The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing
Abstract
Neurexins are neuron-specific vertebrate proteins with hundreds of differentially spliced isoforms that may function in synapse organization. We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from separate promoters. The neurexin genes are very large (up to 1.62 Mb), with the neurexin-3 gene occupying almost 2% of human chromosome 14. Although invertebrate and vertebrate neurexins exhibit a high degree of evolutionary conservation, only vertebrate neurexins are subject to extensive alternative splicing that uses mechanisms ranging from strings of mini-exons to multiple alternative splice donor and acceptor sites. Consistent with their proposed role in synapse specification, neurexins thus have evolved from relatively simple genes in invertebrates to diversified genes in vertebrates with multiple promoters and extensive alternative splicing.
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“Pre-mRNAs from the three Nrxn genes undergo extensive alternative splicing to produce more than 3,000 protein isoforms88,89”
From The neurogenetics of alternative splicing (2016) · cites this paper as [89]
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The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein
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Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons
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Binding of Neuroligins to PSD-95
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Self-citationNeuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses
Song, J.-Y., Ichtchenko, K., Südhof, T. C., & Brose, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1100 · Cited by 696
Self-citationNeurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin
Ushkaryov, Y. A., Petrenko, A. G., Geppert, M., & Südhof, T. C. (1992) · Science · doi:10.1126/science.1621094 · Cited by 682
Self-citationNeuroligin 1: A splice site-specific ligand for β-neurexins
Ichtchenko, K., Hata, Y., Nguyen, T., Ullrich, B., Missler, M., Moomaw, C. R., & Südhof, T. C. (1995) · Cell · doi:10.1016/0092-8674(95)90396-8 · Cited by 663
Self-citationThe structural and functional diversity of dystrophin
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Epithelial Cell Polarity and Cell Junctions inDrosophila
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Research works printed but not linked: 1
- Südhof, T. C.2001. The synaptic cleft and synaptic cell adhesion. In SynapsesW. M. Cowan, T. C. Südhof, and C. F. Stevens, Eds., pp. 177–215. Johns Hopkins University Press, Baltimore, MD, and London, UK.
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Neuroligins and neurexins link synaptic function to cognitive disease
Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849
Self-citationNeurexins Induce Differentiation of GABA and Glutamate Postsynaptic Specializations via Neuroligins
Graf, E. R., Zhang, X., Jin, S., Linhoff, M. W., & Craig, A. M. (2004) · Cell · doi:10.1016/j.cell.2004.11.035 · Cited by 1,029
Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits
Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2017.10.024 · Cited by 810
Self-citationZoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K., & Südhof, T. C. (2003) · Nature · doi:10.1038/nature01755 · Cited by 699
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Metadata
- Authors
- Tabuchi, K., & Südhof, T. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 79
- Issue
- 6
- Pages
- 849-859
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W2051468191
- Cited by
- 305
- References
- 31
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 16 · 2012: 17
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH52804, R01MH052804)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- neurexin, alternative splicing, gene evolution, NRXN3, multiple promoters, mini-exon, alternative splice sites, Drosophila melanogaster, Caenorhabditis elegans, chromosome 14, gene structure
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Alternative Splicing, Sequence Analysis, DNA, Evolution, Molecular, Mice
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