Binding of Neuroligins to PSD-95

A novel genetic system to detect protein–protein interactions

Fields, S., & Song, O.-K. (1989) · Nature · doi:10.1038/340245a0 · Cited by 6,152 · see citing works

Mammalian Ras interacts directly with the serine/threonine kinase Raf.

Vojtek, A., Hollenberg, S., & Cooper, J. A. (1993) · Cell · doi:10.1016/0092-8674(93)90307-c · Cited by 1,971 · see citing works

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

Kornau, H., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995) · Science · doi:10.1126/science.7569905 · Cited by 1,882 · see citing works

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

Cho, K.-O., Hunt, C. A., & Kennedy, M. B. (1992) · Neuron · doi:10.1016/0896-6273(92)90245-9 · Cited by 1,193 · see citing works

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

Doyle, D., Lee, A., Lewis, J. H., Kim, E., Sheng, M., & MacKinnon, R. (1996) · Cell · doi:10.1016/s0092-8674(00)81307-0 · Cited by 1,126 · see citing works

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

Kim, E., Niethammer, M., Rothschild, A., Jan, Y. N., & Sheng, M. (1995) · Nature · doi:10.1038/378085a0 · Cited by 999 · see citing works

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

Woods, D. F., & Bryant, P. J. (1991) · Cell · doi:10.1016/0092-8674(81)90009-x · Cited by 898 · see citing works

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

Niethammer, M., Kim, E., & Sheng, M. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02157.1996 · Cited by 750 · see citing works

Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin

Ushkaryov, Y. A., Petrenko, A. G., Geppert, M., & Südhof, T. C. (1992) · Science · doi:10.1126/science.1621094 · Cited by 682 · see citing works

Neuroligin 1: A splice site-specific ligand for β-neurexins

Ichtchenko, K., Hata, Y., Nguyen, T., Ullrich, B., Missler, M., Moomaw, C. R., & Südhof, T. C. (1995) · Cell · doi:10.1016/0092-8674(95)90396-8 · Cited by 663 · see citing works

Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins.

Kim, E., Cho, K.-O., Rothschild, A., & Sheng, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80284-6 · Cited by 558 · see citing works

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

Hata, Y., Butz, S., & Sudhof, T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02488.1996 · Cited by 553 · see citing works

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones

Uchida, N., Honjo, Y., Johnson, K. R., Wheelock, M. J., & Takeichi, M. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.3.767 · Cited by 501 · see citing works

Cartography of neurexins: More than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons

Ullrich, B., Ushkaryov, Y. A., & Südhof, T. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90306-2 · Cited by 460 · see citing works

Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins

Ichtchenko, K., Nguyen, T., & Südhof, T. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2676 · Cited by 459 · see citing works

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

Jesaitis, L. A., & Goodenough, D. A. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.6.949 · Cited by 458 · see citing works

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

Kistner, U., Wenzel, B., Veh, R. W., Cases-Langhoff, C., Garner, A. M., APPELTAUER, U., Voss, B., Gundelfinger, E. D., & Garner, C. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53433-5 · Cited by 414 · see citing works

PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses

Hunt, C., Schenker, L. J., & Kennedy, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01380.1996 · Cited by 313 · see citing works

A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.

Hata, Y., & Südhof, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13022 · Cited by 188 · see citing works

Interaction of the N-Methyl—aspartate Receptor Complex with a Novel Synapse-associated Protein, SAP102

Lau, L., Mammen, A. L., Ehlers, M., Kindler, S., Chung, W. J., Garner, C. C., & Huganir, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.35.21622 · Cited by 177 · see citing works

Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.

Ushkaryov, Y. A., Hata, Y., Ichtchenko, K., Moomaw, C. R., Afendis, S. J., Slaughter, C. A., & Südhof, T. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32671-6 · Cited by 160 · see citing works

Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.

Ushkaryov, Y. A., & Südhof, T. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6410 · Cited by 149 · see citing works

Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

Ruff, P., Speicher, D. W., & Husain-Chishti, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6595 · Cited by 146 · see citing works

Apical junctions and cell signalling in epithelia

Woods, D. F., & Bryant, P. J. (1993) · Journal of Cell Science · doi:10.1242/jcs.1993.supplement_17.25 · Cited by 88 · see citing works

Dot-blot hybridization: quantitative analysis with direct beta counting.

