2019: 27 · 2018: 16 · 2017: 19 · 2016: 23 · 2015: 27 · 2014: 26 · 2013: 28 · 2012: 34
FWCI: 8.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Cell Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: hyperoxia, telomere shortening, cellular senescence, fibroblast proliferation, oxidative stress, WI-38 cells, G1 cell cycle arrest, telomere length, terminal restriction fragments, S1 nuclease, lipofuscin, postmitotic cells
MeSH terms: Aerobiosis, Cell Cycle, Cells, Cultured, Fibroblasts, Flow Cytometry, Lipofuscin, Microscopy, Electron, Oxygen, Phenotype, Ploidies, Oligonucleotide Probes, Telomere, Cellular Senescence, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks