On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis

Cited by (852)

Items 801–852 of 852

1. Chapter 43. Agents for Neurocognitive Disorders
   Gayle M. Ayers, Frank W. Brown · 2024 · American Psychiatric Association Publishing eBooks
2. GM1 and GD3 Gangliosides Attenuate NGF-TrkA and BDNF-TrkB Signaling Dysfunction Associated with Acute Diisopropylfluorophosphate Exposure in Mouse Brain
   Yutaka Itokazu, Wayne D. Beck, Alvin V. Terry · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
3. Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging mice
   Mathieu Nollet, Wei Ba, Berta Anuncibay Soto, Chunyu Yin, Leda Lignos, Katarina Jović, Sara Wong, Alexei L. Vyssotski, Raquel Yustos, Nicholas P. Franks et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
4. Impaired neuromodulator crosstalk delays arousal-dependent astroglia Ca2+ activation in mouse models of Alzheimer’s disease
   Eunice Y. Heo, Angelica Salinas‐Birt, Liang Ye, Sanaz Sajadi, Mithun K Sarker, Yongjie Yang, Martin Paukert · 2025 · iScience
5. The evolution of Alzheimer’s target identification: Towards a fusion of artificial and cellular intelligence
   Gayle M. Wittenberg, Fiona Elwood, Andrea Houghton, Tommaso Mansi, Bart Smets, Simon Lovestone · 2025 · The Journal of Prevention of Alzheimer s Disease
6. Use of rodent models in drug discovery for Alzheimer’s disease
   James E. Barrett, Joanne R. Mathiasen, Paul McGonigle · 2025 · Elsevier eBooks
7. Metabolomics in Alzheimer's disease
   Mohammed Zubair · 2013 · Research Explorer (The University of Manchester)
8. NEUROTROPHIC FACTORS IN ALZHEIMER'S DISEASE
   Armin Blesch, Mark H. Tuszynski · 2008 · Elsevier eBooks
9. Additional file 2 of Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice
   Debora Cutuli, Eugenia Landolfo, Annalisa Nobili, Paola De Bartolo, Stefano Sacchetti, Doriana Chirico, Marini, Federica, Luisa Pieroni, Ronci, Maurizio, Marcello D’Amelio et al. · 2020 · Figshare
10. Additional file 1 of Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice
    Debora Cutuli, Eugenia Landolfo, Annalisa Nobili, Paola De Bartolo, Stefano Sacchetti, Doriana Chirico, Federica Marini, Luisa Pieroni, Ronci, Maurizio, Marcello D’Amelio et al. · 2020 · Figshare
11. Design, Synthesis, and Biological Evaluation of Novel Acetylcholinesterase and β-Secretase 1 Inhibitors
    Danuta Drozdowska, Damian Pawelski, Agnieszka Wróbel, Marta Eliza Plonska-Brzezinska, Beata Kolesińska, Ryszard Łaźny, Barbara Seroka, Cezary Parzych, Artur Ratkiewicz · 2026 · International Journal of Molecular Sciences
12. Rôle de la D-sérine dans les interactions entre systèmes dopaminergique et glutamatergique dans le cortex préfrontal du rat adulte
    Fabrice R. Turpin · 2010 · theses.fr (ABES)
13. Effets des émotions sur la mémoire dans la maladie d'Alzheimer et dans le viellissement normal : le lien avec des facteurs cognitifs et anatomiques
    Alina-Alexandra Sava · 2015
14. Intérêts des récepteurs 5-HT4 dans la pathologie Alzmeimer : étude préclinique comportementale et électrophysiologie sur tranche d'hippocampe de souris
    Pierre Lecouflet · 2018 · theses.fr (ABES)
15. Effets de l’administration de tétrahydrobioptérine en condition physiologique et pathologique : De la neurobiologie au comportement
    Hortense Fanet · 2018 · theses.fr (ABES)
16. Study on synaptic integration in granule cells of the dentate gyrus during behavioural discrimination in mice navigating in virtual reality
    Ruy Gómez-Ocádiz · 2021 · theses.fr (ABES)
17. Introduction
    Cheorl-Ho Kim · 2026 · Elsevier eBooks
18. Neural circuits and neurotransmitter systems
    Christos Constantinidis · 2026 · Elsevier eBooks
19. A new framework for nicotinic receptor-targeted therapeutic strategies in psychiatric and neurodegenerative disorders
    Khalid Oudaha, Frédéric Causeret, Fani Koukouli · 2026 · Frontiers in Cellular Neuroscience
20. Glycopolymers as emerging modulators of Amyloid-β aggregation: structure-activity relationships and therapeutic potential
    Emanuel Cardoso, Arménio Coimbra Serra, Jorge F. J. Coelho, Patrícia Pereira · 2026 · Carbohydrate Polymers
21. Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging mice
    Mathieu Nollet, Wei Ba, Berta Anuncibay Soto, Chunyu Yin, Leda Lignos, Katarina Jović, Sara Wong, Alexei L. Vyssotski, Raquel Yustos, Nicholas P. Franks et al. · 2026 · eLife
22. Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging mice
    Mathieu Nollet, Wei Ba, Berta Anuncibay Soto, Chunyu Yin, Leda Lignos, Katarina Jović, Sara Wong, Alexei L. Vyssotski, Raquel Yustos, Nicholas P. Franks et al. · 2026 · eLife
23. Therapeutic targeting of G protein-coupled receptors in central nervous system disorders: from novel mechanisms to precision pharmacology
    Chicheng Zhou, ChunTing Zhu, Xueying Wang, Yang Yang, Jinhuan Wei · 2026 · European Journal of Pharmacology
24. Design, synthesis, and biological evaluation of novel benzylidene-N-(3,4 dichlorophenyl) hydrazine-1-carbothioamide derivatives as new acetylcholinesterase inhibitors
    Sazan Haji Ali, Aya Nazhad, Derya Osmani̇ye, Begüm Nurpelin Sağlık · 2026 · European Journal of Life Sciences
25. Structure-Guided Design of a Brain-Penetrant Covalent Inhibitor of Human Butyrylcholinesterase with In Vivo Procognitive Efficacy.
    Peter Mastnak-Sokolov, U. Košak, A. Meden, D. Knez, S. Žakelj, Selena Horvat, A. Pišlar, Jakob Kljun, A. Igert, J. Dias et al. · 2026 · Journal of Medicinal Chemistry
26. Lonicerin from Lonicera japonica Attenuates Scopolamine-Induced Memory Impairment in Mice
    Choong Je Ma · 2026 · Natural Product Sciences
27. BindingDB Entry 50000301: Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.
    BindingDB · 2019 · UC San Diego
28. BindingDB Entry 1261: Rational Approach To Discover Multipotent Anti-Alzheimer Drugs.
    BindingDB · 2006 · UC San Diego
29. BindingDB Entry 50018402: A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective.
    BindingDB · 2024 · UC San Diego
30. BindingDB Entry 1341: Design, Synthesis, and Biological Evaluation of Conformationally Restricted Rivastigmine Analogues.
    BindingDB · 2006 · UC San Diego
31. BindingDB Entry 50008237: Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.
    BindingDB · 2021 · UC San Diego
32. BindingDB Entry 50046798: Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors.
    BindingDB · 2016 · UC San Diego
33. BindingDB Entry 50003138: Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.
    BindingDB · 2020 · UC San Diego
34. BindingDB Entry 50042754: Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.
    BindingDB · 2013 · UC San Diego
35. BindingDB Entry 50043223: Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.
    BindingDB · 2014 · UC San Diego
36. BindingDB Entry 50033494: New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloidß aggregation.
    BindingDB · 2011 · UC San Diego
37. BindingDB Entry 50013332: Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase.
    BindingDB · 2022 · UC San Diego
38. BindingDB Entry 50018638: Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR).
    BindingDB · 2024 · UC San Diego
39. BindingDB Entry 50015068: Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.
    BindingDB · 2023 · UC San Diego
40. BindingDB Entry 50037489: Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
    BindingDB · 2012 · UC San Diego
41. BindingDB Entry 5504: Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties.
    BindingDB · 2012 · UC San Diego
42. BindingDB Entry 50045408: Iminosugars as a new class of cholinesterase inhibitors.
    BindingDB · 2016 · UC San Diego
43. BindingDB Entry 50000342: The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.
    BindingDB · 2019 · UC San Diego
44. BindingDB Entry 50026860: Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors.
    BindingDB · 2010 · UC San Diego
45. BindingDB Entry 50000754: Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?
    BindingDB · 2020 · UC San Diego
46. BindingDB Entry 2300: New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.
    BindingDB · 2007 · UC San Diego
47. BindingDB Entry 1292: Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.
    BindingDB · 2006 · UC San Diego
48. BindingDB Entry 50033771: Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.
    BindingDB · 2012 · UC San Diego
49. BindingDB Entry 50003174: Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives.
    BindingDB · 2020 · UC San Diego
50. BindingDB Entry 50003763: Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
    BindingDB · 2020 · UC San Diego
51. BindingDB Entry 50046108: New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.
    BindingDB · 2016 · UC San Diego
52. Genetische Polymorphismen und Progressionsgeschwindigkeit der Alzheimer-Demenz
    Wolff, Martin · 2013