Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

Blitzer, Robert D.; Gil, Orlando; Landau, Emmanuel M.

doi:10.1016/0304-3940(90)90835-w

Cited by 192Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNicotinic Acetylcholine Receptors Study

Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

Blitzer, Robert D., Gil, Orlando, Landau, Emmanuel M.·1990·Neuroscience Letters

DOI 10.1016/0304-3940(90)90835-w

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Abstract

The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 microM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.

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The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus.
“The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus (Blitzer et al., 1990; Burgard and Sarvey, 1990; Auerbach and Segal, 1994; Isaac et al., 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Blitzer et al., 1990

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Authors: Blitzer, R. D., Gil, O., & Landau, E. M.
Affiliations: United States Department of Veterans Affairs (US)
Mount Sinai Hospital (US)
Corresponding author: Blitzer, Robert D.
ORCID: Blitzer, Robert D.
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1990-11
Volume: 119
Issue: 2
Pages: 207-210
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/0304-3940(90)90835-w
OpenAlex: W2071637530
Cited by: 192
References: 23
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 8 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 8
FWCI: 1.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-02219, P50AG005138, 5-P50-AG05138-02, P01AG002219)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: long-term potentiation, cholinergic stimulation, carbachol, acetylcholine, hippocampal CA1, tetanic stimulation, presynaptic depression, postsynaptic mechanisms, memory
MeSH terms: Animals, Atropine, Carbachol, Electric Stimulation, Hippocampus, Male, Parasympathomimetics, Rats, Inbred Strains, Rats

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Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

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