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Passage of human amyloid β-protein 1–40 across the murine blood-brain barrier
Abstract
Previous studies have suggested that the amyloid beta-protein present in the brains of patients with Alzheimer's disease may be derived in part from peripheral blood. We determined that after IV injection of synthetic amyloid beta-protein 1-40 (A beta), labeled with radioactive 125I (I-A beta), radioactivity accumulated in the brains of mice by a nonsaturable mechanism. Radioactivity also accumulated in the brain after the i.v. injection of radioiodinated reverse amyloid beta-protein 40-1 (I-rA beta). Capillary depletion techniques, however, showed I-A beta to have a much greater degree of association with brain capillaries than I-rA beta. Acid precipitation of radioactivity in CSF samples and recovery from cortical homogenates suggested the presence of intact I-A beta within the CNS after peripheral administration. HPLC analysis of cortical homogenates confirmed the presence of intact I-A beta. Gel electrophoresis of the CSF acid precipitates and of the HPLC fractions further verified the presence of intact blood-derived I-A beta peptide in CNS. These results suggest that endogenous bloodborne A beta can enter the CNS after associating with the capillary endothelium to accumulate intact within the parenchymal and CSF spaces of the brain.
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Circulating free Aβ is metabolized during its transport across the BBB, possibly by pericytes.
“Previous studies have shown that circulating free A b is also metabolized during its transport across the BBB (48, 49, 65, 66), possibly by pericytes, which represent a major enzymatic barrier for the transport of several peptides and proteins across the BBB (67).”
From Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier (2000) · cites this paper as [49]
Previous studies have demonstrated a major role of the BBB in determining the concentrations of Aβ in the CNS by regulating transport of circulating Aβ.
“Previous studies from our laboratory and others have demonstrated a major role of the BBB in determining the concentrations of A b in the CNS by regulating transport of circulating A b (33, 39, 49-51, 62-66).”
From Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier (2000) · cites this paper as [49]
Citations
Cites
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975
Amyloid β-peptide is produced by cultured cells during normal metabolism
Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921
Self-citationIsolation and quantification of soluble Alzheimer's β-peptide from biological fluids
Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schiossmacher, M., Whaley, J., Swindlehurst, C., et al. (1992) · Nature · doi:10.1038/359325a0 · Cited by 1,731
Self-citationProduction of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., et al. (1992) · Science · doi:10.1126/science.1439760 · Cited by 1,447
Flagged first, then by citations
Research works printed but not linked: 37
- Pike, 1991, Eur. J. Pharmacol., 207, 367, 10.1016/0922-4106(91)90014-9 · DOI
- Pike, 1991, Brain Res., 563, 311, 10.1016/0006-8993(91)91553-D · DOI
- Roher, 1991, Biochem. Biophys. Res. Commun., 174, 572, 10.1016/0006-291X(91)91455-L · DOI
- Malouf, 1992, Neurobiol. Aging, 13, 543, 10.1016/0197-4580(92)90054-2 · DOI
- Koh, 1990, Brain Res., 533, 315, 10.1016/0006-8993(90)91355-K · DOI
- Mattson, 1992, J. Neurosci., 12, 367, 10.1523/JNEUROSCI.12-02-00376.1992 · DOI
- Kowall, 1991, 88, 7247
- Frautschy, 1991, 88, 8362
- Kowall, 1992, Neurobiol. Aging, 13, 537, 10.1016/0197-4580(92)90053-Z · DOI
- Emre, 1992, Neurobiol. Aging, 13, 553, 10.1016/0197-4580(92)90055-3 · DOI
- Games, 1992, Neurobiol. Aging, 13, 569, 10.1016/0197-4580(92)90057-5 · DOI
- Stein-Behrens, 1992, Neurobiol. Aging, 13, 577, 10.1016/0197-4580(92)90058-6 · DOI
- Podlisny, 1993, Am. J. Path., 142, 17
- Tagliavini, 1988, Neurosci. Lett., 93, 191, 10.1016/0304-3940(88)90080-8 · DOI
- Yamaguchi, 1988, Acta. Neuropathol., 77, 113, 10.1007/BF00687420 · DOI · Paper page
- Masters, 1985, 82, 4245
