On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis

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Items 301–400 of 853

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2. Fermented Sipjeondaebo-tang Alleviates Memory Deficits and Loss of Hippocampal Neurogenesis in Scopolamine-induced Amnesia in Mice
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3. Cognitive Performances of Cholinergically Depleted Rats Following Chronic Donepezil Administration
   Debora Cutuli, Francesca Foti, Laura Mandolesi, Paola De Bartolo, Francesca Gelfo, Francesca Federico, Laura Petrosini · 2009 · Journal of Alzheimer s Disease
4. Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats
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5. Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice
   Li-Ling Cheng, Xi-Nan Chen, Yu Wang, Lu Yu, Xi Kuang, Lu-Lu Wang, Wen Yang, Junrong Du · 2011 · Fitoterapia
6. Galanin Hyperinnervation Upregulates Choline Acetyltransferase Expression in Cholinergic Basal Forebrain Neurons in Alzheimer’s Disease
   Scott Counts, Bin He, Shaoli Che, Stephen D. Ginsberg, Elliott Jay Mufson · 2008 · Neurodegenerative Diseases
7. Current Therapeutic Targets for Alzheimer's Disease
   Amit Chaudhary, Pramod Kumar Maurya, Birendra Singh Yadav, Swati Singh, Ashutosh Mani · 2018 · Journal of Biomedicine
8. New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation
   Julien Rouleau, Bogdan Iuliu Iorga, Catherine Guillou · 2011 · European Journal of Medicinal Chemistry
9. Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics
   Lai-Wo Stan Leung, Sophie Petropoulos A, Bixia Shen A, Tao Luo, Ian A. Herrick, Nagalingam Rajakumar, Jingyi Ma · 2011 · Experimental Neurology
10. Dose-specific effects of scopolamine on canine cognition: Impairment of visuospatial memory, but not visuospatial discrimination
    J. A. Araujo, Alan D. F. Chan, L.L. Winka, P A Seymour, Norton William Milgram · 2004 · Psychopharmacology
11. Cognitive function and cholinergic transmission in patients with subcortical vascular dementia and microbleeds: a TMS study
    Raffaele Nardone, Pierpaolo De Blasi, Martin Seidl, Yvonne Höller, Francesca Caleri, Frediano Tezzon, G. Ladurner, Stefan Martin Golaszewski, Eugen Trinka · 2011 · Journal of Neural Transmission
12. Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s disease
    Callum Walsh, Wilhelmus H. I. M. Drinkenburg, Abdallah Ahnaou · 2016 · Neuroscience & Biobehavioral Reviews
13. Age-related responses of the rat cerebral cortex: influence of vitamin E and exercise on the cholinergic system
    A.B. Jolitha, Muthangi V. V. Subramanyam, Sambe Asha Devi · 2008 · Biogerontology
14. Iminosugars as a new class of cholinesterase inhibitors
    Camille Decroocq, Fabien Stauffert, Olivier Pamlard, Farah Oulaïdi, Estelle Gallienne, Olivier R. Martin, Catherine Guillou, Philippe Compain · 2014 · Bioorganic & Medicinal Chemistry Letters
15. Cannabinoid receptor ligands suppress memory-related effects of nicotine in the elevated plus maze test in mice
    Grażyna Biała, Marta Kruk · 2008 · Behavioural Brain Research
16. Memory defect induced by beta-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms
    Zhiming Xia, Rui Zhang, Pingping Wu, Zongqin Xia, Yaer Hu · 2012 · Brain Research
17. Diphenyl diselenide improves scopolamine-induced memory impairment in mice
    Ana Cristina Guerra Souza, César Augusto Brüning, Marlon R. Leite, Gilson Rogério Zeni, Cristina Wayne Nogueira · 2010 · Behavioural Pharmacology
18. β-Amyloid-acetylcholine molecular interaction: new role of cholinergic mediators in anti-Alzheimer therapy?
