On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis

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2. Low levels of sarin affect the eeg in marmoset monkeys: a pilot study
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3. Donepezil-Induced Improvement in Delayed Matching Accuracy by Young and Old Rhesus Monkeys
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4. Chronic nicotine administration increases NGF‐like immunoreactivity in frontoparietal cerebral cortex
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5. Working Memory: From Neural Activity to the Sentient Mind
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8. Effects of scallop shell extract on scopolamine-induced memory impairment and MK801-induced locomotor activity
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9. No Acute Effects of Choline Bitartrate Food Supplements on Memory in Healthy, Young, Human Adults
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10. (R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease
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11. Cognitive performance of healthy young rats following chronic donepezil administration
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12. Cognitive deficits in aged rats correlate with levels of l-arginine, not with nNOS expression or 3,4-DAP-evoked transmitter release in the frontoparietal cortex
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13. Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases
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14. Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age
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15. Chromones: privileged scaffolds for the production of multi-target-directed-ligand agents for the treatment of Alzheimer’s disease
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16. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama)
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17. Behavioural effects and regulation of PKCα and MAPK by huprine X in middle aged mice
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18. Muscarinic acetylcholine receptor activation enhances hippocampal neuron excitability and potentiates synaptically evoked Ca2+ signals via phosphatidylinositol 4,5-bisphosphate depletion
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19. Mild cognitive impairment and the cholinergic hypothesis: A very different take on recent data
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20. The 3D-QSAR study of 110 diverse, dual binding, acetylcholinesterase inhibitors based on alignment independent descriptors (GRIND-2). The effects of conformation on predictive power and interpretability of the models
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21. Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer’s Disease: A Sign of Defective Proteostasis?
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22. In silico profiling of systemic effects of drugs to predict unexpected interactions
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23. Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease
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24. Cross-diagnostic determinants of cognitive functioning: the muscarinic cholinergic receptor as a model system
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25. Effect of aqueous antler extract on scopolamine-induced memory impairment in mice and antioxidant activities
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26. New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship
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27. Heterocyclic inhibitors of AChE acylation and peripheral sites
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28. Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine
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29. Importance and prospects for design of selective muscarinic agonists
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30. Progression of age‐associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex
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31. Development, Optimization and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery for Alzheimer's Disease
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32. The relationship between nicotinic receptors and cognitive functioning in healthy aging: An in vivo positron emission tomography (PET) study with 2‐[18F]fluoro‐A‐85380
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33. Blockade of muscarinic receptors impairs the retrieval of well-trained memory
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34. Activation of cortical M1 muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating
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35. Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus
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36. The Amyloid Hypothesis and the clearance and degradation of Alzheimer's β-peptide
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37. Highly Chiral Muscarinic Ligands: The Discovery of (2S,2‘R,3‘S,5‘R)-1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide Methyl Iodide, a Potent, Functionally Selective, M2Partial Agonist
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38. Acylphloroglucinol trimers from Callistemon salignus seeds: Isolation, configurational assignment, hAChE inhibitory effects, and molecular docking studies
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39. Alzheimer therapeutics—what after the cholinesterase inhibitors?
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40. Activation of endocannabinoid system in the rat basolateral amygdala improved scopolamine-induced memory consolidation impairment
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41. Curcumin as a Holistic Treatment for Tau Pathology
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42. Dracaena cochinchinensis stemwood extracts inhibit amyloid-β fibril formation and promote neuronal cell differentiation
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43. Recent developments in the design and synthesis of benzylpyridinium salts: Mimicking donepezil hydrochloride in the treatment of Alzheimer’s disease
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44. Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease
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45. Deep Brain Stimulation as an Emerging Therapy for Cognitive Decline in Alzheimer Disease: Systematic Review of Evidence and Current Targets
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51. Procognitive effect of AC-3933 in aged mice, and synergistic effect of combination with donepezil in scopolamine-treated mice
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52. Evaluation of Choline Acetyltransferase Gene Polymorphism (2384 G/A) in Alzheimer’s Disease and Mild Cognitive Impairment
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53. Cognitive Risks of Anticholinergics in the Elderly
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54. Gestational and lactational exposition to di-n-butyl phthalate increases neurobehavioral perturbations in rats: A three generational comparative study
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55. Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene
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56. Neuroprotective effects of behavioural training and nicotine on age-related deficits in spatial learning
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57. Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments
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58. Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor
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60. Modulation of Neuronal Nicotinic Receptor by Quinolizidine Alkaloids Causes Neuroprotection on a Cellular Alzheimer Model
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61. Acetylcholine Receptor Stimulation for Cognitive Enhancement: Better the Devil You Know?
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62. Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro
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63. Cholinergic Stimulation of the Adult Zebrafish Brain Induces Phosphorylation of Glycogen Synthase Kinase-3 β and Extracellular Signal-Regulated Kinase in the Telencephalon
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64. An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by β-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR-mediated signalling
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65. Combretum mucronatumandCapparis thonningiiprevent scopolamine-induced memory deficit in mice
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66. Cognitive enhancing of pineapple extract and juice in scopolamine-induced amnesia in mice
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67. Cholinergic dysfunction and amnesia in patients with Wernicke–Korsakoff syndrome: a transcranial magnetic stimulation study
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68. Talsaclidine (WAL 2014 FU), a muscarinic M1 receptor agonist for the treatment of Alzheimer's disease
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69. Muscarinic Receptor Antagonists in Rats
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70. Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery
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71. Fighting Alzheimer's naturally: Peptides as multitarget drug leads
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72. Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures
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73. Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice
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74. Caesalpinia mimosoides Leaf Extract Promotes Neurite Outgrowth and Inhibits BACE1 Activity in Mutant APP-Overexpressing Neuronal Neuro2a Cells
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75. New Multifunctional Agents for Potential Alzheimer’s Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones
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76. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats
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77. A novel compound, maltolyl p‐coumarate, attenuates cognitive deficits and shows neuroprotective effects in vitro and in vivo dementia models
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78. Vascular dementia and the cholinergic pathways
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79. Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview
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80. Neurochemistry of Alzheimer's disease
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82. Effects of the excitation or inhibition of basal forebrain cholinergic neurons on cognitive ability in mice exposed to chronic intermittent hypoxia
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83. Sex differences in the association between serum BDNF and cognitive impairment in schizophrenia patients using various antipsychotics
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84. Neuropathology and cholinesterase expression in the brains of octogenarians and older
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85. Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats
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87. Pharmacogenetic Regulation of Acetylcholinesterase Activity in Drosophila Reveals the Regulatory Mechanisms of AChE Inhibitors in Synaptic Plasticity
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92. Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors
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93. Decoding molecular mechanisms: brain aging and Alzheimer’s disease
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95. Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys
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96. Anticholinesterase Agents For Alzheimer's Disease Treatment: An Updated Overview
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97. Neuroprotective effect of Bacopa monniera on memory deficits and ATPase system in Alzheimer's disease (AD) induced mice
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98. GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability
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