- Selkoe, 1986, J. Neurochem., 146, 1820, 10.1111/j.1471-4159.1986.tb08501.x · DOI
- Miyakawa, 1982, Virchows Arch., 40, 121, 10.1007/BF02932857 · DOI
- Glenner, 1984, Biochem. Biophys. Res. Commun., 120, 885, 10.1016/S0006-291X(84)80190-4 · DOI · Paper page
- Joachim, 1988, Nature, 341, 226, 10.1038/341226a0 · DOI
- Monning, 1990, Febs Lett., 277, 261, 10.1016/0014-5793(90)80861-C · DOI
- Allen, 1991, Neurosci. Lett., 132, 109, 10.1016/0304-3940(91)90445-Y · DOI
- Schlossmacher, 1992, Neurobiol. Aging, 13, 421, 10.1016/0197-4580(92)90117-G · DOI
- Gardella, 1992, Lab. Invest., 67, 303
- Gardella, 1992, Neurosci. Lett., 138, 229, 10.1016/0304-3940(92)90921-S · DOI
- Banks, 1991, Brain Res. Bull., 27, 819, 10.1016/0361-9230(91)90215-6 · DOI
- Zlokovic, 1993, Biochem. Biophys. Res. Commun., 197, 1034, 10.1006/bbrc.1993.2582 · DOI · Paper page
- Mori, 1992, J. Biol. Chem., 267, 17082, 10.1016/S0021-9258(18)41896-0 · DOI
- Blasberg, 1983, J. Cereb. Blood Flow Metab., 3, 8, 10.1038/jcbfm.1983.2 · DOI
- Patlak, 1983, J. Cereb. Blood flow Metab., 3, 1, 10.1038/jcbfm.1983.1 · DOI
- Triguero, 1990, J. Neurochem., 54, 1882, 10.1111/j.1471-4159.1990.tb04886.x · DOI
- Gutierrez, 1993, J. Neuroimmunology, 47, 169, 10.1016/0165-5728(93)90027-V · DOI · Paper page
- Banks, 1993, Rev. Neurosci., 4, 365, 10.1515/REVNEURO.1993.4.4.365 · DOI
- Banks, 1993, J. Pharmacol. Exp. Ther., 267, 690
- Banks, 1994, J. Neurochem., 62, 2404, 10.1046/j.1471-4159.1994.62062404.x · DOI
- Banks, 1994, J. Physiol. (London)
- Yamaguchi, 1992, Am. J. Path., 141, 249
Cited by
Sorted by citations
Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development
Chen, G.-F., Xu, T.-H., Yan, Y., Zhou, Y.-R., Jiang, Y., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.28 · Cited by 1,965
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426
Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413
Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R., & Zlokovic, B. V. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600419 · Cited by 670
Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease
Erickson, M. A., & Banks, W. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.135 · Cited by 572
Self-citationAmyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma
Biere, A. L., Ostaszewski, B., Stimson, E. R., Hyman, B. T., Maggio, J. E., & Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32916 · Cited by 331
Self-citationJaeger, L. B., Dohgu, S., Sultana, R., Lynch, J. L., Owen, J. B., Erickson, M. A., Shah, G. N., Price, T. O., Fleegal-Demotta, M. A., Butterfiled, D. A., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.01.017 · Cited by 281
Self-citationMackic, J. B., Stins, M., McComb, J. G., Calero, M., Ghiso, J., Kim, K. S., Yan, S. D., Stern, D., Schmidt, A. M., Frangione, B., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2029 · Cited by 242
Cytokine Signaling Modulates Blood-Brain Barrier Function
Pan, W., P. Stone, K., Hsuchou, H., K. Manda, V., Zhang, Y., & J. Kastin, A. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798220918 · Cited by 241
ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury
Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage
Hafezi-Moghadam, A., Thomas, K. L., & Wagner, D. D. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00563.2005 · Cited by 149
Circulating Biomarkers of Cognitive Decline and Dementia
Solfrizzi, V., D'Introno, A., Colacicco, A. M., Capurso, C., Todarello, O., Pellicani, V., Capurso, S. A., Pietrarossa, G., Santamato, V., Capurso, A., et al. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.06.015 · Cited by 120
Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
Chen, S.-H., Tian, D.-Y., Shen, Y.-Y., Cheng, Y., Fan, D.-Y., Sun, H.-L., He, C.-Y., Sun, P.-Y., Bu, X.-L., Zeng, F., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01113-9 · Cited by 89
Metadata
- Authors
- Maness, L. M., Banks, W. A., Podlisny, M. B., Selkoe, D. J., & Kastin, A. J.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 55
- Issue
- 21
- Pages
- 1643-1650
- ISSN
- 0024-3205
- Cited by
- 97
- References
- 4
- Language
- en
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