    M. Grimaldi, S. Di Marino, F. Florenzano, Mariana Ciotta, S. Nori, M. Rodriquez, G. Sorrentino, A. D'Ursi, M. Scrima · 2016 · Future Medicinal Chemistry
19. Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database
    Irini Atanas Doytchinova, Mariyana Atanasova, Iva Valkova, Georgi Stavrakov, Irena Philipova, Zvetanka Dobreva Zhivkova, Dimitrina Zheleva‐Dimitrova, Spiro Konstantinov, Ivan Dimitrov · 2018 · Journal of Enzyme Inhibition and Medicinal Chemistry
20. Estimation of Working Memory in Macaques for Studying Drugs for the Treatment of Cognitive Disorders
    Jerry J. Buccafusco · 2008 · Journal of Alzheimer s Disease
21. Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer’s Disease
    Andrea Kwakowsky, Michael Milne, Henry John Waldvogel, Richard L. M. Faull · 2016 · International Journal of Molecular Sciences
22. The integrity of the cholinergic system determines memory performance in healthy elderly
    Nils Richter, Inka Allendorf, Oezguer A. Onur, Lutz Kracht, Markus Dietlein, Marc Tittgemeyer, Bernd Neumaier, Gereon R. Fink, Juraj Kukolja · 2014 · NeuroImage
23. Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β1–42
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24. Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer’s disease
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25. Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer’s Disease: An Educational Literature Review
    Mostafa Hossam El Din Moawad, Ibrahim Serag, Ibraheem M. Alkhawaldeh, Abdallah Abbas, Abdulrahman Sharaf, Sumaya Alsalah, Mohammed Ahmed Sadeq, Mahmoud Mohamed Mohamed Shalaby, Mahmoud Tarek Hefnawy, Mohamed Abouzid et al. · 2024 · Molecular Neurobiology
26. Nanotherapeutic strategies for the treatment of neurodegenerative diseases
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27. Phosphodiesterase inhibition facilitates cognitive restoration in rodent models of age-related memory decline
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28. Muscarinic receptor-mediated GTP–Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats
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29. Stochastic cortical neurodynamics underlying the memory and cognitive changes in aging
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30. The interactive effects of nicotinic and muscarinic cholinergic receptor inhibition on fear conditioning in young and aged C57BL/6 mice
    Olivia Feiro, Thomas J. Gould · 2004 · Pharmacology Biochemistry and Behavior
31. Acetylcholine from the nucleus basalis magnocellularis facilitates the retrieval of well-established memory
    Shogo Soma, Naofumi Suematsu, Akinori Sato, Keisuke Tsunoda, Allen Bramian, Anish Reddy, Koki Takabatake, Fuyuki Karube, Fumino Fujiyama, Satoshi Shimegi · 2021 · Neurobiology of Learning and Memory
32. Repeated, intermittent exposures to diisopropylfluorophosphate in rats: protracted effects on cholinergic markers, nerve growth factor-related proteins, and cognitive function
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33. Phytochemical Quantification and the In Vitro Acetylcholinesterase Inhibitory Activity of Phellodendron chinense and Its Components
    Yu Seung Kim, Hye-Sun Lim, Yoonju Kim, Jun Hyung Lee, Bu‐Yeo Kim, Soo‐Jin Jeong · 2017 · Molecules
34. Grape Seed Proanthocyanidin and Swimming Exercise Protects Against Cognitive Decline: A Study on M1 Acetylcholine Receptors in Aging Male Rat Brain
    Abhijit Satpati, Muthangi V. V. Subramanyam, Sambe Asha Devi · 2017 · Neurochemical Research
35. Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location
    Przemysław Jarzębowski, Clara S. Tang, Ole Paulsen, Y. Audrey Hay · 2021 · eLife
36. CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment
    Azadeh Karami, Taher Darreh‐Shori, Marianne Schultzberg, Maria Eriksdotter · 2021 · Frontiers in Aging Neuroscience