Ma, S., Re, N., Roe, A. L., Rl, E., & Ja, B. (1991) · PubMed · Cited by 31 · see citing works

Neuroligins and neurexins link synaptic function to cognitive disease

Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849 · see citing works

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Peça, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z., & Feng, G. (2011) · Nature · doi:10.1038/nature09965 · Cited by 1,570 · see citing works

PSD-95 Involvement in Maturation of Excitatory Synapses

El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094 · see citing works

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits

Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2017.10.024 · Cited by 810 · see citing works

Signal-Processing Machines at the Postsynaptic Density

Kennedy, M. B. (2000) · Science · doi:10.1126/science.290.5492.750 · Cited by 788 · see citing works

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works

Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses

Song, J.-Y., Ichtchenko, K., Südhof, T. C., & Brose, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1100 · Cited by 696 · see citing works

The Postsynaptic Organization of Synapses

Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works

Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2

Chubykin, A. A., Atasoy, D., Etherton, M. R., Brose, N., Kavalali, E. T., Gibson, J. R., & Südhof, T. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.029 · Cited by 594 · see citing works

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

Chen, H.-J., Rojas-Soto, M., Oguni, A., & Kennedy, M. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)80471-7 · Cited by 590 · see citing works

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516 · see citing works

Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior

Blundell, J., Blaiss, C. A., Etherton, M. R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M. F., Südhof, T. C., & Powell, C. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4517-09.2010 · Cited by 450 · see citing works

Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing

Tabuchi, K., & Südhof, T. C. (2002) · Genomics · doi:10.1006/geno.2002.6780 · Cited by 305 · see citing works

NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area

Racca, C., Stephenson, F. A., Streit, P., Roberts, J. D. B., & Somogyi, P. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02512.2000 · Cited by 304 · see citing works

Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization

Takahashi, H., & Craig, A. M. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.002 · Cited by 257 · see citing works

Proline-Rich Synapse-Associated Protein-1/Cortactin Binding Protein 1 (ProSAP1/CortBP1) Is a PDZ-Domain Protein Highly Enriched in the Postsynaptic Density

Boeckers, T. M., Kreutz, M. R., Winter, C., Zuschratter, W., Smalla, K.-H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C. C., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06506.1999 · Cited by 257 · see citing works

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

Garcia, R. A. G., Vasudevan, K., & Buonanno, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3596 · Cited by 278 · see citing works

Synaptic Cell Adhesion

Missler, M., Sudhof, T. C., & Biederer, T. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005694 · Cited by 255 · see citing works

Disorder-associated mutations lead to functional inactivation of neuroligins

Chih, B., Afridi, S. K., Clark, L., & Scheiffele, P. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh158 · Cited by 242 · see citing works

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus

Zhang, W., Vazquez, L., Apperson, M., & Kennedy, M. B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00096.1999 · Cited by 190 · see citing works

An autism‐associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor‐mediated synaptic transmission in hippocampus

Etherton, M. R., Tabuchi, K., Sharma, M., Ko, J., & Südhof, T. C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.182 · Cited by 140 · see citing works

Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein

Mathew, D., Gramates, L. S., Packard, M., Thomas, U., Bilder, D., Perrimon, N., Gorczyca, M., & Budnik, V. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00758-3 · Cited by 134 · see citing works

Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism-linked excitatory synaptic suppressor MDGA2

Connor, S. A., Ammendrup-Johnsen, I., Chan, A. W., Kishimoto, Y., Murayama, C., Kurihara, N., Tada, A., Ge, Y., Lu, H., Yan, R., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.016 · Cited by 100 · see citing works

Synaptogenesis in the CNS: An Odyssey from Wiring Together to Firing Together

Munno, D. W., & Syed, N. I. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045062 · Cited by 86 · see citing works

Dynamics of nascent and active zone ultrastructure as synapses enlarge during long‐term potentiation in mature hippocampus

Bell, M. E., Bourne, J. N., Chirillo, M. A., Mendenhall, J. M., Kuwajima, M., & Harris, K. M. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23646 · Cited by 72 · see citing works

Sema4C, a Transmembrane Semaphorin, Interacts with a Post-synaptic Density Protein, PSD-95

Inagaki, S., Ohoka, Y., Sugimoto, H., Fujioka, S., Amazaki, M., Kurinami, H., Miyazaki, N., Tohyama, M., & Furuyama, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009051200 · Cited by 63 · see citing works

Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking

Chanda, S., Aoto, J., Lee, S.-J., Wernig, M., & Südhof, T. C. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.20 · Cited by 60 · see citing works

Synaptic Organizers in Alzheimer’s Disease: A Classification Based on Amyloid-β Sensitivity

Lee, A. K., Khaled, H., Chofflet, N., & Takahashi, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00281 · Cited by 14 · see citing works

Neuroligin 2 is exclusively localized to inhibitory synapses

Varoqueaux, F., Jamain, S., & Brose, N. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00410 · Cited by 552 · see citing works

Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding

Dresbach, T., Neeb, A., Meyer, G. R. Y. D., Gundelfinger, E. D., & Brose, N. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.013 · Cited by 97 · see citing works

Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses

Song, J.-Y., Ichtchenko, K., Südhof, T. C., & Brose, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1100 · Cited by 696 · see citing works

The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin

Meyer, G. R. Y. D., Varoqueaux, F., Neeb, A., Oschlies, M., & Brose, N. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.023 · Cited by 199 · see citing works

Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter

Nam, C. I., & Chen, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502038102 · Cited by 322 · see citing works