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Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier

Poduslo, Joseph F., Curran, Geoffry L., Haggard, Jill J., Biere, Anja Leona, Selkoe, Dennis J.·1997·Neurobiology of Disease
DOI 10.1006/nbdi.1997.0132
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Abstract

The permeability of normal human, the human Dutch variant, and the rat A beta 1-40 proteins at the blood-brain barrier (BBB) was determined in the normal adult rat by quantifying the permeability coefficient-surface area (PS) product for each protein after correction for the residual plasma volume (Vp) occupied by the protein in the blood vessels of different brain regions. The PS for normal and Dutch A beta ranged from 13 x 10(-6) to 22 x 10(-6) ml/g/s in different brain regions, which is 130 to 220 times greater than albumin. These high PS values compare to that of insulin, whose uptake is decidedly by a receptor-mediated transport process, and suggest a similar mechanism for A beta. Remarkably, the PS for rat A beta was 4 times higher and ranged from 54 x 10(-6) to 82 x 10(-6) ml/g/s for different brain regions, suggesting a distinctive species specificity. While the Vp values of human and rat A beta were comparable, the Dutch variant was 2 to 3 times higher, indicating adherence to the vessel walls in different brain regions, consistent with the heavy A beta deposition that has been described in intracerebral vessel walls with this variant. The high PS values observed for A beta at the BBB suggest that sources outside the nervous system could contribute, at least in part, to the cerebral A beta deposits seen in Alzheimer's disease. SDS-PAGE of 125I-labeled human A beta after 60 min of uptake revealed intact protein in plasma and in different brain regions. In addition, 12…

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Metadata

Authors
Poduslo, J. F., Curran, G. L., Haggard, J. J., Biere, A. L., & Selkoe, D. J.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
1997-01
Volume
4
Issue
1
Pages
27-34
ISSN
0969-9961
DOI
10.1006/nbdi.1997.0132
Cited by
52
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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