M1 Muscarinic Acetylcholine Receptors Activate Extracellular Signal-Regulated Kinase in CA1 Pyramidal Neurons in Mouse Hippocampal Slices

Berkeley, Jennifer L.; Gomeza, Jesus; Wess, Jurgen; Hamilton, Susan E.; Nathanson, Neil M.; Levey, Allan I.

doi:10.1006/mcne.2001.1042

Cited by 98Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study

M1 Muscarinic Acetylcholine Receptors Activate Extracellular Signal-Regulated Kinase in CA1 Pyramidal Neurons in Mouse Hippocampal Slices

Berkeley, Jennifer L., Gomeza, Jesus, Wess, Jurgen, Hamilton, Susan E., Nathanson, Neil M., Levey, Allan I.·2001·Molecular and Cellular Neuroscience

DOI 10.1006/mcne.2001.1042

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Abstract

Activation of extracellular signal-regulated kinases (ERK) is crucial for many neural functions, including learning, memory, and synaptic plasticity. As muscarinic acetylcholine receptors (mAChR) modulate many of the same higher brain functions as ERK, we examined mAChR-mediated ERK activation in mouse hippocampal slices. The cholinergic agonist carbachol caused an atropine-sensitive ERK activation in the dendrites and somata CA1 pyramidal neurons. To determine the responsible mAChR subtype, we combined pharmacologic and genetic approaches. Pretreatment with M1 antagonists inhibited ERK activation. Furthermore, mAChR-induced ERK activation was absent in slices from M1 knockout mice. ERK activation was normal in slices derived from other mAChR subtype knockouts (M2, M3, and M4), although these other subtypes are expressed in many of the same neurons. Thus, we demonstrate divergent functions for the different mAChR subtypes. We conclude that M1 is responsible for mAChR-mediated ERK activation, providing a mechanism by which M1 may modulate learning and memory.

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From Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans (2011) · cites this paper as [37]