37. Blood Cells Cholinesterase Activity in Early Stage Alzheimer’s Disease and Vascular Dementia
    Rommy von Bernhardi M., Rodrigo Alarcón, Diego Mezzano, Patricio Fuentes, Nibaldo C. Inestrosa · 2005 · Dementia and Geriatric Cognitive Disorders
38. Enhanced Calcium Buffering in F344 Rat Cholinergic Basal Forebrain Neurons Is Associated With Age-Related Cognitive Impairment
    David A. Murchison, Angelika N. McDermott, Candi L. LaSarge, Kathryn A. Peebles, Jennifer L. Bizon, William H. Griffith · 2009 · Journal of Neurophysiology
39. Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in rats
    Alvin V. Terry, Sean Warner, Leah Vandenhuerk, Anilkumar Pillai, Sahebarao P. Mahadik, Genfu Zhang, Michael G. Bartlett · 2008 · Neuroscience
40. Neurotrophic signaling molecules associated with cholinergic damage in young and aged rats: Environmental enrichment as potential therapeutic agent
    Véronique Paban, Caroline Chambon, Christine Manrique, Claude F. Touzet, Béatrice Alescio‐Lautier · 2009 · Neurobiology of Aging
41. Cholinesterase as a Target for Drug Development in Alzheimer’s Disease
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42. Potential alternatives to current cholinesterase inhibitors: anin silicodrug repurposing approach
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43. Fractal dimensions: A new paradigm to assess spatial memory and learning using Morris water maze
    Surjeet Singh, Harpreet Kaur, Rajat Sandhir · 2015 · Behavioural Brain Research
44. Long‐term effects of immunotoxic cholinergic lesions in the septum on acquisition of the cone‐field task and noncognitive measures in rats
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45. Potential cognitive actions of (n-propargly-(3r)-aminoindan-5-yl)-ethyl, methyl carbamate (tv3326), a novel neuroprotective agent, as assessed in old rhesus monkeys in their performance of versions of a delayed matching task
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46. An Approach to Discovering Novel Muscarinic M1 Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction
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47. The pathomimetic oAβ25–35 model of Alzheimer's disease: Potential for screening of new therapeutic agents
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48. Procyanidins extracted from the lotus seedpod ameliorate scopolamine‐induced memory impairment in mice
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49. Antimuscarinic Treatment in Overactive Bladder
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50. Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer’s Disease
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51. Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis
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52. Immunolesion‐induced loss of cholinergic projection neurones promotes β‐amyloidosis and tau hyperphosphorylation in the hippocampus of triple‐transgenic mice
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53. Methanesulfonyl fluoride, an acetylcholinesterase inhibitor, attenuates simple learning and memory deficits in ischemic rats
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54. Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys
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55. Sexually dimorphic effects of hippocampal cholinergic deafferentation in rats
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56. Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats
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57. 5-HT6 receptor antagonists as treatment for age-related cognitive decline
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58. Screening for antimalarial and acetylcholinesterase inhibitory activities of some Iranian seaweeds.
