Molecular evolution of fish neurohypophysial hormones: neutral and selective evolutionary mechanisms
Abstract
Chemical identification of neurohypophysial hormones from about 80 vertebrate species reveals that two evolutionary lineages can be traced in bony vertebrates, a vasopressin-like hormone line and an oxytocin-like hormone line, which were derived from the duplication of an ancestral gene that may have been present in agnathans. All of the 13 neurohypophysial hormones are built in the same structural pattern, namely, a nonapeptide with a disulfide bridge linking half-cystines in positions 1 and 6. There is a striking evolutionary stability in bony vertebrates since virtually all species belonging to a given class are endowed with the same peptides. In contrast, in cartilaginous fishes, the oxytocin-like hormone displays a great diversity. Six distinct peptides are characterized in this group. The proposed hypothesis is that the stability in primary structure in bony vertebrates is due to selective pressure. This selective pressure is associated with an ion-based osmoregulation, whereas in Chondrichthyes the occurrence of an urea-based osmoregulation has relieved the hormones from the control of ionic homeostasis. Variations in primary structures in cartilaginous fishes are regarded as relevant to the neutral evolution as defined by Kimura. According to this concept, oxytocin of placental mammals results from selective evolution, whereas the same molecule found in ratfish proceeds from random genetic drift.
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The OT lineage is presumed to have evolutionary origins in reproductive function, while the AVP lineage is presumed to have origins in the regulation of fluid homeostasis.
“The OT lineage (isotocin-mesotocin-oxytocin) is presumed to have evolutionary origins in the service of reproductive function, while the AVP lineage (vasotocin-vasopressin) is presumed to have origins in the regulation of fluid homeostasis”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Acher, 1996
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High hydrostatic pressure effects on arginine vasotocin levels in fish
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“Arginine vasotocin (AVT), the non-mammalian homolog of vasopressin, is a nonapeptide synthesized in the preoptic area of the hypothalamus of fish, amphibians, birds and reptiles (Acher 1996).”
BackgroundКутина, А. В., Marina, A. S., Eliseev, I. I., Titov, M. I., & IuV, N. (2012) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093012050052
“5–6 2012 nine- and lysine-vasopressin [2, 8]) proceeded in parallel with a change of their functional role.”
BackgroundRawat, A., Chaube, R., & Joy, K. P. (2022) · Fish Physiology and Biochemistry · doi:10.1007/s10695-022-01058-4
“…(Vt), the ortholog of vasopressin (VP), is the basic nonapeptide in teleosts and plays diverse roles in the regulation of osmoregulation, blood pressure and cardiovascular activity, reproduction, metabolism, stress, behavior and neural signaling (Acher and Chauvet 1995; Acher1996; Warne et al.”
BackgroundBone, Q., & Moore, R. (2008) · Taylor & Francis eBooks · doi:10.1201/9781134186310-13
Evolution of the arginine-vasopressin system: from chordates to primates
Fogari, R., COSTA, A., MOUSAVI, S. M., & D’Angelo, A. (2025) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.24.05492-5
The Evolution of the Pituitary Gland
Santiago-Andres, Y., Fiordelisio, T., Del-Rio, D., & Cubillos, J. F. (2025) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-80209-6_4
- Authors
- Acher, R.
- Affiliations
- Université Paris Cité (FR)
- Corresponding author
- Acher, Roger
- Venue
- General and Comparative Endocrinology
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 102
- Issue
- 2
- Pages
- 157-172
- ISSN
- 0016-6480 (ISSN-L)
- OpenAlex
- W2074709477
- Cited by
- 99
- References
- 0
- Citations by year
- 2025: 4 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 6
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- General and Comparative Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neurohypophyseal hormones, vasopressin, oxytocin, molecular evolution, gene duplication, Chondrichthyes, osmoregulation, ion homeostasis, neutral evolution, selection pressure, disulfide bonds, ratfish, placental mammals
- MeSH terms
- Animals, Fishes, Pituitary Gland, Posterior, Pituitary Hormones, Evolution, Molecular
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