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
Cowley, S. A. (1994) · Cell · doi:10.1016/0092-8674(94)90133-3 · Cited by 1,988 · see citing works
Specificity and mechanism of action of some commonly used protein kinase inhibitors
Davies, S., Reddy, H., Caivano, M., & Cohen, P. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510095 · Cited by 1,618 · see citing works
Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies
Levey, A. I., Kitt, C. A., Wf, S., Price, D., & Brann, M. R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03218.1991 · Cited by 920 · see citing works
Self-citation
A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation
English, J. D., & Sweatt, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19103 · Cited by 860 · see citing works
Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
Crespo, P., Xu, N., Simonds, W. F., & Gutkind, J. S. (1994) · Nature · doi:10.1038/369418a0 · Cited by 801 · see citing works
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
Buckley, N. J., Bonner, T. I., Buckley, C. M., & Brann, M. R. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11261-3 · Cited by 635 · see citing works
Making New Connections
Impey, S., Obrietan, K. H., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80747-3 · Cited by 613 · see citing works
The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus
Roberson, E. D., English, J. D., Adams, J. P., Selcher, J. C., Kondratick, C. M., & Sweatt, J. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04337.1999 · Cited by 542 · see citing works
Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation
Hawes, B. E., van Biesen, T., Koch, W. J., Luttrell, L. M., & Lefkowitz, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17148 · Cited by 455 · see citing works
Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation
Levey, A. I., Edmunds, S. M., Koliatsos, V. E., Wiley, R. G., & Heilman, C. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04077.1995 · Cited by 423 · see citing works
Self-citation
Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology
Wu, G., Deisseroth, K. A., & Tsien, R. W. (2001) · Nature Neuroscience · doi:10.1038/83976 · Cited by 389 · see citing works
G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
Lu, W.-Y., Xiong, Z.-G., Lei, S., Orser, B. A., Dudek, E. M., Browning, M. D., & MacDonald, J. F. (1999) · Nature Neuroscience · doi:10.1038/7243 · Cited by 374 · see citing works
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
Yamada, M., Miyakawa, T., Duttaroy, A., Yamanaka, A., Moriguchi, T., Makita, R., Ogawa, M., Chou, C. J., Xia, B., Crawley, J. N., et al. (2001) · Nature · doi:10.1038/35065604 · Cited by 373 · see citing works
Self-citation
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice
Hamilton, S. E., Loose, M. D., Qi, M., Levey, A. I., Hille, B., McKnight, G. S., Idzerda, R. L., & Nathanson, N. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13311 · Cited by 366 · see citing works
Self-citation
Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice
Gomeza, J., Shannon, H. E., Kostenis, E., Felder, C. C., Zhang, L., Brodkin, J. D., Grinberg, A., SHENG, H. Z., & Wess, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1692 · Cited by 348 · see citing works
Self-citation
Active ERK/MAP kinase is targeted to newly forming cell–matrix adhesions by integrin engagement and v‐Src
Fincham, V. J., James, M., Frame, M. C., & Winder, S. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2911 · Cited by 340 · see citing works
Glutamate Induces Phosphorylation of Elk-1 and CREB, Along with c -fos Activation, via an Extracellular Signal-Regulated Kinase-Dependent Pathway in Brain Slices
Vanhoutte, P., Barnier, J., Guibert, B., Pagès, C., Besson, M., Hipskind, R. A., & Caboche, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.136 · Cited by 323 · see citing works
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M 4 muscarinic acetylcholine receptor knockout mice
Gomeza, J., Zhang, L., Kostenis, E., Felder, C. C., Bymaster, F. P., Brodkin, J. D., Shannon, H. E., Xia, B., Deng, C., & Wess, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10483 · Cited by 321 · see citing works
Self-citation
MAP2 is localized to the dendrites of hippocampal neurons which develop in culture
Cáceres, A., Banker, G. A., Steward, O., Binder, L. I., & Payne, M. R. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90167-6 · Cited by 320 · see citing works
Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- d -aspartate (NMDA) receptor currents in hippocampal pyramidal cells
Marino, M. J., Rouse, S. T., Levey, A. I., Potter, L. T., & Conn, P. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11465 · Cited by 275 · see citing works
Self-citation
Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade
Rocca, G. J. D., Maudsley, S. R., Daaka, Y., Lefkowitz, R. J., & Luttrell, L. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.13978 · Cited by 261 · see citing works
Role of MAP kinase in neurons
Fukunaga, K., & Miyamoto, E. (1998) · Molecular Neurobiology · doi:10.1007/bf02740604 · Cited by 256 · see citing works
D 2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
Yan, Z., Feng, J., Fienberg, A. A., & Greengard, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11607 · Cited by 224 · see citing works
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses
Bolshakov, V. Y., Carboni, L., Cobb, M. H., Siegelbaum, S. A., & Belardetti, F. (2000) · Nature Neuroscience · doi:10.1038/80624 · Cited by 217 · see citing works
Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus
Blitzer, R. D., Gil, O., & Landau, E. M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90835-w · Cited by 192 · see citing works
ERKI/II Regulation by the Muscarinic Acetylcholine Receptors in Neurons
Rosenblum, K., Futter, M., Jones, M. W., Hulme, E. C., & Bliss, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-00977.2000 · Cited by 180 · see citing works
Muscarinic receptors mediating depression and long‐term potentiation in rat hippocampus.
Auerbach, J. M., & Segal, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021323 · Cited by 168 · see citing works
A novel cholinergic induction of long-term potentiation in rat hippocampus
Auerbach, J. M., & Segal, M. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.4.2034 · Cited by 166 · see citing works
Prevention of PC12 Cell Death byN-Acetylcysteine Requires Activation of the Ras Pathway
Yan, C. Y. I., & Greene, L. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04042.1998 · Cited by 162 · see citing works
In VivoExpression and Regulation of Elk-1, a Target of the Extracellular-Regulated Kinase Signaling Pathway, in the Adult Rat Brain
Sgambato, V., Vanhoutte, P., Pagès, C., Rogard, M., Hipskind, R. A., Besson, M., & Caboche, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00214.1998 · Cited by 157 · see citing works
Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth
Abe, M. K., Kuo, W.-L., Hershenson, M. B., & Rosner, M. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1301 · Cited by 155 · see citing works
Presence and phosphorylation of transcription factors in developing dendrites
Crino, P. B., Khodakhah, K., Becker, K. G., Ginsberg, S. D., Hemby, S. E., & Eberwine, J. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2313 · Cited by 149 · see citing works
Coactivation of β-Adrenergic and Cholinergic Receptors Enhances the Induction of Long-Term Potentiation and Synergistically Activates Mitogen-Activated Protein Kinase in the Hippocampal CA1 Region
Watabe, A. M., Zaki, P. A., & O’Dell, T. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-05924.2000 · Cited by 147 · see citing works
Acetylcholine potentiates responses to in the rat hippocampus
Markram, H., & Segal, M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90495-u · Cited by 141 · see citing works
Mitogen‐Activated Protein Kinase‐Dependent and Protein Kinase C‐Dependent Pathways Link the m1 Muscarinic Receptor to β‐Amyloid Precursor Protein Secretion
Haring, R., Fisher, A., Marciano, D., Pittel, Z., Kloog, Y., Zuckerman, A., Eshhar, N., & Heldman, E. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052094.x · Cited by 122 · see citing works
A multiplicity of muscarinic mechanisms: Enough signaling pathways to take your breath away
Nathanson, N. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6245 · Cited by 121 · see citing works
Self-citation
Differential Coupling of α1-, α2-, and β-Adrenergic Receptors to Mitogen-activated Protein Kinase Pathways and Differentiation in Transfected PC12 Cells
Williams, N. G., Zhong, H., & Minneman, K. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24624 · Cited by 107 · see citing works
Carbachol effects on hippocampal neurons in vitro: dependence on the rate of rise of carbachol tissue concentration
M�ller, W., Misgeld, U., & Heinemann, U. (1988) · Experimental Brain Research · doi:10.1007/bf00250251 · Cited by 107 · see citing works
Stimulation of Mitogen-activated Protein Kinase by G Protein-coupled α2-Adrenergic Receptors Does Not Require Agonist-elicited Endocytosis
Schramm‐Sapyta, N. L., & Limbird, L. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24935 · Cited by 107 · see citing works
The M1 Receptor Is Required for Muscarinic Activation of Mitogen-activated Protein (MAP) Kinase in Murine Cerebral Cortical Neurons
Hamilton, S. E., & Nathanson, N. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011563200 · Cited by 99 · see citing works
Self-citation
Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca 2+ channels by using knockout mice
Shapiro, M. S., Loose, M. D., Hamilton, S. E., Nathanson, N. M., Gomeza, J., Wess, J., & Hille, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10899 · Cited by 99 · see citing works
Self-citation
Phosphorylation of Mitogen‐Activated Protein Kinase in Cultured Rat Cortical Glia by Stimulation of Metabotropic Glutamate Receptors
Peavy, R. D., & Conn, P. J. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71020603.x · Cited by 97 · see citing works
Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
Veeranna, G. J., Shetty, K. T., Takahashi, M., Grant, P. G., & Pant, H. C. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00003-6 · Cited by 83 · see citing works
Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors
Max, S. I., Liang, J., & Potter, L. T. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04293.1993 · Cited by 80 · see citing works
Signal Transduction Pathways of G Protein-coupled Receptors and Their Cross-Talk with Receptor Tyrosine Kinases: Lessons from Bradykinin Signaling
Liebmann, C., & Böhmer, F. (2000) · Current Medicinal Chemistry · doi:10.2174/0929867003374589 · Cited by 72 · see citing works
A Crucial Role for the Mitogen-Activated Protein Kinase Pathway in Nicotinic Cholinergic Signaling to Secretory Protein Transcription in Pheochromocytoma Cells
Tang, K., Wu, H., Mahata, S. K., & O’Connor, D. T. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.59 · Cited by 65 · see citing works
Region‐Specific Targets of p42/p44MAPK Signaling in Rat Brain
Bhat, R. V., Engber, T. M., Finn, J. P., Koury, E. J., Contreras, P. C., Miller, M. S., Dionne, C. A., & Walton, K. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020558.x · Cited by 54 · see citing works
Muscarinic Activation of Mitogen‐Activated Protein Kinase in PC12 Cells
Berkeley, J. L., & Levey, A. I. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750487.x · Cited by 52 · see citing works
Self-citation
M1, M3 and M5 Muscarinic Receptors Stimulate Mitogen-Activated Protein Kinase
Wotta, D. R., Wattenberg, E. V., Langason, R. B., & El‐Fakahany, E. E. (1998) · Pharmacology · doi:10.1159/000028196 · Cited by 39 · see citing works
Use of m1-toxin as a selective antagonist of m1 muscarinic receptors.
Max, S. I., Liang, J. S., Valentine, H. H., & Potter, L. T. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39526-1 · Cited by 35 · see citing works
Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells
Heasley, L. E., Senkfor, S. I., Winitz, S., Strasheim, A., Teitelbaum, I., & Berl, T. (1994) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1994.267.3.f366 · Cited by 25 · see citing works

