On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis

Bartus, Raymond T.·2000·Experimental Neurology

Cited by (853)

Items 501–600 of 853

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  2. Effects of white ginseng and red ginseng extract on learning performance and acetylcholinesterase activity inhibition
    이미라 · 2008 · Journal of Ginseng Research
  3. Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease
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  4. Scrophularia buergeriana Extract (Brainon) Improves Scopolamine-Induced Neuronal Impairment and Cholinergic Dysfunction in Mice through CREB-BDNF Signaling Pathway
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  5. m1 Acetylcholine Receptor Expression is Decreased in Hippocampal CA1 region of Aged Epileptic Animal
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  6. Spatial memory alterations by activation of septal 5HT1A receptors: no implication of cholinergic septohippocampal neurons
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  7. 3,4-DAP-evoked transmitter release in hippocampal slices of aged rats with impaired memory
    Theresa Schweizer, Anja Birthelmer, Anelise Lazaris, Jean‐Christophe Cassel, Rolf Jackisch · 2003 · Brain Research Bulletin
  8. Alzheimer's Disease: It's More Than Aβ
    Joel N. Buxbaum · 2016 · The FASEB Journal
  9. Protective effects of the α2-adrenoceptor antagonist, dexefaroxan, against degeneration of the basalocortical cholinergic system induced by cortical devascularization in the adult rat
    Thomas Debeir, M. R. Marien, Philippe Chopin, J.-C. Martel, Françis C. Colpaert, Rita Raisman‐Vozari · 2002 · Neuroscience
  10. Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates
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  11. No evidence for individual blood–brain barrier phenylalanine transport to influence clinical outcome in typical phenylketonuria patients
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  12. Astragaloside IV as a Memory-Enhancing Agent: In Silico Studies with In Vivo Analysis and Post Mortem ADME-Tox Profiling in Mice
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  13. Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block β‐amyloid aggregation
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  14. Functional characterization of muscarinic autoreceptors in rat and human neocortex
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  15. The effects of abnormalities of glucose homeostasis on the expression and binding of muscarinic receptors in cerebral cortex of rats
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  16. Cognition Models and Drug Discovery
    Michael W. Decker · 2006 · Frontiers in neuroscience
  17. Intraseptal tacrine-induced disruptions of spatial memory performance
    Helen R. Sabolek, Jamie G. Bunce, James J. Chrobak · 2005 · Behavioural Brain Research
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  19. Aging and subcellular localization of m2 muscarinic autoreceptor in basalocortical neurons in vivo
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  23. CNS Gene Therapy and a Nexus of Complexity: Systems and Biology at a Crossroads
    Carolyn M. Tyler, Howard J. Federoff · 2006 · Cell Transplantation
  24. Current drugs and future hopes in the treatment of Alzheimer’s disease
    Manfred Windisch, Birgit Hutter‐Paier, Edith Schreiner · 2002 · Journal of neural transmission. Supplementum
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    Cristina Sanfilippo, P. Castrogiovanni, R. Imbesi, G. Musumeci, Michele Vecchio, Giovanni Li Volti, D. Tibullo, G. Broggi, R. Caltabiano, M. Ulivieri et al. · 2022 · Journal of Neuroimmunology
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    Dang Xuan Du, Nguyen Huu Duy Khang, Nguyen Huu Tri, Pham Cam Nam, Nguyen Minh Thong · 2023 · ACS Omega
  27. Loss of cholinergic receptor muscarinic 1 impairs cortical mitochondrial structure and function: implications in Alzheimer’s disease
    Mohammad Golam Sabbir, Mamiko Swanson, Benedict C. Albensi · 2023 · Frontiers in Cell and Developmental Biology
  28. Pyrimidine-attached oxazolidinone derivatives: Synthesis, kinetic profiling and computational evaluation for anti-Alzheimer’s therapeutics