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59. Preventive Role of Indian Black Pepper in Animal Models of Alzheimer’s Disease
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60. Epidemiology and pathophysiology of Alzheimer's disease
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61. Modulation of cholinergic transmission enhances excitability of hippocampal pyramidal neurons and ameliorates learning impairments in aging animals
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62. Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases
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63. Ameliorating effect of Alpinia oxyphylla—Schisandra chinensis herb pair on cognitive impairment in a mouse model of Alzheimer’s disease
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64. Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice
    D. Cutuli, Eugenia Landolfo, A. Nobili, P. de Bartolo, Stefano Sacchetti, Doriana Chirico, Federica Marini, L. Pieroni, M. Ronci, M. D'Amelio et al. · 2020 · Alzheimer's Research & Therapy
65. Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview
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66. The snake venom peptide Bj‐PRO‐7a is a M1 muscarinic acetylcholine receptor agonist
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67. Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density
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68. A computer-assisted cognitive test battery for aged monkeys
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69. Sex dimorphisms in the cognitive-enhancing action of the Alzheimer’s drug donepezil in aged Rhesus monkeys
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70. Advances in Blood Biomarkers for Alzheimer’s Disease: Ultra-Sensitive Detection Technologies and Impact on Clinical Diagnosis
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71. Translating the therapeutic potential of neurotrophic factors to clinical ‘proof of concept’: A personal saga achieving a career-long quest
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72. Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer’s Disease Brain
    Taher Darreh‐Shori, Sareh Rezaeianyazdi, Erica Lana, Sumonto Mitra, Anna Gellerbring, Azadeh Karami, Nenad Bogdanović, Christina Unger Lithner, Bengt G. Winblad, Homira Behbahani · 2018 · Molecular Neurobiology
73. Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase
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74. Accumulation of reelin‐positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging
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75. Memory-related task performance by aged rhesus monkeys administered the muscarinic M 1 -preferring agonist, talsaclidine
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76. Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats
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77. Functional magnetic resonance imaging of cholinergic modulation in mild cognitive impairment
    Bradford Clark Dickerson · 2006 · Current Opinion in Psychiatry
78. Scopolamine Induces Deficits in Spontaneous Object-Location Recognition and Fear-Learning in Marmoset Monkeys
    Jonathan Melamed, Fernando M. de Jesus, Rafael Souto Maior, Marília Barros · 2017 · Frontiers in Pharmacology
79. Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential
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80. Potentially inappropriate medication use in institutionalized older adults according to the Beers Criteria
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81. DADS Analogues Ameliorated the Cognitive Impairments of Alzheimer-Like Rat Model Induced by Scopolamine
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82. Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype
    Pia Basaure, Laia Guardia-Escote, María Cabré, Fiona Peris‐Sampedro, Fernando Sánchez-Santed, José L. Domingo, María Teresa Colomina · 2019 · Archives of Toxicology
83. Genetic and molecular basis of epilepsy-related cognitive dysfunction
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84. Effects of Chronic Donepezil Treatment and Cholinergic Deafferentation on Parietal Pyramidal Neuron Morphology
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85. The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na+, K+)-, Mg2+-ATPase activities, antioxidant status, and learning performance of aged rats
    Haris Carageorgiou · 2008 · Neuropsychiatric Disease and Treatment
86. RNA Deep Sequencing Analysis Reveals That Nicotine Restores Impaired Gene Expression by Viral Proteins in the Brains of HIV-1 Transgenic Rats
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87. Donepezil induces a cholinergic sprouting in basocortical degeneration
    Laure Ginestet, Juan Esteban Ferrario, Rita Raisman‐Vozari, Étienne C. Hirsch, Thomas Debeir · 2007 · Journal of Neurochemistry
88. Galanin and Cognition
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89. M1-M3 Muscarinic Acetylcholine Receptor-Deficient Mice: Novel Phenotypes
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90. Main plant extracts’active properties effective on scopolamine-induced memory loss
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91. Current Findings and Potential Mechanisms of KarXT (Xanomeline–Trospium) in Schizophrenia Treatment
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92. Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT
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93. Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer’s Disease, Without Altering Amyloid-β and Tau Pathologies
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94. Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives
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95. Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives
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96. Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents
    Anja Birthelmer, Andreas Ehret, Florian Amtage, Stefan Förster, Olivia Lehmann, Hélène Jeltsch‐David, Jean‐Christophe Cassel, Rolf Jackisch · 2002 · Brain Research Bulletin
97. Synthesis and cholinesterase inhibitory activity study of new piperidone grafted spiropyrrolidines
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98. Signaling Pathways Relevant to Cognition-Enhancing Drug Targets
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99. Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening
    Tuan Xu, Shuaizhang Li, Andrew J. Li, Jinghua Zhao, Srilatha Sakamuru, Wenwei Huang, Menghang Xia, Ruili Huang · 2023 · Journal of Chemical Information and Modeling
100. Blockade of the dorsal hippocampal dopamine D1 receptors inhibits the scopolamine-induced state-dependent learning in rats
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