CoChat
Sign Up
Cited by 52

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier

Poduslo, Joseph F., Curran, Geoffry L., Haggard, Jill J., Biere, Anja Leona, Selkoe, Dennis J.·1997·Neurobiology of Disease
DOI 10.1006/nbdi.1997.0132
Open this paper in CoChat — free account

Abstract

The permeability of normal human, the human Dutch variant, and the rat A beta 1-40 proteins at the blood-brain barrier (BBB) was determined in the normal adult rat by quantifying the permeability coefficient-surface area (PS) product for each protein after correction for the residual plasma volume (Vp) occupied by the protein in the blood vessels of different brain regions. The PS for normal and Dutch A beta ranged from 13 x 10(-6) to 22 x 10(-6) ml/g/s in different brain regions, which is 130 to 220 times greater than albumin. These high PS values compare to that of insulin, whose uptake is decidedly by a receptor-mediated transport process, and suggest a similar mechanism for A beta. Remarkably, the PS for rat A beta was 4 times higher and ranged from 54 x 10(-6) to 82 x 10(-6) ml/g/s for different brain regions, suggesting a distinctive species specificity. While the Vp values of human and rat A beta were comparable, the Dutch variant was 2 to 3 times higher, indicating adherence to the vessel walls in different brain regions, consistent with the heavy A beta deposition that has been described in intracerebral vessel walls with this variant. The high PS values observed for A beta at the BBB suggest that sources outside the nervous system could contribute, at least in part, to the cerebral A beta deposits seen in Alzheimer's disease. SDS-PAGE of 125I-labeled human A beta after 60 min of uptake revealed intact protein in plasma and in different brain regions. In addition, 12…

