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Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing

Tabuchi, Katsuhiko, Südhof, Thomas C.·2002·Genomics

DOI 10.1006/geno.2002.6780

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Abstract

Neurexins are neuron-specific vertebrate proteins with hundreds of differentially spliced isoforms that may function in synapse organization. We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from separate promoters. The neurexin genes are very large (up to 1.62 Mb), with the neurexin-3 gene occupying almost 2% of human chromosome 14. Although invertebrate and vertebrate neurexins exhibit a high degree of evolutionary conservation, only vertebrate neurexins are subject to extensive alternative splicing that uses mechanisms ranging from strings of mini-exons to multiple alternative splice donor and acceptor sites. Consistent with their proposed role in synapse specification, neurexins thus have evolved from relatively simple genes in invertebrates to diversified genes in vertebrates with multiple promoters and extensive alternative splicing.

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Authors: Tabuchi, K., & Südhof, T. C.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Tabuchi, Katsuhiko
Südhof, Thomas C.
Venue: Genomics
Publisher: Elsevier BV
Published: 2002-06
Volume: 79
Issue: 6
Pages: 849-859
ISSN: 0888-7543 (ISSN-L)
DOI: 10.1006/geno.2002.6780
OpenAlex: W2051468191
Cited by: 305
References: 31
Citations by year: 2026: 11 · 2025: 12 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 16 · 2012: 17
FWCI: 3.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Genomics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01 MH52804, R01MH052804)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: neurexin, alternative splicing, gene evolution, NRXN3, multiple promoters, mini-exon, alternative splice sites, Drosophila melanogaster, Caenorhabditis elegans, chromosome 14, gene structure
MeSH terms: Animals, Humans, Nerve Tissue Proteins, Alternative Splicing, Sequence Analysis, DNA, Evolution, Molecular, Mice

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Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing

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