Clusterin is Present in Drusen in Age-related Macular Degeneration
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Immunocytochemical evidence supports the existence of annexins I and VI, calgranulin A and B, psoriasin, clusterin, and tissue metalloproteinase inhibitor 3 in drusen.
“we have obtained immunocytochemical evidence supporting the existence of the following proteins in drusen: annexins I and VI, calgranulin A and B, psoriasin (Figs. 4 and 5, which are published as supporting information on the PNAS web site), clusterin (20), and TIMP3 (12).”
From Drusen proteome analysis: an approach to the etiology of age-related macular degeneration (2002) · cites this paper as [20]
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- Authors
- Sakaguchi, H., Miyagi, M., Shadrach, K. G., Rayborn, M. E., Crabb, J. W., & Hollyfield, J. G.
- Affiliations
- Cleveland Clinic (US)
- Venue
- Experimental Eye Research
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 74
- Issue
- 4
- Pages
- 547-549
- ISSN
- 0014-4835 (ISSN-L)
- OpenAlex
- W1971967380
- Cited by
- 54
- References
- 25
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey002362-23)
- National Eye Institute (R01 EY 06603, R01EY006603, EY 02362)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Oncology › Clusterin in disease pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- clusterin, drusen, age-related macular degeneration, retinal pigment epithelium, protein secretion, extracellular matrix, choroid, endoplasmic reticulum stress, protein aggregation, gene therapy, cell therapy
- MeSH terms
- Glycoproteins, Humans, Macular Degeneration, Retinal Drusen, Molecular Chaperones, Clusterin
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