Flagged first, then by citations

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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Wess, J., Eglen, R. M., & Gautam, D. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2379 · Cited by 637 · see citing works
“or CA1 hippocampal pyramidal neurons from M1R −/− mic”
BackgroundSelf-citation
Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes and Clinical Implications
Wess, J. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121622 · Cited by 381 · see citing works
Self-citation
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans
Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D'Angelo, G., Benzinger, T., Yoon, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107411108 · Cited by 370 · see citing works
“M1 muscarinic acetylcholine receptors activate the ERK signaling pathway (37), which is at least in part responsible for their regulation of APP processing (38).”
Background
Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus
Volpicelli‐Daley, L. A., & Levey, A. I. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45003-6 · Cited by 299 · see citing works
Self-citation
The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine
Weiner, D. M., Meltzer, H. Y., Veinbergs, I., Donohue, E. M., Spalding, T. A., Smith, T. T., Mohell, N., Harvey, S. C., Lameh, J., Nash, N. T., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1940-5 · Cited by 253 · see citing works
“We tested clozapine and NDMC for their ability to increase the phosphorylation of mitogen-activated protein kinase (MAP kinase) in the CA1 region of mouse hippocampus, a response that has been shown to reflect M1 receptor activation (Berkeley et al. 2001).”
MethodSelf-citation
G <sub>i/o</sub> protein‐coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission
Durkee, C. A., Covelo, A., Lines, J., Kofuji, P., Aguilar, J., & Araque, A. (2019) · Glia · doi:10.1002/glia.23589 · Cited by 224 · see citing works
“Type 1, 3, and 5 mAChRs, known to be coupled to Gq proteins, are highly expressed in hippocampal neurons (Berkeley et al., 2001; Park & Spruston, 2012; Scheiderer et al., 2008).”
Use of M1–M5 Muscarinic Receptor Knockout Mice as Novel Tools to Delineate the Physiological Roles of the Muscarinic Cholinergic System
Bymaster, F. P., McKinzie, D. L., Felder, C. C., & Wess, J. (2003) · Neurochemical Research · doi:10.1023/a:1022844517200 · Cited by 203 · see citing works
Self-citation
Paradoxical (REM) Sleep Deprivation Causes a Large and Rapidly Reversible Decrease in Long-Term Potentiation, Synaptic Transmission, Glutamate Receptor Protein Levels, and ERK/MAPK Activation in the Dorsal Hippocampus
Ravassard, P., Pachoud, B., Comte, J.-C., Mejia-Perez, C., Scoté-Blachon, C., Gay, N., Claustrat, B., Touret, M., Luppi, P.-H., & Salin, P. A. (2009) · Sleep · doi:10.1093/sleep/32.2.227 · Cited by 177 · see citing works
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine‐induced seizure activity
Bymaster, F. P., Carter, P. A., Yamada, M., Gomeza, J., Wess, J., Hamilton, S. E., Nathanson, N. M., McKinzie, D. L., & Felder, C. C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02588.x · Cited by 167 · see citing works
“Moreover, mitogen-activated protein kinase activation by M1 receptors may be involved in long-term potentiation, learning and memory (Berkeley et al., 2001; Hamilton & Nathanson, 2001).”
BackgroundSelf-citation
The Cu, Zn Superoxide Dismutase: Not Only a Dismutase Enzyme
Mondola, P., Damiano, S., Sasso, A., & Santillo, M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00594 · Cited by 166 · see citing works
“…the predominant subtype of muscarinic acetylcholine receptors in the central nervous system (CNS); this receptor, localized at post-synaptic level in the cortex, hippocampus, striatum, and thalamus (Ellis, 2002), activates the extracellular signal-regulated kinase pathway (Berkeley et al., 2001).”
Background
Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long-Term Depression That Is Affected in Fragile X Syndrome Mental Retardation
Volk, L. J., Pfeiffer, B. E., Gibson, J. R., & Huber, K. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2266-07.2007 · Cited by 164 · see citing works
“1F) (Dufner and Thomas, 1999; Roberson et al., 1999; Rosenblum et al., 2000; Berkeley et al., 2001).”
Developmental aspects of the cholinergic system
Abreu‐Villaça, Y., Filgueiras, C. C., & Manhães, A. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.049 · Cited by 166 · see citing works
Novel insights into muscarinic acetylcholine receptor function using gene targeting technology
Wess, J. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00195-0 · Cited by 139 · see citing works
Self-citation
N-Desmethylclozapine, a Major Metabolite of Clozapine, Increases Cortical Acetylcholine and Dopamine Release In Vivo Via Stimulation of M1 Muscarinic Receptors
Li, Z., Huang, M., Ichikawa, J., Dai, J., & Meltzer, H. Y. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300768 · Cited by 136 · see citing works
“M1 receptors in the hippocampus have been shown to activate extracellular signal-regulated kinases (ERK), which are crucial for many neural functions, including learning, memory, and synaptic plasticity (Berkeley et al, 2001).”
Background
Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice
Salzmann, J., Cynthia Marie-claire, A., Guen, S. L., Roques, B. P., & Noble, F. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705506 · Cited by 122 · see citing works
“…also play a role in the effects observed following MDMA administration, as this compound can directly interact with relatively high affinities to a2-adrenoreceptors, M-1 muscarinic and H-1 histamine receptors (Battaglia et al., 1988), all possibly activating ERK pathways (Berkeley et al., 2001).”
Background
Muscarinic receptor subtypes in the alimentary tract.
Tobin, G., Giglio, D., & Lundgren, O. (2009) · PubMed · Cited by 112 · see citing works
Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
You, Y., Kim, J., Cobb, M. H., & Avery, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.012 · Cited by 95 · see citing works
“One of the widely studied downstream pathways is the MAPK pathway (Berkeley et al., 2001; Hamilton and Nathanson, 2001).”
Background
Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research
