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TRF1 promotes parallel pairing of telomeric tracts in vitro
Abstract
Human telomeres consist of long arrays of TTAGGG repeats bound to the telomere-specific proteins, TRF1 and TRF2. Here we describe the structure of in vitro complexes formed between telomeric DNA and TRF1 as deduced by electron microscopy. Visualization of TRF1 bound to DNA containing six or 12 tandem TTAGGG repeats revealed a population of DNAs containing a spherical protein complex localized just to the repeats. Mass analysis of the protein complexes suggested binding of TRF1 dimers and tetramers to the TTAGGG repeats. The DNA was not significantly compacted or extended by protein binding. TRF1 formed filamentous structures on longer telomeric repeat arrays (>/=27 repeats) consistent with the presence of an array of bound TRF1 dimers. Unexpectedly, there was a strong propensity for two telomeric tracts to form paired synapses over the TRF1 covered segment. Up to 30% of the TRF1-bound DNAs could be found in a paired configuration with a strong bias for a parallel as contrasted to an antiparallel arrangement. TRF1-induced pairing was confirmed using a ligation assay which detected the formation of DNA multimers dependent on the presence of TRF1 and a 27mer repeat array in the DNA. These findings suggests that this protein may have an architectural role at telomeres. We discuss the possibility that TRF1-dependent changes in the conformation of telomeres are involved in the regulation of telomere length.
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“TRF1 has the ability to induce bending, looping, and pairing of duplex telomeric DNA (5, 6, 20, 21), activities that could facilitate the folding back of the telomere.”
From Control of Human Telomere Length by TRF1 and TRF2 (2000) · cites this paper as [20]
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Krutilina, R. I., Smirnova, A., Mudrak, O., Pleskach, N., Svetlova, M., Sl, O., Yau, P. M., Bradbury, E. M., Zalensky, A. O., & Tomilin, N. (2003) · Oncogene · doi:10.1038/sj.onc.1206745 · Cited by 16
Okabe, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddh032 · Cited by 17
Dynamics of TRF1 organizing a single human telomere
Li, X., Wang, M., Zheng, W., Huang, W., Wang, Z., Jin, K., Liu, L., & Yu, Z. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1222 · Cited by 15
Fujimoto, R., Kamata, N., Taki, M., Yokoyama, K., Tomonari, M., Nagayama, M., & Yasumoto, S. (2003) · Oral Oncology · doi:10.1016/s1368-8375(03)00003-4 · Cited by 15
Resolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells
Lisaingo, K., Uringa, E.-J., & Lansdorp, P. M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-10-0564 · Cited by 15
E-type cyclins modulate telomere integrity in mammalian male meiosis
Manterola, M., Siciński, P., & Wolgemuth, D. J. (2015) · Chromosoma · doi:10.1007/s00412-015-0564-3 · Cited by 14
Metadata
- Authors
- Griffith, J., Bianchi, A., & de Lange, T.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Rockefeller University (US)
- Corresponding author
- Griffith, Jack
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 278
- Issue
- 1
- Pages
- 79-88
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W1986492221
- Cited by
- 148
- References
- 32
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 6
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- TRF1, telomeres, TTAGGG repeats, protein-DNA complex, telomere length regulation, TRF2
- MeSH terms
- DNA, DNA-Binding Proteins, Humans, Nuclear Proteins, Telomere, Microsatellite Repeats, Telomeric Repeat Binding Protein 1
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