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Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies

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Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling Properties

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Disruption of protein–protein interactions: hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target – survivin

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Homology Modeling of Human Leptin/ Leptin Receptor Complex

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Identifying the Determinants in the Equatorial Domain of Buchnera GroEL Implicated in Binding Potato Leafroll Virus

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Characterization of a Discontinuous Neutralizing Epitope on Glycoprotein B of Human Cytomegalovirus

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A novel small-molecule PPI inhibitor targeting integrin αvβ3-osteopontin interface blocks bone resorption in vitro and prevents bone loss in mice

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Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants

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A Minimized M13 Coat Protein Defines the Requirements for Assembly into the Bacteriophage Particle

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Determination of the Functional Epitopes of Human Interleukin-18-binding Protein by Site-directed Mutagenesis

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PPI-HotspotDB: Database of Protein–Protein Interaction Hot Spots

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The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity

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Expression of a Recombinant Anti-HIV and Anti-Tumor Protein, MAP30, in Nicotiana tobacum Hairy Roots: A pH-Stable and Thermophilic Antimicrobial Protein

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Stability Characterization of a Vaccine Antigen Based on the Respiratory Syncytial Virus Fusion Glycoprotein

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Modulators of protein–protein interactions as antimicrobial agents

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Assessment of protein–protein interfaces in cryo-EM derived assemblies

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Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase

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Interaction of the Human Adenovirus Proteinase with Its 11-Amino Acid Cofactor pVIc

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Arbitrary protein−protein docking targets biologically relevant interfaces

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The insecticidal spider toxin SFI 1 is a knottin peptide that blocks the pore of insect voltage‐gated sodium channels via a large β‐hairpin loop

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Improving Protocols for Protein Mapping through Proper Comparison to Crystallography Data

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Sequence length dependence in arginine/phenylalanine oligopeptides: Implications for self-assembly and cytotoxicity

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Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides

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Human Proteins with Target Sites of Multiple Post-Translational Modification Types Are More Prone to Be Involved in Disease

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Structural, Energetic, and Functional Analysis of a Protein-Protein Interface at Distinct Stages of Affinity Maturation

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Alignment of Non-Covalent Interactions at Protein-Protein Interfaces

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Modeling the structure of mAb 14B7 bound to the anthrax protective antigen

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Hot Spot Occlusion from Bulk Water: a Comprehensive Study of the Complex between the Lysozyme HEL and the Antibody FVD1.3

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A Sharp Thermal Transition of Fast Aromatic‐Ring Dynamics in Ubiquitin

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Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation

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Unexpected specificity within dynamic transcriptional protein–protein complexes

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Dietary supplementation with aromatic amino acids decreased triglycerides and alleviated hepatic steatosis by stimulating bile acid synthesis in mice

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Development of a peptide aptamer pair-linked rapid fluorescent diagnostic system for Zika virus detection

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Intrinsic protein disorder uncouples affinity from binding specificity

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Monitoring Aromatic Picosecond to Nanosecond Dynamics in Proteins via 13C Relaxation: Expanding Perturbation Mapping of the Rigidifying Core Mutation, V54A, in Eglin c

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Sequences Prior to Conserved Catalytic Motifs of Polysialyltransferase ST8Sia IV Are Required for Substrate Recognition

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Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core Binding Factor β Subunit

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Identification of a Neutralizing Epitope within Antigenic Domain 5 of Glycoprotein B of Human Cytomegalovirus

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Filter-Based Methodology for the Location of Hot Spots in Proteins and Exons in DNA

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Aromatic residues link binding and function of intrinsically disordered proteins

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On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers

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Solvent Exposed Non-contacting Amino Acids Play a Critical Role in NF-κB/IκBα Complex Formation

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Distal Recognition Site for Classical Pathway Convertase Located in the C345C/Netrin Module of Complement Component C5

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Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family

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Clickable tryptophan modification for late-stage diversification of native peptides

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Double-sided α-helix mimetics

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A High-Affinity Gold-Binding Camel Antibody: Antibody Engineering for One-Pot Functionalization of Gold Nanoparticles as Biointerface Molecules

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Smoothing molecular interactions: The “kinetic buffer” effect of intrinsically disordered proteins

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Comparing interfacial dynamics in protein-protein complexes: an elastic network approach

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Oligophenylenaminones as Scaffolds for α-Helix Mimicry

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Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing

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Quantum Molecular Dynamics, Topological, Group Theoretical and Graph Theoretical Studies of Protein-Protein Interactions

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Learning protein binding affinity using privileged information

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Directed Mutagenesis Identifies Amino Acid Residues Involved in Elongation Factor Tu Binding to yeast Phe-tRNAPhe

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Characterizing Changes in the Rate of Protein-Protein Dissociation upon Interface Mutation Using Hotspot Energy and Organization

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NMR Studies of Protein–Ligand Interactions