    Shoaib Khan, Tayyiaba Iqbal, Kasim Sakran Abass, Magda H. Abdellattif, Sobhi M. Gomha, Magdi E. A. Zaki · 2025 · Journal of Molecular Structure
  29. Yokukansan, a traditional Japanese herbal medicine, promotes neurite outgrowth in PC12 cells through the activation of extracellular signal regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt
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  33. Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?
    Marcel Lindemann, Winnie Deuther‐Conrad, Rareş‐Petru Moldovan, Kondapalli Venkata Gowri Chandra Sekhar, Peter Brust, Barbara Wenzel · 2017 · Bioorganic & Medicinal Chemistry
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  36. Lesions of the laterodorsal tegmental nucleus alter the cholinergic innervation and neuropeptide Y expression in the medial prefrontal cortex and nucleus accumbens
    Pedro A. Pereira, Manuel Vilela, S. Sousa, João P. Rocha-Neves, M.M. Paula-barbosa, Maria Dulce Madeira · 2014 · Neuroscience
  37. Maturation and maintenance of cholinergic medial septum neurons require glucocorticoid receptor signaling
    Christian Guijarro, Susanne Rutz, Katharina Rothmaier, Marc Turiault, Qixia Zhi, Thomas Naumann, Michael Frotscher, François Tronche, Rolf Jackisch, Oliver Kretz · 2006 · Journal of Neurochemistry
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  39. [Effect and mechanism of Coeloglossum viride var. bracteatum extract on scopolamine-induced deficits of learning and memory behavior of rodents].
    Min Li, Ya‐Fang Wang, Bo Ma, Geng-Tao Liu, Jianjun Zhang · 2009 · PubMed
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    Paloma Vicens, Rosa Redolat, Ma Del Carmen Carrasco · 2003 · Rovira & Virgili repository
  42. Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C
    Nathan A. Styles, Wawa Zhu, Xiaohua Li · 2005 · Neurochemistry International
  43. Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1
    Patrizia De Sarno, Mathieu J. Lesort, Gautam N. Bijur, Gail V.W. Johnson, Richard Scott Jope · 2001 · Brain Research
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    Qingxu Wu, Qiang He, Xianliang Zhang, Si Chen, Xiangli Xue · 2024 · Aging and Disease
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  47. Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease
    Urban Košak, Nika Strašek Benedik, Damijan Knez, Simon Žakelj, Jurij Trontelj, Anja Hafner Pišlar, Selena Horvat, Aljoša Bolje, Neža Žnidaršič, Neža Grgurevič et al. · 2025 · Journal of Medicinal Chemistry
  48. Tryptophanol-derived oxazolopiperidone lactams: Identification of a hit compound as NMDA receptor antagonist
    Nuno A. L. Pereira, Francesc Xavier Sureda, Roser Esplugas, Maria Pérez, Mercedes Amat, Maria M. M. Santos · 2014 · Bioorganic & Medicinal Chemistry Letters
  49. Cognitive Enhancers in Moderate to Severe Alzheimer's Disease
    Rüdiger Hardeland · 2011 · Clinical Medicine Insights Therapeutics
  50. Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitors
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  51. In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents
    Kazuma Ogawa, K. Shiba · 2018 · Contrast Media & Molecular Imaging
  52. The use of nootropics in Alzheimer’s disease: is there light at the end of the tunnel?
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  53. 7-Pyrrolidinethoxy-4′-Methoxyisoflavone Prevents Amyloid β–Induced Injury by Regulating Histamine H3 Receptor-Mediated cAMP/CREB and AKT/GSK3β Pathways
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  54. Aporphinoid Alkaloids Derivatives as Selective Cholinesterases Inhibitors: Biological Evaluation and Docking Study
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  55. Aged rhesus monkeys: Cognitive performance categorizations and preclinical drug testing
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  57. Enantiomer Effects of Huperzine A on the Aryl Acylamidase Activity of Human Cholinesterases
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  58. Association between Nerve Growth Factor Gene Polymorphism and Executive Dysfunction in Japanese Patients with Early-Stage Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
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