Damar, U., Gersner, R., Johnstone, J. T., Schachter, S. C., & Rotenberg, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1175303 · Cited by 92 · see citing works
“In vitro and in vivo studies in rodents showed that M1 mAChR modulates hippocampal plasticity and plays a role in cognitive enhancement [90,91].”
The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory
Giovannini, M. G., Lana, D., & Pepeu, G. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.12.014 · Cited by 87 · see citing works
Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response
Calandreau, L., Trifilieff, P., Mons, N. E., Costes, L., Marien, M. R., Marighetto, A., Micheau, J., Jaffard, R., & Desmedt, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3713-06.2006 · Cited by 85 · see citing works
“Twenty-four hours later, while animals were drug free, they were tested for freezing behavior (measured second-by-second), used as an index of conditioned fear and defined as a lack of all movement, except for respiratory-related movements (Blanchard and Blanchard, 1969).”
Method
The role of muscarinic acetylcholine receptor‐mediated activation of extracellular signal‐regulated kinase 1/2 in pilocarpine‐induced seizures
Berkeley, J. L., Decker, M. J., & Levey, A. I. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00977.x · Cited by 74 · see citing works
Self-citation
Muscarinic Acetylcholine Receptor Knockout Mice
Wess, J., Zhang, W., Duttaroy, A., Miyakawa, T., Gomeza, J., Cui, Y., Basile, A. S., Bymaster, F. P., McKinzie, D. L., Felder, C. C., et al. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18934-0_3 · Cited by 73 · see citing works
“On the other hand, this activity remained unaffected by the lack of M2–M4 mAChRs ( Berkeley et al. 2001 ).”
BackgroundInfluentialSelf-citation
AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model
Bradley, S. R., Lameh, J., Ohrmund, L., Son, T., Bajpai, A., Nguyen, D., Friberg, M., Burstein, E. S., Spalding, T. A., Ott, T. R., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.10.003 · Cited by 68 · see citing works
“M1 muscarinic receptors activation increases ERK1/2 phosphorylation, which is necessary for several forms of learning and memory (Adams and Sweatt, 2002; Berkeley et al., 2001; Giovannini, 2006; Kelly et al., 2003; Samuels et al., 2008; Thiels and Klann, 2001).”
Agmatine protects against scopolamine-induced water maze performance impairment and hippocampal ERK and Akt inactivation
Moosavi, M., Yadollahikhales, G., Abbasi, L., Zarifkar, A., & Rastegar, K. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.031 · Cited by 67 · see citing works
“…studies have revealed that ERK activation can induces muscarinic receptor expression and activation in CA1 pyramidal neurons of the hippocampus (Berkeley et al., 2001) meaning that even ERK activation by agmatine may increase muscarinic receptor activation which counteracts scopolamine…”
Background
Inactivation of JAK2/STAT3 Signaling Axis and Downregulation of M1 mAChR Cause Cognitive Impairment in klotho Mutant Mice, a Genetic Model of Aging
Park, S.-J., Shin, E., Min, S. S., An, J., Li, Z., Chung, Y. H., Jeong, J. H., Bach, J., Nah, S.-Y., Kim, W.-K., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.39 · Cited by 67 · see citing works
Positive allosteric modulation of M 1 and M 4 muscarinic receptors as potential therapeutic treatments for schizophrenia
Yohn, S. E., & Conn, P. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.012 · Cited by 67 · see citing works
“tein involved in synaptic plasticity (Berkeley et al., 2001).”
Acetylcholine release in the hippocampus and striatum during place and response trainingPreprint
Pych, J. C., Chang, Q., Colon-Rivera, C., Haag, R., & Gold, P. E. (2005) · Learning & Memory · doi:10.1101/lm.33105 · Cited by 64 · see citing works
“…transduction mechanisms including, for example, protein kinase C (Rossi et al. 2005), extra-cellular signal-regulated kinase (Rosenblum et al. 2000; Berkeley et al. 2001), cGMP (Gillette and Mitchell 2002), and activation of transcription factors (Greenberg et al. 1986), such as cyclic AMP…”
Background
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M., & Christopoulos, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.606656 · Cited by 63 · see citing works
“In M4 mAChR knockout mice, ERK1/2 signaling was unaffected; suggesting that activation of ERK1/2 is not a critical pathway downstream of the M4 mAChR (Berkeley et al., 2001; Wess, 2004).”
Background
Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders
Digby, G. J., Shirey-Rice, J. K., & Conn, P. J. (2010) · Molecular BioSystems · doi:10.1039/c002938f · Cited by 62 · see citing works
Coactivation of M1Muscarinic and α1 Adrenergic Receptors Stimulates Extracellular Signal-Regulated Protein Kinase and Induces Long-Term Depression at CA3–CA1 Synapses in Rat Hippocampus
Scheiderer, C. L., Smith, C. C., McCutchen, E., McCoy, P. A., Thacker, E. E., Kolasa, K., Dobrunz, L. E., & McMahon, L. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5058-06.2008 · Cited by 58 · see citing works
“…activation, in addition to stimulating the PLC pathway, stimulates the Src family of tyrosine kinases (Lindquist et al., 2000; Rosenblum et al., 2000; Chan et al., 2005), which subsequently stimulates phosphorylation of ERK (Igishi and Gutkind, 1998; Berkeley et al., 2001; Vanhoose et al., 2002).”
Fustin flavonoid attenuates β‐amyloid (1–42)‐induced learning impairment
Jin, C., Shin, E., Park, J., Jang, C., Li, Z., Kim, M. S., Koo, K. H., Yoon, H., Park, S., Choi, W., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22159 · Cited by 57 · see citing works
“In addition, previous double-label immunocytochemistry results indicate that ERK activation induces M1 receptor expression in CA1 pyramidal neurons (Berkeley et al., 2001).”
Result
Evaluation of N-Desmethylclozapine as a Potential Antipsychotic—Preclinical Studies
Natesan, S., Reckless, G. E., Barlow, K. B. L., Nóbrega, J. N., & Kapur, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301279 · Cited by 54 · see citing works
“…but not clozapine, leads to a dose-dependent activation of mitogen-activated protein kinase (MAPK) in the CA1 region of the hippocampus and also potentiates NDMA receptor currents, actions mediated by the muscarinic M1 receptors (Berkeley et al, 2001; Sur et al, 2003; Weiner et al, 2004).”
Background
The Selective M1 Muscarinic Cholinergic Agonist CDD-0102A Enhances Working Memory and Cognitive Flexibility