Goldflam, M., Tarragó, T., Gairí, M., & Giralt, E. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-480-3_14 · Cited by 33

Monte Carlo simulations of the peptide recognition at the consensus binding site of the constant fragment of human immunoglobulin G: The energy landscape analysis of a hot spot at the intermolecular interface

Verkhivker, G. M., Bouzida, D., Gehlhaar, D. K., Rejto, P. A., Freer, S. T., & Rose, P. W. (2002) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.10164 · Cited by 34

When Monomers Are Preferred: A Strategy for the Identification and Disruption of Weakly Oligomerized Proteins

Tong, Y., Hughes, D., Placanica, L., & Buck, M. (2005) · Structure · doi:10.1016/j.str.2004.10.018 · Cited by 35

Quantifying the Energetics of Cooperativity in a Ternary Protein Complex

Andersen, P. S., Schuck, P., Sundberg, E. J., Geisler, C., Karjalainen, K., & Mariuzza, R. A. (2002) · Biochemistry · doi:10.1021/bi0200209 · Cited by 33

Protein–Protein Recognition: Juxtaposition of Domain and Interface Cores in Immunoglobulins and Other Sandwich-like Proteins

Potapov, V., Sobolev, V. M., Edelman, M., Kister, A. E., & Gelfand, I. M. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.06.072 · Cited by 37

Analysis of Antibody A6 Binding to the Extracellular Interferon γ Receptor α-Chain by Alanine-Scanning Mutagenesis and Random Mutagenesis with Phage Display

Lang, S., Xu, J., Stuart, F., Thomas, R. M., Vrijbloed, J. W., & Robinson, J. A. (2000) · Biochemistry · doi:10.1021/bi000838z · Cited by 33

A window into the human immune system: comprehensive characterization of the complexity of antibody complementary-determining regions in functional antibodies

Mejias-Gomez, O., Madsen, A. V., Skovgaard, K., Pedersen, L. E., Morth, J. P., Jenkins, T. P., Kristensen, P. K., & Goletz, S. (2023) · mAbs · doi:10.1080/19420862.2023.2268255 · Cited by 31

Antibody Epitopes on G Protein-Coupled Receptors Mapped with Genetically Encoded Photoactivatable Cross-Linkers

Ray‐Saha, S., Huber, T., & Sakmar, T. P. (2014) · Biochemistry · doi:10.1021/bi401289p · Cited by 32

Structural and Functional Analysis of the Tandem β-Zipper Interaction of a Streptococcal Protein with Human Fibronectin

Norris, N. C., Bingham, R. J., Harris, G., Speakman, A., Jones, R., Leech, A., Turkenburg, J. P., & Potts, J. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276592 · Cited by 32

In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction

Weber, D. J. (2010) · International Journal of High Throughput Screening · doi:10.2147/ijhts.s8210 · Cited by 32

Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan

Lawson, K. V., Rose, T. E., & Harran, P. G. (2013) · Tetrahedron · doi:10.1016/j.tet.2013.05.060 · Cited by 32

Binding interface prediction by combining protein-protein docking results

Hwang, H., Vreven, T., & Weng, Z. (2013) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24354 · Cited by 32

The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions

Tan, Y. S., Spring, D. R., Abell, C., & Verma, C. S. (2015) · Journal of Chemical Theory and Computation · doi:10.1021/ct5010577 · Cited by 33

Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins

Champeimont, R., Laine, É., Hu, S., Pénin, F., & Carbone, A. (2016) · Scientific Reports · doi:10.1038/srep26401 · Cited by 30

Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5

Bian, Y., Feng, Z., Yang, P., & Xie, X. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0093-5 · Cited by 33

Evolutionary diversification of protein–protein interactions by interface add-ons

Plach, M. G., Semmelmann, F., Büsch, F., Busch, M. R., Heizinger, L., Wysocki, V. H., Merkl, R., & Sterner, R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707335114 · Cited by 32

Empirical estimation of the energetic contribution of individual interface residues in structures of protein–protein complexes

Guharoy, M., & Chakrabarti, P. (2009) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-009-9282-3 · Cited by 21

Hot Spots at the Protein-Protein Interface

Kangueane, P., & Nilofer, C. (2018) · Springer eBooks · doi:10.1007/978-981-10-7347-2_7

Identification of hot spot residues at protein-protein interface

Li, L., Zhao, B. T., Zhanhua, C., Gan, J. G.-K., Sakharkar, M. K., & Kangueane, P. (2006) · Bioinformation · doi:10.6026/97320630001121 · Cited by 40

Hot Spot Occlusion from Bulk Water: a Comprehensive Study of the Complex between the Lysozyme HEL and the Antibody FVD1.3

Moreira, I. S., Fernandes, P. A., & Ramos, M. J. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp067096p · Cited by 34

Analysis and redesign of protein-protein interactions: A hotspot-centric view

Layton, C. J. (2010) · DukeSpace (Duke University)