A novel cholinergic induction of long-term potentiation in rat hippocampus

Auerbach, J. M.; Segal, M.

doi:10.1152/jn.1994.72.4.2034

Cited by 166Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNicotinic Acetylcholine Receptors Study

A novel cholinergic induction of long-term potentiation in rat hippocampus

Auerbach, J. M., Segal, M.·1994·Journal of Neurophysiology

DOI 10.1152/jn.1994.72.4.2034

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Abstract

1. We studied long-term cholinergic effects on synaptic transmission in submerged hippocampal slices using intra- and extracellular recording techniques. 2. Bath application of submicromolar concentrations of carbachol (CCh) produced a gradually developing, long-lasting increase in the CA1 excitatory postsynaptic potential and population spike. This potentiation was blocked by atropine and, hence, named muscarinic long-term potentiation (LTPm). Application of DL-2-amino-5-phosphonovaleric acid had no effect on LTPm, indicating that this phenomenon is N-methyl-D-aspartate receptor independent. 3. These effects of CCh were not likely to be due to the blockade of one of several K+ conductances by the drug; the time and concentration dependence of LTPm were different from those associated with cholinergic blockade of K+ conductances. 4. Removal of extracellular calcium (Cao2+) from the bath blocked synaptic transmission. CCh added in calcium-free medium induced LTPm, which was revealed upon removal of the drug by washing with normal calcium-containing medium. Neither cutting CA1-CA3 connections nor cessation of synaptic stimulation interfered with LTPm induction. 5. Application of thapsigargin or H-7 together with CCh blocked LTPm, suggesting the involvement of intracellular calcium (Cai2+) stores and protein kinases, respectively, in the LTPm mechanism. 6. Subthreshold cholinergic stimulation coupled with subthreshold tetanic stimulation caused LTP. CCh had no effect when administered after the LTP mechanism had been saturated by repeated suprathreshold tetani. Tetanic stimulation failed to cause LTP when applied after LTPm had been induced by CCh. These experiments indicate that tetanus-induced potentiation and LTPm share a common mechanism and provide a direct link between ACh and mechanisms of synaptic plasticity.

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The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus.
“The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus (Blitzer et al., 1990; Burgard and Sarvey, 1990; Auerbach and Segal, 1994; Isaac et al., 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Auerbach and Segal, 1994

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Cholinergic modulation of synaptic transmission and plasticity in entorhinal cortex and hippocampus of the rat
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“can induce long-lasting potentiation of synaptic transmission in hippocampus.(4) Thus ACh is capable of modulating as well as inducing synaptic plasticity in hippocampus.”
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Differential Effects of PACAP-38 on Synaptic Responses in Rat Hippocampal CA1 RegionPreprint
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“…induce a long-lasting muscarinic enhancement of EPSPs (Krnjevic et al. 1981; Marchi and Raitieri 1989; Blitzer et al. 1990; Markram and Segal 1990; Auerbach and Segal 1994) as well as a suppression of the CA1 responses evoked by stimulation of Schaffer collateral-commissural fibers (Krnjevic et…”
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Authors: Auerbach, J. M., & Segal, M.
Affiliations: Weizmann Institute of Science (IL)
ORCID: Segal, M.
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 1994-10-01
Volume: 72
Issue: 4
Pages: 2034-2040
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.1994.72.4.2034
OpenAlex: W1959981723
Cited by: 166
References: 0
Citations by year: 2025: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 9 · 2013: 6 · 2012: 10
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: carbachol, muscarinic receptors, hippocampal CA1, excitatory postsynaptic potentials, population spike, intracellular calcium stores, protein kinases, tetanic stimulation, synaptic transmission
MeSH terms: Acetylcholine, Animals, Cholinergic Fibers, Hippocampus, Male, Synaptic Transmission, Neuronal Plasticity, Receptors, Cholinergic, Synapses, Rats, Wistar, Long-Term Potentiation, Culture Techniques, Rats

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A novel cholinergic induction of long-term potentiation in rat hippocampus

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