Ragozzino, M. E., Artis, S., Singh, A. T., Twose, T. M., Beck, J. E., & Messer, W. S. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.187625 · Cited by 53 · see citing works
Physiological roles of CNS muscarinic receptors gained from knockout mice
Thomsen, M., Sørensen, G., & Dencker, D. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.011 · Cited by 51 · see citing works
“In CA1 pyramidal neurons, cholinergic activation of extracellular signal-regulated kinase (ERK) 1/2 was shown to occur through stimulation of M1 receptors, but not M2, M3, or M4 receptors (Berkeley et al., 2001).”
The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review
Slater, C. L., Liu, Y., Weiss, E., Yu, K., & Wang, Q. (2022) · Brain Sciences · doi:10.3390/brainsci12070890 · Cited by 49 · see citing works
Effects of hypothyroidism induced by perinatal exposure to PTU on rat behavior and synaptic gene expression
Kobayashi, K., Tsuji, R., Yoshioka, T., Kushida, M., Yabushita, S., Sasaki, M., Mino, T., & Seki, T. (2005) · Toxicology · doi:10.1016/j.tox.2005.04.012 · Cited by 49 · see citing works
Altered M1 Muscarinic Acetylcholine Receptor (CHRM1)-Gαq/11 Coupling in a Schizophrenia Endophenotype
Salah-Uddin, H., Scarr, E., Pavey, G., Harris, K., Hagan, J. J., Dean, B., Challiss, R. A. J., & Watson, J. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.41 · Cited by 48 · see citing works
Cell-Specific Extracellular Signal-Regulated Kinase Activation by Multiple G Protein-Coupled Receptor Families in Hippocampus
Berkeley, J. L., & Levey, A. I. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.128 · Cited by 47 · see citing works
“These include acetylcholine acting at muscarinic acetylcholine receptors (mAChRs) (Berkeley et al., 2001), glutamate acting at metabotropic glutamate receptors (mGluRs) (Peavy and Conn, 1998), and norepinephrine acting at -adrenergic receptors ( -AR) (Williams et al., 1998; Winder et al., 1999;…”
BackgroundMethodInfluentialSelf-citation
Presynaptic Metabotropic Receptors for Acetylcholine and Adrenaline/Noradrenaline
Gilsbach, R., & Hein, L. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-74805-2_9 · Cited by 46 · see citing works
Estrogen and progesterone improve scopolamine-induced impairment of spatial memory.
Tanabe, F., Miyasaka, N., Kubota, T., & Asô, T. (2004) · PubMed · Cited by 42 · see citing works
Altered hippocampal muscarinic receptors in acetylcholinesterase‐deficient mice
Volpicelli‐Daley, L. A., Duysen, E. G., Lockridge, O., & Levey, A. I. (2003) · Annals of Neurology · doi:10.1002/ana.10589 · Cited by 42 · see citing works
“signaling cascades associated with synaptic plasticity and cell excitability.(8,20,21) Alterations in dendritic availability of M1 could change the responsiveness of pyramidal cells to agonist activation.”
BackgroundSelf-citation
IL-6 attenuates trimethyltin-induced cognitive dysfunction via activation of JAK2/STAT3, M1 mAChR and ERK signaling network
Kim, B. K., Tran, H.-Y. P., Shin, E., Lee, C., Chung, Y. H., Jeong, J. H., Bach, J., Kim, W.-K., Park, D. H., Saito, K., et al. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.02.017 · Cited by 41 · see citing works
4‐Aminopyridine‐induced epileptogenesis depends on activation of mitogen‐activated protein kinase ERK
Merlo, D., Cifelli, P., Cicconi, S., Tancredi, V., & Avoli, M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02382.x · Cited by 41 · see citing works
Plasticity of burst firing in subiculum induced by synergistic activation of metabotropic glutamate and acetylcholine receptors
Moore, S., Cooper, D. C., & Spruston, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.013 · Cited by 39 · see citing works
“For example, the actions of mGluR1 and mAChRs have been shown to activate extracellular signal-regulated kinase (ERK) in different cellular compartments (Berkeley et al., 2001).”
Constitutive Activity of Muscarinic Acetylcholine Receptors
Spalding, T. A., & Burstein, E. S. (2006) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890600567349 · Cited by 38 · see citing works
“Roles for M5 in maintenance of cerebral vascular tone (104), M1 in hippocampal neuronal activity (105), and M3 in control of smooth muscle tone in bladder, lung, and stomach (106), and in food intake (107) have been reported.”
Background
Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons
Sabbir, M. G., & Fernyhough, P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.020 · Cited by 37 · see citing works
“The muscarinic acetylcholine type 1 receptor (M1R) has been identified as a major receptor subtype that acutely mediates agonist (carbachol/oxotremorine) stimulated ERK activation in cultured primary mouse cortical and hippocampal neurons (Berkeley et al., 2001; Hamilton and Nathanson, 2001).”
Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome
Wattanathorn, J., Palachai, N., Thukham-mee, W., & Muchimapura, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3096826 · Cited by 37 · see citing works
Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease
Giovannini, M. G., Cerbai, F., Bellucci, A., Melani, C., Grossi, C., Bartolozzi, C., Nosi, D., & Casamenti, F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.061 · Cited by 37 · see citing works
Memory enhancing actions of Asiasari radix extracts via activation of insulin receptor and extracellular signal regulated kinase (ERK) I/II in rat hippocampus
Han, Y. C., & Kim, S. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02580-0 · Cited by 36 · see citing works
Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons
Sabbir, M. G., Calcutt, N. A., & Fernyhough, P. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00402 · Cited by 34 · see citing works
The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia
Yohn, S. E., Harvey, P. D., Brannan, S. K., & Horan, W. P. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1421554 · Cited by 33 · see citing works
Inhibition of acetylcholine-induced activation of extracellular regulated protein kinase prevents the encoding of an inhibitory avoidance response in the rat
Giovannini, M. G., Pazzagli, M., Malmberg‐Aiello, P., Corte, L., Rakovska, A., Cerbai, F., Casamenti, F., & Pepeu, G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.046 · Cited by 32 · see citing works
Section I. The Cholinergic System
Smythies, J. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)64001-9 · Cited by 32 · see citing works
