Advanced Glycation End Products Induce Angiogenesis in Vivo
Abstract
Advanced glycation end products (AGEs) have been thought to participate in diabetic microangiopathy. However, the effects of AGEs on angiogenesis have so far been mainly examined either in vitro or by using cultured cells. In the present study, we have analyzed whether AGEs induce angiogenesis in vivo by using the chorioallantoic membrane (CAM) assay. The CAM assay was carried out in embryonated hen eggs to determine the effects of AGEs. Following generation of AGEs based on bovine serum albumin (BSA), either AGE-BSA or nonglycated BSA was administered to the CAM and their effects on angiogenesis were assessed, together with an inhibitory effect of an anti-AGE antibody against AGE-BSA-induced angiogenesis. The histological features of AGE-induced vascular lumens were examined by immunohistochemical analysis for Factor VIII and smooth muscle alpha-actin. AGE-BSA induced angiogenesis in CAM in a dose- and time-dependent manner. AGE-induced angiogenesis on CAM was neutralized by the anti-AGE antibody. Immunohistochemical analysis demonstrated that AGE-induced vascular lumens were devoid of pericytes. Our data demonstrated that AGEs are an angiogenetic factor and that our system of AGE-induced abnormal vessels in CAMs is useful in further investigations of the mechanism of diabetic retinal angiogenesis and can also be used to provide a therapeutic model for diabetic angiopathy.
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Advanced glycation end products stimulate vascular endothelial growth factor expression and angiogenesis in vivo.
“Indeed AGEs stimulate vascular endothelial growth factor expression (35) and angiogenesis in vivo (36)”
From Drusen proteome analysis: an approach to the etiology of age-related macular degeneration (2002) · cites this paper as [36]
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- Authors
- Okamoto, T., Tanaka, S., Stan, A. C., Koike, T., Kase, M., Makita, Z., Sawa, H., & Nagashima, K.
- Affiliations
- Hokkaido University (JP)
- Medizinische Hochschule Hannover (DE)
- Teine Keijinkai Hospital (JP)
- Kurume University (JP)
- Venue
- Microvascular Research
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 63
- Issue
- 2
- Pages
- 186-195
- ISSN
- 0026-2862 (ISSN-L)
- OpenAlex
- W2006104786
- Cited by
- 47
- References
- 33
- Citations by year
- 2022: 2 · 2020: 1 · 2018: 2 · 2017: 3 · 2014: 2 · 2012: 3
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microvascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- advanced glycation end products, angiogenesis, diabetic microangiopathy, chorioallantoic membrane assay, bovine serum albumin, pericytes
- MeSH terms
- Animals, Chick Embryo, Chorion, Dose-Response Relationship, Drug, Humans, Immunohistochemistry, Lymphokines, Neovascularization, Pathologic, Recombinant Proteins, Time Factors, Linear Models, Endothelial Growth Factors, Glycation End Products, Advanced, Fractals, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Diabetes Complications
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