Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice
Abstract
Alzheimer's disease is a neurodegenerative disorder of the elderly and advancing age is the major risk factor for Alzheimer's disease development. Telomere shortening represents one of the molecular causes of ageing that limits the proliferative capacity of cells, including neural stem cells. Studies on telomere lengths in patients with Alzheimer's disease have revealed contrary results and the functional role of telomere shortening on brain ageing and Alzheimer's disease is not known. Here, we have investigated the effects of telomere shortening on adult neurogenesis and Alzheimer's disease progression in mice. The study shows that aged telomerase knockout mice with short telomeres (G3Terc-/-) exhibit reduced dentate gyrus neurogenesis and loss of neurons in hippocampus and frontal cortex, associated with short-term memory deficit in comparison to mice with long telomere reserves (Terc+/+). In contrast, telomere shortening improved the spatial learning ability of ageing APP23 transgenic mice, a mouse model for Alzheimer's disease. Telomere shortening was also associated with an activation of microglia in ageing amyloid-free brain. However, in APP23 transgenic mice, telomere shortening reduced both amyloid plaque pathology and reactive microgliosis. Together, these results provide the first experimental evidence that telomere shortening, despite impairing adult neurogenesis and maintenance of post-mitotic neurons, can slow down the progression of amyloid plaque pathology in Alzheimer's disease, possibly involving telomere-dependent effects on microglia activation.
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Crossing the Terc−/− model with APP23 mice causes an unexpected reduction in Aβ deposition.
“A previous study demonstrated that crossing the Terc−/− model with APP23 mice (which express human APP bearing the Swedish mutation [109]) causes an unexpected reduction in Aβ deposition [95], which the authors linked to telomere-dependent effects on microglia activation.”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [95]
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- Authors
- Rolyan, H., Scheffold, A., Heinrich, A., Begus-Nahrmann, Y., Langkopf, B. H., Hölter, S. M., Vogt-Weisenhorn, D. M., Liss, B., Wurst, W., Lie, D. C., Thal, D. R., Biber, K., & Rudolph, K. L.
- Affiliations
- Universität Ulm (DE)
- University of Freiburg (DE)
- Helmholtz Munich (DE)
- University Medical Center Groningen (NL)
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-14
- Volume
- 134
- Issue
- 7
- Pages
- 2044-2056
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2157771740
- Cited by
- 106
- References
- 79
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 3 · 2012: 10
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- telomere shortening, Alzheimer's disease, amyloid plaques, adult neurogenesis, dentate gyrus, APP23 transgenic mice, microglial activation, reactive microgliosis, spatial learning, memory impairment, brain aging, hippocampus, frontal cortex, neuronal loss
- MeSH terms
- Doublecortin Domain Proteins, Age Factors, Alzheimer Disease, Animals, Bromodeoxyuridine, Calcium-Binding Proteins, Cell Cycle, Cerebral Cortex, Cognition Disorders, Disease Models, Animal, Hippocampus, Mice, Inbred C57BL, Mice, Transgenic, Microfilament Proteins, Microtubule-Associated Proteins, Neurons, Neuropeptides, Synapses, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, Telomere, Microglia, Maze Learning, Telomerase, Microscopy, Electron, Transmission, Mice, Presenilin-1, Amyloid Precursor Protein Secretases, Neurogenesis, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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