Exposure to far-infrared rays attenuates methamphetamine-induced recognition memory impairment via modulation of the muscarinic M1 receptor, Nrf2, and PKC
Nhu, H., Sharma, N., Shin, E., Nguyen, B. T., Nguyen, P. T., Jeong, J. H., Jang, C., Cho, E.-H., Nah, S.-Y., Kim, N., et al. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.03.009 · Cited by 31 · see citing works
“Members of ERK family are also activated in response to M1 mAChR (Berkeley et al., 2001).”
α-Isocubebenol alleviates scopolamine-induced cognitive impairment by repressing acetylcholinesterase activity
Song, S. H., Choi, S. M., Kim, J. E., Sung, J. E., Lee, H. A., Choi, Y. H., Bae, C. J., Choi, Y. W., & Hwang, D. Y. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.012 · Cited by 31 · see citing works
Cu–Zn superoxide dismutase activates muscarinic acetylcholine M1 receptor pathway in neuroblastoma cells
Damiano, S., Petrozziello, T., Ucci, V., Amente, S., Santillo, M., & Mondola, P. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.11.001 · Cited by 29 · see citing works
Modulation of long‐term potentiation by individual subtypes of muscarinic acetylcholine receptor in the rat dentate gyrus
Luo, L., Chen, W., Wang, M., Zhu, D., She, J., & Ruan, D. (2008) · Hippocampus · doi:10.1002/hipo.20461 · Cited by 29 · see citing works
“cellular signaling pathways involved in LTP induction (Berkeley et al., 2001; Hamilton and Nathanson, 2001).”
Background
Differential Effects of Allosteric M1 Muscarinic Acetylcholine Receptor Agonists on Receptor Activation, Arrestin 3 Recruitment, and Receptor Downregulation
Davis, A. A., Heilman, C. J., Brady, A. E., Miller, N., Fuerstenau-Sharp, M., Hanson, B. J., Lindsley, C. W., Conn, P. J., Lah, J. J., & Levey, A. I. (2010) · ACS Chemical Neuroscience · doi:10.1021/cn100011e · Cited by 29 · see citing works
Self-citation
Muscarinic mechanisms in psychotic disorders.
McKinzie, D., & Bymaster, F. (2012) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25758-2_9 · Cited by 22 · see citing works
Pharmacological Assessment of M1 Muscarinic Acetylcholine Receptor-Gq/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue
Salah-Uddin, H., Thomas, D. R., Davies, C. H., Hagan, J. J., Wood, M. D., Watson, J. M., & Challiss, R. A. J. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.137968 · Cited by 23 · see citing works
Theanine attenuates memory impairments induced by <i>klotho</i> gene depletion in mice
Nguyen, B. T., Sharma, N., Shin, E.-J., Jeong, J. H., Lee, S. H., Jang, C.-G., Nah, S.-Y., Nabeshima, T., Yoneda, Y., & Kim, H.-C. (2019) · Food & Function · doi:10.1039/c8fo01577e · Cited by 22 · see citing works
Immunohistochemical Localization of Proteins in the Nervous System
Volpicelli‐Daley, L. A., & Levey, A. I. (2003) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0102s25 · Cited by 21 · see citing works
“Anticipated Results Typical results from Basic Protocols 1 and 3 are shown in many publications (e.g., Levey et al., 1991, 1995a,b; Gilmor et al., 1996; Berkeley et al., 2001).”
BackgroundSelf-citation
Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information
David, O., Barrera, I., Adaikkan, C., Kaphzan, H., Nakazawa, T., Yamamoto, T. S., & Rosenblum, K. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00066 · Cited by 21 · see citing works
“For example, the muscarinic agonist carbachol (Cch) induces prolonged dose-dependent activation of ERK1/2 in the CA1 pyramidal neurons of mice (Rosenblum et al., 2000; Berkeley et al., 2001).”
Background
Cholinergic Hypofunction in Presbycusis-Related Tinnitus With Cognitive Function Impairment: Emerging Hypotheses
Ruan, Q., Yu, Z., Zhang, W., Ruan, J., Liu, C., & Zhang, R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00098 · Cited by 21 · see citing works
“Such activation could improve learning, memory, synaptic plasticity, and cognitive functions via the activation of extracellular signal-regulated kinases (Berkeley et al., 2001; Ragozzino et al., 2012).”
Background
Vitis labruscana leaf extract ameliorates scopolamine-induced impairments with activation of Akt, ERK and CREB in mice
Pariyar, R., Yoon, C., Svay, T., Kim, D. S., Cho, H.-K., Kim, S. Y., Oh, H., Kim, Y., Kim, J.-H., Lee, H.-S., et al. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.008 · Cited by 20 · see citing works
Muscarinic acetylcholine receptors and voltage-gated calcium channels contribute to bidirectional synaptic plasticity at CA1-subiculum synapses
Shor, O., Fidzinski, P., & Behr, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.11.012 · Cited by 20 · see citing works
Conversion of short-term potentiation to long-term potentiation in mouse CA1 by coactivation of β-adrenergic and muscarinic receptorsPreprint
Connor, S. A., Maity, S., Roy, B., Ali, D. W., & Nguyen, P. (2012) · Learning & Memory · doi:10.1101/lm.026898.112 · Cited by 21 · see citing works
“Both b1-ARs (Roberson et al. 1999) and muscarinic receptors (Berkeley et al. 2001) are capable of ERK activation.”
Background
Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain
Deguil, J., Pérault‐Pochat, M. C., Chavant, F., Lafay‐Chebassier, C., Fauconneau, B., & Pain, S. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.08.012 · Cited by 19 · see citing works
The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice
Baral, S., Cho, D., Pariyar, R., Yoon, C., Chang, B., Kim, D. S., Cho, H.-K., Kim, S. Y., Oh, H., Kim, Y., et al. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/925432 · Cited by 18 · see citing works
“The activation of mAChR in the neurons leads to the elevation of intracellular calcium level, phosphoinositol turnover that activates ERK [9].”
Background
Changes in cortical gene expression in the muscarinic M1 receptor knockout mouse: potential relevance to schizophrenia, Alzheimer’s disease and cognition
Dean, B., & Scarr, E. (2021) · Schizophrenia · doi:10.1038/s41537-021-00174-z · Cited by 17 · see citing works
Protection from interferon‐β‐induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation
Olianas, M. C., Dedoni, S., & Onali, P. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13570 · Cited by 17 · see citing works
“This finding is consistent with a previous study showing that M1 receptors activate ERK1/2 in CA1 pyramidal neurons in mouse hippocampal slices (Berkeley et al., 2001).”
Result