Overview

Integrity signals

Registry

Crossref · 10.1006/nbdi.1997.0132

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 1 references

Research works printed but not linked: 36

  1. Biere, 1996, Amyloid β-peptide (Aβ) is transported on lipoproteins and albumin in human plasma, J. Biol. Chem., 271, 32916, 10.1074/jbc.271.51.32916 · DOI · Paper page
  2. Clemens, 1992, Implants containing β-amyloid protein are not neurotoxic to young and old rat brain, Neurobiol. Aging, 13, 581, 10.1016/0197-4580(92)90059-7 · DOI
  3. Emre, 1992, The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected β-amyloid in the rat brain, Neurobiol. Aging, 13, 553, 10.1016/0197-4580(92)90055-3 · DOI
  4. Games, 1992, Lack of Alzheimer pathology after β-amyloid protein injections in rat brain, Neurobiol. Aging, 13, 569, 10.1016/0197-4580(92)90057-5 · DOI
  5. Haan, 1990, Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Clinical and computed tomographic analysis of 24 cases, Arch. Neurol., 47, 649, 10.1001/archneur.1990.00530060059018 · DOI
  6. Kowall, 1991, An in vivo model for the neurodegenerative effects of beta-amyloid and protection by substance-P, Proc. Natl. Acad. Sci. USA, 88, 7247, 10.1073/pnas.88.16.7247 · DOI
  7. Kowall, 1992, In vivo neurotoxicity of β-amyloid [β(1-40)] and the β(25-35) fragment, Neurobiol. Aging, 13, 537, 10.1016/0197-4580(92)90053-Z · DOI
  8. Levy, 1990, Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type, Science, 248, 1124, 10.1126/science.2111584 · DOI
  9. Luyendijk, 1988, Hereditary cerebral haemorrhage caused by cortical amyloid angiopathy, J. Neurol. Sci., 85, 267, 10.1016/0022-510X(88)90186-4 · DOI
  10. Maness, 1994, Passage of human amyloid β-protein 1-40 across the murine blood–brain barrier, Life Sci., 55, 1643, 10.1016/0024-3205(94)00331-9 · DOI · Paper page
  11. Martel, 1996, Blood–brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs, Neurosci. Lett., 206, 157, 10.1016/S0304-3940(96)12462-9 · DOI · Paper page
  12. Ohno, 1978, Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat, Am. J. Physiol., 235, H299
  13. Podlisny, 1993, Microinjection of synthetic amyloid β-protein in monkey cerebral cortex fails to produce acute neurotoxicity, Am. J. Pathol., 142, 17
  14. Poduslo, 1982, Altered blood nerve barrier in experimental lead neuropathy assessed by changes in endoneurial albumin concentration, J. Neurosci., 2, 1507, 10.1523/JNEUROSCI.02-10-01507.1982 · DOI
  15. Poduslo, 1988, Increase in albumin, IgG, and IgM blood–nerve barrier indices in human diabetic neuropathy, Proc. Natl. Acad. Sci. USA, 85, 4879, 10.1073/pnas.85.13.4879 · DOI
  16. Poduslo, 1992, Increased permeability across the blood–nerve barrier of albumin glycatedin vitroin vivo, Proc. Natl. Acad. Sci. USA, 89, 2218, 10.1073/pnas.89.6.2218 · DOI
  17. Poduslo, 1994, Glycation increases in permeability of proteins across the blood–nerve and blood–brain barriers, Molec. Brain Res., 23, 157, 10.1016/0169-328X(94)90222-4 · DOI
  18. Poduslo, 1996, Polyamine modification increases the permeability of proteins at the blood–nerve and blood–brain barriers, J. Neurochem., 66, 1599, 10.1046/j.1471-4159.1996.66041599.x · DOI
  19. Poduslo, 1996, Permeabilities at the blood–brain and blood–nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF, Mol. Brain Res., 36, 280, 10.1016/0169-328X(95)00250-V · DOI · Paper page
  20. Poduslo, 1980, Molecular weight estimation using sodium dodecyl sulfate-pore gradient electrophoresis, Anal. Biochem., 101, 394, 10.1016/0003-2697(80)90205-5 · DOI
  21. Rush, 1992, Intracerebral β-amyloid(25-35) produces tissue damage: Is it neurotoxic?, Neurobiol. Aging, 13, 591, 10.1016/0197-4580(92)90061-2 · DOI
  22. Saito, 1995, Vector-mediated delivery of1251-401-40, Proc. Natl. Acad. Sci. USA, 92, 10227, 10.1073/pnas.92.22.10227 · DOI · Paper page
  23. Smith, 1985, Measurement of protein using bicinchoninic acid, Anal. Biochem., 150, 76, 10.1016/0003-2697(85)90442-7 · DOI · Paper page
  24. Smyth, 1994, Analysis of brain injury following intrahippocampal administration of beta-amyloid in streptozotocin-treated rats, Neurobiol. Aging, 15, 153, 10.1016/0197-4580(94)90106-6 · DOI
  25. Snow, 1994, An important role of heparin sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain, Neuron, 12, 219, 10.1016/0896-6273(94)90165-1 · DOI
  26. Stein-Behrens, 1992, Failure of β-amyloid protein fragment 25-35 to cause hippocampal damage in the rat, Neurobiol. Aging, 13, 577, 10.1016/0197-4580(92)90058-6 · DOI
  27. Stephenson, 1992, In vivo effects of β-amyloid implants in rodents: Lack of potentiation of damage associated with transient global forebrain ischemia, Brain Res., 586, 235, 10.1016/0006-8993(92)91632-O · DOI
  28. Van Broeckhoven, 1990, Amyloid β protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch), Science, 248, 1120, 10.1126/science.1971458 · DOI
  29. van Duinen, 1987, Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease, Proc. Natl. Acad. Sci. USA, 84, 5991, 10.1073/pnas.84.16.5991 · DOI
  30. Waite, 1992, Solvent effects on beta protein toxicity in vivo, Neurobiol. Aging, 13, 595, 10.1016/0197-4580(92)90062-3 · DOI
  31. Wang, 1994, Hippocampal β-amyloid reduces locus coeruleus glutamate and tyrosine hydroxylase, Brain Res. Bull., 35, 485, 10.1016/0361-9230(94)90162-7 · DOI
  32. Wattendorff, 1995, Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): Clinicopathological studies, J. Neurol. Neurosurg. Psychiatry, 58, 699, 10.1136/jnnp.58.6.699 · DOI
  33. Winkler, 1994, Lack of long-term effects after β-amyloid protein injections in rat brain, Neurobiol. Aging, 15, 601, 10.1016/0197-4580(94)00054-9 · DOI
  34. Zlokovic, 1993, Blood–brain barrier transport of circulating Alzheimer's amyloid β, Biochem. Biophys. Res. Commun., 197, 1034, 10.1006/bbrc.1993.2582 · DOI · Paper page
  35. Zlokovic, 1994, Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid β, Biochem. Biophys. Res. Commun., 205, 1431, 10.1006/bbrc.1994.2825 · DOI
  36. Zlokovic, 1996, Glycoprotein 330/megalin: Probable role in receptor-mediated transport of apolipoprotein j alone and in a complex with Alzheimer disease amyloid beta at the blood–brain and blood–cerebrospinal fluid barriers, Proc. Natl. Acad. Sci. USA, 93, 4229, 10.1073/pnas.93.9.4229 · DOI · Paper page

Cited by

Sorted by citations

See all 52

Metadata

Authors
Poduslo, J. F., Curran, G. L., Haggard, J. J., Biere, A. L., & Selkoe, D. J.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
1997-01
Volume
4
Issue
1
Pages
27-34
ISSN
0969-9961
DOI
10.1006/nbdi.1997.0132
Cited by
52
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier. https://app.cochat.ai/papers/10.1006/nbdi.1997.0132
The paper
Poduslo, J. F., Curran, G. L., Haggard, J. J., Biere, A. L., & Selkoe, D. J. (1997). Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier. Neurobiology of Disease. https://doi.org/10.1006/nbdi.1997.0132