The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ethanol-Induced Caspase-3 Activation in the in Vivo Developing Mouse Brain
Open accessAbstract
Recently several methods have been described for triggering extensive apoptotic neurodegeneration in the developing in vivo mammalian brain. These methods include treatment with drugs that block NMDA glutamate receptors, drugs that promote GABA(A) neurotransmission, or treatment with ethanol, which has both NMDA antagonist and GABAmimetic properties. A single intoxication episode induced by any of these agents is sufficient to cause widespread neurodegeneration throughout many brain regions. The cell death process transpires rapidly from early to late stages within several hours. As the neurons die, they become TUNEL positive and show, by both light and electron microscopy, all of the classical morphological characteristics of apoptosis. In the present study, using immunocytochemical methods, we document that ethanol intoxication of 7-day-old infant mice causes a widespread pattern of caspase-3 activation corresponding to the pattern of apoptotic neurodegeneration that is occurring simultaneously.
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Cites
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055
Self-citation
Cited by
Jevtovic-Todorovic, V., Hartman, R. E., Izumi, Y., Benshoff, N. D., Dikranian, K., Zorumski, C. F., Olney, J. W., & Wozniak, D. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00876.2003 · Cited by 1,983
Self-citationYoung, C., Jevtovic‐Todorovic, V., Qin, Y., Tenkova, T., Wang, H., Labruyere, J., & Olney, J. W. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706301 · Cited by 476
Self-citationKetamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain
Brambrink, A. M., Evers, A. S., Avidan, M. S., Farber, N. B., Smith, D. J., Martin, L. D., Dissen, G. A., Creeley, C. E., & Olney, J. W. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318242b2cd · Cited by 425
Self-citationAlcohol Teratogenesis: Mechanisms of Damage and Strategies for Intervention
Goodlett, C. R., Horn, K. H., & Zhou, F. C. (2005) · Experimental Biology and Medicine · doi:10.1177/15353702-0323006-07 · Cited by 383
Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
Donovan, M. H., Yazdani, U., Norris, R. D., Games, D., German, D. C., & Eisch, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20840 · Cited by 351
Metadata
- Authors
- Olney, J. W., Tenkova, T., Dikranian, K., Muglia, L. J., Jermakowicz, W. J., D'Sa, C., & Roth, K. A.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 9
- Issue
- 2
- Pages
- 205-219
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W1973376874
- Cited by
- 241
- References
- 2
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Olney, J. W., Tenkova, T., Dikranian, K., Muglia, L. J., Jermakowicz, W. J., D'Sa, C., & Roth, K. A. (2002). Ethanol-Induced Caspase-3 Activation in the in Vivo Developing Mouse Brain. Neurobiology of Disease. https://doi.org/10.1006/nbdi.2001.0475
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