Kai Xin San aqueous extract improves Aβ 1-40 -induced cognitive deficits on adaptive behavior learning by enhancing memory-related molecules expression in the hippocampus
Lü, C., Shi, Z., Sun, X., Pan, R., Chen, S., Li, Y., Qu, L., Sun, L., Dang, H., Bu, L.-L., et al. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.10.002 · Cited by 17 · see citing works
“…activated protein kinase (MAPK) family and necessary for cell growth, differentiation, survival, molecular information processing and structural changes stabilizing in dendritic spines (Berkeley et al., 2001; Caccamo et al., 2006; Ivanov et al., 2006; Lee and Silva, 2009; Sindreu et al., 2007).”
Background
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor
Chen, K., Park, E., & Abd‐Elrahman, K. S. (2025) · Molecular Pharmacology · doi:10.1016/j.molpha.2025.100027 · Cited by 15 · see citing works
Lack of hippocalcin causes impairment in Ras/extracellular signal‐regulated kinase cascade via a Raf‐mediated activation process
Noguchi, H., Kobayashi, M., Miwa, N., & Takamatsu, K. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21180 · Cited by 14 · see citing works
“Net intensities for phospho-ERK2 bands were calculated by normalizing to the intensities for total ERK2 (Berkeley et al., 2001; Derkinderen et al., 2003).”
Method
Euonymus alatus Twig Extract Protects against Scopolamine-Induced Changes in Brain and Brain-Derived Cells via Cholinergic and BDNF Pathways
Gurung, P., Shrestha, R., Lim, J., Magar, T. B. T., Kim, H.-H., & Kim, Y. (2022) · Nutrients · doi:10.3390/nu15010128 · Cited by 13 · see citing works
“Furthermore, activation of downstream signaling molecules like ERK and CREB signaling molecules is also associated with neurotransmitters like acetylcholine and activation of their receptors [44].”
Background
The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons1
Willets, J. M., Nelson, C. P., Nahorski, S. R., & Challiss, R. A. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04931.x · Cited by 11 · see citing works
Antagonism of Muscarinic Acetylcholine Receptors Alters Synaptic ERK Phosphorylation in the Rat Forebrain
Mao, L., Wang, H. H., & Wang, J. Q. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2157-9 · Cited by 10 · see citing works
Antipsychotic effects of N-desmethylclozapine on sensorimotor gating function in rats — Possible involvement of activation of M1 muscarinic receptors
Maehara, S., Satow, A., Hikichi, H., & Ohta, H. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.063 · Cited by 10 · see citing works
Tong Luo Jiu Nao ameliorates Aβ1–40-induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
Shi, Z., Lü, C., Sun, X., Wang, Q., Chen, S., Li, Y., Qu, L., Chen, L., Bu, L.-L., Liao, D., et al. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0584-9 · Cited by 10 · see citing works
“The ERK-1 and ERK-2 (ERK1/2) are the members of the mitogen activated protein kinase (MAPK) family and necessary for cell growth, differentiation, survival, molecular information processing and structural changes stabilizing in dendritic spines [56,65-68].”
Background
T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus
Yokoyama, I., Sakai, Y., Hatayama, Y., Tsuji, S., Kōyama, Y., Baba, A., & Matsuda, T. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00142-3 · Cited by 7 · see citing works
A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine
Tamijani, S. M. S., Beirami, E., Ghazvini, H., Rafaiee, R., Nazeri, M., & Razavinasab, M. (2023) · Addiction and Health · doi:10.34172/ahj.2023.1307 · Cited by 6 · see citing works
“64 As previously mentioned, ERK1/2 is involved in the cognitive functions and is affected by MA toxicity.”
Background
Cholinesterase inhibitors and stress: Effects on brain muscarinic receptor density in mice
Mauck, B., Lucot, J. B., Paton, S. J., & Grubbs, R. D. (2010) · NeuroToxicology · doi:10.1016/j.neuro.2010.06.001 · Cited by 6 · see citing works
Muscarinic M1receptor and cannabinoid CB1receptor do not modulate paraoxon‐induced seizures
Kow, R. L., Cheng, E. M., Jiang, K., Le, J. H., Stella, N., & Nathanson, N. M. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.100 · Cited by 6 · see citing works
“2005), and M1 receptors mediate muscarinic agonist-induced ERK activation in these regions in vitro (Berkeley et al. 2001; Hamilton and Nathanson 2001).”
BackgroundResultInfluentialSelf-citation
Muscarinic Acetylcholine Receptors in the Central Nervous System: Structure, Function, and Pharmacology
Christopoulos, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-46526-5_5 · Cited by 6 · see citing works
Extracts of Liriopsis tuber protect AMPA induced brain damage and improve memory with the activation of insulin receptor and ERK I/II
Kim, S., & Lee, K. (2008) · Phytotherapy Research · doi:10.1002/ptr.2475 · Cited by 5 · see citing works
Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia
Hopper, S., Udawela, M., Scarr, E., & Dean, B. (2016) · World Journal of Pharmacology · doi:10.5497/wjp.v5.i1.32 · Cited by 4 · see citing works
Muscarinic Acetylcholine Receptors
Wess, J. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn005 · Cited by 4 · see citing works
Self-citation
CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment
Fisher, A., & Levey, A. I. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19088-9.00016-0 · Cited by 4 · see citing works
Self-citation
Antimuscarinic drugs exert β-arrestin–biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis
Amiri, S., Aghanoori, M., Smith, D. R., Waise, T. M. Z., Lao, Y., Inoue, A., Zahedi, R. P., Dunn, H. A., & Fernyhough, P. (2026) · Science Signaling · doi:10.1126/scisignal.ady7187 · Cited by 2 · see citing works
Perinatal mAChR-mediated activation of cortical subplate neurons elicits network activity driving basket cell differentiation
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Ravassard, P., Pachoud, B., Comte, J., Mejia-Perez, C., Scoté-Blachon, C., Claustrat, B., Touret, M., Luppi, P., & Salin, P. A. (2009)
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Shirey-Rice, J. K. (2010)
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Ripoll, N. (2005) · OpenGrey (Institut de l'Information Scientifique et Technique)
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Calandreau, L. (2006) · Oskar-Bordeaux (Universite de Bordeaux)
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Deguil, J. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

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Rosenblum, K., Futter, M., Jones, M. W., Hulme, E. C., & Bliss, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-00977.2000 · Cited by 180 · see citing works
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Hamilton, S. E., & Nathanson, N. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011563200 · Cited by 99 · see citing works
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Futter, M. (2000) · UCL Discovery (University College London)
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Shinoe, T., Matsui, M., Taketo, M. M., & Manabe, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2338-05.2005 · Cited by 237 · see citing works
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Dasari, S., & Gulledge, A. T. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00686.2010 · Cited by 145 · see citing works

Authors: Berkeley, J. L., Gomeza, J., Wess, J., Hamilton, S. E., Nathanson, N. M., & Levey, A. I.
Affiliations: Emory University (US)
University of Washington (US)
Corresponding author: Levey, Allan I.
ORCID: Berkeley, Jennifer L.
Nathanson, Neil M.
Levey, Allan I.
Venue: Molecular and Cellular Neuroscience
Publisher: Elsevier BV
Published: 2001-11
Volume: 18
Issue: 5
Pages: 512-524
ISSN: 1044-7431 (ISSN-L)
DOI: 10.1006/mcne.2001.1042
OpenAlex: W2049272814
Cited by: 98
References: 53
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
FWCI: 1.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Pharmaceutical Research and Manufacturers of America Foundation
National Institute of Neurological Disorders and Stroke (R01NS30454, R01NS26920, R01NS026920, R01NS030454)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: M1 muscarinic receptor, extracellular signal-regulated kinase, ERK activation, CA1 pyramidal neurons, hippocampus, carbachol, cholinergic neurotransmission, learning and memory, synaptic plasticity
MeSH terms: Animals, Atropine, Carbachol, Cell Nucleus, Dendrites, Dose-Response Relationship, Drug, Hippocampus, Male, Mecamylamine, Receptors, Muscarinic, Protein Serine-Threonine Kinases, Pyramidal Cells, Mice, Knockout, Cholinergic Agonists, Muscarinic Antagonists, Nicotinic Antagonists, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, Receptor, Muscarinic M1, Mitogen-Activated Protein Kinase 3, MAP Kinase Kinase 1, Mice

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M1 Muscarinic Acetylcholine Receptors Activate Extracellular Signal-Regulated Kinase in CA1 Pyramidal Neurons in Mouse Hippocampal Slices

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